gentamicin-sulfate has been researched along with Eye-Infections--Fungal* in 1 studies
1 other study(ies) available for gentamicin-sulfate and Eye-Infections--Fungal
| Article | Year |
|---|---|
Rational Design of Short Peptide Variants by Using Kunitzin-RE, an Amphibian-Derived Bioactivity Peptide, for Acquired Potent Broad-Spectrum Antimicrobial and Improved Therapeutic Potential of Commensalism Coinfection of Pathogens.
Commensalism coinfection of pathogens has seriously jeopardized human health. Currently, Kunitzin-RE, as an amphibian-derived bioactivity peptide, is regarded as a potential antimicrobial candidate. However, its antimicrobial properties were unsatisfactory. In this study, a set of shortened variants of Kunitzin-RE was developed by the interception of a peptide fragment and single-site mutation to investigate the effect of chain length, positive charge, hydrophobicity, amphipathicity, and secondary structure on antimicrobial properties. Among them, W8 (AARIILRWRFR) significantly broadened the antimicrobial spectrum and showed the highest antimicrobial activity (GM Topics: Amino Acid Sequence; Animals; Anti-Bacterial Agents; Antifungal Agents; Antimicrobial Cationic Peptides; Candida albicans; Cell Membrane; Cell Membrane Permeability; Coinfection; Drug Design; Escherichia coli; Eye Infections, Fungal; Keratitis; Mice; Microbial Sensitivity Tests; Protein Conformation, alpha-Helical; Protein Engineering; RAW 264.7 Cells; Salmonella typhimurium; Staphylococcus aureus | 2019 |