gentamicin and Vertigo studies

Gentamicins: A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.

Vertigo: An illusion of movement, either of the external world revolving around the individual or of the individual revolving in space. Vertigo may be associated with disorders of the inner ear (EAR, INNER); VESTIBULAR NERVE; BRAINSTEM; or CEREBRAL CORTEX. Lesions in the TEMPORAL LOBE and PARIETAL LOBE may be associated with FOCAL SEIZURES that may feature vertigo as an ictal manifestation. (From Adams et al., Principles of Neurology, 6th ed, pp300-1)

Research Excerpts

Excerpt	Relevance	Reference
"Intratympanic application of gentamicin is a relatively safe and efficient treatment for the reduction of complaints of vertigo attacks associated with Menière's disease."	9.13	Intratympanic gentamicin therapy for control of vertigo in unilateral Menire's disease: a prospective, double-blind, randomized, placebo-controlled trial. ( Albers, FW; Kingma, CM; Postema, RJ; Van Der Laan, BF; Wit, HP, 2008)
" Intratympanic gentamicin (ITG) was superior to intratympanic steroid (ITS) in reducing the number of vertigo attacks (odds ratio (OR) 3."	9.12	What is the efficacy of gentamicin on the incidence of vertigo attacks and hearing in patients with Meniere's disease compared with steroids? A meta-analysis. ( Jiang, M; Zhang, Z; Zhao, C, 2021)
"We investigated the effect of intratympanic gentamicin and dexamethasone treatments on the control of vertigo and hearing loss in patients with Meniere's disease."	9.12	[Intratympanic treatment in Meniere's disease: the effect of gentamicin and dexamethasone on vertigo control and hearing]. ( Akkuzu, B; Ozgirgin, N; Ozlüoğlu, LN, 2006)
"To determine if a protocol of weekly intratympanic gentamicin injections administered until development of signs of unilateral vestibular hypofunction can alleviate vertigo while preserving hearing in patients with intractable vertigo caused by unilateral Meniere's disease."	9.09	Intratympanic gentamicin for control of vertigo in Meniere's disease: vestibular signs that specify completion of therapy. ( Minor, LB, 1999)
"To assess the effectiveness of intratympanic gentamicin in the treatment of vertigo in Ménière's disease."	8.87	Intratympanic gentamicin for Ménière's disease or syndrome. ( Pullens, B; van Benthem, PP, 2011)
"Titration therapy with intratympanic gentamicin offers class A or B control of vertigo in 87% (range, 75%-100%) of patients with unilateral Ménière's disease."	8.82	Intratympanic gentamicin for the treatment of Meniere's disease and other forms of peripheral vertigo. ( Carey, J, 2004)
"To describe the long-term clinical vertigo control along with measured lateral canal vestibular function in patients with unilateral refractory Menière's disease (MD) treated with gentamicin transtympanic injections (TTI)."	7.91	Long-term Vertigo Control and Vestibular Function After Low-dose On-demand Transtympanic Gentamicin for Refractory Menière's Disease. ( Deguine, O; Fraysse, B; Fraysse, ME; Kmeid, M; Mansour, C; Marx, M; Nicolas, S, 2019)
"To evaluate the objective and subjective effects of intratympanic gentamicin treatment in patients with small vestibular schwannomas who exhibit intractable vertigo."	7.88	Intratympanic Gentamicin for Small Vestibular Schwannomas With Intractable Vertigo. ( Huang, M; Jia, H; Li, G; Li, Y; Wang, Z; Wu, H; Yang, J; Zhu, W, 2018)
"To document the effect of intratympanic gentamicin as treatment of disabling vertigo secondary to a vestibular schwannoma in elderly patients."	7.79	The use of intratympanic gentamicin in patients with vestibular schwannoma and disabling vertigo. ( Falcioni, M; Giannuzzi, AL; Merkus, P, 2013)
"To compare the cochlear distribution of low-dose fluorescent gentamicin after intra-tympanic administration in guinea pig (GPs) with clinical data of low dose intra-tympanic gentamicin in patients with intractable vertigo."	7.76	Evidence-based modification of intratympanic gentamicin injections in patients with intractable vertigo. ( Dai, CF; Liu, JP; Steyger, PS; Wang, Q; Zhai, F, 2010)
"To compare proportions of the combined outcome of vertigo control and hearing preservation between intratympanic gentamicin injections and endolymphatic sac shunt surgery for intractable vertigo in Ménière's disease patients."	7.76	Outcomes of endolymphatic shunt surgery for Ménière's disease: comparison with intratympanic gentamicin on vertigo control and hearing loss. ( Berliner, K; Chung, J; Derebery, MJ; Fisher, LM; Green, K, 2010)
"The aim of this study was to correlate long-term vertigo control with reduction in vestibular function after intratympanic (IT) gentamicin therapy for unilateral Ménière's disease."	7.75	Vestibular function and vertigo control after intratympanic gentamicin for Ménière's disease. ( Carey, JP; Della Santina, CC; Minor, LB; Nguyen, KD, 2009)
"To assess long-term vertigo symptom control in patients after intratympanic gentamicin instillation for incapacitating unilateral Ménière's disease."	7.74	Long-term vertigo control in patients after intratympanic gentamicin instillation for Ménière's disease. ( Alexander, A; Bodmer, D; Chen, JM; Morong, S; Nedzelski, JM; Stewart, C, 2007)
"This retrospective study reports the overall efficacy and comparative results of intratympanic gentamicin injections for disabling vertigo episodes."	7.74	Gentamicin injections for Ménière disease: comparison of subjective and objective end points. ( Cronin, GW; Hardin, RB; Steenerson, RL, 2008)
"To look for factors relating to the vertigo control and hearing changes after intratympanic injections of gentamicin (GM)."	7.73	Factors relating to the vertigo control and hearing changes following intratympanic gentamicin for intractable Ménière's disease. ( Fukushima, M; Horii, A; Kitahara, T; Kizawa, K; Kubo, T; Masumura, C; Mitani, K; Nakagawa, A; Nishiike, S; Nishimura, M; Saika, T; Sasaki, T; Uno, A, 2006)
"The objective of our study was to determine whether angular vestibulo-ocular reflex (aVOR) gains correlated with vertigo control after intratympanic gentamicin treatment for Meniere's disease."	7.73	Angular vestibulo-ocular reflex gains correlate with vertigo control after intratympanic gentamicin treatment for Meniere's disease. ( Carey, JP; Haslwanter, T; Lin, FR; Migliaccio, AA; Minor, LB, 2005)
"Treatment of drop attacks is still a matter of discussion; most cases have a benign course with spontaneous remission and no treatment is necessary."	5.33	Drop attacks and vertical vertigo after transtympanic gentamicin: diagnosis and management. ( Bignami, M; Bruschini, L; Casani, AP; Dallan, I; Nacci, A, 2005)
"Of these, 68 patients had Meniere's disease; 4 patients had recurrent vertigo after endolymphatic sac surgery and were followed for at least 1 year."	5.31	Intratympanic gentamicin therapy for persistent vertigo after endolymphatic sac surgery. ( Leonetti, JP; Marzo, SJ, 2002)
" We concluded that intratympanic gentamicin may improve the control of vertigo, and result in little or no difference to tinnitus, but the certainty of the evidence is low."	5.22	Intratympanic gentamicin compared with placebo for Ménière's disease. ( de Amesti, F; Santander, MJ; Winter, M, 2022)
"Background The intratympanic application of the ototoxic aminoglycoside gentamicin has shown promising results as an ablative treatment for vertigo associated with Ménière's disease."	5.22	The effect of intratympanic gentamicin for treatment of Ménière's disease on lower frequency hearing. ( Becker, M; Chung, DW; Sam, G; van der Hoeven, R; Verweij, S, 2016)
"Intratympanic application of gentamicin is a relatively safe and efficient treatment for the reduction of complaints of vertigo attacks associated with Menière's disease."	5.13	Intratympanic gentamicin therapy for control of vertigo in unilateral Menire's disease: a prospective, double-blind, randomized, placebo-controlled trial. ( Albers, FW; Kingma, CM; Postema, RJ; Van Der Laan, BF; Wit, HP, 2008)
" Intratympanic gentamicin (ITG) was superior to intratympanic steroid (ITS) in reducing the number of vertigo attacks (odds ratio (OR) 3."	5.12	What is the efficacy of gentamicin on the incidence of vertigo attacks and hearing in patients with Meniere's disease compared with steroids? A meta-analysis. ( Jiang, M; Zhang, Z; Zhao, C, 2021)
"We investigated the effect of intratympanic gentamicin and dexamethasone treatments on the control of vertigo and hearing loss in patients with Meniere's disease."	5.12	[Intratympanic treatment in Meniere's disease: the effect of gentamicin and dexamethasone on vertigo control and hearing]. ( Akkuzu, B; Ozgirgin, N; Ozlüoğlu, LN, 2006)
"To determine if a protocol of weekly intratympanic gentamicin injections administered until development of signs of unilateral vestibular hypofunction can alleviate vertigo while preserving hearing in patients with intractable vertigo caused by unilateral Meniere's disease."	5.09	Intratympanic gentamicin for control of vertigo in Meniere's disease: vestibular signs that specify completion of therapy. ( Minor, LB, 1999)
"We evaluated the hypothesis that topical intratympanic gentamicin can relieve the vertigo of disabling Menière's disease, reduce or ablate vestibular caloric excitability, and preserve hearing."	5.07	Treatment of Menière's disease with topical gentamicin: a preliminary report. ( Bryce, GE; Nedzelski, JM; Pfleiderer, AG, 1992)
"To assess the effectiveness of intratympanic gentamicin in the treatment of vertigo in Ménière's disease."	4.87	Intratympanic gentamicin for Ménière's disease or syndrome. ( Pullens, B; van Benthem, PP, 2011)
"To assess and summarize the best available evidence for the use of intratympanic gentamicin in patients with Meniere's disease with respect to improvement of vertigo, tinnitus, and change in hearing."	4.82	Systematic review of intratympanic gentamicin in Meniere's disease. ( Diamond, C; Hornig, JD; Liu, R; O'Connell, DA, 2003)
"Titration therapy with intratympanic gentamicin offers class A or B control of vertigo in 87% (range, 75%-100%) of patients with unilateral Ménière's disease."	4.82	Intratympanic gentamicin for the treatment of Meniere's disease and other forms of peripheral vertigo. ( Carey, J, 2004)
"Inclusion criteria to select articles for meta-analysis were clear description of gentamicin delivery technique, clearly reported vertigo control results, and report of hearing loss posttreatment."	4.82	Intratympanic gentamicin therapy for Ménière's disease: a meta-analysis. ( Anderson, JP; Chia, SH; Gamst, AC; Harris, JP, 2004)
"At least 11 articles have been published that indicate that intratympanic gentamicin treatments control vertigo well and provide acceptable rates of hearing loss."	4.79	Clinical forum: a review of intratympanic therapy. ( Blakley, BW, 1997)
"Ménière's disease (MD), characterized by episodic vertigo attacks and fluctuating progressive hearing loss, is treated by low-dose intratympanic gentamicin (ITG) injections."	4.02	Intratympanic gentamicin injection for refractory ménière's disease (MD) has potential effect in preventing contralateral MD occurrence. ( Dai, C; Song, Z; Wang, J; Wu, Y; Yu, J; Zhou, Y, 2021)
