germanium and Lead-Poisoning

The kidney is one of the organs susceptible to heavy metal intoxication. The total body burden and "saturation" level in renal tissue are important limiting factors to the onset of renal injuries. Acute or chronic exposure to many of heavy metals can induce renal tubulointerstitial injuries, including acute tubular necrosis, chronic tubulointerstitial nephritis, Fanconi syndrome, renal tubular acidosis, and renal tubular dysfunction without morphological changes. Chronic cadmium intoxication can cause irreversible Fanconi syndrome with chronic tubulointerstitial nephritis. Both urinary low-molecular weight protein excretion and urinary cadmium excretion (greater than 200-400 ppm) are the most reliable earlier markers of tubulointerstitial injury in chronic cadmium intoxication. The role of metallothionein is central to an understanding of cadmium-induced nephropathy. Acute lead intoxication in children can cause reversible Fanconi syndrome. Hypertension, hyperuricemia, and elevated serum creatinine, without Fanconi syndrome, are clinical manifestations of chronic lead exposure in adults. Nuclear inclusion body in proximal tubular cell is characteristic. Chronic exposure to inorganic germanium can cause chronic renal failure without urinary abnormalities, due to tubular degeneration and interstitial fibrosis, mainly in the thick ascending limb of Henle and distal tubulus.

Topics: Adult; Animals; Cadmium Poisoning; Germanium; Humans; Lead Poisoning; Mercury Poisoning; Nephritis, Interstitial

A 4 x 500 mm2 "cloverleaf" low energy germanium detector array has been assembled for the purpose of in vivo bone lead measurement through x-ray fluorescence. Using 109Cd as an exciting source, results are reported from a leg phantom simulating measurement of lead in a human tibia. For high activity (4.0-4.4 GBq) and low activity (0.18-0.19 GBq) sources, measurement results are reported for both the cloverleaf system and a conventional single detector system of equivalent surface area (2000 mm2). The mean uncertainty and reproducibility of measurement were both significantly improved for the cloverleaf system with a high activity 109Cd source. When using a source activity of 4.4 GBq, measurement of the phantom resulted in an average bone lead uncertainty of 0.79 microg/g and a reproducibility of 0.84 microg/g. These results represent the highest precision yet reported from a bone lead x-ray fluorescence system.

Topics: Bone and Bones; Cadmium Radioisotopes; Cyclotrons; Environmental Exposure; Germanium; Humans; Lead; Lead Poisoning; Phantoms, Imaging; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, X-Ray Emission