germacrone and Liver-Cirrhosis

germacrone has been researched along with Liver-Cirrhosis* in 1 studies

Other Studies

1 other study(ies) available for germacrone and Liver-Cirrhosis

Article	Year
Co-delivery of miR-29b and germacrone based on cyclic RGD-modified nanoparticles for liver fibrosis therapy. Journal of nanobiotechnology, 2020, Jun-08, Volume: 18, Issue:1 Hepatic stellate cells (HSCs) were activated and secreted excessive amounts of extracellular matrix (ECM) proteins during pathogenetic progress of liver fibrosis. Germacrone (GMO) and miR-29b can play an important role in inhibiting growth of HSCs and production of type I collagen. GMO and miR-29b were co-encapsulated into nanoparticles (NPs) based on poly(ethylene glycol)-block-poly(lactide-co-glycolide) (PEG-PLGA). Then, NPs were modified with cyclic RGD peptides (cRGDfK). cRGDfK is an effective ligand to bind integrin α Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Hepatic Stellate Cells; Liver; Liver Cirrhosis; Male; Mice; Mice, Inbred C57BL; MicroRNAs; Nanoparticles; Peptides, Cyclic; Sesquiterpenes, Germacrane; Tissue Distribution	2020

Article

Year

Co-delivery of miR-29b and germacrone based on cyclic RGD-modified nanoparticles for liver fibrosis therapy.

Journal of nanobiotechnology, 2020, Jun-08, Volume: 18, Issue:1

Hepatic stellate cells (HSCs) were activated and secreted excessive amounts of extracellular matrix (ECM) proteins during pathogenetic progress of liver fibrosis. Germacrone (GMO) and miR-29b can play an important role in inhibiting growth of HSCs and production of type I collagen. GMO and miR-29b were co-encapsulated into nanoparticles (NPs) based on poly(ethylene glycol)-block-poly(lactide-co-glycolide) (PEG-PLGA). Then, NPs were modified with cyclic RGD peptides (cRGDfK). cRGDfK is an effective ligand to bind integrin α

Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Hepatic Stellate Cells; Liver; Liver Cirrhosis; Male; Mice; Mice, Inbred C57BL; MicroRNAs; Nanoparticles; Peptides, Cyclic; Sesquiterpenes, Germacrane; Tissue Distribution

2020