geranylgeranylacetone and Leukemia--Myeloid

geranylgeranylacetone has been researched along with Leukemia--Myeloid* in 1 studies

Other Studies

1 other study(ies) available for geranylgeranylacetone and Leukemia--Myeloid

Article	Year
Geranylgeranylacetone used as an antiulcer agent is a potent inducer of differentiation of various human myeloid leukemia cell lines. Biochemical and biophysical research communications, 1993, Mar-31, Volume: 191, Issue:3 Low concentrations of geranylgeranylacetone (GGA), known as an antiulcer agent (Teprenone), induces differentiation of various human myeloid leukemia cell lines. The cell lines examined in the present study were myeloblastic ML1, histiocytic U937, promyelocytic HL60, and multipotential K562. All of these cell lines were induced to differentiate by 20 microM GGA, as measured by NBT staining. Neither polyprenylacetones, with more or fewer isoprene units than the geranylgeranyl group, nor polyprenylalcohols had no differentiation-inducing activity. GGA used in combination with RA or TNF-alpha increased ML1 cell differentiation. The present results suggest that GGA may be a useful agent in differentiation therapy of leukemia. Topics: Cell Differentiation; Diterpenes; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Leukemia, Myeloid; Structure-Activity Relationship; Tretinoin; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha	1993

Article

Year

Geranylgeranylacetone used as an antiulcer agent is a potent inducer of differentiation of various human myeloid leukemia cell lines.

Biochemical and biophysical research communications, 1993, Mar-31, Volume: 191, Issue:3

Low concentrations of geranylgeranylacetone (GGA), known as an antiulcer agent (Teprenone), induces differentiation of various human myeloid leukemia cell lines. The cell lines examined in the present study were myeloblastic ML1, histiocytic U937, promyelocytic HL60, and multipotential K562. All of these cell lines were induced to differentiate by 20 microM GGA, as measured by NBT staining. Neither polyprenylacetones, with more or fewer isoprene units than the geranylgeranyl group, nor polyprenylalcohols had no differentiation-inducing activity. GGA used in combination with RA or TNF-alpha increased ML1 cell differentiation. The present results suggest that GGA may be a useful agent in differentiation therapy of leukemia.

Topics: Cell Differentiation; Diterpenes; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Leukemia, Myeloid; Structure-Activity Relationship; Tretinoin; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha

1993