ginsenoside-rg3 and Hypoxia

ginsenoside-rg3 has been researched along with Hypoxia* in 1 studies

Other Studies

1 other study(ies) available for ginsenoside-rg3 and Hypoxia

Article	Year
Ginsenoside Rg3 sensitizes hypoxic lung cancer cells to cisplatin via blocking of NF-κB mediated epithelial-mesenchymal transition and stemness. Cancer letters, 2018, 02-28, Volume: 415 Cisplatin is a first line chemotherapy in lung cancer, but decreased susceptibility may limit its application. In solid tumors, hypoxia alters the microenvironment and is associated with proliferation, metastasis, and drug sensitivity. The hypoxia-induced desensitization of cisplatin is not clearly elucidated. 20 (R)-Ginsenoside (Rg3), the traditional Chinese medicine, is extracted from ginseng and has antitumor activities. In this study, we evaluated if Rg3 is effective in improving cisplatin sensitivity by blocking hypoxia. We found that the inhibition of proliferation potential by cisplatin was reduced in cobalt chloride (CoCl Topics: A549 Cells; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cell Hypoxia; Cell Line, Tumor; Cisplatin; Epithelial-Mesenchymal Transition; Ginsenosides; Humans; Hypoxia; Lung Neoplasms; Male; Mice, Inbred BALB C; Mice, Nude; Molecular Structure; Neoplastic Stem Cells; NF-kappa B; Tumor Burden; Xenograft Model Antitumor Assays	2018

Article

Year

Ginsenoside Rg3 sensitizes hypoxic lung cancer cells to cisplatin via blocking of NF-κB mediated epithelial-mesenchymal transition and stemness.

Cancer letters, 2018, 02-28, Volume: 415

Cisplatin is a first line chemotherapy in lung cancer, but decreased susceptibility may limit its application. In solid tumors, hypoxia alters the microenvironment and is associated with proliferation, metastasis, and drug sensitivity. The hypoxia-induced desensitization of cisplatin is not clearly elucidated. 20 (R)-Ginsenoside (Rg3), the traditional Chinese medicine, is extracted from ginseng and has antitumor activities. In this study, we evaluated if Rg3 is effective in improving cisplatin sensitivity by blocking hypoxia. We found that the inhibition of proliferation potential by cisplatin was reduced in cobalt chloride (CoCl

Topics: A549 Cells; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cell Hypoxia; Cell Line, Tumor; Cisplatin; Epithelial-Mesenchymal Transition; Ginsenosides; Humans; Hypoxia; Lung Neoplasms; Male; Mice, Inbred BALB C; Mice, Nude; Molecular Structure; Neoplastic Stem Cells; NF-kappa B; Tumor Burden; Xenograft Model Antitumor Assays

2018