glimepiride has been researched along with Alzheimer Disease in 2 studies
glimepiride: structure given in first source
Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Glimepiride treatment was associated with altered synaptic membranes including the loss of specific glycosylphosphatidylinositol (GPI)-anchored proteins including the cellular prion protein (PrP(C)) that acts as a receptor for Aβ42, increased synaptic gangliosides and altered cell signalling." | 1.43 | Glimepiride protects neurons against amyloid-β-induced synapse damage. ( Bate, C; McHale-Owen, H; Nolan, W; Osborne, C; West, E; Williams, A, 2016) |
| "Glimepiride was found to interact with AChE enzyme at the same locus as that of substrate acetylcholine iodide (AChI)." | 1.43 | Kinetics and Molecular Docking Study of an Anti-diabetic Drug Glimepiride as Acetylcholinesterase Inhibitor: Implication for Alzheimer's Disease-Diabetes Dual Therapy. ( Abuzenadah, AM; Ahmad, A; Haneef, M; Naaz, D; Rizvi, SM; Shaikh, S; Shakil, S, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Osborne, C | 1 |
| West, E | 1 |
| Nolan, W | 1 |
| McHale-Owen, H | 1 |
| Williams, A | 1 |
| Bate, C | 1 |
| Rizvi, SM | 1 |
| Shaikh, S | 1 |
| Naaz, D | 1 |
| Shakil, S | 1 |
| Ahmad, A | 1 |
| Haneef, M | 1 |
| Abuzenadah, AM | 1 |
2 other studies available for glimepiride and Alzheimer Disease
| Article | Year |
|---|---|
Glimepiride protects neurons against amyloid-β-induced synapse damage.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Cell Membrane Structures; Cells, Cultured; Cholester | 2016 |
Kinetics and Molecular Docking Study of an Anti-diabetic Drug Glimepiride as Acetylcholinesterase Inhibitor: Implication for Alzheimer's Disease-Diabetes Dual Therapy.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents | 2016 |