gentamicin has been researched along with Renal Insufficiency in 57 studies
Gentamicins: A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.
Renal Insufficiency: Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ELECTROLYTE BALANCE; BLOOD PRESSURE; and CALCIUM metabolism. Renal insufficiency can be classified by the degree of kidney damage (as measured by the level of PROTEINURIA) and reduction in GLOMERULAR FILTRATION RATE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Current guidelines recommend either ampicillin plus ceftriaxone (AC) or amoxicillin/ampicillin plus gentamicin (AG) with an equivalent class IB recommendation in Enterococcus faecalis endocarditis." | 9.22 | Time to abandon ampicillin plus gentamicin in favour of ampicillin plus ceftriaxone in Enterococcus faecalis infective endocarditis? A meta-analysis of comparative trials. ( Hoppe, UC; Lichtenauer, M; Mirna, M; Schmutzler, L; Topf, A, 2022) |
| "The aim of this study was to assess changes in antibiotic resistance, epidemiology and outcome among patients with Enterococcus faecalis infective endocarditis (EFIE) and to compare the efficacy and safety of the combination of ampicillin and gentamicin (A+G) with that of ampicillin plus ceftriaxone (A+C)." | 7.80 | Changes in the treatment of Enterococcus faecalis infective endocarditis in Spain in the last 15 years: from ampicillin plus gentamicin to ampicillin plus ceftriaxone. ( Almela, M; Armero, Y; Castañeda, X; Cervera, C; del Rio, A; Falces, C; Garcia de la Maria, C; Gatell, JM; Marco, F; Mestres, CA; Miro, JM; Moreno, A; Ninot, S; Pericas, JM; Soy, D, 2014) |
| "Gentamicin and standard-dose ibuprofen were administered to an adolescent with cystic fibrosis who developed renal failure and severe vestibulotoxicity." | 7.71 | Renal failure and vestibular toxicity in an adolescent with cystic fibrosis receiving gentamicin and standard-dose ibuprofen. ( Henry, MM; Retsch-Bogart, GZ; Scott, CS, 2001) |
| " In the present study, we compared the in vivo toxic effects of three aminoglycosides, gentamicin, amikacin, and etimicin, in zebrafish embryos." | 5.62 | A new aminoglycoside etimicin shows low nephrotoxicity and ototoxicity in zebrafish embryos. ( Chen, D; Han, Y; Jiang, H; Jing, L; Li, R; Qian, X; Shao, W; Yin, Y; Zhong, D, 2021) |
| "Clinical features (except for chronic renal failure) were similar in both groups of patients." | 5.30 | Comparative study of bacteremias caused by Enterococcus spp. with and without high-level resistance to gentamicin. The Grupo Andaluz para el estudio de las Enfermedades Infecciosas. ( Caballero-Granado, FJ; Cisneros, JM; Díez, F; Gamboa, F; López-Ruz, MA; Luque, R; Menchero, A; Merino, D; Mora, D; Pasquau, J; Pérez-Cano, R; Torres-Tortosa, M; Vergara, A; Villanueva, JL, 1998) |
| "Current guidelines recommend either ampicillin plus ceftriaxone (AC) or amoxicillin/ampicillin plus gentamicin (AG) with an equivalent class IB recommendation in Enterococcus faecalis endocarditis." | 5.22 | Time to abandon ampicillin plus gentamicin in favour of ampicillin plus ceftriaxone in Enterococcus faecalis infective endocarditis? A meta-analysis of comparative trials. ( Hoppe, UC; Lichtenauer, M; Mirna, M; Schmutzler, L; Topf, A, 2022) |
| "Renal failure caused by gentamicin is mainly mediated through oxidative damage, inflammation, and apoptosis." | 4.31 | Comparison of the effect of vitamin C and selenium nanoparticles on gentamicin-induced renal impairment in male rats: a biochemical, molecular and histological study. ( Akbari, A; Hameed Sultan, A; Kareem, LA; Kurtas, PT; Zheng, S, 2023) |
| " In this nested case-control study, independent AKI risk factors were vancomycin coadministration, high AG trough levels and heart failure." | 3.81 | Acute Kidney Injury and Renal Recovery with the Use of Aminoglycosides: A Large Retrospective Study. ( Ammann, H; Bernier-Jean, A; Bouchard, J; Brunette, V; Lavergne, V; Paquette, F; Pichette, V; Troyanov, S, 2015) |
