Compounds > geranylgeraniol
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geranylgeraniol and Bone Loss, Osteoclastic

geranylgeraniol has been researched along with Bone Loss, Osteoclastic in 7 studies

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (28.57)18.2507
2000's3 (42.86)29.6817
2010's2 (28.57)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ikebe, T; Kajiya, H; Kimachi, K; Nakayama, S; Okabe, K1
Capecchi, PL; Capperucci, C; Ferrata, P; Frediani, B; Galeazzi, M; Laghi-Pasini, F; Lazzerini, PE; Niccolini, S; Spreafico, A1
Fisher, JE; Glantschnig, H; Reszka, AA; Rodan, GA; Wesolowski, G1
Fujikawa, Y; Itonaga, I; Kudo, O; Taira, H; Torisu, T1
Karperien, M; Löwik, C; Papapoulos, S; van Beek, E1
Akiyama, Y; Hara, K; Morita, I; Murota, S; Nakamura, T1
Fisher, JE; Halasy, JM; Hughes, DE; Luckman, SP; Masarachia, PJ; Reszka, AA; Rodan, GA; Rogers, MJ; Russell, RG; Wesolowski, G1

Other Studies

7 other study(ies) available for geranylgeraniol and Bone Loss, Osteoclastic

ArticleYear
Zoledronic acid inhibits RANK expression and migration of osteoclast precursors during osteoclastogenesis.
    Naunyn-Schmiedeberg's archives of pharmacology, 2011, Volume: 383, Issue:3

    Topics: Acid Phosphatase; Animals; Bone Marrow Cells; Bone Resorption; Cell Differentiation; Cell Line, Tumor; Cell Movement; Diphosphonates; Diterpenes; Dose-Response Relationship, Drug; Gene Expression; I-kappa B Proteins; Imidazoles; Isoenzymes; Macrophages; Mice; Mice, Inbred Strains; NF-kappa B; NF-KappaB Inhibitor alpha; Osteoclasts; Phosphorylation; Protein Prenylation; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; Signal Transduction; Stem Cells; Tartrate-Resistant Acid Phosphatase; Transcription, Genetic; Tumor Necrosis Factor-alpha; Up-Regulation; Zoledronic Acid

2011
Rosuvastatin inhibits spontaneous and IL-1β-induced interleukin-6 production from human cultured osteoblastic cells.
    Joint bone spine, 2013, Volume: 80, Issue:2

    Topics: Aged; Bone Resorption; Cell Proliferation; Cell Survival; Cells, Cultured; Culture Media; Diterpenes; Farnesol; Femur Head; Fluorobenzenes; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Interleukin-1beta; Interleukin-6; Mevalonic Acid; Middle Aged; Osteoblasts; Osteoporosis; Osteoprotegerin; Pyrimidines; RNA, Messenger; Rosuvastatin Calcium; Sulfonamides; Terpenes

2013
M-CSF, TNFalpha and RANK ligand promote osteoclast survival by signaling through mTOR/S6 kinase.
    Cell death and differentiation, 2003, Volume: 10, Issue:10

    Topics: Acid Phosphatase; Actins; Adaptor Proteins, Signal Transducing; Alendronate; Alkyl and Aryl Transferases; Animals; Apoptosis; Blotting, Western; Bone Marrow Cells; Bone Resorption; Carrier Proteins; Caspase 3; Caspase 9; Caspases; Cell Cycle Proteins; Cell Survival; Collagen; Collagen Type I; Cytokines; Diterpenes; Enzyme Inhibitors; Eukaryotic Initiation Factors; Immunohistochemistry; Interleukin-1; Isoenzymes; Macrophage Colony-Stimulating Factor; Membrane Glycoproteins; Mice; Models, Biological; NF-kappa B; Osteoclasts; Peptides; Phosphoproteins; Protein Kinases; Protein Serine-Threonine Kinases; Protein Synthesis Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; Ribosomal Protein S6; Ribosomal Protein S6 Kinases, 70-kDa; Serine-Threonine Kinase 3; Signal Transduction; Sirolimus; Tartrate-Resistant Acid Phosphatase; TOR Serine-Threonine Kinases; Tumor Necrosis Factor-alpha

2003
Menatetrenone (vitamin K2) acts directly on circulating human osteoclast precursors.
    Calcified tissue international, 2003, Volume: 73, Issue:1

    Topics: Acid Phosphatase; Antifibrinolytic Agents; Bone Resorption; Cell Count; Cell Differentiation; Cells, Cultured; Diterpenes; Dose-Response Relationship, Drug; Drug Combinations; Giant Cells; Humans; Isoenzymes; Leukocytes, Mononuclear; Osteoclasts; Phytol; Stem Cells; Tartrate-Resistant Acid Phosphatase; Vitamin K 1; Vitamin K 2

2003
Independent pathways in the modulation of osteoclastic resorption by intermediates of the mevalonate biosynthetic pathway: the role of the retinoic acid receptor.
    Bone, 2006, Volume: 38, Issue:2

    Topics: Animals; Bone and Bones; Bone Density Conservation Agents; Bone Resorption; Calcium; Diphosphonates; Diterpenes; Dose-Response Relationship, Drug; Drug Synergism; Female; Ibandronic Acid; Mevalonic Acid; Mice; Osteoclasts; Polyisoprenyl Phosphates; Pregnancy; Protein Prenylation; Receptors, Retinoic Acid

2006
The inhibitory effect of vitamin K2 (menatetrenone) on bone resorption may be related to its side chain.
    Bone, 1995, Volume: 16, Issue:2

    Topics: Acid Phosphatase; Analysis of Variance; Animals; Bone Resorption; Calcitriol; Calcium; Cells, Cultured; Dinoprostone; Diterpenes; Giant Cells; Male; Mice; Mice, Inbred ICR; Organ Culture Techniques; Osteoclasts; Phytol; Spleen; Stromal Cells; Structure-Activity Relationship; Vitamin K; Vitamin K 1; Vitamin K 2; Warfarin

1995
Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro.
    Proceedings of the National Academy of Sciences of the United States of America, 1999, Jan-05, Volume: 96, Issue:1

    Topics: Alendronate; Animals; Bone Resorption; Cell Differentiation; Cells, Cultured; Cholesterol; Clodronic Acid; Diterpenes; Enzyme Activation; Farnesol; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mevalonic Acid; Mice; Osteoclasts; Protein Kinases; Rabbits; Skull; Squalene

1999