glpg0634 and Liver-Cirrhosis

glpg0634 has been researched along with Liver-Cirrhosis* in 1 studies

Other Studies

1 other study(ies) available for glpg0634 and Liver-Cirrhosis

Article	Year
Discovery and Biological Evaluation of Journal of medicinal chemistry, 2021, 01-28, Volume: 64, Issue:2 Janus kinase 1 (JAK1) plays a key role in most cytokine-mediated inflammatory and autoimmune responses through JAK/STAT signaling; thus, JAK1 inhibition is a promising therapeutic strategy for several diseases. Analysis of the binding modes of current JAK inhibitors to JAK isoforms allowed the design of Topics: Animals; Cell Line; Drug Design; Drug Discovery; Gene Expression Regulation; Hepatic Stellate Cells; Humans; Janus Kinase 1; Liver Cirrhosis; Mice; Models, Molecular; Protein Kinase Inhibitors; Structure-Activity Relationship; Substrate Specificity; Transforming Growth Factor beta; Wound Healing	2021

Article

Year

Journal of medicinal chemistry, 2021, 01-28, Volume: 64, Issue:2

Janus kinase 1 (JAK1) plays a key role in most cytokine-mediated inflammatory and autoimmune responses through JAK/STAT signaling; thus, JAK1 inhibition is a promising therapeutic strategy for several diseases. Analysis of the binding modes of current JAK inhibitors to JAK isoforms allowed the design of

Topics: Animals; Cell Line; Drug Design; Drug Discovery; Gene Expression Regulation; Hepatic Stellate Cells; Humans; Janus Kinase 1; Liver Cirrhosis; Mice; Models, Molecular; Protein Kinase Inhibitors; Structure-Activity Relationship; Substrate Specificity; Transforming Growth Factor beta; Wound Healing

2021