| "The aim of this study was to assess changes in antibiotic resistance, epidemiology and outcome among patients with Enterococcus faecalis infective endocarditis (EFIE) and to compare the efficacy and safety of the combination of ampicillin and gentamicin (A+G) with that of ampicillin plus ceftriaxone (A+C)." | 3.80 | Changes in the treatment of Enterococcus faecalis infective endocarditis in Spain in the last 15 years: from ampicillin plus gentamicin to ampicillin plus ceftriaxone. ( Almela, M; Armero, Y; Castañeda, X; Cervera, C; del Rio, A; Falces, C; Garcia de la Maria, C; Gatell, JM; Marco, F; Mestres, CA; Miro, JM; Moreno, A; Ninot, S; Pericas, JM; Soy, D, 2014) |
| " Panipenem and betamipron were administered intravenously to rats with a variety of renal failures, such as nephritis induced by glycerol, gentamicin, uranium and antiserum against glomerular basement membrane as well as 5/6 subtotal nephrectomy." | 3.73 | Quantitative evaluation of effect of renal failure on the pharmacokinetics of panipenem in rats. ( Ishizuka, H; Naganuma, H; Soma, M; Tajima, N, 2005) |
| "Initial CPOE dose values for prescribing gentamycin and tobramycin, which are based on a fixed default value, form a source of potential ADEs for patients with renal insufficiency." | 3.73 | Errors associated with applying decision support by suggesting default doses for aminoglycosides. ( Abu-Hanna, A; de Jonge, E; de Keizer, NF; Eslami, S, 2006) |
| "Gentamicin and standard-dose ibuprofen were administered to an adolescent with cystic fibrosis who developed renal failure and severe vestibulotoxicity." | 3.71 | Renal failure and vestibular toxicity in an adolescent with cystic fibrosis receiving gentamicin and standard-dose ibuprofen. ( Henry, MM; Retsch-Bogart, GZ; Scott, CS, 2001) |
| "Ninety-six patients were randomly assigned to either the once-daily dosing group (4 mg/kg) or the pharmacokinetic dosing group (initial dose of 2 mg/kg every 12 hours)." | 2.68 | Comparison of once-daily versus pharmacokinetic dosing of aminoglycosides in elderly patients. ( Hawa, Z; Koo, J; Rajkumar, V; Tight, R, 1996) |
| "Celecoxib was administered orally either before or after intraperitoneal therapy with gentamicin in mice." | 1.72 | Celecoxib has Preventive and Therapeutic Benefits against Nephrotoxicity Caused by Gentamicin in Mice. ( Abd-Eldayem, AM; Alnasser, SM; Badary, DM; Dahpy, MA; Hareedy, MS, 2022) |
| " In the present study, we compared the in vivo toxic effects of three aminoglycosides, gentamicin, amikacin, and etimicin, in zebrafish embryos." | 1.62 | A new aminoglycoside etimicin shows low nephrotoxicity and ototoxicity in zebrafish embryos. ( Chen, D; Han, Y; Jiang, H; Jing, L; Li, R; Qian, X; Shao, W; Yin, Y; Zhong, D, 2021) |
| " The aim of this study was to compare renal function, renal recovery and mortality in a large cohort of patients with bacteraemia, who were empirically treated with regimens with and without a short course (≤ 3 days) of once daily dosing of gentamicin." | 1.48 | The effect of short-course gentamicin therapy on kidney function in patients with bacteraemia-a retrospective cohort study. ( Arpi, M; Boel, J; Carlsen, S; Gjørup, I; Jarløv, JO; Søborg, C, 2018) |
| "Increased oxidative stress and disturbance in nitric oxide bioavailability lead to endothelial dysfunction and cardiovascular complication in renal disease." | 1.46 | Vascular function and arginine and dimethylarginines in gentamicin-induced renal failure: a possible effect of heme oxygenase 1 inducer hemin. ( Alp-Yıldırım, FI; Aycan-Ustyol, E; Bekpinar, S; Giris, M; Kabasakal, M; Ozluk, Y; Tepe, O; Unlucerci, Y; Uydes-Dogan, BS; Uysal, M, 2017) |
