ginsenoside-rg3 and Arthritis--Rheumatoid

Ginsenoside Rg3 (GRg3) is one of the major bioactive ingredients of ginseng, which is not only used as a herbal medicine but also used as a functional food to support body functions. In this study, the beneficial effects of GRg3 on rheumatoid arthritis (RA) mice was evaluated from anti-inflammatory and immunosuppressive aspects. The footpad swelling rate, pathological changes of the ankle joint, and levels of tumor necrosis factor α, interleukin 6, interleukin 10, and tumor necrosis factor β were used to assess the anti-inflammatory effect of GRg3 on RA mice. Flow cytometric analysis of CD4

Topics: Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Forkhead Transcription Factors; Freund's Adjuvant; Ginsenosides; Humans; Interleukin-2 Receptor alpha Subunit; Male; Mice; Mice, Inbred C57BL; T-Lymphocytes, Regulatory