"To describe the long-term clinical vertigo control along with measured lateral canal vestibular function in patients with unilateral refractory Menière's disease (MD) treated with gentamicin transtympanic injections (TTI)."	3.91	Long-term Vertigo Control and Vestibular Function After Low-dose On-demand Transtympanic Gentamicin for Refractory Menière's Disease. ( Deguine, O; Fraysse, B; Fraysse, ME; Kmeid, M; Mansour, C; Marx, M; Nicolas, S, 2019)
"To determine whether long term (>48 months) symptomatic vertigo control is sustained in patients with Menière's disease from a previous comparative trial of intratympanic methylprednisolone versus gentamicin, and if the two treatments remain nonsignificantly different at long-term follow-up."	3.91	Long-Term Follow-Up of Intratympanic Methylprednisolone Versus Gentamicin in Patients With Unilateral Menière's Disease. ( Agarwal, K; Bronstein, AM; Golding, JF; Harcourt, JP; Lambert, A; Patel, M; Wong, PY, 2019)
"In the last 4 years the authors observed a trend that correcting vitamin D deficiency in newly diagnosed cases of Meniere's disease decreased the necessity of the ablative therapy with intratympanic gentamicin."	3.88	Vitamin D supplementation may improve symptoms in Meniere's disease. ( Büki, B; Jünger, H; Lundberg, YW, 2018)
"To evaluate the objective and subjective effects of intratympanic gentamicin treatment in patients with small vestibular schwannomas who exhibit intractable vertigo."	3.88	Intratympanic Gentamicin for Small Vestibular Schwannomas With Intractable Vertigo. ( Huang, M; Jia, H; Li, G; Li, Y; Wang, Z; Wu, H; Yang, J; Zhu, W, 2018)
"To compare the efficacy of intratympanic gentamicin injection (ITG) on vertigo control, drop attacks, and functional level in Menière's disease patients with and without a history of migraine."	3.85	Efficacy of Intratympanic Gentamicin in Menière's Disease With and Without Migraine. ( Liu, YF; Rauch, SD; Renk, E; Xu, HX, 2017)
" Further repeated ITD courses or intratympanic gentamicin (ITG) were given if the vertigo was not satisfactorily controlled."	3.83	Intratympanic steroids injection is effective for the treatment of drop attacks with Ménière's disease and delayed endolymphatic hydrops: A retrospective study. ( Kong, WJ; Leng, Y; Liu, B; Liu, D; Liu, J; Zhang, SL; Zhou, R, 2016)
"1) To evaluate the efficacy of, and problems with, intratympanic gentamicin injection (ITG) in medically intractable definite Ménière's disease (MD) and secondary endolymphatic hydrops (EH); and 2) to review the vestibular status and treatment options of intractable vertigo even after ITG."	3.81	Management of intractable Ménière's disease after intratympanic injection of gentamicin. ( Choi, BY; Han, JJ; Koo, JW; Park, J; Rah, YC, 2015)
" Moreover, intratympanic gentamicin injection (ITG), as a chemical labyrinthectomy, is a simple alternative for controlling vertigo in patients with ipsilateral DEH."	3.81	Intratympanic injection in delayed endolymphatic hydrops. ( Kong, W; Leng, Y; Liu, B; Liu, J; Zhang, S; Zhou, R, 2015)
"In recent years, several titration or on-demand protocols using low-dose repeated intratympanic (IT) gentamicin injections have been adopted for the vertigo control in unilateral medical refractory Menière's disease (MD)."	3.80	Intratympanic gentamicin treatment 'as needed' for Meniere's disease. Long-term analysis using the Kaplan-Meier method. ( Benazzo, M; Gatti, O; Manfrin, M; Mira, E; Quaglieri, S; Rebecchi, E; Tinelli, C, 2014)
"A 79-year-old male, with bilateral loss of vestibular function caused by gentamicin toxicity after surgery for prosthetic valve endocarditis, complained of dizziness, difficulty in walking and an increased risk of falling."	3.80	Treatment of vertigo and postural instability using visual illusions. ( De Ru, JA; Mert, A; van Kerckhoven, G, 2014)
"To document the effect of intratympanic gentamicin as treatment of disabling vertigo secondary to a vestibular schwannoma in elderly patients."	3.79	The use of intratympanic gentamicin in patients with vestibular schwannoma and disabling vertigo. ( Falcioni, M; Giannuzzi, AL; Merkus, P, 2013)
"To compare the cochlear distribution of low-dose fluorescent gentamicin after intra-tympanic administration in guinea pig (GPs) with clinical data of low dose intra-tympanic gentamicin in patients with intractable vertigo."	3.76	Evidence-based modification of intratympanic gentamicin injections in patients with intractable vertigo. ( Dai, CF; Liu, JP; Steyger, PS; Wang, Q; Zhai, F, 2010)
"Patients with stage 1 Ménière's disease appear to have similar vertigo control with better hearing preservation than patients with advanced disease when treated with low-dose intratympanic gentamicin (10 mg/mL)."	3.76	Intratympanic gentamicin treatment of patients with Ménière's disease with normal hearing. ( Alameda, YA; Daugherty, J; Silverstein, H; Van Ess, MJ; Wazen, J, 2010)
"To compare proportions of the combined outcome of vertigo control and hearing preservation between intratympanic gentamicin injections and endolymphatic sac shunt surgery for intractable vertigo in Ménière's disease patients."	3.76	Outcomes of endolymphatic shunt surgery for Ménière's disease: comparison with intratympanic gentamicin on vertigo control and hearing loss. ( Berliner, K; Chung, J; Derebery, MJ; Fisher, LM; Green, K, 2010)
"The aim of this study was to correlate long-term vertigo control with reduction in vestibular function after intratympanic (IT) gentamicin therapy for unilateral Ménière's disease."	3.75	Vestibular function and vertigo control after intratympanic gentamicin for Ménière's disease. ( Carey, JP; Della Santina, CC; Minor, LB; Nguyen, KD, 2009)
"Administration of high-dose gentamicin for intractable Meniere's disease appears to be effective in achieving long-term control of vertigo."	3.75	High-dose intratympanic gentamicin instillations for treatment of Meniere's disease: long-term results. ( Hsieh, LC; Ko, YC; Lin, HC; Lin, LH; Shu, MT; Tsai, HT, 2009)
"In Ménière's disease (MD), when patients have incapacitating vertigo that is resistant to drug treatment, an intratympanic gentamicin application (ITG) is often proposed."	3.75	Tenotomy of the tensor tympani and stapedius tendons in Ménière's disease. ( De Valck, CF; Van de Heyning, PH; Van Rompaey, V; Wuyts, EL, 2009)
"Intratympanic gentamicin perfusion provides effective control of vertigo in patients with Ménière's disease."	3.75	Hearing results following intratympanic gentamicin perfusion for Ménière's disease. ( Aidonis, I; Kyrodimos, E; Sismanis, A, 2009)
"Transtympanic gentamicin therapy via the Silverstein MicroWick results in good vertigo control."	3.75	Transtympanic gentamicin treatment using Silverstein MicroWick in Ménière's disease patients: long term outcome. ( O'Sullivan, G; Srinivasan, VR; Suryanarayanan, R, 2009)
"To assess long-term vertigo symptom control in patients after intratympanic gentamicin instillation for incapacitating unilateral Ménière's disease."	3.74	Long-term vertigo control in patients after intratympanic gentamicin instillation for Ménière's disease. ( Alexander, A; Bodmer, D; Chen, JM; Morong, S; Nedzelski, JM; Stewart, C, 2007)
"To describe the histopathology and morphometry of the vestibular end organs from a 59-year-old Meniere's patient who underwent transmastoid labyrinthectomy for recurrent vertigo after failed intratympanic gentamicin."	3.74	Histopathology of the vestibular end organs after intratympanic gentamicin failure for Meniere's disease. ( Baloh, RW; Ishiyama, A; Ishiyama, G; Lopez, I, 2007)
"This retrospective study reports the overall efficacy and comparative results of intratympanic gentamicin injections for disabling vertigo episodes."	3.74	Gentamicin injections for Ménière disease: comparison of subjective and objective end points. ( Cronin, GW; Hardin, RB; Steenerson, RL, 2008)
"Gentamicin ototoxicity presents with gait imbalance and oscillopsia, but only rarely with hearing loss and vertigo."	3.73	Gentamicin ototoxicity: clinical features and the effect on the human vestibulo-ocular reflex. ( Baloh, RW; Ishiyama, A; Ishiyama, G; Kerber, K, 2006)
"Intratympanic gentamicin treatment ought to be offered to Ménière's patients suffering from disabling vertigo, with the proviso that they be made aware of the possibility of hearing deterioration."	3.73	Intratympanic gentamicin treatment in Meniere's disease: patients' experiences and outcomes. ( Prinsley, PR; Sandooram, D; Smith, WK, 2006)
"The aim of this study was to verify the efficacy of a modified Odkvist titration protocol of intratympanic gentamicin application in the control of vertigo attacks and the effects on the auditory and vestibular function in a group of 71 patients affected by monolateral MD resistant to medical therapy."	3.73	Intratympanic gentamicin in monolateral Meniere's disease: our experience. ( Bertino, G; Casati, L; Durso, D; Manfrin, M; Mira, E, 2006)
"To determine the long-term hearing and vestibular outcomes in patients with intractable vertigo caused by unilateral Meniere's disease, who were treated with transtympanic injection of gentamicin."	3.73	[Long-term results of transtympanic gentamicin treatment in Meniere's disease]. ( Bartoszewicz, R; Kowalska, M; Krzeska-Malinowska, I; Niemczyk, K; Pierchała, K, 2005)
"The objective of our study was to determine whether angular vestibulo-ocular reflex (aVOR) gains correlated with vertigo control after intratympanic gentamicin treatment for Meniere's disease."	3.73	Angular vestibulo-ocular reflex gains correlate with vertigo control after intratympanic gentamicin treatment for Meniere's disease. ( Carey, JP; Haslwanter, T; Lin, FR; Migliaccio, AA; Minor, LB, 2005)
"Interval treatment with up to three intratympanic gentamicin injections once weekly effectively controlled vertigo while preserving hearing in patients with Ménière's disease and recurrent or resistant vertigo after saccotomy."	3.73	Intratympanic gentamicin treatment after endolymphatic sac surgery. ( Gouveris, H; Lange, G; Mann, WJ, 2005)
"To look for factors relating to the vertigo control and hearing changes after intratympanic injections of gentamicin (GM)."	3.73	Factors relating to the vertigo control and hearing changes following intratympanic gentamicin for intractable Ménière's disease. ( Fukushima, M; Horii, A; Kitahara, T; Kizawa, K; Kubo, T; Masumura, C; Mitani, K; Nakagawa, A; Nishiike, S; Nishimura, M; Saika, T; Sasaki, T; Uno, A, 2006)
"To determine the long-term hearing outcome in patients with intractable vertigo caused by unilateral Ménière's disease who were treated with intratympanic injection of gentamicin."	3.72	Long-term hearing outcome in patients receiving intratympanic gentamicin for Ménière's disease. ( Minor, LB; Wu, IC, 2003)
"Intratympanic gentamicin is an accepted mode of treatment for patients with Meniere's disease who suffer from recurrent vertigo attacks in spite of conservative medical treatment."	3.72	[Intratympanic gentamicin treatment for intractable Menière's disease]. ( Gilony, D; Kronenberg, J; Wolf, M, 2004)