| "Gentamicin treated rats revealed a highly significant increase in renal function tests, tubular dilatation with marked vacuolar degeneration and desquamation of cells, interstitial hemorrhage and cellular infiltration." | 1.43 | 6-gingerol ameliorates gentamicin induced renal cortex oxidative stress and apoptosis in adult male albino rats. ( Bayomy, NA; Elshafey, SH; Hegazy, AM; Mosaed, MM, 2016) |
| "Chronic kidney disease, end-stage renal failure, and liver diseases are increasing worldwide and constitute a huge burden on health care costs, with attendant high morbidity and debility." | 1.40 | Hepato- and nephroprotective activities of a Nigerian local king tuber oyster mushroom, Pleurotus tuberregium (higher Basidiomycetes), in chemically induced organ toxicities in rats. ( Akah, PA; Ihim, SA; Laiyemo, KA; Nworu, CS; Ugwu, LE, 2014) |
| "The renal safety of gentamicin has been questioned even when dosed once daily." | 1.37 | Short-term gentamicin therapy and risk of renal toxicity in patients with bacteraemia. ( Hønge, BL; Nielsen, H; Schønheyder, HC; Spanggaard, MH, 2011) |
| " The once-a-day dosing regimen gave better results both in efficacy and toxicity, except for patients with creatinine clearance lower than 60 mL/min, where the incidence of potential toxicity was above 25%." | 1.36 | Evaluation of various gentamicin dosage regimens in geriatric patients: a simulation study. ( Bourguignon, L; De Saint-Martin, JB; Ducher, M; Goutelle, S; Maire, P, 2010) |
| "paniculata on gentamicin-induced renal failure." | 1.35 | Renoprotective effects of Andrographis paniculata (Burm. f.) Nees in rats. ( Khemani, LD; Singh, P; Srivastava, MM, 2009) |
| "When gentamicin-treated groups were compared with the control group, it was observed that BUN and creatinine levels increased significantly." | 1.33 | Protective effect of L-arginine intake on the impaired renal vascular responses in the gentamicin-treated rats. ( Buyukafşar, K; Dikmen, A; Doran, F; Inal, TC; Karataş, Y; Seçilmiş, MA; Singirik, E; Yorulmaz, O, 2005) |
| "Pre-treatment with lycopene produced amelioration in biochemical indices of nephrotoxicity in plasma." | 1.33 | Protective effect of lycopene on gentamicin-induced oxidative stress and nephrotoxicity in rats. ( Ateşşahin, A; Ceribaşi, AO; Karahan, I; Sakin, F; Yilmaz, S, 2005) |
| "for 5 days to rats induced a marked renal failure, characterised by a significant decrease in creatinine clearance and increased plasma creatinine levels, fractional excretion of sodium, lithium, urine gamma glutamyl transferase (gamma GT) and daily urine volume." | 1.31 | A role for superoxide in gentamicin-mediated nephropathy in rats. ( Britti, D; Caputi, A; Cuzzocrea, S; De Sarro, A; Di Paola, R; Dugo, L; Masini, E; Mazzon, E; Pierpaoli, S; Salvemini, D; Serraino, I, 2002) |
| " Now, for the establishment of a toxicity screening approach using 5/6 NX rats, our concept, "Differential toxicity synchronized with renal dysfunction process could be identified using 5/6 NX rats" was examined by dosing gentamicin." | 1.31 | Differential toxicity expression of gentamicine in five-sixths nephrectomized rats assigned to three progressive stages of renal dysfunction--establishment of a new screening approach. ( Barata, K; Harada, E; Hokao, R; Imai, S; Maekawa, A; Takahashi, S; Yoshida, M, 2001) |
| "Clinical features (except for chronic renal failure) were similar in both groups of patients." | 1.30 | Comparative study of bacteremias caused by Enterococcus spp. with and without high-level resistance to gentamicin. The Grupo Andaluz para el estudio de las Enfermedades Infecciosas. ( Caballero-Granado, FJ; Cisneros, JM; Díez, F; Gamboa, F; López-Ruz, MA; Luque, R; Menchero, A; Merino, D; Mora, D; Pasquau, J; Pérez-Cano, R; Torres-Tortosa, M; Vergara, A; Villanueva, JL, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (10.53) | 18.2507 |
