gentamicin has been researched along with Puerperal Disorders in 18 studies
Gentamicins: A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.
Puerperal Disorders: Disorders or diseases associated with PUERPERIUM, the six-to-eight-week period immediately after PARTURITION in humans.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The objective of the study was to evaluate the efficacy of gentamicin and clindamycin given once daily versus the more common 8-hour dosing regimen for the treatment of postpartum endometritis." | 9.10 | Gentamicin and clindamycin therapy in postpartum endometritis: the efficacy of daily dosing versus dosing every 8 hours. ( Haddad, B; Leidwanger, C; Livingston, JC; Llata, E; Mabie, B; Rinehart, E; Sibai, B, 2003) |
| "We compared the pharmacokinetics of two methods for dosing gentamicin for the treatment of postpartum endometritis with the goal of achieving adequate peak serum concentrations (>12 mg/L) and prolonged trough levels below 2 mg/L." | 9.09 | Single daily dosing of gentamicin: pharmacokinetic comparison of two dosing methodologies for postpartum endometritis. ( Abate, B; Gonik, B; Liu, C; Reyes, M, 1999) |
| "In patients with post partum endometritis once daily intramuscular administration of gentamicin may be convenient in certain clinical settings." | 9.09 | Comparative pharmacokinetics of once daily intravenous and intramuscular gentamicin in patients with post partum endometritis. ( Gemer, O; Harari, D; Mishal, J; Segal, S, 2001) |
| "Sixty-two patients who had postpartum endometritis were treated with clindamycin in combination with either aztreonam or the aminoglycoside gentamicin." | 9.06 | Comparison trial of clindamycin with aztreonam or gentamicin in the treatment of postpartum endometritis. ( Bollinger, M; Greenberg, RN; Ojile, JM; Reilly, PM; Weinandt, WJ; Wilson, KM, 1987) |
| "To evaluate the pharmacokinetics and cost of once-daily dosing with gentamicin in women with postpartum endometritis." | 7.70 | The pharmacokinetics of once-daily dosing with gentamicin in women with postpartum endometritis. ( Heine, RP; Sunyecz, JA; Wiesenfeld, HC, 1998) |
| "Gentamicin is an aminoglycoside antibiotic frequently used in the treatment of mixed polymicrobial infections." | 5.27 | Delayed gentamicin elimination in patients with severe preeclampsia. ( Beitel, R; Dilts, PV; Lee, M; McNeeley, SG; Moise, C, 1985) |
| "The objective of the study was to evaluate the efficacy of gentamicin and clindamycin given once daily versus the more common 8-hour dosing regimen for the treatment of postpartum endometritis." | 5.10 | Gentamicin and clindamycin therapy in postpartum endometritis: the efficacy of daily dosing versus dosing every 8 hours. ( Haddad, B; Leidwanger, C; Livingston, JC; Llata, E; Mabie, B; Rinehart, E; Sibai, B, 2003) |
| "We compared the pharmacokinetics of two methods for dosing gentamicin for the treatment of postpartum endometritis with the goal of achieving adequate peak serum concentrations (>12 mg/L) and prolonged trough levels below 2 mg/L." | 5.09 | Single daily dosing of gentamicin: pharmacokinetic comparison of two dosing methodologies for postpartum endometritis. ( Abate, B; Gonik, B; Liu, C; Reyes, M, 1999) |
| "In patients with post partum endometritis once daily intramuscular administration of gentamicin may be convenient in certain clinical settings." | 5.09 | Comparative pharmacokinetics of once daily intravenous and intramuscular gentamicin in patients with post partum endometritis. ( Gemer, O; Harari, D; Mishal, J; Segal, S, 2001) |
| "Patients with a clinical diagnosis of chorioamnionitis treated with ampicillin during labor and who required cesarean delivery for obstetric indications received preoperative intravenous clindamycin and gentamicin and were randomized into 2 groups." | 5.08 | Chorioamnionitis: is continuation of antibiotic therapy necessary after cesarean section? ( Brown, HL; Cook, CR; Cureton, AC; How, HY; O'Rourke, TP; Spinnato, JA; Turnquest, MA, 1998) |