"To investigate the effect and toxicity of intratympanic gentamicin injection therapy for intractable vertigo of Menière's disease."	3.72	[Intratympanic gentamicin in Menière's disease]. ( Gao, B; Huang, W; Xu, H, 2004)
"Transtympanic administration of gentamicin is reported to be a useful treatment for vertigo in such conditions as Meniere's disease, and determining appropriate clinical dosage of gentamicin is difficult."	3.72	Inner ear changes with intracochlear gentamicin administration in Guinea pigs. ( Okuda, T; Shimogori, H; Sugahara, K; Yamashita, H, 2004)
"Vestibular nerve section and transtympanic gentamicin administration are procedures with proven efficacy in the treatment of vertigo associated with Meniere's disease refractory to medical management."	3.72	Vestibular nerve section versus intratympanic gentamicin for Meniere's disease. ( Arriaga, MA; Chen, DA; Hillman, TA, 2004)
"It was concluded that increasing the gentamicin concentration to 40 mg/ml probably produces similar rates of vertigo control as those of the lower dose, at least initially, but requires fewer injections."	3.71	Efficacy of increased gentamicin concentration for intratympanic injection therapy in Ménière's disease. ( Abou-Halawa, AS; Poe, DS, 2002)
"It appears that a single transtympanic gentamicin injection is effective in controlling the vertigo of Ménière's syndrome."	3.71	Long-term follow-up of transtympanic gentamicin for Ménière's syndrome. ( Beatty, CW; Driscoll, CL; Facer, GW; Harner, SG; McDonald, TJ, 2001)
" There was no difference in general quality of life, present hearing loss, or tinnitus between the three treatment groups, but the gentamicin-treated patients had less vertigo than did the other groups."	3.71	Patients' subjective evaluations of quality of life related to disease-specific symptoms, sense of coherence, and treatment in Ménière's disease. ( Bagger-Sjöbäck, D; Bergenius, J; Langius, A; Söderman, AC; Tjell, C, 2001)
"On the basis of an average 10-month follow-up period, of the methods currently available to treat Meniere's patients with gentamicin, low-flow CGT seems to provide an excellent combination of vertigo control and tinnitus and pressure improvement, with a relatively low risk to hearing and vestibular function."	3.71	Continuous gentamicin therapy using an IntraEAR microcatheter for Meniere's disease: a retrospective study. ( Seidman, M, 2002)
"The vestibulotoxic effect of gentamicin is well documented; however, there is no general agreement on the gentamicin dose needed to control vertigo attacks without affecting the hearing."	3.70	Round window gentamicin mu-catheter--a new therapeutic tool in Ménière's disease. ( Charabi, S; Thomsen, J; Tos, M, 2000)
"Intratympanic injections of a prepared gentamicin concentration of approximately 30 mg/ml were given weekly until the patient reported cessation of vertigo attacks."	3.70	Intratympanic gentamicin injection for the treatment of Meniere's disease. ( Poe, DS; Youssef, TF, 1998)
"The subjective visual horizontal (SVH) was measured by means of a small, rotatable, luminous line in darkness in the upright head and body position and at 10, 20 and 30 degrees of tilt to the right and left before, and repeatedly during a follow-up period of 1 year after intratympanic gentamicin instillations in 12 patients with recurrent vertigo attacks."	3.70	Subjective visual horizontal during follow-up after unilateral vestibular deafferentation with gentamicin. ( Bergenius, J; Brantberg, K; Tribukait, A, 1998)
"Vertigo frequency, hearing status, personal disability ratings, tinnitus level, and caloric responses before and after gentamicin therapy were measured."	3.70	Intratympanic gentamicin titration therapy for intractable Meniere's disease. ( Atlas, JT; Parnes, LS, 1999)
"Intratympanic gentamicin therapy for vertigo in Meniere's disease was shown to be an effective treatment choice, as shown by our results."	3.69	Treatment of intractable Menière's disease with intratympanic gentamicin: review of the University of Ottawa experience. ( Corsten, M; Marsan, J; Robichaud, J; Schramm, D, 1997)
"Adhering to the American Academy of Otolaryngology--Head and Neck Surgery 1985 criteria for reporting treatment results in Meniere's disease, the hearing status, control of vertigo, and disability scores using intratympanic gentamicin therapy were reported and compared with historical controls."	3.69	Intratympanic gentamicin therapy for Ménière's disease. ( Hirsch, BE; Kamerer, DB, 1997)
"To control attacks of vertigo while preserving both hearing and labyrinthine function, low doses of gentamicin were instilled intratympanically in nine patients with intractable unilateral Meniere's disease."	3.69	Low-dose intratympanic gentamicin treatment of Menière's disease. ( Inoue, H; Nogami, K; Uchi, Y; Uemura, T, 1994)
"To define better the benefits and risks of intratympanic gentamicin injection treatment of intractable vertigo or drop attacks due to Ménière's disease, we reviewed the charts of 18 patients whom we have now observed for > 1 year after having completed this mode of therapy."	3.69	Intratympanic gentamicin in Ménière's disease: results of therapy. ( Halmagyi, GM; Murofushi, T; Yavor, RA, 1997)
"Gentamicin given as local therapy for severe Menière's disease is of considerable value in the control of vertigo."	3.69	When and how to use gentamicin in the treatment of Menière's disease. ( Bergenius, J; Möller, C; Odkvist, LM, 1997)
"Five patients with Menière's disease and disabling vertigo were treated with two intratympanic instillations of gentamicin given at an interval of about 12 h."	3.68	Delayed onset of ototoxic effects of gentamicin in treatment of Menière's disease. Rationale for extremely low dose therapy. ( Magnusson, M; Padoan, S, 1991)
"For the medically refractory Meniere's disease patient, treatment options include intratympanic steroid injection, endolymphatic sac decompression, medical or surgical labyrinthectomy, and vestibular nerve section."	3.01	Recent surgical advances and continued controversies in medically refractory Meniere's disease. ( Hong, RS; Lucas, JC, 2023)
"Diagnosis criteria of Meniere's disease are classified into Meniere's disease with typical cochlear and vestibular symptoms, and atypical Meniere's disease with either cochlear symptoms or vestibular symptoms."	2.72	Diagnostic and therapeutic strategies for Meniere's disease of the Japan Society for Equilibrium Research. ( Iwasaki, S; Kitahara, T; Murofushi, T; Origasa, H; Seo, T; Shojaku, H; Suzuki, M; Takeda, N; Watanabe, Y, 2021)
"At two years post-treatment, the vertigo cure rate was 91."	2.40	[Chemical labyrinthectomy: results and applications]. ( Biboulet, R; Makeieff, M; Marlier, F; Mondain, M; Mouchet, F; Uziel, A, 1998)
"Gentamicin has a well-known potential for damaging the peripheral vestibular organs."	1.72	Central nystagmus and alterations in vestibular tests due to an inadvertent gentamicin administration into spinal space: A CARE case report. ( Breinbauer, HA; Delano, PH; Eyzaguirre, M; Herrero, D, 2022)
"Vertigo control, Meniere's Disease Functional Level Scale (MDFLS), Dizziness Handicap Inventory (DHI), and pure tone audiometry pre and posttreatment."	1.56	On-Demand and Low Dose Intratympanic Gentamicin for Meniere's Disease: A Customized Approach. ( Alarid-Coronel, JM; Burgos-Paez, A; Castro-Bórquez, KM; Celis-Aguilar, E; Escobar-Aispuro, L; León-Leyva, IC; López-Favela, LM; Martínez-Román, L; Obeso-Pereda, A; Trejo-González, CF; Verdiales-Lugo, S, 2020)
"A high success rates of treating vertigo attacks with low concentration ITG in refractory unilateral MD patients is herein reported, while a significant difference was not observed in the hearing threshold compared with the healthy contralateral ear."	1.48	Low Concentration Intra-Tympanic Gentamicin Treatment for Menière's Disease: A Long-Term Follow Up. ( Ephraim, E; Gavriel, H; Lasry, R; Marom, T; Nathan, S, 2018)
"However, moderate to flat sensorineural hearing loss was also observed."	1.46	Intralabyrinthine Vestibular Schwannoma Responsive to Intratympanic Gentamicin Treatment. ( Barbara, M; Covelli, E; Filippi, C; Marrone, V; Monini, S; Tarantini, S; Volpini, L, 2017)
"Surgical removal of vestibular schwannoma causes acute vestibular symptoms, including postoperative vertigo and oscillopsia due to nystagmus."	1.43	Vertigo Perception and Quality of Life in Patients after Surgical Treatment of Vestibular Schwannoma with Pretreatment Prehabituation by Chemical Vestibular Ablation. ( Balatková, Z; Betka, J; Čada, Z; Čakrt, O; Černý, R; Chovanec, M; Fík, Z; Hrubá, S; Jeřábek, J; Kluh, J; Komarc, M; Profant, O; Zvěřina, E, 2016)
"Nineteen patients with Meniere's disease were treated with intratympanic gentamicin injection."	1.34	[The effects of small dose of intratympanic gentamicin injection on intractable Meniere's disease]. ( Chi, F; Dai, C; Liu, J; Wang, Z; Zhang, G; Zhang, R, 2007)
"Treatment of drop attacks is still a matter of discussion; most cases have a benign course with spontaneous remission and no treatment is necessary."	1.33	Drop attacks and vertical vertigo after transtympanic gentamicin: diagnosis and management. ( Bignami, M; Bruschini, L; Casani, AP; Dallan, I; Nacci, A, 2005)
"Relief of vertigo was assessed by chart review and telephone interviews."	1.33	Long-term follow-up after gentamicin application via the Silverstein MicroWick in the treatment of Ménière's disease. ( Digges, EN; Hill, SL; Silverstein, H, 2006)
"Vertigo was controlled in 95 per cent, whilst preserving hearing in 77 per cent."	1.32	Long-term results of gentamicin inner ear perfusion in Ménière's disease. ( Cook, JA; Suryanarayanan, R, 2004)
"Gentamicin was applied by a high-precision insulin pump with a flow rate of 40 mg per day directly in front of the round window."	1.31	Continuous intratympanic infusion of gentamicin via a microcatheter in Menière's disease. ( Michel, O; Neugebauer, P; Schoendorf, J, 2001)
"Of these, 68 patients had Meniere's disease; 4 patients had recurrent vertigo after endolymphatic sac surgery and were followed for at least 1 year."	1.31	Intratympanic gentamicin therapy for persistent vertigo after endolymphatic sac surgery. ( Leonetti, JP; Marzo, SJ, 2002)
"Clinically significant sensorineural hearing loss occurred in 5 (20%) of 25 ears."	1.30	Intratympanic gentamicin treatment for Meniere's disease. ( Antonelli, PJ; McFeely, WJ; Rodriguez, FJ; Singleton, GT, 1998)
"Two years after the treatment, rotatory vertigo was abolished in 81% of subjects, Tumarkin attacks were cured in 60%, and work capacity was severely reduced in 10% and moderately reduced in 17% of subjects."	1.30	Intratympanic gentamicin in Meniere's disease. ( Aalto, H; Ishizaki, H; Kaasinen, S; Pyykkö, I, 1998)
"A future policy for surgical treatment of vertigo is discussed."	1.29	Surgical treatment of vertigo--the Karolinska Hospital policy. ( Ahlner, K; Bagger-Sjöbäck, D; Bergenius, J; Söderman, AC, 1996)

