ginsenoside-rk1 and Diabetic-Retinopathy

A series of glucal-conjugated sterols as novel vascular leakage blocker were identified through design, synthesis and biologically evaluation. In addition, the structure-activity relationship (SAR) of the glucal-conjugated sterols focusing on the C17-side chain was also established. The sterol analogs linked with the rigid C17-side chain side chains exhibited potent cell survival activities. In particular, analog 21l, which possesses a cyclopentyl oxime moiety, was shown to have excellent pharmacological effects on retinal vascular leakage in a diabetic mouse model.

Topics: Animals; Apoptosis; Calcium Gluconate; Cell Line; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Endothelial Cells; Human Umbilical Vein Endothelial Cells; Mice; Mice, Inbred C57BL; Oximes; Permeability; Retina; Sterols; Structure-Activity Relationship