gentamicin has been researched along with Tibial Fractures in 37 studies
Gentamicins: A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.
Tibial Fractures: Fractures of the TIBIA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the clinical effect of gastrocnemius muscle flaps combined with vancomycin/gentamicin-calcium sulfate combined and autologous iliac bone graft in the phase I treatment of traumatic focal osteomyelitis (Cierny-Mader type III) after tibial plateau fracture surgery." | 8.02 | Gastrocnemius muscle flap with vancomycin/gentamicin-calcium sulfate and autogenous iliac bone graft for the phase I treatment of localized osteomyelitis after tibial plateau fracture surgery. ( Guo, Q; Li, M; Lin, B; Ruan, W, 2021) |
| " We report a case of recovery from methicillin-susceptible Staphylococcus aureus (MSSA) osteomyelitis after multidisciplinary management with antibiotics, anti-thrombotics and prostaglandin E1 (PGE1) vasodilator, in a patient with tibial plateau fracture repaired with internal fixation devices." | 7.81 | Leg ulcer and osteomyelitis due to methicillin-susceptible Staphylococcus aureus infection after fracture repair treatment: a case highlighting the potential role of prostaglandin E₁ vasodilator. ( Bentivegna, E; Casuccio, A; Citarrella, E; De Luca, D; Di Carlo, P; Maira, GG; Vivaldi, R, 2015) |
| "To investigate the clinical effect of gastrocnemius muscle flaps combined with vancomycin/gentamicin-calcium sulfate combined and autologous iliac bone graft in the phase I treatment of traumatic focal osteomyelitis (Cierny-Mader type III) after tibial plateau fracture surgery." | 4.02 | Gastrocnemius muscle flap with vancomycin/gentamicin-calcium sulfate and autogenous iliac bone graft for the phase I treatment of localized osteomyelitis after tibial plateau fracture surgery. ( Guo, Q; Li, M; Lin, B; Ruan, W, 2021) |
| " We report a case of recovery from methicillin-susceptible Staphylococcus aureus (MSSA) osteomyelitis after multidisciplinary management with antibiotics, anti-thrombotics and prostaglandin E1 (PGE1) vasodilator, in a patient with tibial plateau fracture repaired with internal fixation devices." | 3.81 | Leg ulcer and osteomyelitis due to methicillin-susceptible Staphylococcus aureus infection after fracture repair treatment: a case highlighting the potential role of prostaglandin E₁ vasodilator. ( Bentivegna, E; Casuccio, A; Citarrella, E; De Luca, D; Di Carlo, P; Maira, GG; Vivaldi, R, 2015) |
| "Deep surgical site infections occurred in 3 fresh fractures and two in revision surgeries." | 1.46 | Clinical experiences in the use of a gentamicin-coated titanium nail in tibia fractures. ( Kerstan, M; Raschke, M; Schmidmaier, G; Schwabe, P; Südkamp, N, 2017) |
| "Gentamicin was released rapidly with an initial burst in aqueous solution and followed by a slow release." | 1.36 | Gentamycin delivered from a PDLLA coating of metallic implants: In vivo and in vitro characterisation for local prophylaxis of implant-related osteomyelitis. ( Lucke, M; Schmidmaier, G; Stöckle, U; Vester, H; Wildemann, B, 2010) |