| 2000's | 18 (31.58) | 29.6817 |
| 2010's | 24 (42.11) | 24.3611 |
| 2020's | 9 (15.79) | 2.80 |
| Authors | Studies |
|---|---|
| Mirna, M | 1 |
| Topf, A | 1 |
| Schmutzler, L | 1 |
| Hoppe, UC | 1 |
| Lichtenauer, M | 1 |
| Abd-Eldayem, AM | 1 |
| Dahpy, MA | 1 |
| Badary, DM | 1 |
| Alnasser, SM | 1 |
| Hareedy, MS | 1 |
| Zheng, S | 1 |
| Hameed Sultan, A | 1 |
| Kurtas, PT | 1 |
| Kareem, LA | 1 |
| Akbari, A | 1 |
| Suhett, WG | 1 |
| Gerez, JR | 1 |
| Hohmann, MS | 1 |
| Staurengo-Ferrari, L | 1 |
| Verri, WA | 1 |
| Pinho, FHO | 1 |
| de Barros, LD | 1 |
| Cardim, ST | 1 |
| Flaiban, KMC | 1 |
| Bracarense, APFRL | 1 |
| Al-Amer, HA | 1 |
| Al-Sowayan, NS | 1 |
| Alfheeaid, HA | 1 |
| Althwab, SA | 1 |
| Alrobaish, SA | 1 |
| Hamad, EM | 1 |
| Musa, KH | 1 |
| Mousa, HM | 1 |
| Ashrafi, MR | 1 |
| Khalili, A | 1 |
| Hashemi, SA | 1 |
| Mazloom, R | 1 |
| Changizi-Ashtiyani, S | 1 |
| Bayat, G | 1 |
| Ding, L | 1 |
| Li, L | 1 |
| Liu, S | 1 |
| Bao, X | 1 |
| Dickman, KG | 1 |
| Sell, SS | 1 |
| Mei, C | 1 |
| Zhang, QY | 1 |
| Gu, J | 1 |
| Ding, X | 1 |
| Shao, W | 1 |
| Zhong, D | 1 |
| Jiang, H | 1 |
| Han, Y | 1 |
| Yin, Y | 1 |
| Li, R | 1 |
| Qian, X | 1 |
| Chen, D | 1 |
| Jing, L | 1 |
| Mousavinasab, SR | 1 |
| Akhoundi-Meybodi, Z | 1 |
| Mahmoudi, L | 1 |
| Karimzadeh, I | 1 |
| Aycan-Ustyol, E | 1 |
| Kabasakal, M | 1 |
| Bekpinar, S | 1 |
| Alp-Yıldırım, FI | 1 |
| Tepe, O | 1 |
| Giris, M | 1 |
| Ozluk, Y | 1 |
| Unlucerci, Y | 1 |
| Uydes-Dogan, BS | 1 |
| Uysal, M | 1 |
| Ramos-Martínez, A | 1 |
| Muñoz Serrano, A | 1 |
| de Alarcón González, A | 1 |
| Muñoz, P | 1 |
| Fernández-Cruz, A | 1 |
| Valerio, M | 1 |
| Fariñas, MC | 1 |
| Gutiérrez-Cuadra, M | 1 |
| Miró, JM | 2 |
| Ruiz-Morales, J | 1 |
| Sousa-Regueiro, D | 1 |
| Montejo, JM | 1 |
| Gálvez-Acebal, J | 1 |
| HidalgoTenorio, C | 1 |
| Domínguez, F | 1 |
| Carlsen, S | 1 |
| Boel, J | 1 |
| Jarløv, JO | 1 |
| Gjørup, I | 1 |
| Søborg, C | 1 |
| Arpi, M | 1 |
| Nafiu, AO | 1 |
| Akomolafe, RO | 1 |
| Alabi, QK | 1 |
| Idowu, CO | 1 |
| Odujoko, OO | 1 |
| Affonso, AC | 1 |
| Machado, DG | 1 |
| Malgarin, F | 1 |
| Fraga, DB | 1 |
| Ghedim, F | 1 |
| Zugno, A | 1 |
| Streck, EL | 1 |
| Schuck, PF | 1 |
| Ferreira, GC | 1 |
| Marchand, S | 1 |
| Lauda, M | 1 |
| Le Moal, G | 1 |
| Gobin, P | 1 |
| Couet, W | 1 |
| Roblot, F | 1 |
| White, RW | 1 |
| West, R | 1 |
| Howard, P | 1 |
| Sandoe, J | 1 |
| Pericas, JM | 1 |
| Cervera, C | 1 |
| del Rio, A | 1 |
| Moreno, A | 1 |
| Garcia de la Maria, C | 1 |
| Almela, M | 1 |
| Falces, C | 1 |
| Ninot, S | 1 |
| Castañeda, X | 1 |
| Armero, Y | 1 |
| Soy, D | 1 |
| Gatell, JM | 1 |
| Marco, F | 1 |
| Mestres, CA | 1 |
| Ibraheem, ZO | 2 |
| Basir, R | 1 |
| Aljobory, AKh | 1 |
| Ibrahim, OE | 1 |
| Alsumaidaee, A | 1 |
| Yam, MF | 1 |
| Fouad, AA | 1 |
| Albuali, WH | 1 |
| Zahran, A | 1 |
| Gomaa, W | 1 |
| Nworu, CS | 1 |
| Ihim, SA | 1 |
| Ugwu, LE | 1 |
| Laiyemo, KA | 1 |
| Akah, PA | 1 |
| Beckman, JM | 1 |
| Amankwah, EK | 1 |
| Tetreault, LL | 1 |
| Perlman, SA | 1 |
| Tuite, GF | 1 |
| Paquette, F | 1 |
| Bernier-Jean, A | 1 |
| Brunette, V | 1 |
| Ammann, H | 1 |
| Lavergne, V | 1 |
| Pichette, V | 1 |
| Troyanov, S | 1 |
| Bouchard, J | 1 |
| Cárdenas-González, M | 1 |
| Jacobo Estrada, T | 1 |
| Rodríguez-Muñoz, R | 1 |
| Barrera-Chimal, J | 1 |
| Bobadilla, NA | 1 |
| Barbier, OC | 1 |
| Del Razo, LM | 1 |
| Hegazy, AM | 1 |
| Mosaed, MM | 1 |
| Elshafey, SH | 1 |
| Bayomy, NA | 1 |
| Peterson, SC | 1 |
| Lau, TTY | 1 |
| Ensom, MHH | 1 |
| Langlais, F | 1 |
| Judet, H | 1 |
| Vielpeau, C | 1 |
| Bernard, L | 2 |
| Chauveaux, D | 1 |
| Beaufils, P | 1 |
| Dujardin, F | 1 |
| Hamadouche, M | 1 |
| Mamoudy, P | 1 |
