glu-asp-arg and Disease-Models--Animal

While studying the effects of Cortexin and Pinealon (Glu-Asp-Arg) on the caspase-3 activity in the brain, an interleykin-6 and a factor of tumor necrosis in blood serum of old rats under the sharp hypoxic hypoxia it was suggested that in hypoxia of brain conditions Pinealon forwards the increase of the neurogenesis and the decrease neuroinflammatory reactions to a reference level. With the sharp hypoxic hypoxia Cortexin reduces an ability of brain tissue of programmed cells death, but saves the content of interleykin-6 at high level.

Topics: Acute Disease; Animals; Apoptosis; Brain; Caspase 3; Disease Models, Animal; Hypoxia; Intercellular Signaling Peptides and Proteins; Interleukin-6; Male; Neurogenesis; Oligopeptides; Peptides; Rats; Tumor Necrosis Factor-alpha

The comparative research of effect of Pinealon and Cortexin on behavior and activity of caspase-3 in a brain of old rats in a model of carotid arteries occlusion was conducted. It is shown that introduction of short peptides promotes a survival rate of the animals that have modeled occlusion of carotid arteries. Under Pinealon before occlusion of carotid arteries, behavioral dream has been increased and a position-finding behavior, a motivational behavior and a motor performance have been reduced. The rats that were introduced Cortexin before carotid arteries occlusion demonstrated the raise of behavioral dream time. At introduction of Pinealon activity of caspase-3 moderately raises in false-operated animals and in a model of occlusion of carotid arteries.

Topics: Aging; Animals; Behavior, Animal; Brain; Carotid Stenosis; Caspase 3; Disease Models, Animal; Injections, Intraperitoneal; Intercellular Signaling Peptides and Proteins; Male; Oligopeptides; Peptides; Rats; Survival Analysis