glaziovianin-a has been researched along with Neoplasms* in 3 studies
3 other study(ies) available for glaziovianin-a and Neoplasms
| Article | Year |
|---|---|
Design, synthesis, and biological evaluation of the analogues of glaziovianin A, a potent antitumor isoflavone.
Various analogues of glaziovianin A, an antitumor isoflavone, were synthesized, and their biological activities were evaluated. O(7)-modified glaziovianin A showed strong cytotoxicity against HeLa S(3) cells. Compared to glaziovianin A, the O(7)-benzyl and O(7)-propargyl analogues were more cytotoxic against HeLa S(3) cells and more potent M-phase inhibitors. Furthermore, O(7)-modified molecular probes of glaziovianin A were synthesized for biological studies. Topics: Antineoplastic Agents; Cell Survival; Drug Design; HeLa Cells; Humans; Isoflavones; M Phase Cell Cycle Checkpoints; Neoplasms; Structure-Activity Relationship | 2012 |
Structure-activity relationship study of glaziovianin A against cell cycle progression and spindle formation of HeLa S3 cells.
Various derivatives of glaziovianin A, an antitumor isoflavone, were synthesized, and the cytotoxicity of each against HeLa S3 cells was investigated. Compared to glaziovianin A, the O7-allyl derivative was found to be more cytotoxic against HeLa S3 cells and a more potent M-phase inhibitor. Topics: Antineoplastic Agents, Phytogenic; Cell Cycle; Fabaceae; HeLa Cells; Humans; Isoflavones; Neoplasms; Structure-Activity Relationship | 2010 |
Glaziovianin A, a new isoflavone, from the leaves of Ateleia glazioviana and its cytotoxic activity against human cancer cells.
A new isoflavone, named glaziovianin A (1), was isolated from the leaves of Ateleia glazioviana (Legminosae) by means of a cytotoxicity-guided fractionation procedure against HL-60 leukemia cells. The chemical structure of 1 was determined by analysis of its extensive spectroscopic data. Glaziovianin A (1) displayed differential cytotoxicities in the Japanese Foundation for Cancer Research 39 cell line panel assay. The pattern of the differential cytotoxicities of 1 was found to correlate to that shown by TZT-1027, suggesting that 1 inhibited tubulin polymerization as an action mechanism. Although 1 had little influence on microtubule networks in interphase cells, 1-treated cells showed abnormal structures with unaligned chromosomes. Topics: Antineoplastic Agents; Cell Division; Cell Line, Tumor; Fabaceae; HL-60 Cells; Humans; Isoflavones; Neoplasms; Oligopeptides; Plant Leaves; Tubulin | 2007 |