glasdegib and Asthma

Allergic asthma is a common inflammatory airway disease in which Th2 immune response and inflammation are thought to be triggered by inhalation of environmental allergens. Many studies using mouse models and human tissues and genome-wide association have indicated that Sonic Hedgehog (Shh) and the Hedgehog (Hh) signaling pathway are involved in allergic asthma and that Shh is upregulated in the lung on disease induction. We used a papain-induced mouse model of allergic airway inflammation to investigate the impact of systemic pharmacological inhibition of the Hh signal transduction molecule smoothened on allergic airway disease induction and severity. Smoothened-inhibitor treatment reduced the induction of Shh, IL-4, and IL-13 in the lung and decreased serum IgE, as well as the expression of

Topics: Animals; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Asthma; Benzimidazoles; Chemotaxis, Leukocyte; Cytokines; Disease Models, Animal; Female; Injections, Intraperitoneal; Lung; Male; Mice, Inbred C57BL; Phenylurea Compounds; Pneumonia; Signal Transduction; Smoothened Receptor; Th2 Cells