germacranolide has been researched along with Liver-Neoplasms* in 2 studies
2 other study(ies) available for germacranolide and Liver-Neoplasms
| Article | Year |
|---|---|
Design and synthesis of guaianolide-germacranolide heterodimers as novel anticancer agents against hepatocellular carcinoma.
Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Proliferation; Drug Screening Assays, Antitumor; Hep G2 Cells; Humans; Liver Neoplasms; Molecular Structure; Sorafenib; Structure-Activity Relationship | 2023 |
Germacranolides from Elephantopus scaber L. and their cytotoxic activities.
Seven undescribed germacranolides, named as scabertopinolide A-G were obtained from whole herbs of Elephantopus scaber L. The determination of their structures was conducted via comprehensive spectroscopic analyses combined with experimental electronic circular dichroism (ECD) spectroscopic data and quantum mechanical ECD calculations. The absolute configuration of scabertopinolide A was determined by X-ray crystallography data analysis. The cytotoxicity of all compounds was evaluated against three human cancer cell lines HepG2, Hep3B (human hepatocellular carcinoma cell lines), and MCF-7 (human breast adenocarcinoma cell line). Scabertopinolide G exhibited the most significant cytotoxic activities against the three cancer cell lines with IC Topics: Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Asteraceae; Cell Line, Tumor; Humans; Liver Neoplasms; Sesquiterpenes, Germacrane | 2020 |