glaucarubolone and Breast-Neoplasms

glaucarubolone has been researched along with Breast-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for glaucarubolone and Breast-Neoplasms

Article	Year
Glaucarubulone glucoside from Castela macrophylla suppresses MCF-7 breast cancer cell growth and attenuates benzo[a]pyrene-mediated CYP1A gene induction. Journal of applied toxicology : JAT, 2017, Volume: 37, Issue:7 Quassinoids often exhibit antioxidant and antiproliferative activity. Emerging evidence suggests that these natural metabolites also display chemopreventive actions. In this study, we investigated the potential for the quassinoid glaucarubulone glucoside (Gg), isolated from the endemic Jamaican plant Castela macrophylla (Simaroubaceae), to display potent cytotoxicity and inhibit human cytochrome P450s (CYPs), particularly CYP1A enzymes, known to convert polyaromatic hydrocarbons into carcinogenic metabolites. Gg reduced the viability of MCF-7 breast adenocarcinoma cells (IC Topics: Antineoplastic Agents, Phytogenic; Antioxidants; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cytochrome P-450 Enzyme System; Cytotoxins; Female; Gene Expression; Glaucarubin; Humans; Jamaica; MCF-7 Cells; Plant Extracts; Quassins; Simaroubaceae	2017

Article

Year

Glaucarubulone glucoside from Castela macrophylla suppresses MCF-7 breast cancer cell growth and attenuates benzo[a]pyrene-mediated CYP1A gene induction.

Journal of applied toxicology : JAT, 2017, Volume: 37, Issue:7

Quassinoids often exhibit antioxidant and antiproliferative activity. Emerging evidence suggests that these natural metabolites also display chemopreventive actions. In this study, we investigated the potential for the quassinoid glaucarubulone glucoside (Gg), isolated from the endemic Jamaican plant Castela macrophylla (Simaroubaceae), to display potent cytotoxicity and inhibit human cytochrome P450s (CYPs), particularly CYP1A enzymes, known to convert polyaromatic hydrocarbons into carcinogenic metabolites. Gg reduced the viability of MCF-7 breast adenocarcinoma cells (IC

Topics: Antineoplastic Agents, Phytogenic; Antioxidants; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cytochrome P-450 Enzyme System; Cytotoxins; Female; Gene Expression; Glaucarubin; Humans; Jamaica; MCF-7 Cells; Plant Extracts; Quassins; Simaroubaceae

2017