| Migaud, H | 1 |
| Minet, J | 1 |
| Pégoix, M | 1 |
| Senneville, E | 1 |
| Tabutin, J | 1 |
| Bonnomet, F | 1 |
| Caillon, J | 1 |
| Potel, G | 1 |
| Rosencher, N | 1 |
| Samama, CM | 1 |
| Bourguignon, L | 1 |
| Goutelle, S | 1 |
| De Saint-Martin, JB | 1 |
| Maire, P | 1 |
| Ducher, M | 1 |
| Singh, P | 1 |
| Srivastava, MM | 1 |
| Khemani, LD | 1 |
| Karakoyun, B | 1 |
| Yuksel, M | 1 |
| Turan, P | 1 |
| Arbak, S | 1 |
| Alican, I | 1 |
| Romero, F | 1 |
| Pérez, M | 1 |
| Chávez, M | 1 |
| Parra, G | 1 |
| Durante, P | 1 |
| Smyth, AR | 1 |
| Zhou, W | 1 |
| Boucher, RC | 1 |
| Bollig, F | 1 |
| Englert, C | 1 |
| Hildebrandt, F | 1 |
| Spanggaard, MH | 1 |
| Hønge, BL | 1 |
| Schønheyder, HC | 1 |
| Nielsen, H | 1 |
| Sattar, MA | 1 |
| Abdullah, NA | 1 |
| Rathore, HA | 1 |
| Johns, EJ | 1 |
| Kalkan, Y | 1 |
| Kapakin, KA | 1 |
| Kara, A | 1 |
| Atabay, T | 1 |
| Karadeniz, A | 1 |
| Simsek, N | 1 |
| Karakus, E | 1 |
| Can, I | 1 |
| Yildirim, S | 1 |
| Ozkanlar, S | 1 |
| Sengul, E | 1 |
| Cabral, RM | 1 |
| Ferraz, MS | 1 |
| Rizzo, M | 1 |
| Sousa, FD | 1 |
| Rodrigues, NM | 1 |
| Ibiapina, PB | 1 |
| Ambrósio, CE | 1 |
| De Carvalho, MA | 1 |
| Jankauskas, SS | 1 |
| Plotnikov, EY | 1 |
| Morosanova, MA | 1 |
| Pevzner, IB | 1 |
| Zorova, LD | 1 |
| Skulachev, VP | 1 |
| Zorov, DB | 1 |
| Cuzzocrea, S | 2 |
| Mazzon, E | 2 |
| Dugo, L | 1 |
| Serraino, I | 1 |
| Di Paola, R | 1 |
| Britti, D | 2 |
| De Sarro, A | 2 |
| Pierpaoli, S | 1 |
| Caputi, A | 1 |
| Masini, E | 1 |
| Salvemini, D | 1 |
| Kos, M | 1 |
| Jazwinska-Tarnawska, E | 1 |
| Hurkacz, M | 1 |
| Orzechowska-Juzwenko, K | 1 |
| Pilecki, W | 1 |
| Klempous, J | 1 |
| Seçilmiş, MA | 1 |
| Karataş, Y | 1 |
| Yorulmaz, O | 1 |
| Buyukafşar, K | 1 |
| Singirik, E | 1 |
| Doran, F | 1 |
| Inal, TC | 1 |
| Dikmen, A | 1 |
| Karahan, I | 1 |
| Ateşşahin, A | 1 |
| Yilmaz, S | 1 |
| Ceribaşi, AO | 1 |
| Sakin, F | 1 |
| Tajima, N | 1 |
| Soma, M | 1 |
| Ishizuka, H | 1 |
| Naganuma, H | 1 |
| Ekor, M | 1 |
| Farombi, EO | 1 |
| Emerole, GO | 1 |
| Eslami, S | 1 |
| Abu-Hanna, A | 1 |
| de Keizer, NF | 1 |
| de Jonge, E | 1 |
| Servais, H | 1 |
| Ortiz, A | 1 |
| Devuyst, O | 1 |
| Denamur, S | 1 |
| Tulkens, PM | 1 |
| Mingeot-Leclercq, MP | 1 |
| Diwan, V | 1 |
| Jaggi, AS | 1 |
| Singh, M | 1 |
| Singh, N | 1 |
| Singh, D | 1 |
| Rivas-Cabañero, L | 1 |
| Montero, A | 1 |
| López-Novoa, JM | 1 |
| Johnson, JH | 1 |
| Wolf, AM | 1 |
| Johnson, TL | 1 |
| Jensen, JM | 1 |
| Jolobe, OM | 1 |
| Koo, J | 1 |
| Tight, R | 1 |
| Rajkumar, V | 1 |
| Hawa, Z | 1 |
| Caballero-Granado, FJ | 1 |
| Cisneros, JM | 1 |
| Luque, R | 1 |
| Torres-Tortosa, M | 1 |
| Gamboa, F | 1 |
| Díez, F | 1 |
| Villanueva, JL | 1 |
| Pérez-Cano, R | 1 |
| Pasquau, J | 1 |
| Merino, D | 1 |
| Menchero, A | 1 |
| Mora, D | 1 |
| López-Ruz, MA | 1 |
| Vergara, A | 1 |
| Can, C | 1 |
| Sen, S | 1 |
| Boztok, N | 1 |
| Tuglular, I | 1 |
| Vaidyanathan, S | 1 |
| Watt, JW | 1 |
| Singh, G | 1 |
| Soni, BM | 1 |
| Sett, P | 1 |
| Scott, CS | 1 |
| Retsch-Bogart, GZ | 1 |
| Henry, MM | 1 |
| Barata, K | 1 |
| Yoshida, M | 1 |
| Hokao, R | 1 |
| Imai, S | 1 |
| Takahashi, S | 1 |
| Harada, E | 1 |
| Maekawa, A | 1 |
| Caputi, AP | 1 |
| Gulati, S | 1 |
| Sharma, RK | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| N-acetylcysteine to Prevent Renal Failure in Patients With Chronic Kidney Disease Undergoing Coronary Artery Bypass Surgery[NCT01359722] | 50 participants (Anticipated) | Interventional | 2010-03-31 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for gentamicin and Renal Insufficiency
| Article | Year |
|---|---|
Time to abandon ampicillin plus gentamicin in favour of ampicillin plus ceftriaxone in Enterococcus faecalis infective endocarditis? A meta-analysis of comparative trials.
