germacrone and Swine-Diseases

Porcine parvovirus (PPV) infections can lead to significant losses to the swine industry by causing reproductive failure in pigs. Germacrone has been reported to efficiently suppress the replication of influenza virus. In this report, the antiviral activity of germacrone on PPV in swine testis (ST) cells was investigated. Here, we show for the first time that germacrone protects cells from PPV infection and suppresses the synthesis of viral mRNA and protein. Furthermore, we show that germacrone inhibits PPV replication at an early stage in a dose-dependent manner. These findings suggest that germacrone is a potential candidate for anti-PPV therapy.

Topics: Animals; Antiviral Agents; Cells, Cultured; Dose-Response Relationship, Drug; Fluorescent Antibody Technique, Indirect; In Vitro Techniques; Parvoviridae Infections; Parvovirus, Porcine; Real-Time Polymerase Chain Reaction; Sesquiterpenes, Germacrane; Swine; Swine Diseases; Virus Attachment; Virus Internalization; Virus Replication