glaucarubin and Breast-Neoplasms

glaucarubin has been researched along with Breast-Neoplasms* in 2 studies

Other Studies

2 other study(ies) available for glaucarubin and Breast-Neoplasms

ArticleYear
Glaucarubulone glucoside from Castela macrophylla suppresses MCF-7 breast cancer cell growth and attenuates benzo[a]pyrene-mediated CYP1A gene induction.
    Journal of applied toxicology : JAT, 2017, Volume: 37, Issue:7

    Quassinoids often exhibit antioxidant and antiproliferative activity. Emerging evidence suggests that these natural metabolites also display chemopreventive actions. In this study, we investigated the potential for the quassinoid glaucarubulone glucoside (Gg), isolated from the endemic Jamaican plant Castela macrophylla (Simaroubaceae), to display potent cytotoxicity and inhibit human cytochrome P450s (CYPs), particularly CYP1A enzymes, known to convert polyaromatic hydrocarbons into carcinogenic metabolites. Gg reduced the viability of MCF-7 breast adenocarcinoma cells (IC

    Topics: Antineoplastic Agents, Phytogenic; Antioxidants; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cytochrome P-450 Enzyme System; Cytotoxins; Female; Gene Expression; Glaucarubin; Humans; Jamaica; MCF-7 Cells; Plant Extracts; Quassins; Simaroubaceae

2017
Phase II trial of bruceantin in metastatic breast carcinoma.
    American journal of clinical oncology, 1982, Volume: 5, Issue:4

    A phase II evaluation of bruceantin was carried out in 15 patients with refractory metastatic breast cancer. All patients had received extensive prior therapy including adriamycin, cytoxan, 5-FU, methotrexate, and a vinca alkaloid. Except for two patients with stable disease, no complete or partial response was observed. Drug toxicity, mainly nonhematologic, was severe, with nausea, vomiting, mild hypotension, and fever being the most frequently encountered.

    Topics: Adult; Aged; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Drug Evaluation; Female; Glaucarubin; Humans; Hypotension; Leukocyte Count; Middle Aged; Nausea; Neoplasm Metastasis; Phenanthrenes; Quassins; Vomiting

1982