| "Sixteen patients were identified in whom once daily gentamicin dosing was used as part of an antibiotic prophylaxis regimen in patients with types II and III open tibial shaft fractures." | 1.31 | Once daily high-dose gentamicin to prevent infection in open fractures of the tibial shaft: a preliminary investigation. ( King, C; May, CG; Pearsall, AW; Russell, GV, 2001) |
| "In the treatment of pseudarthrosis with only a segmental loss of bone elements a reconstruction by the Ilizarov method is too complicated, and simple decortication and plastic surgery with cancellous bone grafting is usually too slow." | 1.29 | [The value of intramedullary boring and intramedullary splinting in revision of infected pseudarthroses]. ( Hügli, RW; Ochsner, PE, 1995) |
| "In the treatment of osteomyelitis, flap coverage provides the necessary blood supply for healing." | 1.27 | [Skin-soft tissue replacement on the lower leg--therapy and prophylaxis of osteomyelitis]. ( Scharnagl, E, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (16.22) | 18.7374 |
| 1990's | 11 (29.73) | 18.2507 |
| 2000's | 3 (8.11) | 29.6817 |
| 2010's | 10 (27.03) | 24.3611 |
| 2020's | 7 (18.92) | 2.80 |
| Authors | Studies |
|---|---|
| Patel, KH | 1 |
| Galanis, A | 1 |
| Balasubramanian, P | 1 |
| Iliadis, AD | 1 |
| Heidari, N | 1 |
| Vris, A | 1 |
| Rohilla, R | 1 |
| Arora, S | 1 |
| Kundu, A | 1 |
| Singh, R | 1 |
| Govil, V | 1 |
| Khokhar, A | 1 |
| Haonga, BT | 1 |
| O'Marr, JM | 1 |
| Ngunyale, P | 1 |
| Ngahyoma, J | 1 |
| Kessey, J | 1 |
| Sasillo, I | 1 |
| Rodarte, P | 1 |
| Belaye, T | 1 |
| Berhaneselase, E | 1 |
| Eliezer, E | 1 |
| Porco, TC | 1 |
| Morshed, S | 1 |
| Shearer, DW | 1 |
| Pinto, D | 1 |
| Manjunatha, K | 1 |
| Savur, AD | 1 |
| Ahmed, NR | 1 |
| Mallya, S | 1 |
| Ramya, V | 1 |
| Vicenti, G | 1 |
| Bizzoca, D | 1 |
| Cotugno, D | 1 |
| Carrozzo, M | 1 |
| Riefoli, F | 1 |
| Rifino, F | 1 |
| Belviso, V | 1 |
| Elia, R | 1 |
| Solarino, G | 1 |
| Moretti, B | 1 |
| De Meo, D | 1 |
| Cannari, FM | 1 |
| Petriello, L | 1 |
| Persiani, P | 1 |
| Villani, C | 1 |
| Walter, N | 1 |
| Popp, D | 1 |
| Freigang, V | 1 |
| Nerlich, M | 1 |
| Alt, V | 1 |
| Rupp, M | 1 |
| Ruan, W | 1 |
| Li, M | 1 |
| Guo, Q | 1 |
| Lin, B | 1 |
| Schmidmaier, G | 5 |
| Kerstan, M | 1 |
| Schwabe, P | 1 |
| Südkamp, N | 1 |
| Raschke, M | 1 |
| Fassbender, M | 1 |
| Minkwitz, S | 1 |
| Kronbach, Z | 1 |
| Strobel, C | 1 |
| Kadow-Romacker, A | 1 |
| Wildemann, B | 2 |
| Bentivegna, E | 1 |
| Citarrella, E | 1 |
| Vivaldi, R | 1 |
| De Luca, D | 1 |
| Maira, GG | 1 |
| Casuccio, A | 1 |
| Di Carlo, P | 1 |
| Metsemakers, WJ | 1 |
| Reul, M | 1 |
| Nijs, S | 1 |
| Moghaddam, A | 1 |
| Zietzschmann, S | 1 |
| Bruckner, T | 1 |
| Kienast, B | 1 |
| Kiene, J | 1 |
| Gille, J | 1 |
| Thietje, R | 1 |
| Gerlach, U | 1 |
| Schulz, AP | 1 |
| Vester, H | 1 |
| Stöckle, U | 1 |
| Lucke, M | 1 |
| Fuchs, T | 1 |
| Stange, R | 1 |
