ginsenoside-rg2 and Myocardial-Ischemia

This study investigates the effect of ginsenoside Rg2 on myocardial fibrosis in myocardial ischaemia rats.. Compared with myocardial ischaemic rats, ginsenoside Rg2 at doses of 5, 20 mg/kg abated partially the augment of LVEDP (8.9 ± 1.3 vs. 7.5 ± 0.7, 7.2 ± 1.0 mmHg) and the decreases of the LVSP (96.75 ± 13.2 vs. 118.3 ± 19.4, 124.3 ± 21.3 mmHg), the + dp/dt (2142.8 ± 309.3 vs. 2598.6 ± 404.0, 2661.5 ± 445.2 mmHg/s), and the -dp/dt (1996.3 ± 306.3 vs. 2476.6 ± 289.7, 2509.6 ± 353.1 mmHg/s). Ginsenoside Rg2 (9.2 ± 0.9%, 8.5 ± 0.8%) alleviated myocardial fibrosis when compared with the isoproterenol group (10.1 ± 1.0%), which was accompanied by suppressed TGF-β1/Smad signalling in heart tissues.. Ginsenosides from ginseng possess the property of alleviating myocardial fibrosis, improving cardiac function after myocardial ischaemia. Ginsenosides may be promising agents for improving the outcomes of patients with myocardial ischaemia.

Topics: Animals; Cardiotonic Agents; Dose-Response Relationship, Drug; Fibrosis; Ginsenosides; Isoproterenol; Male; Myocardial Ischemia; Panax; Rats; Rats, Wistar; Signal Transduction; Smad Proteins; Transforming Growth Factor beta1

To investigate the protective effect of Ginsenoside Rg2 on Chemical myocardial ischemia.. The models of myocardial ischemia were built in rats with isoproterenol, sodium nitrite,pituitrin. Ginsenoside Rg2 (iv 2.5, 5.0, 10.0 mg x kg(-1)) were intravenously administered.. Ginsenoside Rg2 could improve the abnormal electrocardiogram (ECG), reduce the arca of myocardial ischemia and improve the abnormal zymologic value of myocardial.. Ginsenoside Rg2 has inhibitory function on myocardialischemia.

Topics: Animals; Creatine Kinase; Electrocardiography; Female; Ginsenosides; Isoproterenol; Male; Malondialdehyde; Myocardial Ischemia; Myocardium; Panax; Pituitary Hormones, Posterior; Plant Leaves; Plants, Medicinal; Rats; Rats, Wistar; Sodium Nitrite; Superoxide Dismutase