geranylgeranylacetone has been researched along with Seizures* in 1 studies
1 other study(ies) available for geranylgeranylacetone and Seizures
| Article | Year |
|---|---|
A single oral dose of geranylgeranylacetone attenuates kainic acid-induced seizures and neuronal cell death in rat hippocampus.
The present study evaluated the potential effect of geranylgeranylacetone (GGA), which is known as an antiulcer agent, against kainic acid (KA)-induced neurotoxicity. Pretreatment with a single oral GGA dose (800 mg/kg, 2 days before KA) significantly attenuated KA-induced seizures and cell death in rat hippocampus. These effects of GGA were prevented by the coinjection of MK801, a noncompetitive N-methyl-D-aspartate glutamate receptor antagonist, which indicates that the protection was indeed mediated by glutamate receptor activation. Topics: Administration, Oral; Animals; Anti-Ulcer Agents; Cell Death; Convulsants; Diterpenes; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Hippocampus; Kainic Acid; Male; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Seizures | 2004 |