geranylgeranyl-pyrophosphate has been researched along with Leukemia* in 1 studies
1 other study(ies) available for geranylgeranyl-pyrophosphate and Leukemia
| Article | Year |
|---|---|
Inhibition of farnesyl transferases from malignant and non-malignant cultured human lymphocytes by prenyl substrate analogues.
Cytosolic prenyl transferases from two human lymphoid tissue-derived cell lines, IM-9 and Molt-4 cells, are shown to isoprenylate recombinant p21H-ras. Isoprenylation was inhibited by an N-acetylated pentapeptide (N-Ac-Lys-Cys-Val-Leu-Ser), c,t-farnesyl diphosphate, c,t,t-geranylgeranyl diphosphate, t,t,t-geranylgeranyl diphosphate and a photolabile farnesyl diphosphate analogue. c,t-Farnesyl and t,t,t-geranylgeranyl monophosphates were also effective inhibitors of the Molt-4 enzyme but not the IM-9 enzyme. Topics: Alkyl and Aryl Transferases; Amino Acid Sequence; Humans; Leukemia; Molecular Sequence Data; Polyisoprenyl Phosphates; Proto-Oncogene Proteins p21(ras); Sesquiterpenes; Transferases; Tumor Cells, Cultured | 1991 |