| Raschke, MJ | 1 |
| Chaudhary, S | 1 |
| Sen, RK | 1 |
| Saini, UC | 1 |
| Soni, A | 1 |
| Gahlot, N | 1 |
| Singh, D | 1 |
| Chen, CE | 1 |
| Ko, JY | 1 |
| Pan, CC | 1 |
| Ochsner, PE | 1 |
| Hügli, RW | 1 |
| Hettfleisch, J | 1 |
| Schöttle, H | 1 |
| Krüger-Franke, M | 1 |
| Carl, C | 1 |
| Haus, J | 1 |
| Ueng, SW | 1 |
| Wei, FC | 1 |
| Shih, CH | 1 |
| Russell, GV | 1 |
| King, C | 1 |
| May, CG | 1 |
| Pearsall, AW | 1 |
| Ohtsuka, H | 1 |
| Yokoyama, K | 1 |
| Higashi, K | 1 |
| Tsutsumi, A | 1 |
| Fukushima, N | 1 |
| Noumi, T | 1 |
| Itoman, M | 1 |
| Klemm, K | 2 |
| Schnettler, R | 1 |
| Lucena, M | 1 |
| Andrade, R | 1 |
| Cabello, M | 1 |
| Clavijo, E | 1 |
| Queipo de Llano, E | 1 |
| Schmidt, HG | 1 |
| Wittek, F | 1 |
| Fink, B | 1 |
| Buck-Gramcko, U | 1 |
| Walz, M | 1 |
| Ascherl, R | 1 |
| Stemberg, A | 1 |
| Lechner, F | 1 |
| Blümel, G | 1 |
| Dmitriev, AE | 1 |
| Vyrenkov, IuE | 1 |
| Zorokhovich, OL | 1 |
| Vtorenko, VI | 1 |
| Polinov, AV | 1 |
| Shishlo, VK | 1 |
| Weise, K | 1 |
| Müller, HP | 1 |
| Knopp, W | 1 |
| Neumann, K | 1 |
| Muhr, G | 1 |
| Scharnagl, E | 1 |
| Schein, CS | 1 |
| Black, JR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Prophylactic Antibiotic Coated Nail to Prevent Infection: A Clinical Trial[NCT05421741] | Phase 4 | 484 participants (Anticipated) | Interventional | 2023-05-15 | Recruiting | ||
| Results of the Staged Surgical Approach for Management of Infected Un-united Femoral Shaft Fractures in Adults[NCT04681846] | 40 participants (Anticipated) | Observational | 2021-03-31 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for gentamicin and Tibial Fractures
| Article | Year |
|---|---|
Gentamicin-Coated Tibia Nail in Fractures and Nonunion to Reduce Fracture-Related Infections: A Systematic Review.
Topics: Animals; Bone Nails; Coated Materials, Biocompatible; Gentamicins; Humans; Osteomyelitis; Postoperat | 2020 |
The use of gentamicin-coated nails in complex open tibia fracture and revision cases: A retrospective analysis of a single centre case series and review of the literature.
Topics: Adult; Aged; Anti-Bacterial Agents; Belgium; Bone Nails; Female; Fracture Fixation, Intramedullary; | 2015 |
2 trials available for gentamicin and Tibial Fractures
| Article | Year |
|---|---|
Functional and radiological outcomes of primary ring fixator versus antibiotic nail in open tibial diaphyseal fractures: A prospective study.
Topics: Anti-Bacterial Agents; Bone Nails; Diaphyses; Fracture Fixation, Intramedullary; Fracture Healing; F | 2022 |
GO-Tibia: a masked, randomized control trial evaluating gentamicin versus saline in open tibia fractures.
Topics: Adult; Anti-Bacterial Agents; Fracture Healing; Gentamicins; Humans; Middle Aged; Prospective Studie | 2023 |
33 other studies available for gentamicin and Tibial Fractures
| Article | Year |
|---|---|
A major trauma centre experience with gentamicin-coated tibial intramedullary nails (ETN PROtect™) in acute primary open fracture fixation and complex revision surgery.
