ginkgolide-k has been researched along with Parkinsonian-Disorders* in 1 studies
1 other study(ies) available for ginkgolide-k and Parkinsonian-Disorders
| Article | Year |
|---|---|
The neuroprotective effects and transdifferentiation of astrocytes into dopaminergic neurons of Ginkgolide K on Parkinson' disease mice.
Parkinson's disease (PD) is a chronic and progressive movement disorder caused by the selective loss of midbrain dopaminergic neurons of unknown etiology. Up to now, although there is a great development on treatments of PD, cures with neuroprotective or nerve regenerative effects are underway for PD patients. Here we reported neuroprotective effects of Ginkgolide K (GK) when mice were upon acute MPTP exposure, in which GK ameliorated the gait dysfunction and dopaminergic neuron loss. GK exhibits its ability in immunomodulation, including switching microglia to M2 phenotype and decreasing the microglia-mediated inflammation, inhibiting peripheral CD4 Topics: Animals; Astrocytes; Cell Transdifferentiation; Dopaminergic Neurons; Ginkgolides; Lactones; Male; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Parkinsonian Disorders | 2022 |