| "Sixty-two patients who had postpartum endometritis were treated with clindamycin in combination with either aztreonam or the aminoglycoside gentamicin." | 5.06 | Comparison trial of clindamycin with aztreonam or gentamicin in the treatment of postpartum endometritis. ( Bollinger, M; Greenberg, RN; Ojile, JM; Reilly, PM; Weinandt, WJ; Wilson, KM, 1987) |
| "To evaluate the pharmacokinetics and cost of once-daily dosing with gentamicin in women with postpartum endometritis." | 3.70 | The pharmacokinetics of once-daily dosing with gentamicin in women with postpartum endometritis. ( Heine, RP; Sunyecz, JA; Wiesenfeld, HC, 1998) |
| "A prospective protocol consisting of clindamycin-gentamicin plus the selective addition of ampicillin or vancomycin cured 303 of 322 (94%) women with postcesarean endometritis." | 3.70 | Puerperal infection after cesarean delivery: evaluation of a standardized protocol. ( Andrews, WW; Brumfield, CG; Hauth, JC, 2000) |
| "Post-partum endometritis are frequent and account for the fifth cause of maternal death." | 2.48 | [Management of post-partum infections]. ( Delaporte, MO; Gauchotte, E; Judlin, P; Lamy, C; Morel, O; Perdriolle, E; Villeroy-de-Galhau, S; Wahl, D; Zuily, S, 2012) |
| " Traditional dosing regimens for gentamicin have called for 3 times daily dosing, but recent insights into the pharmacodynamics of the drug have led to multiple studies of once-daily dosing regimens." | 2.44 | Once-daily dosing of gentamicin in obstetrics and gynecology. ( Theiler, RN; Ward, K, 2008) |
| "Gentamicin is an aminoglycoside antibiotic frequently used in the treatment of mixed polymicrobial infections." | 1.27 | Delayed gentamicin elimination in patients with severe preeclampsia. ( Beitel, R; Dilts, PV; Lee, M; McNeeley, SG; Moise, C, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (33.33) | 18.7374 |
| 1990's | 6 (33.33) | 18.2507 |
| 2000's | 4 (22.22) | 29.6817 |
| 2010's | 2 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Moulton, LJ | 1 |
| Lachiewicz, M | 1 |
| Liu, X | 1 |
| Goje, O | 1 |
| Ward, K | 1 |
| Theiler, RN | 1 |
| Lamy, C | 1 |
| Zuily, S | 1 |
| Perdriolle, E | 1 |
| Gauchotte, E | 1 |
| Villeroy-de-Galhau, S | 1 |
| Delaporte, MO | 1 |
| Wahl, D | 1 |
| Morel, O | 1 |
| Judlin, P | 1 |
| Livingston, JC | 1 |
| Llata, E | 1 |
| Rinehart, E | 1 |
| Leidwanger, C | 1 |
| Mabie, B | 1 |
| Haddad, B | 1 |
| Sibai, B | 1 |
| Steudel, HC | 1 |
| Gugler, R | 1 |
| Montoya Romero, JD | 1 |
| Pérez de Salazar, JL | 1 |
| Kunhardt Rasch, J | 1 |
| Díaz Loya, FD | 1 |
| Ortiz Ibarra, FJ | 1 |
| Figueroa, R | 1 |
| Gutiérrez, C | 1 |
| Carrillo, C | 1 |
| Escudero, F | 1 |
| Caciano, S | 1 |
| García Hjarles, M | 1 |
| Sunyecz, JA | 1 |
| Wiesenfeld, HC | 1 |
| Heine, RP | 1 |
| Turnquest, MA | 1 |
| How, HY | 1 |
| Cook, CR | 1 |
| O'Rourke, TP | 1 |
| Cureton, AC | 1 |
| Spinnato, JA | 1 |
| Brown, HL | 1 |
| Liu, C | 1 |
| Abate, B | 1 |
| Reyes, M | 1 |
| Gonik, B | 1 |
| Brumfield, CG | 1 |
| Hauth, JC | 1 |
| Andrews, WW | 1 |
| Gemer, O | 1 |
| Harari, D | 1 |
| Mishal, J | 1 |
| Segal, S | 1 |
| Gibbs, RS | 1 |
| Weinstein, AJ | 1 |
| Lysikiewicz, A | 1 |
| Sliwiński, W | 1 |
| Stoukides, CA | 1 |
| Souney, PF | 1 |
| Greenberg, RN | 1 |
| Reilly, PM | 1 |
| Weinandt, WJ | 1 |
| Wilson, KM | 1 |
| Bollinger, M | 1 |
| Ojile, JM | 1 |
| McNeeley, SG | 1 |
| Beitel, R | 1 |
| Lee, M | 1 |
| Moise, C | 1 |
| Dilts, PV | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized Clinical Trial Between Clindamycin Once and Thrice a Day in Septic Abortion.[NCT02309346] | Phase 4 | 190 participants (Anticipated) | Interventional | 2014-12-31 | Recruiting | ||
