gingerol and Anorexia

gingerol has been researched along with Anorexia* in 1 studies

Other Studies

1 other study(ies) available for gingerol and Anorexia

Article	Year
10-Gingerol, a component of rikkunshito, improves cisplatin-induced anorexia by inhibiting acylated ghrelin degradation. Biochemical and biophysical research communications, 2011, Sep-02, Volume: 412, Issue:3 Rikkunshito (RKT), a Japanese traditional medicine, has been shown to stimulate food intake in rats with cisplatin-induced anorexia; however, the underlying mechanisms remain unknown. In this study, we investigated whether RKT is involved in the degradation of peripheral ghrelin. RKT inhibited decreases in plasma ghrelin level and enhanced acyl- to desacyl-ghrelin (A/D) ratio in cisplatin-treated rats. Several components of RKT demonstrated inhibitory activity against ghrelin deacylating enzymes. In addition, 10-gingerol, a component of RKT, inhibited exogenous ghrelin deacylation. Therefore, RKT may enhance plasma acyl-ghrelin level, at least in part, by inhibiting the circulating ghrelin degrading enzyme. Topics: Acylation; Animals; Anorexia; Carboxylesterase; Catechols; Cisplatin; Drugs, Chinese Herbal; Fatty Alcohols; Ghrelin; Male; Rats; Rats, Sprague-Dawley	2011

Article

Year

10-Gingerol, a component of rikkunshito, improves cisplatin-induced anorexia by inhibiting acylated ghrelin degradation.

Biochemical and biophysical research communications, 2011, Sep-02, Volume: 412, Issue:3

Rikkunshito (RKT), a Japanese traditional medicine, has been shown to stimulate food intake in rats with cisplatin-induced anorexia; however, the underlying mechanisms remain unknown. In this study, we investigated whether RKT is involved in the degradation of peripheral ghrelin. RKT inhibited decreases in plasma ghrelin level and enhanced acyl- to desacyl-ghrelin (A/D) ratio in cisplatin-treated rats. Several components of RKT demonstrated inhibitory activity against ghrelin deacylating enzymes. In addition, 10-gingerol, a component of RKT, inhibited exogenous ghrelin deacylation. Therefore, RKT may enhance plasma acyl-ghrelin level, at least in part, by inhibiting the circulating ghrelin degrading enzyme.

Topics: Acylation; Animals; Anorexia; Carboxylesterase; Catechols; Cisplatin; Drugs, Chinese Herbal; Fatty Alcohols; Ghrelin; Male; Rats; Rats, Sprague-Dawley

2011