gentamicin has been researched along with Rett Syndrome in 6 studies
Gentamicins: A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.
Rett Syndrome: An inherited neurological developmental disorder that is associated with X-LINKED INHERITANCE and may be lethal in utero to hemizygous males. The affected female is normal until the age of 6-25 months when progressive loss of voluntary control of hand movements and communication skills; ATAXIA; SEIZURES; autistic behavior; intermittent HYPERVENTILATION; and HYPERAMMONEMIA appear. (From Menkes, Textbook of Child Neurology, 5th ed, p199)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Rett syndrome is a pediatric neurological condition that affects primarily girls." | 1.36 | Aminoglycoside-mediated partial suppression of MECP2 nonsense mutations responsible for Rett syndrome in vitro. ( Eubanks, JH; Popescu, AC; Sidorova, E; Zhang, G, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 3 (50.00) | 24.3611 |
| 2020's | 2 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Wong, KM | 1 |
| Wegener, E | 1 |
| Baradaran-Heravi, A | 1 |
| Huppke, B | 1 |
| Gärtner, J | 2 |
| Huppke, P | 2 |
| Merritt, JK | 2 |
| Collins, BE | 1 |
| Erickson, KR | 1 |
| Dong, H | 1 |
| Neul, JL | 2 |
| Pitcher, MR | 1 |
| Herrera, JA | 1 |
| Buffington, SA | 1 |
| Kochukov, MY | 1 |
| Fisher, AR | 1 |
| Schanen, NC | 1 |
| Costa-Mattioli, M | 1 |
| Brendel, C | 1 |
| Klahold, E | 1 |
| Popescu, AC | 1 |
| Sidorova, E | 1 |
| Zhang, G | 1 |
| Eubanks, JH | 1 |
| Vecsler, M | 1 |
| Ben Zeev, B | 1 |
| Nudelman, I | 1 |
| Anikster, Y | 1 |
| Simon, AJ | 1 |
| Amariglio, N | 1 |
| Rechavi, G | 1 |
| Baasov, T | 1 |
| Gak, E | 1 |
6 other studies available for gentamicin and Rett Syndrome
| Article | Year |
|---|---|
Evaluation of Novel Enhancer Compounds in Gentamicin-Mediated Readthrough of Nonsense Mutations in Rett Syndrome.
Topics: Animals; Codon, Nonsense; Gentamicins; HeLa Cells; Humans; Methyl-CpG-Binding Protein 2; Mice; Mutat | 2023 |
Pharmacological read-through of R294X Mecp2 in a novel mouse model of Rett syndrome.
Topics: Animals; Brain; Disease Models, Animal; Gentamicins; Humans; Methyl-CpG-Binding Protein 2; Mice; Mut | 2020 |
Rett syndrome like phenotypes in the R255X Mecp2 mutant mouse are rescued by MECP2 transgene.
Topics: Alleles; Amino Acid Substitution; Animals; Behavior, Animal; Disease Models, Animal; Fibroblasts; Ge | 2015 |
Suppression of nonsense mutations in Rett syndrome by aminoglycoside antibiotics.
Topics: Anti-Bacterial Agents; Blotting, Western; Chromosomes, Human, X; Codon, Nonsense; Dose-Response Rela | 2009 |
Aminoglycoside-mediated partial suppression of MECP2 nonsense mutations responsible for Rett syndrome in vitro.
Topics: Amikacin; Aminoglycosides; Blotting, Western; Cell Line; Cell Nucleus; Child; Codon, Nonsense; Dose- | 2010 |
Ex vivo treatment with a novel synthetic aminoglycoside NB54 in primary fibroblasts from Rett syndrome patients suppresses MECP2 nonsense mutations.
Topics: Aminoglycosides; Brain-Derived Neurotrophic Factor; Cell Death; Cell Nucleus; Cells, Cultured; Codon | 2011 |