ginsenoside-m1 and Glomerulonephritis--IGA

ginsenoside-m1 has been researched along with Glomerulonephritis--IGA* in 1 studies

Other Studies

1 other study(ies) available for ginsenoside-m1 and Glomerulonephritis--IGA

Article	Year
IgA Nephropathy Benefits from Compound K Treatment by Inhibiting NF-κB/NLRP3 Inflammasome and Enhancing Autophagy and SIRT1. Journal of immunology (Baltimore, Md. : 1950), 2020, 07-01, Volume: 205, Issue:1 IgA nephropathy (IgAN), the most common primary glomerular disorder, has a relatively poor prognosis yet lacks a pathogenesis-based treatment. Compound K (CK) is a major absorbable intestinal bacterial metabolite of ginsenosides, which are bioactive components of ginseng. The present study revealed promising therapeutic effects of CK in two complementary IgAN models: a passively induced one developed by repeated injections of IgA immune complexes and a spontaneously occurring model of spontaneous grouped ddY mice. The potential mechanism for CK includes 1) inhibiting the activation of NLRP3 inflammasome in renal tissues, macrophages and bone marrow-derived dendritic cells, 2) enhancing the induction of autophagy through increased SIRT1 expression, and 3) eliciting autophagy-mediated NLRP3 inflammasome inhibition. The results support CK as a drug candidate for IgAN. Topics: Animals; Autophagy; Cell Line; Dendritic Cells; Disease Models, Animal; Ginsenosides; Glomerulonephritis, IGA; Humans; Inflammasomes; Kidney Glomerulus; Macrophages; Mice; Mice, Inbred Strains; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Primary Cell Culture; Signal Transduction; Sirtuin 1	2020

Article

Year

IgA Nephropathy Benefits from Compound K Treatment by Inhibiting NF-κB/NLRP3 Inflammasome and Enhancing Autophagy and SIRT1.

Journal of immunology (Baltimore, Md. : 1950), 2020, 07-01, Volume: 205, Issue:1

IgA nephropathy (IgAN), the most common primary glomerular disorder, has a relatively poor prognosis yet lacks a pathogenesis-based treatment. Compound K (CK) is a major absorbable intestinal bacterial metabolite of ginsenosides, which are bioactive components of ginseng. The present study revealed promising therapeutic effects of CK in two complementary IgAN models: a passively induced one developed by repeated injections of IgA immune complexes and a spontaneously occurring model of spontaneous grouped ddY mice. The potential mechanism for CK includes 1) inhibiting the activation of NLRP3 inflammasome in renal tissues, macrophages and bone marrow-derived dendritic cells, 2) enhancing the induction of autophagy through increased SIRT1 expression, and 3) eliciting autophagy-mediated NLRP3 inflammasome inhibition. The results support CK as a drug candidate for IgAN.

Topics: Animals; Autophagy; Cell Line; Dendritic Cells; Disease Models, Animal; Ginsenosides; Glomerulonephritis, IGA; Humans; Inflammasomes; Kidney Glomerulus; Macrophages; Mice; Mice, Inbred Strains; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Primary Cell Culture; Signal Transduction; Sirtuin 1

2020