Page last updated: 2024-10-27

glimepiride and Diabetic Neuropathies

glimepiride has been researched along with Diabetic Neuropathies in 3 studies

glimepiride: structure given in first source

Diabetic Neuropathies: Peripheral, autonomic, and cranial nerve disorders that are associated with DIABETES MELLITUS. These conditions usually result from diabetic microvascular injury involving small blood vessels that supply nerves (VASA NERVORUM). Relatively common conditions which may be associated with diabetic neuropathy include third nerve palsy (see OCULOMOTOR NERVE DISEASES); MONONEUROPATHY; mononeuropathy multiplex; diabetic amyotrophy; a painful POLYNEUROPATHY; autonomic neuropathy; and thoracoabdominal neuropathy. (From Adams et al., Principles of Neurology, 6th ed, p1325)

Research Excerpts

ExcerptRelevanceReference
"Time-dependent effects of alpha-lipoic acid/nifedipine/glimepiride combination on diabetic neuropathies were investigated in rats."8.12Diurnal efficacy of alpha-lipoic acid/nifedipine/glimepiride combination mitigates diabetic neuropathies in rats. ( Anafi, SB; Bisalla, M; Olurishe, TO; Oraebosi, MI, 2022)
"Time-dependent effects of alpha-lipoic acid/nifedipine/glimepiride combination on diabetic neuropathies were investigated in rats."4.12Diurnal efficacy of alpha-lipoic acid/nifedipine/glimepiride combination mitigates diabetic neuropathies in rats. ( Anafi, SB; Bisalla, M; Olurishe, TO; Oraebosi, MI, 2022)
"In participants with type 2 diabetes, the incidences of microvascular complications and death were not materially different among the four treatment groups."3.11Glycemia Reduction in Type 2 Diabetes - Microvascular and Cardiovascular Outcomes. ( Bebu, I; Burch, HB; Buse, JB; Cherrington, AL; Fortmann, SP; Green, JB; Kahn, SE; Kirkman, MS; Krause-Steinrauf, H; Lachin, JM; Larkin, ME; Nathan, DM; Phillips, LS; Pop-Busui, R; Steffes, M; Tiktin, M; Tripputi, M; Wexler, DJ; Younes, N, 2022)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (33.33)29.6817
2010's0 (0.00)24.3611
2020's2 (66.67)2.80

Authors

AuthorsStudies
Oraebosi, MI1
Olurishe, TO1
Anafi, SB1
Bisalla, M1
Nathan, DM1
Lachin, JM1
Bebu, I1
Burch, HB1
Buse, JB1
Cherrington, AL1
Fortmann, SP1
Green, JB1
Kahn, SE1
Kirkman, MS1
Krause-Steinrauf, H1
Larkin, ME1
Phillips, LS1
Pop-Busui, R1
Steffes, M1
Tiktin, M1
Tripputi, M1
Wexler, DJ1
Younes, N1
Duckworth, W1
Abraira, C1
Moritz, T1
Reda, D1
Emanuele, N1
Reaven, PD1
Zieve, FJ1
Marks, J1
Davis, SN1
Hayward, R1
Warren, SR1
Goldman, S1
McCarren, M1
Vitek, ME1
Henderson, WG1
Huang, GD1

Clinical Trials (5)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study[NCT01794143]Phase 35,047 participants (Actual)Interventional2013-05-31Completed
CSP #465 - Glycemic Control and Complications in Diabetes Mellitus Type 2 (VADT)[NCT00032487]Phase 31,791 participants (Actual)Interventional2000-12-01Completed
Does Glycated Hemoglobin Variability in Type 2 Diabetes Differ Depending on the Diabetes Treatment Threshold Used in the Qatari Population: Implication on Diabetes Complication Risk?[NCT02879409]150 participants (Anticipated)Interventional2016-11-30Active, not recruiting
FLAT-SUGAR: FLuctuATion Reduction With inSULin and Glp-1 Added togetheR[NCT01524705]Phase 4102 participants (Actual)Interventional2012-08-31Completed
Allopurinol in the Treatment of Patients With Diabetes Mellitus and Multivessel Coronary Artery Disease Treated by Either PCI or CABG: Pilot Study[NCT03700645]Phase 4100 participants (Anticipated)Interventional2018-12-01Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Primary Major Macrovascular Events

Myocardial infarction (MI), intervention for coronary artery or Peripheral Vascular Disease (PVD), severe inoperable Coronary Artery Disease (CAD), new or worsening Congestive Heart Failure (CHF), stroke, Cardiovascular (CV) death, or amputation for ischemic gangrene. (NCT00032487)
Timeframe: Post baseline time to the first major macrovascular event up to 82 months

Interventionparticipants (Number)
Arm 1264
Arm 2235

Secondary Endpoint

New or worsening angina, new transient ischemic attack (TIA), new intermittent claudication or critical limb ischemia with Doppler evidence or total mortality. (NCT00032487)
Timeframe: Post baseline time to first event up to 82 months

Interventionparticipants (Number)
Arm 1283
Arm 2312

Coefficient of Variation at 26 Weeks Minus Coefficient of Variation at Baseline

The change in the coefficient of variation (CV) of continuous glucose readings, as assessed by Continuous Glucose Monitoring (CGM) (NCT01524705)
Timeframe: At baseline, 6 months of intervention

