glaucocalyxin-a and Neoplasms

glaucocalyxin-a has been researched along with Neoplasms* in 2 studies

Other Studies

2 other study(ies) available for glaucocalyxin-a and Neoplasms

Article	Year
Preparation, optimization of the inclusion complex of glaucocalyxin A with sulfobutylether-β-cyclodextrin and antitumor study. Drug delivery, 2019, Volume: 26, Issue:1 Glaucocalyxin A (GLA), is a diterpenoid extracted from Hara and has been studied for decades for its diverse bioactivities. However, GLA presents poor solubility in water and low bioavailability through oral administration which has hindered its application in the clinic. So in this study, we prepared the inclusion complex of GLA in SBE-β-CD by ultrasound method and evaluated its antitumor effect and cytotoxic effect on cancer cells. The production of GLA-SBE-β-CD inclusion complex was optimized using Box-Behnken design. The inhibitory effects of GLA and GLA-SBE-β-CD were investigated on the Hela, A549, HepG2, and SiHa cells in vitro by MTT staining assay. Pharmacokinetic studies were conducted on Sprague-Dawley mice via caudal injection to study the distribution, metabolism, and elimination of GLA-SBE-β-CD in vivo. Tumor-bearing nude mice were taken as the model and adopted to evaluate the inhibitory rate of GLA and GLA-SBE-β-CD on the transplanted tumor. A series of physical characterization results confirmed the fact that GLA-SBE-β-CD inclusion complex was successfully prepared. A production of 87.28% was achieved based on the Box-Behnken design. In the cancer cell inhibition studies, GLA and GLA-SBE-β-CD exhibited apparent concentration-dependent inhibitory actions on four kinds of tumor cells and better inhibition was achieved in GLA-SBE-β-CD group. The pharmacokinetic results showed that the duration of GLA in blood was prolonged and enhanced bioavailability was achieved. GLA and GLA-SBE-β-CD both showed an effective inhibition on the transplanted tumor growth, while the anti-tumor effect of GLA-SBE-β-CD (inhibitory rate of 45.80%) was significantly stronger than that of GLA (30.76%) based on the change of tumor weight and tumor volume. Topics: A549 Cells; Administration, Oral; Animals; Antineoplastic Agents; beta-Cyclodextrins; Biological Availability; Chemistry, Pharmaceutical; Diterpenes, Kaurane; Dose-Response Relationship, Drug; Drug Carriers; Drug Compounding; Female; HeLa Cells; Hep G2 Cells; Humans; Male; Mice; Mice, Nude; Neoplasms; Rats; Rats, Sprague-Dawley; Solubility	2019
A nanoparticulate drug-delivery system for glaucocalyxin A: formulation, characterization, increased in vitro, and vivo antitumor activity. Drug delivery, 2016, Volume: 23, Issue:7 Topics: Animals; Calorimetry, Differential Scanning; Diterpenes, Kaurane; Drug Delivery Systems; Mice; Nanoparticles; Neoplasms; Solubility; Suspensions	2016

Article

Year

Preparation, optimization of the inclusion complex of glaucocalyxin A with sulfobutylether-β-cyclodextrin and antitumor study.

Drug delivery, 2019, Volume: 26, Issue:1

Glaucocalyxin A (GLA), is a diterpenoid extracted from Hara and has been studied for decades for its diverse bioactivities. However, GLA presents poor solubility in water and low bioavailability through oral administration which has hindered its application in the clinic. So in this study, we prepared the inclusion complex of GLA in SBE-β-CD by ultrasound method and evaluated its antitumor effect and cytotoxic effect on cancer cells. The production of GLA-SBE-β-CD inclusion complex was optimized using Box-Behnken design. The inhibitory effects of GLA and GLA-SBE-β-CD were investigated on the Hela, A549, HepG2, and SiHa cells in vitro by MTT staining assay. Pharmacokinetic studies were conducted on Sprague-Dawley mice via caudal injection to study the distribution, metabolism, and elimination of GLA-SBE-β-CD in vivo. Tumor-bearing nude mice were taken as the model and adopted to evaluate the inhibitory rate of GLA and GLA-SBE-β-CD on the transplanted tumor. A series of physical characterization results confirmed the fact that GLA-SBE-β-CD inclusion complex was successfully prepared. A production of 87.28% was achieved based on the Box-Behnken design. In the cancer cell inhibition studies, GLA and GLA-SBE-β-CD exhibited apparent concentration-dependent inhibitory actions on four kinds of tumor cells and better inhibition was achieved in GLA-SBE-β-CD group. The pharmacokinetic results showed that the duration of GLA in blood was prolonged and enhanced bioavailability was achieved. GLA and GLA-SBE-β-CD both showed an effective inhibition on the transplanted tumor growth, while the anti-tumor effect of GLA-SBE-β-CD (inhibitory rate of 45.80%) was significantly stronger than that of GLA (30.76%) based on the change of tumor weight and tumor volume.

Topics: A549 Cells; Administration, Oral; Animals; Antineoplastic Agents; beta-Cyclodextrins; Biological Availability; Chemistry, Pharmaceutical; Diterpenes, Kaurane; Dose-Response Relationship, Drug; Drug Carriers; Drug Compounding; Female; HeLa Cells; Hep G2 Cells; Humans; Male; Mice; Mice, Nude; Neoplasms; Rats; Rats, Sprague-Dawley; Solubility

2019

A nanoparticulate drug-delivery system for glaucocalyxin A: formulation, characterization, increased in vitro, and vivo antitumor activity.

Drug delivery, 2016, Volume: 23, Issue:7

Topics: Animals; Calorimetry, Differential Scanning; Diterpenes, Kaurane; Drug Delivery Systems; Mice; Nanoparticles; Neoplasms; Solubility; Suspensions

2016