Research

Studies (156)

Authors

Clinical Trials (6)

Trial Overview

Trial Outcomes

Change in Hearing

Timeframe	Studies, this research(%)	All Research%
pre-1990	14 (8.97)	18.7374
1990's	28 (17.95)	18.2507
2000's	56 (35.90)	29.6817
2010's	38 (24.36)	24.3611
2020's	20 (12.82)	2.80

Authors	Studies
Breinbauer, HA	1
Eyzaguirre, M	1
Herrero, D	1
Delano, PH	1
de Amesti, F	1
Santander, MJ	1
Winter, M	1
Li, S	2
Pyykkö, I	3
Zhang, Q	2
Yang, J	3
Duan, M	2
Ilmari, P	1
Spiegel, JL	1
Stoycheva, I	1
Weiss, BG	1
Bertlich, M	1
Rader, T	1
Canis, M	1
Ihler, F	1
Webster, KE	1
Galbraith, K	1
Lee, A	1
Harrington-Benton, NA	1
Judd, O	1
Kaski, D	1
Maarsingh, OR	1
MacKeith, S	1
Ray, J	1
Van Vugt, VA	1
Burton, MJ	1
Phillips, J	1
Mikulec, AA	1
Robinson, JM	1
Skarinsky, D	1
Anderson, JJ	1
Lucas, JC	1
Hong, RS	1
Lee, JY	1
Kim, MB	1
Celis-Aguilar, E	1
Castro-Bórquez, KM	1
Obeso-Pereda, A	1
Escobar-Aispuro, L	1
Burgos-Paez, A	1
Alarid-Coronel, JM	1
Verdiales-Lugo, S	1
León-Leyva, IC	1
Trejo-González, CF	1
López-Favela, LM	1
Martínez-Román, L	1
Quaranta, N	2
Picciotti, P	1
Molnár, A	1
Maihoub, S	1
Gáborján, A	1
Tamás, L	1
Szirmai, Á	1
Basura, GJ	1
Adams, ME	1
Monfared, A	1
Schwartz, SR	1
Antonelli, PJ	2
Burkard, R	1
Bush, ML	1
Bykowski, J	1
Colandrea, M	1
Derebery, J	1
Kelly, EA	1
Kerber, KA	1
Koopman, CF	1
Kuch, AA	1
Marcolini, E	1
McKinnon, BJ	1
Ruckenstein, MJ	1
Valenzuela, CV	1
Vosooney, A	1
Walsh, SA	1
Nnacheta, LC	1
Dhepyasuwan, N	1
Buchanan, EM	1
Scarpa, A	1
Cassandro, C	1
De Luca, P	1
Viola, P	1
Greco, A	1
de Vincentiis, M	1
Cassandro, E	1
Ralli, M	1
Espinosa-Sanchez, JM	1
Lopez-Escamez, JA	1
Jiang, M	1
Zhang, Z	1
Zhao, C	1
Iwasaki, S	2
Shojaku, H	1
Murofushi, T	3
Seo, T	1
Kitahara, T	2
Origasa, H	1
Watanabe, Y	1
Suzuki, M	1
Takeda, N	1
Gill, C	1
Muzaffar, J	1
Kumar, R	1
Irving, R	1
Zhang, D	1
Lv, Y	1
Li, X	1
Li, Y	2
Song, Y	1
Fan, Z	1
Wang, H	1
Wu, Y	1
Zhou, Y	1
Yu, J	1
Song, Z	1
Dai, C	2
Wang, J	2
Liu, YF	1
Renk, E	1
Rauch, SD	1
Xu, HX	1
Pullen, RL	1
Covelli, E	1
Volpini, L	1
Filippi, C	1
Tarantini, S	1
Marrone, V	1
Monini, S	1
Barbara, M	1
Lee, MY	1
Hyun, JH	1
Suh, MW	1
Ahn, JC	1
Chung, PS	1
Jung, JY	1
Rhee, CK	1
Wang, XY	1
Büki, B	4
Jünger, H	4
Lundberg, YW	1
Nathan, S	1
Lasry, R	1
Ephraim, E	1
Marom, T	1
Gavriel, H	1
Jia, H	1
Li, G	1
Huang, M	1
Zhu, W	1
Wang, Z	2
Wu, H	1
Reynard, P	1
Karkas, A	1
Gavid, M	1
Lelonge, Y	1
Bertholon, P	1
Reichmayr, C	1
Sterrer, E	1
Bachtiar, A	1
Layr, M	1
Loader, B	1
Zhai, F	3
Shi, F	1
Dai, CF	3
Fan, C	1
Nicolas, S	1
Kmeid, M	1
Mansour, C	1
Fraysse, B	1
Deguine, O	1
Marx, M	1
Fraysse, ME	1
Hertz, J	1
Djurhuus, BD	1
Harcourt, JP	2
Lambert, A	1
Wong, PY	1
Patel, M	2
Agarwal, K	2
Golding, JF	2
Bronstein, AM	2
Huang, CJ	1
Wan, TK	1
Fang, TY	1
Wang, PC	1
Ward, B	1
Wettstein, V	1
Golding, J	1
Corallo, G	1
Nuti, D	1
Trabalzini, F	1
Mandala, M	1
Quaglieri, S	1
Gatti, O	1
Rebecchi, E	1
Manfrin, M	2
Tinelli, C	1
Mira, E	2
Benazzo, M	1
Kumar, E	1
Sharma, H	1
Giannuzzi, AL	2
Zhang, R	2
Zhang, T	1
Steyger, PS	2
Olusesi, AD	1
Hassan, SB	1
Oyeyipo, Y	1
Ukwuije, UC	1
Oyeniran, O	1
van Kerckhoven, G	1
Mert, A	1
De Ru, JA	1
Rah, YC	1
Han, JJ	1
Park, J	1
Choi, BY	1
Koo, JW	1
Liu, B	3
Zhang, S	1
Leng, Y	2
Zhou, R	2
Liu, J	3
Kong, W	1
Leng, YM	1
Shi, H	1
Zhou, RH	1
Liu, JJ	1
Zhang, WJ	1
Zhang, SL	2
Kong, WJ	2
Sam, G	1
Chung, DW	1
van der Hoeven, R	1
Verweij, S	1
Becker, M	1
Arshad, Q	1
Hariri, M	1
Rea, P	1
Seemungal, BM	1
Liu, D	1
Čada, Z	1
Balatková, Z	1
Chovanec, M	1
Čakrt, O	1
Hrubá, S	1
Jeřábek, J	1
Zvěřina, E	1
Profant, O	1
Fík, Z	1
Komarc, M	1
Betka, J	1
Kluh, J	1
Černý, R	1
Suryanarayanan, R	2
Srinivasan, VR	1
O'Sullivan, G	1
Postema, RJ	1
Kingma, CM	1
Wit, HP	1
Albers, FW	1
Van Der Laan, BF	1
Steenerson, RL	1
Hardin, RB	1
Cronin, GW	1
Kyrodimos, E	1
Aidonis, I	1
Sismanis, A	1
Lee, L	1
Pensak, ML	1
De Valck, CF	1
Van Rompaey, V	1
Wuyts, EL	1
Van de Heyning, PH	1
Hsieh, LC	1
Lin, HC	1
Tsai, HT	1
Ko, YC	1
Shu, MT	1
Lin, LH	1
Nguyen, KD	1
Minor, LB	6
Della Santina, CC	3
Carey, JP	4
Silverstein, H	2
Wazen, J	1
Van Ess, MJ	1
Daugherty, J	1
Alameda, YA	1
Liu, JP	1
Wang, Q	1
Derebery, MJ	1
Fisher, LM	1
Berliner, K	1
Chung, J	1
Green, K	1
Platz, M	1
Haslwanter, T	4
Avan, P	2
Katzenell, U	1
Gordon, M	1
Page, M	1
Pullens, B	1
van Benthem, PP	1
Merkus, P	1
Falcioni, M	1
Perez, N	1
Martin, E	1
Zubieta, JL	1
Romero, MD	1
Garcia-Tapia, R	1
Abou-Halawa, AS	1
Poe, DS	2
Marín Garrido, C	1
Fraile Rodrigo, J	1
Naya Gálvez, MJ	1
Samperiz, LC	1
Hernández Montero, E	1
Ortiz García, A	1
Peng, GC	2
Cremer, PD	2
Assimakopoulos, D	1
Patrikakos, G	1
Wu, IC	1
Marzo, SJ	2
Gilony, D	1
Wolf, M	1
Kronenberg, J	1
Hillman, TA	1
Chen, DA	1
Arriaga, MA	1
Diamond, C	1
O'Connell, DA	1
Hornig, JD	1
Liu, R	1
Okuda, T	1
Sugahara, K	1
Shimogori, H	1
Yamashita, H	1
Huang, W	1
Xu, H	1
Gao, B	1
Chia, SH	1
Gamst, AC	1
Anderson, JP	1
Harris, JP	1
Cook, JA	1
Carey, J	1
Longridge, NS	1
Bertino, G	1
Durso, D	1
Casati, L	1
Pierchała, K	1
Krzeska-Malinowska, I	1
Kowalska, M	1
Bartoszewicz, R	1
Niemczyk, K	1
Picciotti, PM	1
Fiorita, A	1
Di Nardo, W	1
Paludetti, G	1
Maurizi, M	1
Lin, FR	1
Migliaccio, AA	1
Gouveris, H	1
Lange, G	3
Mann, WJ	1
Helling, K	1
Scherer, H	1
Flanagan, S	1
Mukherjee, P	1
Tonkin, J	1
Ghossaini, SN	1
Wazen, JJ	1
Dallan, I	1
Bruschini, L	1
Nacci, A	1
Bignami, M	1
Casani, AP	1
Horii, A	1
Saika, T	1
Uno, A	1
Nishiike, S	1
Mitani, K	1
Nishimura, M	1
Fukushima, M	1
Nakagawa, A	1
Masumura, C	1
Sasaki, T	1
Kizawa, K	1
Kubo, T	1
Smith, WK	1
Sandooram, D	1
Prinsley, PR	1
Takai, Y	1
Ushio, M	1
Ishiyama, G	2
Ishiyama, A	2
Kerber, K	1
Baloh, RW	2
Hill, SL	1
Digges, EN	1
Akkuzu, B	1
Ozgirgin, N	1
Ozlüoğlu, LN	1
Lopez, I	1
Kasemsuwan, L	1
Jariengprasert, C	1
Ruencharopen, S	1
Orathai, P	1
Zhang, G	1
Chi, F	1
Magnusson, M	4
Kahlon, B	1
Karlberg, M	3
Lindberg, S	1
Siesjö, P	1
Bodmer, D	1
Morong, S	1
Stewart, C	1
Alexander, A	1
Chen, JM	1
Nedzelski, JM	4
Katzke, D	1
Hellström, S	1
Odkvist, L	1
Chiong, CM	1
Fradet, G	1
Schessel, DA	2
Bryce, GE	3
Pfleiderer, AG	3
Söderman, AC	2
Ahlner, K	1
Bagger-Sjöbäck, D	2
Bergenius, J	4
Hirsch, BE	1
Kamerer, DB	1
Halmagyi, GM	2
Yavor, RA	1
Driscoll, CL	2
Kasperbauer, JL	1
Facer, GW	2
Harner, SG	2
Beatty, CW	2
Odkvist, LM	1
Möller, C	1
Wong, DL	1
Rutka, JA	2
Blakley, BW	1
Sala, T	1
Corsten, M	1
Marsan, J	1
Schramm, D	1
Robichaud, J	1
McFeely, WJ	1
Singleton, GT	1
Rodriguez, FJ	1
Kaasinen, S	1
Ishizaki, H	2
Aalto, H	2
Youssef, TF	1
Waterston, JA	1
Tribukait, A	1
Brantberg, K	1
Mondain, M	1
Mouchet, F	1
Marlier, F	1
Makeieff, M	1
Biboulet, R	1
Uziel, A	1
Eklund, S	1
Atlas, JT	1
Parnes, LS	1
Bath, AP	1
Walsh, RM	1
Bance, ML	1
Quaranta, A	1
Aloisi, A	1
De Benedittis, G	1
Scaringi, A	1
Charabi, S	1
Thomsen, J	1
Tos, M	1
Schoendorf, J	1
Neugebauer, P	1
Michel, O	1
Walsted, A	1
McDonald, TJ	1
Tjell, C	1
Langius, A	1
Akagi, H	1
Yuen, K	1
Maeda, Y	1
Fukushima, K	1
Kariya, S	1
Orita, Y	1
Kataoka, Y	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Effectiveness of Transtympanic Steroids in Unilateral Ménière's Disease: a Randomised Controlled Double-Blind Trial[NCT00802529]	Phase 2/Phase 3	60 participants (Actual)	Interventional	2009-04-30	Completed
Vertigo Perception and Quality of Life in Patients After Surgical Treatment of Vestibular Schwannoma With Pretreatment Prehabituation by Chemical Vestibular Ablation[NCT02963896]		20 participants (Actual)	Interventional	2014-01-31	Completed
Assessment of Visual Sensitivity, Psychiatric Profile and Quality of Life Following Vestibular Schwannoma Surgery in Patients Prehabituated by Chemical Vestibular Ablation[NCT03638310]		37 participants (Actual)	Interventional	2016-01-01	Completed
Is 3D Optokinetic Stimulation in Virtual Reality Space an Efficient Tool for Improvement of Central Compensation in Patients After Vestibular Schwannoma Surgery?[NCT05578560]		60 participants (Anticipated)	Interventional	2020-01-01	Recruiting
Gentamicin Treatment Prior to Vestibular Schwannoma Surgery in Patients With Definite Remaining Vestibular Function[NCT02379754]	Phase 4	0 participants (Actual)	Interventional	2015-01-31	Withdrawn
Gentamicin Treatment Prior to Vestibular Schwannoma Surgery in Patients With no Measurable Remaining Vestibular Function[NCT02415257]	Phase 4	0 participants (Actual)	Interventional	2015-04-30	Withdrawn
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Hearing was measured as ipsilesional pure-tone threshold at Baseline, 1month, 2months, 6months, 12month, 18months and 24 months follow-up. Hearing level was taken as the average threshold across 0.5, 1, 2 and 3KHz. (NCT00802529)
Timeframe: Baseline, 1,2,6,12,18 and 24months after initial treatment

