gestonorone-caproate has been researched along with Erectile-Dysfunction* in 2 studies
1 trial(s) available for gestonorone-caproate and Erectile-Dysfunction
Article | Year |
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Treatment of benign prostatic hyperplasia with hydroxyprogesterone-caproate: placebo-controlled study.
A placebo-controlled study with progesterone compound, 17-alpha-hydroxyprogesterone 17-n-caproate (Primostat), in 39 patients with benign enlargement of the prostate is reported. Statistical analysis of the results showed no evidence of significant improvement in patients receiving hydroxyprogesterone-caproate. No evidence of an effect as compared with the placebo was found when the residual urine, prostatic size, and histologic and ultrastructural changes of the removed prostatic gland in 6 of the patients, and in the luteinizing hormone, follicle-stimulating hormone, and estrogen urine levels in 21 patients were examined. Subjective effects, when carefully analyzed, provided some beneficial evidence, however not substantiated, when the patients' mode of voiding was carefully watched. The reported beneficial subjective improvement might be attributed to the enhancement of the beta-adrenergic response by the progesterone compound of the adrenergic receptors in the posterior urethra and bladder, presumably causing relaxation of its smooth muscle. The problems associated with the choice and measurement of parameters to be used in this type of investigation are discussed, and the absolute necessity of proper controls, statistical analysis, and close follow-up of the patients is pointed out. Topics: Aged; Erectile Dysfunction; Estrogens; Follicle Stimulating Hormone; Gestonorone Caproate; Humans; Luteinizing Hormone; Male; Placebos; Prostate; Prostatic Hyperplasia | 1977 |
1 other study(ies) available for gestonorone-caproate and Erectile-Dysfunction
Article | Year |
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Conservative treatment of benign prostatic hyperplasia.
A study was carried out in 30 male patients with benign prostate hyperplasia to assess the effectiveness of treatment with a progestational agent, gestonorone caproate (200 mg), given intramucularly every 7 days over a period of 2 to 3 months. The results showed definite subjective and objective improvement after treatment. Residual urine determination diminished significantly after therapy in 78% of the cases completing the study; uroflometry also showed improvement. There appeared to be some reduction in the degree of occlusion of the urethral lumen in at least 13(65%) out of 20 patients given follow-up cystopanendoscopy after 6 months. This result was further supported by improvement in urinary flow rates and uroflometrograms in the same patients. The only adverse effect of treatment noted was the development of impotency in 21 patients. Topics: Aged; Cystoscopy; Drug Evaluation; Erectile Dysfunction; Gestonorone Caproate; Humans; Male; Middle Aged; Prostatic Hyperplasia; Urination; Urination Disorders | 1977 |