Topics: Amoxicillin; Ampicillin; Anti-Bacterial Agents; Ceftriaxone; Drug Therapy, Combination; Endocarditis | 2022 |
Combination of Ceftriaxone and Ampicillin for the Treatment of Enterococcal Endocarditis: A Qualitative Systematic Review.
Topics: Ampicillin; Anti-Bacterial Agents; Ceftriaxone; Drug Therapy, Combination; Endocarditis, Bacterial; | 2017 |
Renal cell apoptosis induced by nephrotoxic drugs: cellular and molecular mechanisms and potential approaches to modulation.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Caspases; Cisplatin; Cyclosporine; Gentamicins; H | 2008 |
3 trials available for gentamicin and Renal Insufficiency
| Article | Year |
|---|---|
A randomized double-blinded placebo-controlled clinical trial on protective effects of pentoxifylline on gentamicin nephrotoxicity in infectious patients.
Topics: Adult; Anti-Bacterial Agents; Brucellosis; Double-Blind Method; Female; Gentamicins; Humans; Male; M | 2021 |
The influence of locally implanted high doses of gentamicin on hearing and renal function of newborns treated for acute hematogenous osteomyelitis.
Topics: Acetylglucosaminidase; Anti-Bacterial Agents; Creatinine; Drug Implants; Female; Gentamicins; Hearin | 2003 |
Comparison of once-daily versus pharmacokinetic dosing of aminoglycosides in elderly patients.
Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; Drug Administration Schedule; Female; Gentamicins; H | 1996 |
51 other studies available for gentamicin and Renal Insufficiency
| Article | Year |
|---|---|
Celecoxib has Preventive and Therapeutic Benefits against Nephrotoxicity Caused by Gentamicin in Mice.
Topics: Animals; Celecoxib; Cyclooxygenase 2; Gentamicins; Glutathione; Interleukin-6; Kidney; Mice; NF-kapp | 2022 |
Comparison of the effect of vitamin C and selenium nanoparticles on gentamicin-induced renal impairment in male rats: a biochemical, molecular and histological study.
Topics: Animals; Antioxidants; Ascorbic Acid; Gentamicins; Inflammation; Kidney; Male; Oxidative Stress; Rat | 2023 |
Exploring porcine kidney explants as a model for the study of nephrotoxins and the therapeutic potential of phytic acid.
Topics: Animals; Antioxidants; Creatinine; Gentamicins; Kidney; Kidney Diseases; Oxidative Stress; Phytic Ac | 2023 |
Oral administration of naringenin and a mixture of coconut water and Arabic gum attenuate oxidative stress and lipid peroxidation in gentamicin-induced nephrotoxicity in rats.
Topics: Administration, Oral; Animals; Antioxidants; Cholesterol; Cocos; Creatinine; Gentamicins; Kidney; Li | 2023 |
Role of Farnesoid Receptors and Nrf2-mediated Genes in Gentamicin-induced Nephrotoxicity in Rat: A Time-course Study.
Topics: Animals; Drug-Related Side Effects and Adverse Reactions; Gentamicins; Kidney; Male; NF-E2-Related F | 2023 |
Proximal Tubular Vacuolization and Hypersensitivity to Drug-Induced Nephrotoxicity in Male Mice With Decreased Expression of the NADPH-Cytochrome P450 Reductase.
Topics: Animals; Blood Urea Nitrogen; Cisplatin; Creatinine; Gentamicins; Kidney Tubules, Proximal; Lysosome | 2020 |
A new aminoglycoside etimicin shows low nephrotoxicity and ototoxicity in zebrafish embryos.
Topics: Aminoglycosides; Animals; Anti-Bacterial Agents; Embryo, Nonmammalian; Gentamicins; Gram-Negative Ba | 2021 |
Vascular function and arginine and dimethylarginines in gentamicin-induced renal failure: a possible effect of heme oxygenase 1 inducer hemin.
Topics: Animals; Aorta; Arginine; Enzyme Induction; Gene Expression Regulation, Enzymologic; Gentamicins; He | 2017 |
Gentamicin may have no effect on mortality of staphylococcal prosthetic valve endocarditis.
Topics: Aged; Anti-Bacterial Agents; Cloxacillin; Endocarditis, Bacterial; Female; Gentamicins; Heart Failur | 2018 |
The effect of short-course gentamicin therapy on kidney function in patients with bacteraemia-a retrospective cohort study.
Topics: Acute Kidney Injury; Adolescent; Adult; Aged; Aged, 80 and over; Bacteremia; Denmark; Female; Gentam | 2018 |
Effect of fatty acids from ethanol extract of Moringa oleifera seeds on kidney function impairment and oxidative stress induced by gentamicin in rats.