Topics: Adult; Bone Nails; Fracture Fixation, Intramedullary; Fracture Healing; Fractures, Open; Gentamicins | 2023 |
Comparative study of the efficacy of gentamicin-coated intramedullary interlocking nail versus regular intramedullary interlocking nail in Gustilo type I and II open tibia fractures.
Topics: Adult; Anti-Bacterial Agents; Antibiotic Prophylaxis; Bone Nails; Follow-Up Studies; Fracture Fixati | 2019 |
The use of a gentamicin-coated titanium nail, combined with RIA system, in the management of non-unions of open tibial fractures: A single centre prospective study.
Topics: Adult; Bone Nails; Female; Follow-Up Studies; Fracture Fixation, Intramedullary; Fracture Healing; F | 2020 |
Treatment of severely open tibial fractures, non-unions, and fracture-related infections with a gentamicin-coated tibial nail-clinical outcomes including quality of life analysis and psychological ICD-10-based symptom rating.
Topics: Adult; Aged; Anti-Bacterial Agents; Bone Nails; Device Removal; Female; Fracture Fixation, Intramedu | 2021 |
Gastrocnemius muscle flap with vancomycin/gentamicin-calcium sulfate and autogenous iliac bone graft for the phase I treatment of localized osteomyelitis after tibial plateau fracture surgery.
Topics: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Bone Transplantation; Calcium Sulfate; Combin | 2021 |
Clinical experiences in the use of a gentamicin-coated titanium nail in tibia fractures.
Topics: Adult; Anti-Bacterial Agents; Bone Nails; Female; Fracture Fixation, Intramedullary; Fracture Healin | 2017 |
Local gentamicin application does not interfere with bone healing in a rat model.
Topics: Animals; Anti-Bacterial Agents; Bacterial Infections; Bone Wires; Coated Materials, Biocompatible; F | 2013 |
Leg ulcer and osteomyelitis due to methicillin-susceptible Staphylococcus aureus infection after fracture repair treatment: a case highlighting the potential role of prostaglandin E₁ vasodilator.
Topics: Alprostadil; Anti-Bacterial Agents; Drug Therapy, Combination; Fibrinolytic Agents; Gentamicins; Hum | 2015 |
Treatment of atrophic tibia non-unions according to 'diamond concept': Results of one- and two-step treatment.
Topics: Adult; Aged; Anti-Bacterial Agents; Bone Morphogenetic Protein 7; Bone Nails; Bone Transplantation; | 2015 |
Posttraumatic severe infection of the ankle joint - long term results of the treatment with resection arthrodesis in 133 cases.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Ankle Injuries; Ankle Joint; Anti-Bacterial Agents; Arth | 2010 |
Gentamycin delivered from a PDLLA coating of metallic implants: In vivo and in vitro characterisation for local prophylaxis of implant-related osteomyelitis.
Topics: Animals; Anti-Bacterial Agents; Coated Materials, Biocompatible; Delayed-Action Preparations; Drug A | 2010 |
The use of gentamicin-coated nails in the tibia: preliminary results of a prospective study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Bone Nails; Coated Materials, Bio | 2011 |
Use of gentamicin-loaded collagen sponge in internal fixation of open fractures.
Topics: Animals; Collagen; Fracture Fixation, Internal; Fractures, Open; Gentamicins; Humans; Porifera; Tibi | 2011 |
Results of vancomycin-impregnated cancellous bone grafting for infected tibial nonunion.
Topics: Adult; Aged; Anti-Bacterial Agents; Bacterial Infections; Bone Transplantation; Debridement; Female; | 2005 |
[Chronic and insidious infections].
Topics: Adult; Bone and Bones; Chronic Disease; Follow-Up Studies; Fracture Fixation, Internal; Fractures, C | 1982 |
[Infected pseudarthrosis].
Topics: Adult; Female; Fracture Fixation, Internal; Gentamicins; Hand Injuries; Humans; Male; Osteomyelitis; | 1982 |
[The value of intramedullary boring and intramedullary splinting in revision of infected pseudarthroses].
