ginsenoside-m1 has been researched along with Reperfusion-Injury* in 1 studies
1 other study(ies) available for ginsenoside-m1 and Reperfusion-Injury
| Article | Year |
|---|---|
Compound K inhibits autophagy-mediated apoptosis induced by oxygen and glucose deprivation/reperfusion via regulating AMPK-mTOR pathway in neurons.
Oxygen and glucose deprivation and reperfusion (OGD/R) injury contributes to the pathophysiology after ischemic stroke, which needs to urgently develop treatment strategies. Previous studies have demonstrated that autophagy in reperfusion period exerted adverse effects on the cerebral ischemic injury. Ginsenoside monomer compound K (CK) is the main intestinal metabolite of ginseng that exerts the pharmacological activities and has a protective effect against cerebral OGD/R injury. However, the specific molecular mechanism of CK protects against OGD/R injury in neurons is still unclear.. Taken together, our study provides credible experimental evidence and explains the potential molecular mechanism of CK as one of the main bioactive ingredients of ginseng for the treatment of cerebral ischemia/reperfusion injury. Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Autophagic Cell Death; Autophagosomes; Cell Survival; Cells, Cultured; Ginsenosides; Glucose; Hypoxia; Membrane Potential, Mitochondrial; Neurons; Rats; Reperfusion Injury; Signal Transduction; TOR Serine-Threonine Kinases | 2020 |