Topics: Animals; Antioxidants; Creatinine; Ethanol; Fatty Acids; Gentamicins; Kidney; Kidney Function Tests; | 2019 |
Increased susceptibility of brain acetylcholinesterase activity to methylmalonate in young rats with renal failure.
Topics: Acetylcholinesterase; Amino Acid Metabolism, Inborn Errors; Analysis of Variance; Animals; Brain; Ch | 2013 |
Pharmacokinetics of daptomycin in a patient with severe renal failure not receiving dialysis.
Topics: Anti-Bacterial Agents; Daptomycin; Female; Gentamicins; Humans; Middle Aged; Renal Dialysis; Renal I | 2013 |
Antimicrobial regime for cardiac surgery: the safety and effectiveness of short-course flucloxacillin (or teicoplanin) and gentamicin-based prophylaxis.
Topics: Aged; Antibiotic Prophylaxis; Cardiac Surgical Procedures; Cefuroxime; Cohort Studies; Drug Substitu | 2013 |
Changes in the treatment of Enterococcus faecalis infective endocarditis in Spain in the last 15 years: from ampicillin plus gentamicin to ampicillin plus ceftriaxone.
Topics: Aged; Aged, 80 and over; Ampicillin; Anti-Bacterial Agents; Ceftriaxone; Cohort Studies; Drug Resist | 2014 |
Impact of gentamicin coadministration along with high fructose feeding on progression of renal failure and metabolic syndrome in Sprague-Dawley rats.
Topics: Animals; Blood Glucose; Body Weight; Disease Progression; Drug Combinations; Fructose; Gentamicins; | 2014 |
Protective effect of naringenin against gentamicin-induced nephrotoxicity in rats.
Topics: Animals; Anti-Bacterial Agents; Drug Antagonism; Flavanones; Gene Expression Regulation; Gentamicins | 2014 |
Hepato- and nephroprotective activities of a Nigerian local king tuber oyster mushroom, Pleurotus tuberregium (higher Basidiomycetes), in chemically induced organ toxicities in rats.
Topics: Acetaminophen; Animals; Anti-Bacterial Agents; Carbon Tetrachloride; Complex Mixtures; Disease Model | 2014 |
Complications associated with bacitracin powder in surgical wounds.
Topics: Adolescent; Anaphylaxis; Anti-Bacterial Agents; Anti-Infective Agents, Local; Antibiotic Prophylaxis | 2015 |
Acute Kidney Injury and Renal Recovery with the Use of Aminoglycosides: A Large Retrospective Study.
Topics: Acute Kidney Injury; Aged; Aged, 80 and over; Aminoglycosides; Antineoplastic Agents; Case-Control S | 2015 |
Sub-chronic exposure to fluoride impacts the response to a subsequent nephrotoxic treatment with gentamicin.
Topics: Animals; Fluorides; Gentamicins; Glomerular Filtration Rate; Kidney; Kidney Tubules, Proximal; Male; | 2016 |
6-gingerol ameliorates gentamicin induced renal cortex oxidative stress and apoptosis in adult male albino rats.
Topics: Animals; Antioxidants; Apoptosis; Caspase 3; Catechols; Fatty Alcohols; Gentamicins; HSP47 Heat-Shoc | 2016 |
[Use of acrylic cement with antibiotic in primary arthroplasty].
Topics: Anti-Bacterial Agents; Antibiotic Prophylaxis; Arthroplasty; Bone Cements; Gentamicins; Humans; Poly | 2008 |
Evaluation of various gentamicin dosage regimens in geriatric patients: a simulation study.
Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; Computer Simulation; Creatinine; Dose-Response Relat | 2010 |
Renoprotective effects of Andrographis paniculata (Burm. f.) Nees in rats.
Topics: Andrographis; Animals; Anti-Bacterial Agents; Blood Urea Nitrogen; Gentamicins; Kidney; Male; Plant | 2009 |
Halofuginone has a beneficial effect on gentamicin-induced acute nephrotoxicity in rats.
Topics: Animals; Antioxidants; Chlorides; Drug Interactions; Female; Gentamicins; Hydroxymethylglutaryl-CoA | 2009 |
Effect of uric acid on gentamicin-induced nephrotoxicity in rats - role of matrix metalloproteinases 2 and 9.
Topics: Animals; Anti-Bacterial Agents; Gentamicins; Kidney; Kidney Function Tests; Kidney Tubular Necrosis, | 2009 |
Minimizing the toxicity of aminoglycosides in cystic fibrosis.
Topics: Acute Kidney Injury; Aminoglycosides; Anti-Bacterial Agents; Chronic Disease; Cystic Fibrosis; DNA, | 2010 |
Characterization of mesonephric development and regeneration using transgenic zebrafish.
Topics: Animals; Animals, Genetically Modified; Cadherins; Cloning, Molecular; Genes, Wilms Tumor; Genetic M | 2010 |
Short-term gentamicin therapy and risk of renal toxicity in patients with bacteraemia.
Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; Bacteremia; Cohort Studies; Community-Acquired Infec | 2011 |
Effect of high saturated free fatty acids feeding on progression of renal failure in rat model of experimental nephrotoxicity.
Topics: Animals; Anti-Bacterial Agents; Disease Models, Animal; Disease Progression; Fatty Acids; Fatty Acid | 2012 |
Protective effect of Panax ginseng against serum biochemical changes and apoptosis in kidney of rats treated with gentamicin sulphate.
Topics: Animals; Apoptosis; Blood Urea Nitrogen; Creatinine; Gentamicins; Immunohistochemistry; Kidney; Live | 2012 |
Kidney injury and cell therapy: Preclinical study.
Topics: Animals; Anti-Bacterial Agents; Cell- and Tissue-Based Therapy; Disease Models, Animal; Gentamicins; | 2012 |
Mitochondria-targeted antioxidant SkQR1 ameliorates gentamycin-induced renal failure and hearing loss.
Topics: Animals; Antioxidants; Gentamicins; Hearing Loss; Humans; Kidney; Male; Mitochondria; Organ of Corti | 2012 |
A role for superoxide in gentamicin-mediated nephropathy in rats.
Topics: Animals; Anti-Bacterial Agents; Enzyme Activation; Free Radical Scavengers; Gentamicins; Kidney; Lip | 2002 |
Protective effect of L-arginine intake on the impaired renal vascular responses in the gentamicin-treated rats.
Topics: Administration, Oral; Animals; Arginine; Blood Pressure; Drinking; Endothelium, Vascular; Gentamicin | 2005 |
Protective effect of lycopene on gentamicin-induced oxidative stress and nephrotoxicity in rats.
Topics: Animals; Anti-Bacterial Agents; Antioxidants; Carotenoids; Drug Antagonism; Drug Therapy, Combinatio | 2005 |
Quantitative evaluation of effect of renal failure on the pharmacokinetics of panipenem in rats.
Topics: Animals; Anti-Bacterial Agents; Area Under Curve; Autoantibodies; Basement Membrane; Blood Urea Nitr | 2005 |
Modulation of gentamicin-induced renal dysfunction and injury by the phenolic extract of soybean (Glycine max).
Topics: Animals; Antioxidants; Aspartate Aminotransferases; Catalase; Disease Models, Animal; Dose-Response | 2006 |
Errors associated with applying decision support by suggesting default doses for aminoglycosides.
Topics: Adult; Aminoglycosides; Anti-Bacterial Agents; Creatinine; Decision Support Systems, Clinical; Drug | 2006 |
Possible involvement of erythropoietin in remote renal preconditioning-induced cardioprotection in rats.
Topics: Analysis of Variance; Animals; Coronary Circulation; Creatine Kinase; Erythropoietin; Gentamicins; I | 2008 |
Increased glomerular nitric oxide synthesis in gentamicin-induced renal failure.
Topics: Animals; Cyclic GMP; Female; Gentamicins; Kidney Glomerulus; Nitric Oxide; Rats; Rats, Wistar; Renal | 1994 |
Gentamicin toxicosis in a North American cougar.
Topics: Alopecia; Animals; Anorexia; Bites and Stings; Carnivora; Drug Overdose; Gentamicins; Kidney; Male; | 1993 |
Renal dysfunction in obstructive jaundice.
Topics: Cholestasis; Gentamicins; Humans; Renal Insufficiency; Retrospective Studies | 1995 |
Comparative study of bacteremias caused by Enterococcus spp. with and without high-level resistance to gentamicin. The Grupo Andaluz para el estudio de las Enfermedades Infecciosas.
Topics: Adult; Aged; Anti-Bacterial Agents; Bacteremia; Catheterization; Cross Infection; Drug Resistance, M | 1998 |
Protective effect of oral L-arginine administration on gentamicin-induced renal failure in rats.
Topics: Administration, Oral; Animals; Arginine; Creatinine; Enzyme Inhibitors; gamma-Glutamyltransferase; G | 2000 |
Dosage of once-daily gentamicin in spinal cord injury patients.
Topics: Adult; Creatinine; Drug Administration Schedule; Drug Monitoring; Gentamicins; Humans; Kidney Functi | 2000 |
Renal failure and vestibular toxicity in an adolescent with cystic fibrosis receiving gentamicin and standard-dose ibuprofen.
Topics: Adolescent; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Cystic Fibrosis; Gentami | 2001 |
Differential toxicity expression of gentamicine in five-sixths nephrectomized rats assigned to three progressive stages of renal dysfunction--establishment of a new screening approach.
Topics: Albumins; Amino Acid Sequence; Animals; Anti-Bacterial Agents; Blood Proteins; Creatinine; Disease M | 2001 |
Effect of N-acetylcysteine on gentamicin-mediated nephropathy in rats.
Topics: Acetylcysteine; Animals; Free Radical Scavengers; Gentamicins; Kidney; Male; Malondialdehyde; Peroxi | 2001 |
Aminoglycoside nephrotoxicity in clinical practice.
Topics: Child; Child, Preschool; Female; Gentamicins; Humans; Kidney; Male; Polyuria; Renal Insufficiency; R | 1992 |