germanium and Nephritis--Interstitial

germanium has been researched along with Nephritis--Interstitial* in 3 studies

Reviews

1 review(s) available for germanium and Nephritis--Interstitial

ArticleYear
[Tubulointerstitial injuries in heavy metal intoxications].
    Nihon rinsho. Japanese journal of clinical medicine, 1995, Volume: 53, Issue:8

    The kidney is one of the organs susceptible to heavy metal intoxication. The total body burden and "saturation" level in renal tissue are important limiting factors to the onset of renal injuries. Acute or chronic exposure to many of heavy metals can induce renal tubulointerstitial injuries, including acute tubular necrosis, chronic tubulointerstitial nephritis, Fanconi syndrome, renal tubular acidosis, and renal tubular dysfunction without morphological changes. Chronic cadmium intoxication can cause irreversible Fanconi syndrome with chronic tubulointerstitial nephritis. Both urinary low-molecular weight protein excretion and urinary cadmium excretion (greater than 200-400 ppm) are the most reliable earlier markers of tubulointerstitial injury in chronic cadmium intoxication. The role of metallothionein is central to an understanding of cadmium-induced nephropathy. Acute lead intoxication in children can cause reversible Fanconi syndrome. Hypertension, hyperuricemia, and elevated serum creatinine, without Fanconi syndrome, are clinical manifestations of chronic lead exposure in adults. Nuclear inclusion body in proximal tubular cell is characteristic. Chronic exposure to inorganic germanium can cause chronic renal failure without urinary abnormalities, due to tubular degeneration and interstitial fibrosis, mainly in the thick ascending limb of Henle and distal tubulus.

    Topics: Adult; Animals; Cadmium Poisoning; Germanium; Humans; Lead Poisoning; Mercury Poisoning; Nephritis, Interstitial

1995

Other Studies

2 other study(ies) available for germanium and Nephritis--Interstitial

ArticleYear
Tubulointerstitial nephropathy persisting 20 months after discontinuation of chronic intake of germanium lactate citrate.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 1993, Volume: 21, Issue:5

    Two young human immunodeficiency virus (HIV)-infected patients, a 25-year-old woman and a 26-year-old man, consumed large amounts of germanium lactate citrate 18% as an "immunostimulant" for 9 months. The woman, who had stage II HIV infection, developed severe renal dysfunction (creatinine clearance, 7 mL/min/1.73 m2) and slight proteinuria (0.28 g/d) after ingesting 260 g germanium lactate citrate 18%. Hepatomegaly with liver dysfunction (SGOT, 102 U/L; gamma-glutamyl transferase (GT), 159 U/L) and lactic acidosis (plasma lactate, 7.3 mmol/L) developed simultaneously. Renal biopsy revealed tubulointerstitial nephropathy with vacuolar cell degeneration and periodic acid-Schiff-positive intracellular deposits mainly in distal tubules. Liver biopsy disclosed severe hepatic steatosis; liver function tests returned to normal within 5 weeks. Since renal failure persisted for 2 years after ingestion of germanium (creatinine clearance, 14 mL/min/1.73 m2; proteinuria, 0.84 g/d), a second renal biopsy was performed, which showed marked but focal distal tubular atrophy and slight interstitial fibrosis. The male patient, who had stage III HIV infection, had ingested the same compound; he presented with a creatinine clearance of 43 mL/min/m2 and proteinuria of 0.36 g/d. Renal biopsy disclosed tubulointerstitial changes similar to those found in the female patient. After 9 months off germanium, creatinine clearance remained unchanged. Neutron activation analysis of all biopsy specimens in both cases documented germanium concentrations 10 to 70 times normal in renal tissue and 140 times normal in liver tissue.

    Topics: Adult; Chronic Disease; Female; Germanium; HIV Infections; Humans; Kidney Tubules; Male; Microscopy, Electron; Nephritis, Interstitial; Time Factors

1993
[Two cases of various symptoms and renal dysfunction induced by longterm germanium intake].
    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 1988, Volume: 77, Issue:11

    Topics: Child; Female; Gastrointestinal Diseases; Germanium; Humans; Kidney; Male; Middle Aged; Nephritis, Interstitial; Peripheral Nerves; Peripheral Nervous System Diseases

1988