gkt137831 and Neoplasms

gkt137831 has been researched along with Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for gkt137831 and Neoplasms

Article	Year
T-cell tumour exclusion and immunotherapy resistance: a role for CAF targeting. British journal of cancer, 2020, Volume: 123, Issue:9 Recent studies have highlighted a major role for cancer-associated fibroblasts (CAFs) in promoting immunotherapy resistance by excluding T cells from tumours. Recently, we showed that CAFs can be effectively targeted by inhibiting the enzyme NOX4; this 'normalises' CAFs and overcomes immunotherapy resistance. Here we discuss our study and other strategies for CAF targeting. Topics: Antineoplastic Agents, Immunological; Antineoplastic Combined Chemotherapy Protocols; Cancer-Associated Fibroblasts; Drug Resistance, Neoplasm; Drug Synergism; Humans; Immunotherapy; Molecular Targeted Therapy; NADPH Oxidase 4; Neoplasms; Pyrazolones; Pyridones; T-Lymphocytes; Tumor Microenvironment	2020

Article

Year

T-cell tumour exclusion and immunotherapy resistance: a role for CAF targeting.

British journal of cancer, 2020, Volume: 123, Issue:9

Recent studies have highlighted a major role for cancer-associated fibroblasts (CAFs) in promoting immunotherapy resistance by excluding T cells from tumours. Recently, we showed that CAFs can be effectively targeted by inhibiting the enzyme NOX4; this 'normalises' CAFs and overcomes immunotherapy resistance. Here we discuss our study and other strategies for CAF targeting.

Topics: Antineoplastic Agents, Immunological; Antineoplastic Combined Chemotherapy Protocols; Cancer-Associated Fibroblasts; Drug Resistance, Neoplasm; Drug Synergism; Humans; Immunotherapy; Molecular Targeted Therapy; NADPH Oxidase 4; Neoplasms; Pyrazolones; Pyridones; T-Lymphocytes; Tumor Microenvironment

2020