Page last updated: 2024-10-27

gentamicin and Reperfusion Injury

gentamicin has been researched along with Reperfusion Injury in 11 studies

Gentamicins: A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.

Reperfusion Injury: Adverse functional, metabolic, or structural changes in tissues that result from the restoration of blood flow to the tissue (REPERFUSION) following ISCHEMIA.

Research Excerpts

ExcerptRelevanceReference
" This paper reports the results of studies concerning carnosine's role in kidney diseases, particularly in ischemia/reperfusion induced acute renal failure, diabetic nephropathy, gentamicin-induced nephrotoxicity and also in blood pressure regulation."8.88[Carnosine, carnosinase and kidney diseases]. ( Kiliś-Pstrusińska, K, 2012)
" This paper reports the results of studies concerning carnosine's role in kidney diseases, particularly in ischemia/reperfusion induced acute renal failure, diabetic nephropathy, gentamicin-induced nephrotoxicity and also in blood pressure regulation."4.88[Carnosine, carnosinase and kidney diseases]. ( Kiliś-Pstrusińska, K, 2012)
" Three models of experimental AKI were undertaken in adult male Wistar rats; renal ischemia-reperfusion injury (IRI) and gentamicin (G) and cisplatin (Cisp) nephrotoxicity."3.96Impaired Tubular Reabsorption Is the Main Mechanism Explaining Increases in Urinary NGAL Excretion Following Acute Kidney Injury in Rats. ( Blanco-Gozalo, V; Docherty, NG; López-Hernández, FJ; López-Novoa, JM; Martínez-Salgado, C; Montero-Gómez, MJ; Morales, AI; Prieto-García, L; Quiros, Y; Sancho-Martínez, SM, 2020)
" Tetramethylpyrazine (TMP) is a compound purified from the rhizome of Ligusticum wallichi (Chuanxiong) and has been found to protect against ischaemia-reperfusion injury, nephritis and alcohol-induced toxicity in rat kidneys."3.74Tetramethylpyrazine protects rat renal tubular cell apoptosis induced by gentamicin. ( Chen, CH; Chen, TH; Chu, YL; Hou, CC; Hsu, YH; Juan, SH; Lin, H; Sue, YM, 2007)
" The results indicated that long-term VI-28 treatment invariably protected against oxidative tissue damage in the rat models of cerebral/myocardial ischemia-reperfusion injury, CCl4 hepatotoxicity, and gentamicin nephrotoxicity."3.74Long-term treatment with a Yang-invigorating Chinese herbal formula produces generalized tissue protection against oxidative damage in rats. ( Chen, N; Chiu, PY; Ko, KM; Leung, HY; Poon, MK; Siu, AH, 2008)
"Acute renal failure following hemorrhagic shock was studied in awake rats."1.28Acute renal failure following hemorrhagic shock: protective and aggravating factors. ( Rocha, AS; Seguro, AC; Yu, L, 1992)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (27.27)18.2507
2000's2 (18.18)29.6817
2010's5 (45.45)24.3611
2020's1 (9.09)2.80

Authors

AuthorsStudies
Sancho-Martínez, SM1
Blanco-Gozalo, V1
Quiros, Y1
Prieto-García, L1
Montero-Gómez, MJ1
Docherty, NG1
Martínez-Salgado, C1
Morales, AI1
López-Novoa, JM1
López-Hernández, FJ1
Zamorskii, II1
Shchudrova, TS1
Lin'kova, NS1
Nichik, TE1
Khavinson, VK1
Matsushita, K1
Takasu, S1
Kuroda, K1
Ishii, Y1
Kijima, A1
Ogawa, K1
Umemura, T1
Vaidya, VS1
Ozer, JS1
Dieterle, F1
Collings, FB1
Ramirez, V1
Troth, S1
Muniappa, N1
Thudium, D1
Gerhold, D1
Holder, DJ1
Bobadilla, NA1
Marrer, E1
Perentes, E1
Cordier, A1
Vonderscher, J1
Maurer, G1
Goering, PL1
Sistare, FD1
Bonventre, JV1
Kelly, KJ1
Kluve-Beckerman, B1
Zhang, J1
Dominguez, JH1
Kiliś-Pstrusińska, K1
Juan, SH1
Chen, CH1
Hsu, YH1
Hou, CC1
Chen, TH1
Lin, H1
Chu, YL1
Sue, YM1
Chiu, PY1
Leung, HY1
Siu, AH1
Chen, N1
Poon, MK1
Ko, KM1
Vorbach, H1
Robibaro, B1
Armbruster, C1
Atteneder, M1
Reiter, M1
Hlousek, M1
Schaumann, R1
Georgopoulos, A1
Yu, L1
Seguro, AC1
Rocha, AS1
Zager, RA1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Comparison Effect Between Lower Pressure and Standard Pressure Pneumoperitoneum on Sign of Acute Systemic Inflammation, Endothelial Injury, and Acute Kidney Injury: A Randomized Clinical Trial in Living Donor Laparoscopic Nephrectomy[NCT03219398]44 participants (Actual)Interventional2017-08-01Completed
Assessment of Renal Tubular Injury and Transplant Outcomes in Cardiac Recipients Converting From Immediate Release Tacrolimus to Extended Release Tacrolimus.[NCT04917718]Phase 442 participants (Anticipated)Interventional2021-08-16Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for gentamicin and Reperfusion Injury