Change in Speech Discrimination

Intervention	dB (Mean)
	Baseline	1month	2months	6months	12months	18months	24months
Gentamicin	51.5	52.18	48.99	45.48	47.34	44.82	49.1
Steroid (Methylprednisolone)	53.25	49.29	49.83	46.67	47.02	48.44	46.9

"Speech discrimination was measured at Baseline, 1month, 2months, 6months, 12month and 24 months follow-up.~Speech discrimination was assessed by means of ipsilesional suprathreshold word recognition (%). Arthur Boothroyd's isophonemic word lists (AB wordlists, Guymark, Southampton) comprising sets of 10 words were played to the ipsilesional ear at the low-frequency pure-tone threshold of 0·5, 1 and 2 kHz +30dB with masking sound in the contralesional ear if necessary. The formula for masking level was: low-frequency pure-tone threshold in ipsilesional ear - bone conduction mean threshold (0·5, 1 and 2KHz) in contralesional ear - 40dB. Speech loudness and masking were rounded to the nearest 5dB. Step increments and decrements of 10dB for speech loudness and masking were used to attain the maximum speech discrimination score." (NCT00802529)
Timeframe: Baseline, 1,2,6,12 and 24months after initial treatment

Vertigo Attacks

Intervention	Percentage correct (Mean)
	Baseline	1month	2months	6months	12months	24months
Gentamicin	72.10	69.43	74.31	76.35	71.58	64.99
Steroid (Methylprednisolone)	64.97	71.78	76.10	75.63	73.43	76.32

The number of vertigo attacks between 18-24months follow-up were taken retrospectively during a face-to-face appointment at 24 months follow-up and compared to 6 month pre-enrollment baseline (as per Committee on Hearing and Equilibrium guidelines). (NCT00802529)
Timeframe: 6month pre-enrollment baseline, 18-24 months after initial treatment

Article	Year
Intratympanic gentamicin compared with placebo for Ménière's disease. Medwave, 2022, Mar-22, Volume: 22, Issue:2 Topics: Gentamicins; Humans; Meniere Disease; Systematic Reviews as Topic; Tinnitus; Vertigo	2022
Consensus on intratympanic drug delivery for Menière's disease. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2022, Volume: 279, Issue:8 Topics: Anti-Bacterial Agents; Consensus; Gentamicins; Humans; Injection, Intratympanic; Meniere Disease; Tr	2022
Intratympanic gentamicin for Ménière's disease. The Cochrane database of systematic reviews, 2023, 02-27, Volume: 2 Topics: Adult; Aminoglycosides; Anti-Bacterial Agents; Gentamicins; Humans; Meniere Disease; Tinnitus; Verti	2023
Recent surgical advances and continued controversies in medically refractory Meniere's disease. Current opinion in otolaryngology & head and neck surgery, 2023, Oct-01, Volume: 31, Issue:5 Topics: Deafness; Ear, Inner; Gentamicins; Hearing Loss; Humans; Meniere Disease; Vertigo	2023
The pharmacological management of vertigo in Meniere disease. Expert opinion on pharmacotherapy, 2020, Volume: 21, Issue:14 Topics: Adrenal Cortex Hormones; Betahistine; Clinical Trials as Topic; Diuretics; Female; Gentamicins; Huma	2020
What is the efficacy of gentamicin on the incidence of vertigo attacks and hearing in patients with Meniere's disease compared with steroids? A meta-analysis. Journal of neurology, 2021, Volume: 268, Issue:10 Topics: Anti-Bacterial Agents; Gentamicins; Hearing; Humans; Incidence; Meniere Disease; Steroids; Treatment	2021
Diagnostic and therapeutic strategies for Meniere's disease of the Japan Society for Equilibrium Research. Auris, nasus, larynx, 2021, Volume: 48, Issue:1 Topics: Anti-Bacterial Agents; Audiometry; Endolymphatic Hydrops; Endolymphatic Sac; Gentamicins; Healthy Li	2021
Intratympanic gentamicin for Ménière's disease or syndrome. The Cochrane database of systematic reviews, 2011, Mar-16, Issue:3 Topics: Anti-Bacterial Agents; Ear, Middle; Gentamicins; Humans; Meniere Disease; Randomized Controlled Tria	2011
Treatment of Ménière's disease by intratympanic gentamicin application. The Journal of laryngology and otology, 2003, Volume: 117, Issue:1 Topics: Absorption; Administration, Topical; Anti-Bacterial Agents; Gentamicins; Humans; Meniere Disease; Tr	2003
Intratympanic therapies for sensorineural hearing loss and vertigo. ORL-head and neck nursing : official journal of the Society of Otorhinolaryngology and Head-Neck Nurses, 2003,Summer, Volume: 21, Issue:3 Topics: Anti-Bacterial Agents; Catheterization; Diagnosis, Differential; Gentamicins; Hearing Loss, Sensorin	2003
Systematic review of intratympanic gentamicin in Meniere's disease. The Journal of otolaryngology, 2003, Volume: 32, Issue:6 Topics: Administration, Topical; Anti-Bacterial Agents; Ear, Inner; Gentamicins; Hearing; Humans; Meniere Di	2003
Intratympanic gentamicin therapy for Ménière's disease: a meta-analysis. Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 2004, Volume: 25, Issue:4 Topics: Anti-Bacterial Agents; Catheter Ablation; Gentamicins; Hearing Loss; Humans; Meniere Disease; Treatm	2004
Intratympanic gentamicin for the treatment of Meniere's disease and other forms of peripheral vertigo. Otolaryngologic clinics of North America, 2004, Volume: 37, Issue:5 Topics: Administration, Topical; Anti-Bacterial Agents; Gentamicins; Humans; Meniere Disease; Round Window,	2004
Meta-analysis of intratympanic gentamicin. Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 2005, Volume: 26, Issue:3 Topics: Anti-Bacterial Agents; Gentamicins; Humans; Meniere Disease; Tympanic Membrane; Vertigo	2005
An update on the surgical treatment of Ménière's diseases. Journal of the American Academy of Audiology, 2006, Volume: 17, Issue:1 Topics: Anti-Bacterial Agents; Ear, Inner; Endolymphatic Sac; Gentamicins; Hearing Loss; Humans; Meniere Dis	2006
Intratympanic gentamicin instillation as treatment of unilateral Menière's disease: update of an ongoing study. The American journal of otology, 1993, Volume: 14, Issue:3 Topics: Adult; Aged; Audiometry, Pure-Tone; Female; Gentamicins; Hearing; Humans; Male; Meniere Disease; Tym	1993
Clinical forum: a review of intratympanic therapy. The American journal of otology, 1997, Volume: 18, Issue:4 Topics: Anti-Bacterial Agents; Gentamicins; Hearing Disorders; Humans; Meniere Disease; Streptomycin; Termin	1997
[Chemical labyrinthectomy: results and applications]. Annales d'oto-laryngologie et de chirurgie cervico faciale : bulletin de la Societe d'oto-laryngologie des hopitaux de Paris, 1998, Volume: 115, Issue:4 Topics: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Ear, Inner; Female; Gentamicins; Humans; Male	1998

Article	Year
Efficacy of Intratympanic OTO-104 for the Treatment of Ménière's Disease: The Outcome of Three Randomized, Double-Blind, Placebo-Controlled Studies. Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 2023, 07-01, Volume: 44, Issue:6 Topics: Double-Blind Method; Gentamicins; Humans; Injection, Intratympanic; Injections; Meniere Disease; Tre	2023
Author's reply to the Letter to the Editor "Therapeutic strategies in the treatment of Menière's disease: the Italian experience". European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2020, Volume: 277, Issue:6 Topics: Anti-Bacterial Agents; Gentamicins; Humans; Italy; Meniere Disease; Treatment Outcome; Vertigo	2020
The effect of intratympanic gentamicin for treatment of Ménière's disease on lower frequency hearing. International journal of clinical pharmacy, 2016, Volume: 38, Issue:4 Topics: Aged; Anti-Bacterial Agents; Audiometry, Pure-Tone; Female; Gentamicins; Hearing; Humans; Injection,	2016
Intratympanic methylprednisolone versus gentamicin in patients with unilateral Ménière's disease: a randomised, double-blind, comparative effectiveness trial. Lancet (London, England), 2016, 12-03, Volume: 388, Issue:10061 Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents; Double-Blind Method; Female; Gentamicins; Hearing L	2016
Intratympanic gentamicin therapy for control of vertigo in unilateral Menire's disease: a prospective, double-blind, randomized, placebo-controlled trial. Acta oto-laryngologica, 2008, Volume: 128, Issue:8 Topics: Anti-Bacterial Agents; Double-Blind Method; Drug Administration Schedule; Ear, Middle; Female; Follo	2008
Recovery of subjective visual horizontal after unilateral vestibular deafferentation by intratympanic instillation of gentamicin. Journal of vestibular research : equilibrium & orientation, 2006, Volume: 16, Issue:1-2 Topics: Adult; Aged; Caloric Tests; Drug Administration Routes; Ear, Middle; Electronystagmography; Female;	2006
[Intratympanic treatment in Meniere's disease: the effect of gentamicin and dexamethasone on vertigo control and hearing]. Kulak burun bogaz ihtisas dergisi : KBB = Journal of ear, nose, and throat, 2006, Volume: 16, Issue:5 Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents; Dexamethasone; Drug Therapy, Combination; Female; G	2006
Preoperative vestibular ablation with gentamicin and vestibular 'prehab' enhance postoperative recovery after surgery for pontine angle tumours--first report. Acta oto-laryngologica, 2007, Volume: 127, Issue:12 Topics: Adult; Aged; Female; Gentamicins; Humans; Male; Middle Aged; Neuroma, Acoustic; Otorhinolaryngologic	2007
Preoperative vestibular ablation with gentamicin and vestibular 'prehab' enhance postoperative recovery after surgery for pontine angle tumours--first report. Acta oto-laryngologica, 2007, Volume: 127, Issue:12 Topics: Adult; Aged; Female; Gentamicins; Humans; Male; Middle Aged; Neuroma, Acoustic; Otorhinolaryngologic	2007
Preoperative vestibular ablation with gentamicin and vestibular 'prehab' enhance postoperative recovery after surgery for pontine angle tumours--first report. Acta oto-laryngologica, 2007, Volume: 127, Issue:12 Topics: Adult; Aged; Female; Gentamicins; Humans; Male; Middle Aged; Neuroma, Acoustic; Otorhinolaryngologic	2007
Preoperative vestibular ablation with gentamicin and vestibular 'prehab' enhance postoperative recovery after surgery for pontine angle tumours--first report. Acta oto-laryngologica, 2007, Volume: 127, Issue:12 Topics: Adult; Aged; Female; Gentamicins; Humans; Male; Middle Aged; Neuroma, Acoustic; Otorhinolaryngologic	2007
Intratympanic gentamicin for control of vertigo in Meniere's disease: vestibular signs that specify completion of therapy. The American journal of otology, 1999, Volume: 20, Issue:2 Topics: Adult; Aged; Caloric Tests; Clinical Protocols; Ear, Inner; Female; Gentamicins; Hearing Disorders;	1999
Treatment of Menière's disease with topical gentamicin: a preliminary report. The Journal of otolaryngology, 1992, Volume: 21, Issue:2 Topics: Administration, Topical; Caloric Tests; Catheterization; Contraindications; Ear, Middle; Follow-Up S	1992

