ginsenoside-rg3 and Sepsis

Sepsis-led mitochondrial dysfunction has become a critical pathophysiological procedure in sepsis. Since ginsenosides have been applied in the treatment of mitochondrial dysfunction, ginsenoside Rg3 was employed to study its effects on the mitochondrial dysfunction induced by sepsis. The apoptosis rate, oxygen consumption rate (OCR), reactive oxygen species (ROS), antioxidant glutathione (GSH) pools, and mitochondrial transmembrane potential (MTP) were determined in LPS-induced sepsis hepatocytes treated with different concentrations of Rg3. Then, the protein expression levels of mitochondrial biogenesis related transcription factors, autophagy-related proteins, and AMP-activated protein kinase (AMPK) signal pathway related proteins were determined by Western blotting in both

Topics: AMP-Activated Protein Kinases; Animals; Autophagy; Chemical and Drug Induced Liver Injury; Ginsenosides; Humans; Lipopolysaccharides; Male; Mice; Mitochondria, Liver; Mitochondrial Diseases; Reactive Oxygen Species; Sepsis