| A Randomized Clinical Trial on the Use or Not of Antibiotics After Hospital Discharge in Septic Abortion.[NCT00353743] | 56 participants (Actual) | Interventional | 2006-05-31 | Terminated (stopped due to Rate of cure was higher than expected, IRB suspended for no additional benefit) | |||
| Treatment Utility of Postpartum Antibiotics in Chorioamnionitis[NCT01585129] | Phase 4 | 80 participants (Actual) | Interventional | 2010-09-30 | Terminated (stopped due to Futility in patient enrollment) | ||
| Prolonged Treatment for Infected Abortion After Hospital Discharge.[NCT00376493] | Phase 4 | 56 participants (Actual) | Interventional | 2006-05-31 | Terminated (stopped due to The rate of cure in both arms was higher than expected) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
This is the duration of hospital stay (in days) after their cesarean delivery. (NCT01585129)
Timeframe: Up to 7 Days
| Intervention | days (Mean) |
|---|---|
| Postpartum Antibiotics | 4 |
| No Postpartum Antibiotics | 4 |
Endometritis is defined as uterine infection and is diagnosed by maternal temp > 38.0C on two occasions over a 4 hour period or any temp > 39.0C after delivery > 12 hours after delivery. Endometritis will be managed per currently accepted endometritis protocol - (Amp 2 gQ6, Gentamicin 5 mg/kg q24, Clindamycin 900 mg q8). (NCT01585129)
Timeframe: 7 days post-partum
| Intervention | Participants (Count of Participants) |
|---|---|
| Postpartum Antibiotics | 4 |
| No Postpartum Antibiotics | 3 |
Infection related complications will include common complications attributed to infections there are not the primary outcome (endometritis). This will include infections of the wound and pelvic abscesses. (NCT01585129)
Timeframe: 7 days post-partum
| Intervention | Participants (Count of Participants) |
|---|---|
| Postpartum Antibiotics | 7 |
| No Postpartum Antibiotics | 2 |
2 reviews available for gentamicin and Puerperal Disorders
| Article | Year |
|---|---|
Once-daily dosing of gentamicin in obstetrics and gynecology.
Topics: Adult; Anti-Bacterial Agents; Chorioamnionitis; Dose-Response Relationship, Drug; Drug Administratio | 2008 |
[Management of post-partum infections].
Topics: Anti-Bacterial Agents; Antibiotic Prophylaxis; Anticoagulants; Cesarean Section; Clindamycin; Drug T | 2012 |
8 trials available for gentamicin and Puerperal Disorders
| Article | Year |
|---|---|
Gentamicin and clindamycin therapy in postpartum endometritis: the efficacy of daily dosing versus dosing every 8 hours.
Topics: Adolescent; Adult; Body Weight; Chorioamnionitis; Clindamycin; Double-Blind Method; Endometritis; Fe | 2003 |
[Treatment of puerperal endometritis].
Topics: Bacteria; Bacteriological Techniques; Chloramphenicol; Clindamycin; Drug Therapy, Combination; Endom | 1995 |
[Treatment of puerperal endometritis. Evaluation of the efficacy and safety of clindamycin + gentamycin vs. penicillin + chloramphenicol + gentamycin].
Topics: Adult; Bacteria; Chloramphenicol; Clindamycin; Drug Therapy, Combination; Endometritis; Female; Gent | 1994 |
Chorioamnionitis: is continuation of antibiotic therapy necessary after cesarean section?
Topics: Adult; Ampicillin; Anti-Bacterial Agents; Cesarean Section; Chorioamnionitis; Clindamycin; Drug Admi | 1998 |
Chorioamnionitis: is continuation of antibiotic therapy necessary after cesarean section?
Topics: Adult; Ampicillin; Anti-Bacterial Agents; Cesarean Section; Chorioamnionitis; Clindamycin; Drug Admi | 1998 |
Chorioamnionitis: is continuation of antibiotic therapy necessary after cesarean section?
Topics: Adult; Ampicillin; Anti-Bacterial Agents; Cesarean Section; Chorioamnionitis; Clindamycin; Drug Admi | 1998 |
Chorioamnionitis: is continuation of antibiotic therapy necessary after cesarean section?