Article	Year
Central nystagmus and alterations in vestibular tests due to an inadvertent gentamicin administration into spinal space: A CARE case report. European annals of otorhinolaryngology, head and neck diseases, 2022, Volume: 139, Issue:4 Topics: Bilateral Vestibulopathy; Gentamicins; Humans; Male; Middle Aged; Nystagmus, Pathologic; Vertigo; Ve	2022
[Consensus on intratympanic drug delivery for Menière's disease]. Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery, 2022, Volume: 36, Issue:7 Topics: Anti-Bacterial Agents; Consensus; Gentamicins; Humans; Meniere Disease; Vertigo	2022
Vestibular and audiometric results after endolymphatic mastoid shunt surgery in patients with Menière's disease. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2023, Volume: 280, Issue:3 Topics: Endolymphatic Shunt; Gentamicins; Humans; Mastoid; Meniere Disease; Retrospective Studies; Vertigo;	2023
Change of VOR gain and pure-tone threshold after single low-dose intratympanic gentamicin injection in Meniere's disease. Acta oto-laryngologica, 2020, Volume: 140, Issue:4 Topics: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Audiometry, Pure-Tone; Auditory Threshold; Ge	2020
On-Demand and Low Dose Intratympanic Gentamicin for Meniere's Disease: A Customized Approach. Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 2020, Volume: 41, Issue:4 Topics: Aged; Anti-Bacterial Agents; Audiometry, Pure-Tone; Female; Gentamicins; Humans; Male; Meniere Disea	2020
Intratympanic gentamycine for Ménière's disease: is there a selective vestibulotoxic effect? European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2020, Volume: 277, Issue:7 Topics: Anti-Bacterial Agents; Audiometry, Pure-Tone; Gentamicins; Hearing Loss; Humans; Meniere Disease; Tr	2020
Clinical Practice Guideline: Ménière's Disease. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2020, Volume: 162, Issue:2_suppl Topics: Audiometry; Counseling; Diagnosis, Differential; Diuretics; Ear, Inner; Gentamicins; Glucocorticoids	2020
Letter to the Editor: Intratympanic gentamicin for Ménière's disease: is there a selective vestibulotoxic effect? European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2020, Volume: 277, Issue:8 Topics: Audiometry, Pure-Tone; Gentamicins; Humans; Meniere Disease; Vertigo	2020
Triple Canal Occlusion for the Treatment of Intractable Menière's Disease. Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 2021, Volume: 42, Issue:1 Topics: Endolymphatic Sac; Female; Gentamicins; Humans; Male; Meniere Disease; Middle Aged; Otologic Surgica	2021
Long-term efficacy of triple semicircular canal plugging in the treatment of patients with ipsilateral delayed endolymphatic hydrops. Scientific reports, 2021, 02-04, Volume: 11, Issue:1 Topics: Anti-Bacterial Agents; Audiometry, Pure-Tone; Complementary Therapies; Endolymphatic Hydrops; Female	2021
Intratympanic gentamicin injection for refractory ménière's disease (MD) has potential effect in preventing contralateral MD occurrence. Acta oto-laryngologica, 2021, Volume: 141, Issue:7 Topics: Adult; Aged; Caloric Tests; Female; Gentamicins; Hearing Loss; Humans; Injection, Intratympanic; Mal	2021
Efficacy of Intratympanic Gentamicin in Menière's Disease With and Without Migraine. Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 2017, Volume: 38, Issue:7 Topics: Adult; Aged; Anti-Bacterial Agents; Female; Gentamicins; Humans; Male; Meniere Disease; Middle Aged;	2017
Navigating the challenges of Meniere disease. Nursing, 2017, Volume: 47, Issue:7 Topics: Gentamicins; Humans; Injection, Intratympanic; Male; Meniere Disease; Middle Aged; Nursing Assessmen	2017
Intralabyrinthine Vestibular Schwannoma Responsive to Intratympanic Gentamicin Treatment. The journal of international advanced otology, 2017, Volume: 13, Issue:2 Topics: Adult; Anti-Bacterial Agents; Female; Gentamicins; Hearing Loss, Sensorineural; Humans; Neuroma, Aco	2017
Treatment of peripheral vestibular dysfunction using photobiomodulation. Journal of biomedical optics, 2017, Volume: 22, Issue:8 Topics: Animals; Anti-Bacterial Agents; Cochlea; Ear, Inner; Gentamicins; Low-Level Light Therapy; Male; Rat	2017
[Small doses of gentamicin drum indoor injection treatment of intractableMénière disease clinical observation of the impact of the hearing]. Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery, 2016, Jun-20, Volume: 30, Issue:12 Topics: Adult; Aged; Anti-Bacterial Agents; Audiometry, Pure-Tone; Audiometry, Speech; Female; Gentamicins;	2016
Vitamin D supplementation may improve symptoms in Meniere's disease. Medical hypotheses, 2018, Volume: 116 Topics: Anti-Bacterial Agents; Autoimmunity; Cytokines; Dietary Supplements; Gentamicins; Humans; Inflammati	2018
Low Concentration Intra-Tympanic Gentamicin Treatment for Menière's Disease: A Long-Term Follow Up. Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 2018, Volume: 39, Issue:7 Topics: Anti-Bacterial Agents; Cohort Studies; Female; Follow-Up Studies; Gentamicins; Humans; Injections; M	2018
Intratympanic Gentamicin for Small Vestibular Schwannomas With Intractable Vertigo. Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 2018, Volume: 39, Issue:8 Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; Caloric Tests; Female; Gentamicins; Humans; Injectio	2018
Delayed endolymphatic hydrops. Special emphasis on nystagmus associated with episodes and contribution of chemical labyrinthectomy. European annals of otorhinolaryngology, head and neck diseases, 2018, Volume: 135, Issue:5 Topics: Adult; Aged; Anti-Bacterial Agents; Caloric Tests; Deafness; Endolymphatic Hydrops; Female; Gentamic	2018
Tenotomy of the middle ear muscles : An unknown surgical approach in Meniere's disease. Wiener klinische Wochenschrift, 2019, Volume: 131, Issue:3-4 Topics: Adult; Ear, Middle; Female; Gentamicins; Humans; Meniere Disease; Tenotomy; Treatment Outcome; Verti	2019
Preliminary study on the mechanism underlying the interaction of balance dysfunction and anxiety disorder. Neuroreport, 2019, 01-16, Volume: 30, Issue:2 Topics: Animals; Anti-Bacterial Agents; Anxiety Disorders; Biogenic Amines; Gentamicins; Locus Coeruleus; Po	2019
Long-term Vertigo Control and Vestibular Function After Low-dose On-demand Transtympanic Gentamicin for Refractory Menière's Disease. Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 2019, Volume: 40, Issue:2 Topics: Adult; Anti-Bacterial Agents; Caloric Tests; Female; Gentamicins; Humans; Injection, Intratympanic;	2019
[Bilateral vestibulopathy after intravenous gentamicin therapy]. Ugeskrift for laeger, 2019, Jan-28, Volume: 181, Issue:5 Topics: Aged; Bilateral Vestibulopathy; Gentamicins; Head Impulse Test; Humans; Male; Reflex, Vestibulo-Ocul	2019
Long-Term Follow-Up of Intratympanic Methylprednisolone Versus Gentamicin in Patients With Unilateral Menière's Disease. Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 2019, Volume: 40, Issue:4 Topics: Adult; Aged; Anti-Bacterial Agents; Ear, Inner; Female; Follow-Up Studies; Gentamicins; Humans; Inje	2019
CASP9 genotype confers gentamicin susceptibility in intratympanic treatment of intractable vertigo caused by Ménière's disease. Acta oto-laryngologica, 2019, Volume: 139, Issue:4 Topics: Adult; Aged; Aged, 80 and over; Caspase 9; Female; Follow-Up Studies; Gentamicins; Humans; Injection	2019
Patient Perceptions of Effectiveness in Treatments for Menière's Disease: a National Survey in Italy. The journal of international advanced otology, 2019, Volume: 15, Issue:1 Topics: Absenteeism; Anti-Bacterial Agents; Betahistine; Cross-Sectional Studies; Diet Therapy; Diuretics; F	2019
Intratympanic gentamicin treatment 'as needed' for Meniere's disease. Long-term analysis using the Kaplan-Meier method. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2014, Volume: 271, Issue:6 Topics: Adult; Aged; Anti-Bacterial Agents; Drug Administration Schedule; Female; Gentamicins; Humans; Kapla	2014
The disabling vertigo in vestibular schwannoma: is labyrinthine or retrolabyrinthine? Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 2013, Volume: 34, Issue:8 Topics: Anti-Bacterial Agents; Female; Gentamicins; Humans; Neuroma, Acoustic; Tympanic Membrane; Vertigo	2013
The disabling vertigo in vestibular schwannoma: is labyrinthine or retro-labyrinthine? Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 2013, Volume: 34, Issue:8 Topics: Anti-Bacterial Agents; Female; Gentamicins; Humans; Neuroma, Acoustic; Tympanic Membrane; Vertigo	2013
Preclinical and clinical studies of unrelieved aural fullness following intratympanic gentamicin injection in patients with intractable Ménière's disease. Audiology & neuro-otology, 2013, Volume: 18, Issue:5 Topics: Adult; Animals; Anti-Bacterial Agents; Female; Gentamicins; Guinea Pigs; Humans; Male; Meniere Disea	2013
Chemical labyrinthectomy for the worse ear of adult Nigerians with bilateral Meniere's disease: preliminary report of treatment outcomes. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2015, Volume: 272, Issue:6 Topics: Anti-Bacterial Agents; Audiometry, Pure-Tone; Ear, Inner; Female; Gentamicins; Humans; Injection, In	2015
Treatment of vertigo and postural instability using visual illusions. The Journal of laryngology and otology, 2014, Volume: 128, Issue:11 Topics: Aged; Dizziness; Gentamicins; Humans; Illusions; Male; Postural Balance; Treatment Outcome; Vertigo;	2014
Management of intractable Ménière's disease after intratympanic injection of gentamicin. The Laryngoscope, 2015, Volume: 125, Issue:4 Topics: Adult; Aged; Cohort Studies; Endolymphatic Hydrops; Female; Follow-Up Studies; Gentamicins; Hearing	2015
Intratympanic injection in delayed endolymphatic hydrops. Acta oto-laryngologica, 2015, Volume: 135, Issue:10 Topics: Adolescent; Adult; Anti-Bacterial Agents; Audiometry; Dexamethasone; Dose-Response Relationship, Dru	2015
Modified titration intratympanic gentamicin injection for unilateral intractable Ménière's disease. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, 2015, Volume: 35, Issue:5 Topics: Adult; Drug Administration Schedule; Ear, Inner; Female; Follow-Up Studies; Gentamicins; Hearing; Hu	2015
Intratympanic steroids injection is effective for the treatment of drop attacks with Ménière's disease and delayed endolymphatic hydrops: A retrospective study. Medicine, 2016, Volume: 95, Issue:52 Topics: Adult; Anti-Bacterial Agents; Dexamethasone; Drug Therapy, Combination; Endolymphatic Hydrops; Femal	2016
Vertigo Perception and Quality of Life in Patients after Surgical Treatment of Vestibular Schwannoma with Pretreatment Prehabituation by Chemical Vestibular Ablation. BioMed research international, 2016, Volume: 2016 Topics: Adult; Aged; Caloric Tests; Female; Gentamicins; Humans; Male; Middle Aged; Neuroma, Acoustic; Posto	2016
Vertigo Perception and Quality of Life in Patients after Surgical Treatment of Vestibular Schwannoma with Pretreatment Prehabituation by Chemical Vestibular Ablation. BioMed research international, 2016, Volume: 2016 Topics: Adult; Aged; Caloric Tests; Female; Gentamicins; Humans; Male; Middle Aged; Neuroma, Acoustic; Posto	2016
Vertigo Perception and Quality of Life in Patients after Surgical Treatment of Vestibular Schwannoma with Pretreatment Prehabituation by Chemical Vestibular Ablation. BioMed research international, 2016, Volume: 2016 Topics: Adult; Aged; Caloric Tests; Female; Gentamicins; Humans; Male; Middle Aged; Neuroma, Acoustic; Posto	2016
