geranylgeranylacetone and Cataract

geranylgeranylacetone has been researched along with Cataract* in 1 studies

Other Studies

1 other study(ies) available for geranylgeranylacetone and Cataract

Article	Year
Effect of Geranylgeranylacetone on Ultraviolet Radiation Type B-Induced Cataract in Heat-Shock Transcription Factor 1 Heterozygous Mouse. Current eye research, 2017, Volume: 42, Issue:5 We investigated whether heat-shock transcription factor 1 (HSF1) was involved in ultraviolet radiation type B (UVR-B)-induced lens opacity (cataract) using HSF1 heterozygous mice. We also examined the effects of geranylgeranylacetone (GGA), an inducer of heat-shock proteins via activation of HSF, on the UVR-B-induced cataract.. The HSF1 expression was more greatly decreased in the lens from HSF1. These data suggest that HSF1 plays an important role in the occurrence of UVR-B-induced cataracts, possibly via regulation of HSPs such as HSP25. Topics: Animals; Blotting, Western; Cataract; Diterpenes; DNA Mutational Analysis; Dose-Response Relationship, Radiation; Female; Gene Expression Regulation; Heat Shock Transcription Factors; Heterozygote; Lens, Crystalline; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Radiation Injuries, Experimental; Real-Time Polymerase Chain Reaction; RNA; Transcription Factors; Ultraviolet Rays	2017

Article

Year

Effect of Geranylgeranylacetone on Ultraviolet Radiation Type B-Induced Cataract in Heat-Shock Transcription Factor 1 Heterozygous Mouse.

Current eye research, 2017, Volume: 42, Issue:5

We investigated whether heat-shock transcription factor 1 (HSF1) was involved in ultraviolet radiation type B (UVR-B)-induced lens opacity (cataract) using HSF1 heterozygous mice. We also examined the effects of geranylgeranylacetone (GGA), an inducer of heat-shock proteins via activation of HSF, on the UVR-B-induced cataract.. The HSF1 expression was more greatly decreased in the lens from HSF1. These data suggest that HSF1 plays an important role in the occurrence of UVR-B-induced cataracts, possibly via regulation of HSPs such as HSP25.

Topics: Animals; Blotting, Western; Cataract; Diterpenes; DNA Mutational Analysis; Dose-Response Relationship, Radiation; Female; Gene Expression Regulation; Heat Shock Transcription Factors; Heterozygote; Lens, Crystalline; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Radiation Injuries, Experimental; Real-Time Polymerase Chain Reaction; RNA; Transcription Factors; Ultraviolet Rays

2017