Topics: Adult; Ampicillin; Anti-Bacterial Agents; Cesarean Section; Chorioamnionitis; Clindamycin; Drug Admi | 1998 |
Chorioamnionitis: is continuation of antibiotic therapy necessary after cesarean section?
Topics: Adult; Ampicillin; Anti-Bacterial Agents; Cesarean Section; Chorioamnionitis; Clindamycin; Drug Admi | 1998 |
Chorioamnionitis: is continuation of antibiotic therapy necessary after cesarean section?
Topics: Adult; Ampicillin; Anti-Bacterial Agents; Cesarean Section; Chorioamnionitis; Clindamycin; Drug Admi | 1998 |
Chorioamnionitis: is continuation of antibiotic therapy necessary after cesarean section?
Topics: Adult; Ampicillin; Anti-Bacterial Agents; Cesarean Section; Chorioamnionitis; Clindamycin; Drug Admi | 1998 |
Chorioamnionitis: is continuation of antibiotic therapy necessary after cesarean section?
Topics: Adult; Ampicillin; Anti-Bacterial Agents; Cesarean Section; Chorioamnionitis; Clindamycin; Drug Admi | 1998 |
Chorioamnionitis: is continuation of antibiotic therapy necessary after cesarean section?
Topics: Adult; Ampicillin; Anti-Bacterial Agents; Cesarean Section; Chorioamnionitis; Clindamycin; Drug Admi | 1998 |
Single daily dosing of gentamicin: pharmacokinetic comparison of two dosing methodologies for postpartum endometritis.
Topics: Adolescent; Adult; Anti-Bacterial Agents; Dose-Response Relationship, Drug; Endometritis; Female; Ge | 1999 |
Comparative pharmacokinetics of once daily intravenous and intramuscular gentamicin in patients with post partum endometritis.
Topics: Anti-Bacterial Agents; Endometritis; Female; Gentamicins; Humans; Injections, Intramuscular; Injecti | 2001 |
Bacteriologic effects of prophylactic antibiotics in cesarean section.
Topics: Ampicillin; Bacteria; Cesarean Section; Clindamycin; Clinical Trials as Topic; Drug Therapy, Combina | 1976 |
Comparison trial of clindamycin with aztreonam or gentamicin in the treatment of postpartum endometritis.
Topics: Adolescent; Adult; Aztreonam; Clindamycin; Clinical Trials as Topic; Drug Therapy, Combination; Endo | 1987 |
8 other studies available for gentamicin and Puerperal Disorders
| Article | Year |
|---|---|
Endomyometritis after cesarean delivery in the era of antibiotic prophylaxis: incidence and risk factors.
Topics: Adult; Antibiotic Prophylaxis; Cefazolin; Cesarean Section; Chorioamnionitis; Clindamycin; Endometri | 2018 |
[Postpartum pseudomembranous colitis].
Topics: Adult; Cefotaxime; Colon; Colonoscopy; Drug Therapy, Combination; Enterocolitis, Pseudomembranous; F | 1984 |
[Sisomycin sulfate in obstetric and gynecologic infections].
Topics: Abortion, Induced; Adult; Aged; Bacterial Infections; Drug Evaluation; Female; Genital Diseases, Fem | 1981 |
The pharmacokinetics of once-daily dosing with gentamicin in women with postpartum endometritis.
Topics: Adolescent; Adult; Drug Costs; Endometritis; Female; Gentamicins; Humans; Puerperal Disorders | 1998 |
Puerperal infection after cesarean delivery: evaluation of a standardized protocol.
Topics: Ampicillin; Anti-Bacterial Agents; Cesarean Section; Clindamycin; Drug Resistance, Microbial; Drug T | 2000 |
[Use of garamycin and gentamicin preparations in obstetrics and gynecology].
Topics: Cephalothin; Drug Therapy, Combination; Female; Genital Diseases, Female; Gentamicins; Humans; Infec | 1975 |
Postpartum gentamicin dosing and endometritis.
Topics: Costs and Cost Analysis; Dose-Response Relationship, Drug; Endometritis; Female; Gentamicins; Humans | 1990 |
Delayed gentamicin elimination in patients with severe preeclampsia.
Topics: Adult; Endometritis; Female; Gentamicins; Half-Life; Humans; Kinetics; Pre-Eclampsia; Pregnancy; Pue | 1985 |