Vertigo Perception and Quality of Life in Patients after Surgical Treatment of Vestibular Schwannoma with Pretreatment Prehabituation by Chemical Vestibular Ablation. BioMed research international, 2016, Volume: 2016 Topics: Adult; Aged; Caloric Tests; Female; Gentamicins; Humans; Male; Middle Aged; Neuroma, Acoustic; Posto	2016
Vertigo Perception and Quality of Life in Patients after Surgical Treatment of Vestibular Schwannoma with Pretreatment Prehabituation by Chemical Vestibular Ablation. BioMed research international, 2016, Volume: 2016 Topics: Adult; Aged; Caloric Tests; Female; Gentamicins; Humans; Male; Middle Aged; Neuroma, Acoustic; Posto	2016
Vertigo Perception and Quality of Life in Patients after Surgical Treatment of Vestibular Schwannoma with Pretreatment Prehabituation by Chemical Vestibular Ablation. BioMed research international, 2016, Volume: 2016 Topics: Adult; Aged; Caloric Tests; Female; Gentamicins; Humans; Male; Middle Aged; Neuroma, Acoustic; Posto	2016
Vertigo Perception and Quality of Life in Patients after Surgical Treatment of Vestibular Schwannoma with Pretreatment Prehabituation by Chemical Vestibular Ablation. BioMed research international, 2016, Volume: 2016 Topics: Adult; Aged; Caloric Tests; Female; Gentamicins; Humans; Male; Middle Aged; Neuroma, Acoustic; Posto	2016
Vertigo Perception and Quality of Life in Patients after Surgical Treatment of Vestibular Schwannoma with Pretreatment Prehabituation by Chemical Vestibular Ablation. BioMed research international, 2016, Volume: 2016 Topics: Adult; Aged; Caloric Tests; Female; Gentamicins; Humans; Male; Middle Aged; Neuroma, Acoustic; Posto	2016
Vertigo Perception and Quality of Life in Patients after Surgical Treatment of Vestibular Schwannoma with Pretreatment Prehabituation by Chemical Vestibular Ablation. BioMed research international, 2016, Volume: 2016 Topics: Adult; Aged; Caloric Tests; Female; Gentamicins; Humans; Male; Middle Aged; Neuroma, Acoustic; Posto	2016
Intratympanal gentamicin in Meniere's disease: Effects on individual semicircular canals. Auris, nasus, larynx, 2018, Volume: 45, Issue:1 Topics: Adult; Female; Gentamicins; Head Impulse Test; Humans; Injection, Intratympanic; Male; Meniere Disea	2018
Transtympanic gentamicin treatment using Silverstein MicroWick in Ménière's disease patients: long term outcome. The Journal of laryngology and otology, 2009, Volume: 123, Issue:1 Topics: Adult; Aged; Anti-Bacterial Agents; Drug Delivery Systems; Ear, Middle; Female; Gentamicins; Hearing	2009
Gentamicin injections for Ménière disease: comparison of subjective and objective end points. Ear, nose, & throat journal, 2008, Volume: 87, Issue:8 Topics: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Female; Gentamicins; Health Status Indicators	2008
Hearing results following intratympanic gentamicin perfusion for Ménière's disease. The Journal of laryngology and otology, 2009, Volume: 123, Issue:4 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Audiometry, Pure-Tone; Female; Ge	2009
Contemporary role of endolymphatic mastoid shunt surgery in the era of transtympanic perfusion strategies. The Annals of otology, rhinology, and laryngology, 2008, Volume: 117, Issue:12 Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Ear, Inner; Endolymphatic Shunt; Female; Follow-Up S	2008
Tenotomy of the tensor tympani and stapedius tendons in Ménière's disease. B-ENT, 2009, Volume: 5, Issue:1 Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Dizziness; Ear, Middle; Female; Gentamicins; Humans;	2009
High-dose intratympanic gentamicin instillations for treatment of Meniere's disease: long-term results. Acta oto-laryngologica, 2009, Volume: 129, Issue:12 Topics: Adult; Aged; Female; Follow-Up Studies; Gentamicins; Hearing Loss; Humans; Male; Meniere Disease; Mi	2009
Vestibular function and vertigo control after intratympanic gentamicin for Ménière's disease. Audiology & neuro-otology, 2009, Volume: 14, Issue:6 Topics: Anti-Bacterial Agents; Caloric Tests; Chi-Square Distribution; Databases, Factual; Drug Administrati	2009
Intratympanic gentamicin treatment of patients with Ménière's disease with normal hearing. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2010, Volume: 142, Issue:4 Topics: Adult; Aged; Aged, 80 and over; Audiometry; Audiometry, Pure-Tone; Caloric Tests; Electronystagmogra	2010
Evidence-based modification of intratympanic gentamicin injections in patients with intractable vertigo. Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 2010, Volume: 31, Issue:4 Topics: Analysis of Variance; Animals; Anti-Bacterial Agents; Biological Availability; Ear, Middle; Gentamic	2010
Outcomes of endolymphatic shunt surgery for Ménière's disease: comparison with intratympanic gentamicin on vertigo control and hearing loss. Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 2010, Volume: 31, Issue:4 Topics: Adult; Aged; Anti-Bacterial Agents; Audiometry, Pure-Tone; Chi-Square Distribution; Ear, Inner; Endo	2010
Results of electrocochleography in Ménière's disease after successful vertigo control by single intratympanic gentamicin injection. Audiology & neuro-otology, 2011, Volume: 16, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Audiometry, Evoked Response; Audiometry, Pure-Tone; Cochlea; Female;	2011
Intratympanic gentamicin injections for the treatment of Ménière's disease. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2010, Volume: 143, Issue:5 Suppl 3 Topics: Adult; Aged; Aged, 80 and over; Audiometry, Pure-Tone; Female; Gentamicins; Hearing Disorders; Human	2010
Cochlear function in Ménière's disease. International journal of audiology, 2012, Volume: 51, Issue:5 Topics: Adult; Aged; Aged, 80 and over; Audiometry, Evoked Response; Cochlea; Female; Gentamicins; Humans; I	2012
The use of intratympanic gentamicin in patients with vestibular schwannoma and disabling vertigo. Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 2013, Volume: 34, Issue:6 Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; Audiometry, Pure-Tone; Caloric Tests; Female; Gentam	2013
Benign paroxysmal positional vertigo in patients with Ménière's disease treated with intratympanic gentamycin. The Laryngoscope, 2002, Volume: 112, Issue:6 Topics: Adult; Aged; Anti-Bacterial Agents; Female; Follow-Up Studies; Gentamicins; Humans; Male; Meniere Di	2002
Efficacy of increased gentamicin concentration for intratympanic injection therapy in Ménière's disease. Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 2002, Volume: 23, Issue:4 Topics: Caloric Tests; Deafness; Dose-Response Relationship, Drug; Female; Gentamicins; Hearing; Humans; Inj	2002
[Intra-tympanic gentamicin in the treatment of Ménière's disease: preliminary results ]. Acta otorrinolaringologica espanola, 2002, Volume: 53, Issue:5 Topics: Adult; Audiometry, Pure-Tone; Audiometry, Speech; Drug Evaluation; Ear, Middle; Female; Gentamicins;	2002
Changes in the three-dimensional angular vestibulo-ocular reflex following intratympanic gentamicin for Ménière's disease. Journal of the Association for Research in Otolaryngology : JARO, 2002, Volume: 3, Issue:4 Topics: Adult; Aged; Cold Temperature; Female; Gentamicins; Head; Humans; Male; Meniere Disease; Middle Aged	2002
Long-term hearing outcome in patients receiving intratympanic gentamicin for Ménière's disease. The Laryngoscope, 2003, Volume: 113, Issue:5 Topics: Adult; Aged; Anti-Bacterial Agents; Audiometry, Pure-Tone; Female; Follow-Up Studies; Gentamicins; H	2003
[Intratympanic gentamicin treatment for intractable Menière's disease]. Harefuah, 2004, Volume: 143, Issue:1 Topics: Anti-Bacterial Agents; Female; Follow-Up Studies; Gentamicins; Humans; Injections; Male; Meniere Dis	2004
Vestibular nerve section versus intratympanic gentamicin for Meniere's disease. The Laryngoscope, 2004, Volume: 114, Issue:2 Topics: Anti-Bacterial Agents; Audiometry, Pure-Tone; Gentamicins; Humans; Injections; Meniere Disease; Post	2004
Inner ear changes with intracochlear gentamicin administration in Guinea pigs. The Laryngoscope, 2004, Volume: 114, Issue:4 Topics: Administration, Topical; Animals; Anti-Bacterial Agents; Cochlea; Cytoplasm; Drug Administration Rou	2004
[Intratympanic gentamicin in Menière's disease]. Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology, 2004, Volume: 18, Issue:1 Topics: Adult; Audiometry, Pure-Tone; Auditory Threshold; Ear, Middle; Female; Follow-Up Studies; Gentamicin	2004
Long-term results of gentamicin inner ear perfusion in Ménière's disease. The Journal of laryngology and otology, 2004, Volume: 118, Issue:7 Topics: Administration, Topical; Adult; Aged; Anti-Bacterial Agents; Caloric Tests; Catheters, Indwelling; D	2004
Intratympanic gentamicin in monolateral Meniere's disease: our experience. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2006, Volume: 263, Issue:3 Topics: Adult; Aged; Anti-Bacterial Agents; Ear, Middle; Female; Gentamicins; Humans; Injections; Male; Meni	2006
[Long-term results of transtympanic gentamicin treatment in Meniere's disease]. Otolaryngologia polska = The Polish otolaryngology, 2005, Volume: 59, Issue:3 Topics: Adult; Anti-Bacterial Agents; Female; Follow-Up Studies; Gentamicins; Hearing; Humans; Injections; M	2005
VEMPs and dynamic posturography after intratympanic gentamycin in Menière's disease. Journal of vestibular research : equilibrium & orientation, 2005, Volume: 15, Issue:3 Topics: Adult; Aged; Evoked Potentials, Auditory; Female; Gentamicins; Humans; Male; Meniere Disease; Middle	2005
Angular vestibulo-ocular reflex gains correlate with vertigo control after intratympanic gentamicin treatment for Meniere's disease. The Annals of otology, rhinology, and laryngology, 2005, Volume: 114, Issue:10 Topics: Adult; Aged; Anti-Bacterial Agents; Caloric Tests; Gentamicins; Humans; Injections, Intralesional; M	2005
Intratympanic gentamicin treatment after endolymphatic sac surgery. Acta oto-laryngologica, 2005, Volume: 125, Issue:11 Topics: Adult; Aged; Audiometry, Pure-Tone; Auditory Threshold; Ear, Middle; Electronystagmography; Endolymp	2005
[Vertigo attacks -- current therapy]. Laryngo- rhino- otologie, 2005, Volume: 84, Issue:11 Topics: Acetazolamide; Adult; Aged; Betahistine; Dexamethasone; Ear, Middle; Gentamicins; Humans; Injections	2005
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Factors relating to the vertigo control and hearing changes following intratympanic gentamicin for intractable Ménière's disease. Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 2006, Volume: 27, Issue:6 Topics: Adult; Aged; Anti-Bacterial Agents; Audiometry, Evoked Response; Female; Gentamicins; Hearing Loss;	2006
Intratympanic gentamicin treatment in Meniere's disease: patients' experiences and outcomes. The Journal of laryngology and otology, 2006, Volume: 120, Issue:9 Topics: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Audiometry, Pure-Tone; Auditory Threshold; Fe	2006
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Long-term follow-up after gentamicin application via the Silverstein MicroWick in the treatment of Ménière's disease. Ear, nose, & throat journal, 2006, Volume: 85, Issue:8 Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Drug Delivery System	2006
