geranylgeranylacetone and Poisoning

This review deals with the three candidate compounds which may combat with dioxins' toxicity. Geranylgeranylacetone (GGA), an antiulcer drug, counteracts suppression of body weight gain and lethality produced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in C57BL/6J mice. Similarly, curcumin, a food ingredient anticipates the TCDD's toxicity on body weight gain. Both GGA and curcumin had no effect on the induction of hepatic ethoxyresorufin O-deethylase activity by TCDD. These data suggest that both compounds exhibit a protective effect against some forms of dioxin toxicity by a mechanism without involving inhibition of aryl hydrocarbon receptor activation. Further, the mechanism involved in resveratrol action on dioxin's toxicity was also discussed. Prior to the application of these compounds to Yusho patients, the limitation and possibility of these candidate compounds are seemed to be further studied.

Topics: Animals; Anti-Ulcer Agents; Curcumin; Cytochrome P-450 CYP1A1; Diterpenes; Food Contamination; Humans; Mice; Mice, Inbred C57BL; Oryza; Plant Oils; Poisoning; Polychlorinated Biphenyls; Polychlorinated Dibenzodioxins; Receptors, Aryl Hydrocarbon; Resveratrol; Stilbenes