genz10850 has been researched along with Tuberculosis* in 1 studies
1 other study(ies) available for genz10850 and Tuberculosis
| Article | Year |
|---|---|
Synthesis of 3-heteryl substituted pyrrolidine-2,5-diones via catalytic Michael reaction and evaluation of their inhibitory activity against InhA and Mycobacterium tuberculosis.
In the present paper, we report the synthesis via catalytic Michael reaction and biological results of a series of 3-heteryl substituted pyrrolidine-2,5-dione derivatives as moderate inhibitors against Mycobacterium tuberculosis H37Rv growth. Some of them present also inhibition activities against InhA. Topics: Antitubercular Agents; Bacterial Proteins; Humans; Microbial Sensitivity Tests; Models, Molecular; Mycobacterium tuberculosis; Oxidoreductases; Pyrrolidines; Structure-Activity Relationship; Tuberculosis | 2014 |