Histopathology of the vestibular end organs after intratympanic gentamicin failure for Meniere's disease. Acta oto-laryngologica, 2007, Volume: 127, Issue:1 Topics: Administration, Topical; Anti-Bacterial Agents; Atrophy; Ear, Inner; Gentamicins; Hair Cells, Audito	2007
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Long-term vertigo control in patients after intratympanic gentamicin instillation for Ménière's disease. Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 2007, Volume: 28, Issue:8 Topics: Adult; Anti-Bacterial Agents; Caloric Tests; Dizziness; Drug Implants; Ear, Middle; Electronystagmog	2007
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Intratympanic gentamicin therapy for Ménière's disease. The American journal of otology, 1997, Volume: 18, Issue:1 Topics: Adult; Aged; Audiometry, Pure-Tone; Auditory Threshold; Female; Gentamicins; Hearing Disorders; Huma	1997
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When and how to use gentamicin in the treatment of Menière's disease. Acta oto-laryngologica. Supplementum, 1997, Volume: 526 Topics: Anti-Bacterial Agents; Gentamicins; Humans; Meniere Disease; Vertigo	1997
Do aminoglycoside otic preparations cause ototoxicity in the presence of tympanic membrane perforations? Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 1997, Volume: 116, Issue:3 Topics: Administration, Topical; Adult; Aged; Anti-Bacterial Agents; Ear, Inner; Female; Gentamicins; Hearin	1997
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Treatment of intractable Menière's disease with intratympanic gentamicin: review of the University of Ottawa experience. The Journal of otolaryngology, 1997, Volume: 26, Issue:6 Topics: Auditory Threshold; Ear, Middle; Female; Follow-Up Studies; Gentamicins; Humans; Infusions, Parenter	1997
Intratympanic gentamicin treatment for Meniere's disease. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 1998, Volume: 118, Issue:5 Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Audiometry, Pure-Ton	1998
Intratympanic gentamicin in Meniere's disease. Acta oto-laryngologica, 1998, Volume: 118, Issue:3 Topics: Adult; Aged; Anti-Bacterial Agents; Audiometry, Pure-Tone; Chi-Square Distribution; Electronystagmog	1998
Intratympanic gentamicin injection for the treatment of Meniere's disease. The American journal of otology, 1998, Volume: 19, Issue:4 Topics: Anti-Bacterial Agents; Caloric Tests; Female; Gentamicins; Humans; Male; Meniere Disease; Middle Age	1998
Unilateral vestibulotoxicity due to systemic gentamicin therapy. Acta oto-laryngologica, 1998, Volume: 118, Issue:4 Topics: Aged; Anti-Bacterial Agents; Caloric Tests; Female; Gentamicins; Humans; Male; Middle Aged; Vertigo;	1998
Subjective visual horizontal during follow-up after unilateral vestibular deafferentation with gentamicin. Acta oto-laryngologica, 1998, Volume: 118, Issue:4 Topics: Afferent Pathways; Anti-Bacterial Agents; Caloric Tests; Electrooculography; Female; Follow-Up Studi	1998
Postural compensation after intratympanic gentamicin treatment of Menière's disease. Journal of vestibular research : equilibrium & orientation, 1999, Volume: 9, Issue:1 Topics: Adult; Aged; Female; Follow-Up Studies; Gentamicins; Humans; Locomotion; Male; Meniere Disease; Midd	1999
Intratympanic gentamicin titration therapy for intractable Meniere's disease. The American journal of otology, 1999, Volume: 20, Issue:3 Topics: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Caloric Tests; Dose-Response Relationship, Dr	1999
Ototoxicity of topical gentamicin preparations. The Laryngoscope, 1999, Volume: 109, Issue:7 Pt 1 Topics: Administration, Topical; Adult; Aged; Ear, Inner; Female; Gentamicins; Hearing Disorders; Humans; Ma	1999
Intratympanic therapy for Ménière's disease. High-concentration gentamicin with round-window protection. Annals of the New York Academy of Sciences, 1999, Nov-28, Volume: 884 Topics: Adult; Anti-Bacterial Agents; Ear, Middle; Female; Follow-Up Studies; Gentamicins; Hearing; Humans;	1999
Round window gentamicin mu-catheter--a new therapeutic tool in Ménière's disease. Acta oto-laryngologica. Supplementum, 2000, Volume: 543 Topics: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Catheterization; Equipment Design; Female; Ge	2000
Continuous intratympanic infusion of gentamicin via a microcatheter in Menière's disease. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2001, Volume: 124, Issue:2 Topics: Administration, Topical; Anti-Bacterial Agents; Auditory Threshold; Caloric Tests; Catheterization;	2001
Unpredictable hearing loss after intratympanic gentamicin treatment for vertigo. A new theory. Acta oto-laryngologica, 2001, Volume: 121, Issue:1 Topics: Adult; Aged; Anti-Bacterial Agents; Deafness; Female; Gentamicins; Humans; Male; Meniere Disease; Ve	2001
Long-term follow-up of transtympanic gentamicin for Ménière's syndrome. Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 2001, Volume: 22, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Audiometry, Pure-Tone; Drug Administration Ro	2001
Patients' subjective evaluations of quality of life related to disease-specific symptoms, sense of coherence, and treatment in Ménière's disease. Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 2001, Volume: 22, Issue:4 Topics: Adult; Aged; Anti-Bacterial Agents; Cross-Sectional Studies; Endolymphatic Sac; Female; Gentamicins;	2001
Ménière's disease in childhood. International journal of pediatric otorhinolaryngology, 2001, Dec-01, Volume: 61, Issue:3 Topics: Adolescent; Anti-Bacterial Agents; Child; Deafness; Female; Gentamicins; Hearing Tests; Humans; Meni	2001
Microdose gentamicin administration via the round window microcatheter: results in patients with Meniere's disease. Annals of the New York Academy of Sciences, 2001, Volume: 942 Topics: Adult; Aged; Audiometry; Audiometry, Evoked Response; Catheterization; Female; Gentamicins; Humans;	2001
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Vertical eye-movement oscillation with a frequency double that of lateral linear acceleration in patients with long-standing unilateral vestibular loss. Auris, nasus, larynx, 2002, Volume: 29, Issue:2 Topics: Adult; Anti-Bacterial Agents; Case-Control Studies; Eye Movements; Female; Gentamicins; Humans; Male	2002
Low-dose intratympanic gentamicin treatment of Menière's disease. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 1994, Volume: 251 Suppl 1 Topics: Administration, Topical; Adult; Aged; Anti-Bacterial Agents; Caloric Tests; Drug Administration Sche	1994
Continuous gentamicin therapy using an IntraEAR microcatheter for Meniere's disease: a retrospective study. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2002, Volume: 126, Issue:3 Topics: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Catheterization; Female; Follow-Up Studies; G	2002
Changes in the angular vestibulo-ocular reflex after a single dose of intratympanic gentamicin for Ménière's disease. Annals of the New York Academy of Sciences, 2002, Volume: 956 Topics: Functional Laterality; Gentamicins; Humans; Injections; Meniere Disease; Reflex, Vestibulo-Ocular; T	2002
Vestibular nerve section in a child with intractable Menière's disease. International journal of pediatric otorhinolaryngology, 2002, May-31, Volume: 64, Issue:1 Topics: Anti-Bacterial Agents; Child, Preschool; Ear, Middle; Gentamicins; Hearing; Humans; Male; Meniere Di	2002
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Chemical labyrinthectomy: local application of gentamicin for the treatment of unilateral Menière's disease. The American journal of otology, 1992, Volume: 13, Issue:1 Topics: Adult; Aged; Female; Follow-Up Studies; Gentamicins; Hearing; Humans; Instillation, Drug; Male; Meni	1992
Delayed onset of ototoxic effects of gentamicin in patients with Meniére's disease. Acta oto-laryngologica. Supplementum, 1991, Volume: 485 Topics: Adult; Audiometry, Pure-Tone; Caloric Tests; Cochlea; Electrooculography; Female; Gentamicins; Human	1991
Delayed onset of ototoxic effects of gentamicin in treatment of Menière's disease. Acta oto-laryngologica. Supplementum, 1991, Volume: 481 Topics: Adult; Gentamicins; Hearing Disorders; Humans; Meniere Disease; Middle Aged; Nystagmus, Pathologic;	1991
Delayed onset of ototoxic effects of gentamicin in treatment of Menière's disease. Rationale for extremely low dose therapy. Acta oto-laryngologica, 1991, Volume: 111, Issue:4 Topics: Adult; Caloric Tests; Cochlea; Dizziness; Gentamicins; Humans; Instillation, Drug; Meniere Disease;	1991
Delayed onset of ototoxic effects of gentamicin in treatment of Menière's disease. Rationale for extremely low dose therapy. Acta oto-laryngologica, 1991, Volume: 111, Issue:4 Topics: Adult; Caloric Tests; Cochlea; Dizziness; Gentamicins; Humans; Instillation, Drug; Meniere Disease;	1991
Delayed onset of ototoxic effects of gentamicin in treatment of Menière's disease. Rationale for extremely low dose therapy. Acta oto-laryngologica, 1991, Volume: 111, Issue:4 Topics: Adult; Caloric Tests; Cochlea; Dizziness; Gentamicins; Humans; Instillation, Drug; Meniere Disease;	1991
Delayed onset of ototoxic effects of gentamicin in treatment of Menière's disease. Rationale for extremely low dose therapy. Acta oto-laryngologica, 1991, Volume: 111, Issue:4 Topics: Adult; Caloric Tests; Cochlea; Dizziness; Gentamicins; Humans; Instillation, Drug; Meniere Disease;	1991
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Topical gentamicin-induced positional vertigo. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 1985, Volume: 93, Issue:4 Topics: Administration, Topical; Ataxia; Gentamicins; Humans; Male; Middle Aged; Posture; Time Factors; Vert	1985
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The dizzy patient. Postgraduate medicine, 1972, Volume: 52, Issue:2 Topics: Diazepam; Drainage; Ear; Ear Neoplasms; Ethacrynic Acid; Gentamicins; Hearing Disorders; Humans; Inf	1972
Untoward effects of antimicrobial agents on major organ systems. The Medical clinics of North America, 1974, Volume: 58, Issue:3 Topics: Agranulocytosis; Amphotericin B; Anemia, Aplastic; Anemia, Hemolytic; Anti-Bacterial Agents; Ataxia;	1974
Retrospective study of the ototoxicity of gentamicin. Acta pathologica et microbiologica Scandinavica. Section B: Microbiology and immunology, 1973 Topics: Adult; Age Factors; Aged; Creatinine; Dose-Response Relationship, Drug; Electrooculography; Gentamic	1973
Prospective study of the ototoxicity of gentamicin. Acta pathologica et microbiologica Scandinavica. Section B: Microbiology and immunology, 1973 Topics: Adult; Age Factors; Aged; Creatinine; Electrooculography; Gentamicins; Hearing Disorders; Humans; Ki	1973
The ototoxicity of gentamicin. Acta pathologica et microbiologica Scandinavica. Section B: Microbiology and immunology, 1973 Topics: Age Factors; Aged; Body Temperature; Cochlea; Creatinine; Electrooculography; Female; Gentamicins; H	1973
Vertigo and its treatment. Drugs, 1974, Volume: 7, Issue:3 Topics: Air Pressure; Anxiety; Brain Diseases; Cardiovascular Diseases; Cervical Vertebrae; Ear Diseases; Et	1974
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Intervention	Vertigo Attacks (Mean)
	Baseline	18-24months
Gentamicin	19.93	2.5
Steroid (Methylprednisolone)	16.4	1.6

gentamicin and Vertigo