ArticleYear
[Carnosine, carnosinase and kidney diseases].
    Postepy higieny i medycyny doswiadczalnej (Online), 2012, Apr-20, Volume: 66

    Topics: Acute Kidney Injury; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Carnosine; Diabetic N

2012

Other Studies

10 other studies available for gentamicin and Reperfusion Injury

ArticleYear
Impaired Tubular Reabsorption Is the Main Mechanism Explaining Increases in Urinary NGAL Excretion Following Acute Kidney Injury in Rats.
    Toxicological sciences : an official journal of the Society of Toxicology, 2020, 05-01, Volume: 175, Issue:1

    Topics: Acute Kidney Injury; Animals; Biomarkers; Cisplatin; Disease Models, Animal; Gentamicins; Kidney Tub

2020
Nephroprotective Effect of EDL Peptide at Acute Injury of Kidneys of Different Genesis.
    Bulletin of experimental biology and medicine, 2017, Volume: 163, Issue:3

    Topics: Acute Kidney Injury; Animals; Animals, Outbred Strains; Antioxidants; Azotemia; Gentamicins; Kidney

2017
Mechanisms Underlying Exacerbation of Osmotic Nephrosis Caused by Pre-existing Kidney Injury.
    Toxicological sciences : an official journal of the Society of Toxicology, 2018, 10-01, Volume: 165, Issue:2

    Topics: Acute Kidney Injury; Animals; Dextrans; Disease Models, Animal; Disease Progression; Female; Gentami

2018
Kidney injury molecule-1 outperforms traditional biomarkers of kidney injury in preclinical biomarker qualification studies.
    Nature biotechnology, 2010, Volume: 28, Issue:5

    Topics: Acetylglucosaminidase; Animals; Biomarkers, Pharmacological; Blood Urea Nitrogen; Cell Adhesion Mole

2010
Kidney injury molecule-1 outperforms traditional biomarkers of kidney injury in preclinical biomarker qualification studies.
    Nature biotechnology, 2010, Volume: 28, Issue:5

    Topics: Acetylglucosaminidase; Animals; Biomarkers, Pharmacological; Blood Urea Nitrogen; Cell Adhesion Mole

2010
Kidney injury molecule-1 outperforms traditional biomarkers of kidney injury in preclinical biomarker qualification studies.
    Nature biotechnology, 2010, Volume: 28, Issue:5

    Topics: Acetylglucosaminidase; Animals; Biomarkers, Pharmacological; Blood Urea Nitrogen; Cell Adhesion Mole

2010
Kidney injury molecule-1 outperforms traditional biomarkers of kidney injury in preclinical biomarker qualification studies.
    Nature biotechnology, 2010, Volume: 28, Issue:5

    Topics: Acetylglucosaminidase; Animals; Biomarkers, Pharmacological; Blood Urea Nitrogen; Cell Adhesion Mole

2010
Intravenous cell therapy for acute renal failure with serum amyloid A protein-reprogrammed cells.
    American journal of physiology. Renal physiology, 2010, Volume: 299, Issue:2

    Topics: Acute Kidney Injury; Animals; Apoptosis; Cell Line; Cell Proliferation; Cell Transplantation; Cispla

2010
Tetramethylpyrazine protects rat renal tubular cell apoptosis induced by gentamicin.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2007, Volume: 22, Issue:3

    Topics: Animals; Anti-Bacterial Agents; Apoptosis; bcl-X Protein; Blotting, Western; Caspase 3; Caspase 8; C

2007
Long-term treatment with a Yang-invigorating Chinese herbal formula produces generalized tissue protection against oxidative damage in rats.
    Rejuvenation research, 2008, Volume: 11, Issue:1

    Topics: Animals; Carbon Tetrachloride; Carnosine; Chemical and Drug Induced Liver Injury; Cholecalciferol; C

2008
Endothelial cell compatibility of clindamycin, gentamicin, ceftriaxone and teicoplanin in Bier's arterial arrest.
    The Journal of antimicrobial chemotherapy, 1999, Volume: 44, Issue:2

    Topics: Anti-Bacterial Agents; Ceftriaxone; Cells, Cultured; Clindamycin; Endothelium, Vascular; Gentamicins

1999
Acute renal failure following hemorrhagic shock: protective and aggravating factors.
    Renal failure, 1992, Volume: 14, Issue:1

    Topics: Acute Kidney Injury; Allopurinol; Animals; Calcium; Dehydration; Free Radicals; Gentamicins; Kidney;

1992
Gentamicin effects on renal ischemia/reperfusion injury.
    Circulation research, 1992, Volume: 70, Issue:1

    Topics: Acute Kidney Injury; Acylation; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Female; Gent

1992