Topics: Adult; Bone Marrow; Bone Transplantation; Combined Modality Therapy; Fracture Fixation, Internal; Fr | 1995 |
[Local preventive antibiotic treatment in intramedullary nailing with gentamycin impregnated biomaterials].
Topics: Drug Implants; Fracture Fixation, Intramedullary; Gentamicins; Humans; Metabolic Clearance Rate; Met | 1993 |
[Treatment of infected intramedullary osteosynthesis. A comparison of various therapeutic procedures].
Topics: Adolescent; Adult; Bone Transplantation; Combined Modality Therapy; External Fixators; Female; Femor | 1993 |
Management of large infected tibial defects with antibiotic beads local therapy and staged fibular osteoseptocutaneous free transfer.
Topics: Adult; Bacterial Infections; Chronic Disease; Combined Modality Therapy; Debridement; Female; Follow | 1997 |
Once daily high-dose gentamicin to prevent infection in open fractures of the tibial shaft: a preliminary investigation.
Topics: Adolescent; Adult; Anti-Bacterial Agents; Antibiotic Prophylaxis; Debridement; Fractures, Open; Gent | 2001 |
Use of antibiotic-impregnated bone cement nail to treat septic nonunion after open tibial fracture.
Topics: Adult; Anti-Bacterial Agents; Bone Nails; Fracture Fixation, Intramedullary; Fractures, Open; Fractu | 2002 |
The use of gentamicin-PMMA chains in the treatment of infected tibial nonunion.
Topics: Drug Therapy, Combination; Fractures, Ununited; Gentamicins; Humans; Methylmethacrylates; Tibial Fra | 1992 |
Imipenem/cilastatin-associated hiccups.
Topics: Anti-Bacterial Agents; Bacterial Infections; Cilastatin; Cilastatin, Imipenem Drug Combination; Drug | 1992 |
[Treatment of chronic osteitis of the tibia].
Topics: Adult; Aged; Combined Modality Therapy; External Fixators; Female; Fracture Healing; Gentamicins; Hu | 1992 |
[Use of a collagen-gentamicin compound in open spongiosaplasty in chronic post-traumatic osteomyelitis].
Topics: Adult; Anti-Infective Agents, Local; Bone Transplantation; Collagen; Combined Modality Therapy; Exte | 1990 |
[Local treatment of infection with gentamicin-PMMA chains and minichains].
Topics: Aged; Chronic Disease; Combined Modality Therapy; Female; Follow-Up Studies; Fracture Fixation, Inte | 1990 |
[Local treatment of infection with collagen gentamicin].
Topics: Adult; Aged; Aged, 80 and over; Anti-Infective Agents, Local; Bacterial Infections; Bone Transplanta | 1990 |
[Primary controlled endolymphatic antibiotic therapy in traumatology and orthopedics].
Topics: Gentamicins; Hip Fractures; Hip Prosthesis; Humans; Injections, Intralymphatic; Osteomyelitis; Posto | 1991 |
[Local antibiotic therapy in postoperative and post-traumatic osteitis with the Septopal chain].
Topics: Femoral Fractures; Fracture Fixation, Internal; Gentamicins; Humans; Methylmethacrylates; Osteitis; | 1988 |
[Open spongiosaplasty in infected defect pseudarthroses of the tibia--a still justifiable treatment principle?].
Topics: Bone Transplantation; Fracture Fixation, Internal; Gentamicins; Humans; Methylmethacrylates; Osteomy | 1988 |
[Skin-soft tissue replacement on the lower leg--therapy and prophylaxis of osteomyelitis].
Topics: Accidents, Traffic; Adolescent; Adult; Bone Transplantation; Fracture Fixation, Internal; Fractures, | 1986 |
Implanted gentamicin beads in the treatment of osteomyelitis. A case report.
Topics: Aged; Fractures, Open; Gentamicins; Humans; Male; Methylmethacrylates; Osteomyelitis; Tibial Fractur | 1987 |