gingerol and Chemical-and-Drug-Induced-Liver-Injury--Chronic

Diethylnitrosamine (DEN) is a well-known hepatocarcinogen, and its oral administration causes severe liver damage including cancer. DEN induces the pathogenesis of the liver through reactive oxygen species mediated inflammation and modulation of various biological activities. 6-Gingerol, a major component of ginger, is reported to prevent liver diseases by reducing the oxidative stress and proinflammatory mediators. The present study investigated the hepatoprotective effects of 6-gingerol through the measurement of oxidative stress, anti-inflammatory markers, liver function enzyme parameter, and histopathological analysis. The rats were randomly divided into four groups as the control, DEN treated (50 mg/kg b.w.), DEN+6-gingerol (each 50 mg/kg b.w.), and 6-gingerol only. To evaluate the hepatoprotective effects, liver function enzymes (ALT, AST, and ALP), oxidative stress markers (SOD, GSH, GST, and TAC), lipid peroxidation, inflammatory markers (CRP, TNF-

Topics: Albumins; Animals; Anti-Inflammatory Agents; Biphenyl Compounds; Catechols; Chemical and Drug Induced Liver Injury, Chronic; Diethylnitrosamine; Fatty Alcohols; Free Radical Scavengers; Free Radicals; Glutathione; Hydrogen Peroxide; In Vitro Techniques; Inflammation; Lipid Peroxidation; Liver; Male; Mitochondria; Oxidative Stress; Picrates; Rats; Zingiber officinale