Interventionpercentage (Mean)
Insulin Glargine, Metformin, Exenatide-2.43
Insulin Glargine, Metformin, Prandial Insulin0.44

HbA1C Levels

% of glycosylated hemoglobin in whole blood at 26 weeks (NCT01524705)
Timeframe: Baseline vs 26 weeks

Intervention% of HbA1C (Mean)
Insulin Glargine, Metformin, Exenatide7.1
Insulin Glargine, Metformin, Prandial Insulin7.2

Number of Participants With Hypoglycemia

Severe hypoglycemia-documented glucose <50mg/dl (participant journal), and hypoglycemic attacks requiring hospitalization, or treatment by emergency personnel. (NCT01524705)
Timeframe: 26 weeks

InterventionParticipants (Count of Participants)
Insulin Glargine, Metformin, Exenatide0
Insulin Glargine, Metformin, Prandial Insulin0

Weight Change During Trial

Weight in kg at 26 weeks minus weight at baseline. (NCT01524705)
Timeframe: Baseline vs 26 weeks

Interventionkg (Mean)
Insulin Glargine, Metformin, Exenatide-4.8
Insulin Glargine, Metformin, Prandial Insulin0.7

Trials

2 trials available for glimepiride and Diabetic Neuropathies

ArticleYear
Glycemia Reduction in Type 2 Diabetes - Microvascular and Cardiovascular Outcomes.
    The New England journal of medicine, 2022, 09-22, Volume: 387, Issue:12

    Topics: Albuminuria; Blood Glucose; Cardiovascular Diseases; Comparative Effectiveness Research; Diabetes Co

2022
Glucose control and vascular complications in veterans with type 2 diabetes.
    The New England journal of medicine, 2009, Jan-08, Volume: 360, Issue:2

    Topics: Blood Glucose; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Diabetic N

2009
Glucose control and vascular complications in veterans with type 2 diabetes.
    The New England journal of medicine, 2009, Jan-08, Volume: 360, Issue:2

    Topics: Blood Glucose; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Diabetic N

2009
Glucose control and vascular complications in veterans with type 2 diabetes.
    The New England journal of medicine, 2009, Jan-08, Volume: 360, Issue:2

    Topics: Blood Glucose; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Diabetic N

2009
Glucose control and vascular complications in veterans with type 2 diabetes.
    The New England journal of medicine, 2009, Jan-08, Volume: 360, Issue:2

    Topics: Blood Glucose; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Diabetic N

2009
Glucose control and vascular complications in veterans with type 2 diabetes.
    The New England journal of medicine, 2009, Jan-08, Volume: 360, Issue:2

    Topics: Blood Glucose; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Diabetic N

2009
Glucose control and vascular complications in veterans with type 2 diabetes.
    The New England journal of medicine, 2009, Jan-08, Volume: 360, Issue:2

    Topics: Blood Glucose; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Diabetic N

2009
Glucose control and vascular complications in veterans with type 2 diabetes.
    The New England journal of medicine, 2009, Jan-08, Volume: 360, Issue:2

    Topics: Blood Glucose; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Diabetic N

2009
Glucose control and vascular complications in veterans with type 2 diabetes.
    The New England journal of medicine, 2009, Jan-08, Volume: 360, Issue:2

    Topics: Blood Glucose; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Diabetic N

2009
Glucose control and vascular complications in veterans with type 2 diabetes.
    The New England journal of medicine, 2009, Jan-08, Volume: 360, Issue:2

    Topics: Blood Glucose; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Diabetic N

2009
Glucose control and vascular complications in veterans with type 2 diabetes.
    The New England journal of medicine, 2009, Jan-08, Volume: 360, Issue:2

    Topics: Blood Glucose; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Diabetic N

2009
Glucose control and vascular complications in veterans with type 2 diabetes.
    The New England journal of medicine, 2009, Jan-08, Volume: 360, Issue:2

    Topics: Blood Glucose; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Diabetic N

2009
Glucose control and vascular complications in veterans with type 2 diabetes.
    The New England journal of medicine, 2009, Jan-08, Volume: 360, Issue:2

    Topics: Blood Glucose; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Diabetic N

2009
Glucose control and vascular complications in veterans with type 2 diabetes.
    The New England journal of medicine, 2009, Jan-08, Volume: 360, Issue:2

    Topics: Blood Glucose; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Diabetic N

2009
Glucose control and vascular complications in veterans with type 2 diabetes.
    The New England journal of medicine, 2009, Jan-08, Volume: 360, Issue:2

    Topics: Blood Glucose; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Diabetic N

2009
Glucose control and vascular complications in veterans with type 2 diabetes.
    The New England journal of medicine, 2009, Jan-08, Volume: 360, Issue:2

    Topics: Blood Glucose; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Diabetic N

2009
Glucose control and vascular complications in veterans with type 2 diabetes.
    The New England journal of medicine, 2009, Jan-08, Volume: 360, Issue:2

    Topics: Blood Glucose; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Diabetic N

2009

Other Studies

1 other study available for glimepiride and Diabetic Neuropathies

ArticleYear
Diurnal efficacy of alpha-lipoic acid/nifedipine/glimepiride combination mitigates diabetic neuropathies in rats.
    Annales pharmaceutiques francaises, 2022, Volume: 80, Issue:3

    Topics: Animals; Antioxidants; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Nifedipine; Rats; Sul

2022