glabrol and Atherosclerosis

glabrol has been researched along with Atherosclerosis* in 1 studies

Other Studies

1 other study(ies) available for glabrol and Atherosclerosis

Article	Year
Glabrol, an acyl-coenzyme A: cholesterol acyltransferase inhibitor from licorice roots. Journal of ethnopharmacology, 2007, Apr-04, Volume: 110, Issue:3 Acyl-coenzyme A: cholesterol acyltransferase (ACAT) esterifies free cholesterol in the liver and the intestine. It has relations with production of lipoproteins and accumulation of cholesteryl esters of the atheroma. Therefore, ACAT inhibitors may act as antihypercholesterolemic and antiatherosclerotic agents. One isoprenyl flavonoid was isolated from ethanol extract of licorice roots. On the basis of spectral evidences, the compound was identified as glabrol (1). Compound 1 inhibited rat liver microsomal ACAT activity with an IC(50) value of 24.6 microM and decreased cholesteryl ester formation with an IC(50) value of 26.0 microM in HepG2 cells. In addition, 1 showed a non-competitive type of inhibition against ACAT. Topics: Animals; Anticholesteremic Agents; Atherosclerosis; Cell Line, Tumor; Cholesterol Esters; Dose-Response Relationship, Drug; Flavonoids; Glycyrrhiza; Microsomes, Liver; Phytotherapy; Plant Roots; Plants, Medicinal; Rats; Sterol O-Acyltransferase	2007

Article

Year

Glabrol, an acyl-coenzyme A: cholesterol acyltransferase inhibitor from licorice roots.

Journal of ethnopharmacology, 2007, Apr-04, Volume: 110, Issue:3

Acyl-coenzyme A: cholesterol acyltransferase (ACAT) esterifies free cholesterol in the liver and the intestine. It has relations with production of lipoproteins and accumulation of cholesteryl esters of the atheroma. Therefore, ACAT inhibitors may act as antihypercholesterolemic and antiatherosclerotic agents. One isoprenyl flavonoid was isolated from ethanol extract of licorice roots. On the basis of spectral evidences, the compound was identified as glabrol (1). Compound 1 inhibited rat liver microsomal ACAT activity with an IC(50) value of 24.6 microM and decreased cholesteryl ester formation with an IC(50) value of 26.0 microM in HepG2 cells. In addition, 1 showed a non-competitive type of inhibition against ACAT.

Topics: Animals; Anticholesteremic Agents; Atherosclerosis; Cell Line, Tumor; Cholesterol Esters; Dose-Response Relationship, Drug; Flavonoids; Glycyrrhiza; Microsomes, Liver; Phytotherapy; Plant Roots; Plants, Medicinal; Rats; Sterol O-Acyltransferase

2007