gkt137831 has been researched along with Neoplasms* in 1 studies
1 other study(ies) available for gkt137831 and Neoplasms
Article | Year |
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T-cell tumour exclusion and immunotherapy resistance: a role for CAF targeting.
Recent studies have highlighted a major role for cancer-associated fibroblasts (CAFs) in promoting immunotherapy resistance by excluding T cells from tumours. Recently, we showed that CAFs can be effectively targeted by inhibiting the enzyme NOX4; this 'normalises' CAFs and overcomes immunotherapy resistance. Here we discuss our study and other strategies for CAF targeting. Topics: Antineoplastic Agents, Immunological; Antineoplastic Combined Chemotherapy Protocols; Cancer-Associated Fibroblasts; Drug Resistance, Neoplasm; Drug Synergism; Humans; Immunotherapy; Molecular Targeted Therapy; NADPH Oxidase 4; Neoplasms; Pyrazolones; Pyridones; T-Lymphocytes; Tumor Microenvironment | 2020 |