Page last updated: 2024-10-27

gentamicin and Puerperal Disorders

gentamicin has been researched along with Puerperal Disorders in 18 studies

Gentamicins: A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.

Puerperal Disorders: Disorders or diseases associated with PUERPERIUM, the six-to-eight-week period immediately after PARTURITION in humans.

Research Excerpts

ExcerptRelevanceReference
"The objective of the study was to evaluate the efficacy of gentamicin and clindamycin given once daily versus the more common 8-hour dosing regimen for the treatment of postpartum endometritis."9.10Gentamicin and clindamycin therapy in postpartum endometritis: the efficacy of daily dosing versus dosing every 8 hours. ( Haddad, B; Leidwanger, C; Livingston, JC; Llata, E; Mabie, B; Rinehart, E; Sibai, B, 2003)
"We compared the pharmacokinetics of two methods for dosing gentamicin for the treatment of postpartum endometritis with the goal of achieving adequate peak serum concentrations (>12 mg/L) and prolonged trough levels below 2 mg/L."9.09Single daily dosing of gentamicin: pharmacokinetic comparison of two dosing methodologies for postpartum endometritis. ( Abate, B; Gonik, B; Liu, C; Reyes, M, 1999)
"In patients with post partum endometritis once daily intramuscular administration of gentamicin may be convenient in certain clinical settings."9.09Comparative pharmacokinetics of once daily intravenous and intramuscular gentamicin in patients with post partum endometritis. ( Gemer, O; Harari, D; Mishal, J; Segal, S, 2001)
"Sixty-two patients who had postpartum endometritis were treated with clindamycin in combination with either aztreonam or the aminoglycoside gentamicin."9.06Comparison trial of clindamycin with aztreonam or gentamicin in the treatment of postpartum endometritis. ( Bollinger, M; Greenberg, RN; Ojile, JM; Reilly, PM; Weinandt, WJ; Wilson, KM, 1987)
"To evaluate the pharmacokinetics and cost of once-daily dosing with gentamicin in women with postpartum endometritis."7.70The pharmacokinetics of once-daily dosing with gentamicin in women with postpartum endometritis. ( Heine, RP; Sunyecz, JA; Wiesenfeld, HC, 1998)
"Gentamicin is an aminoglycoside antibiotic frequently used in the treatment of mixed polymicrobial infections."5.27Delayed gentamicin elimination in patients with severe preeclampsia. ( Beitel, R; Dilts, PV; Lee, M; McNeeley, SG; Moise, C, 1985)
"The objective of the study was to evaluate the efficacy of gentamicin and clindamycin given once daily versus the more common 8-hour dosing regimen for the treatment of postpartum endometritis."5.10Gentamicin and clindamycin therapy in postpartum endometritis: the efficacy of daily dosing versus dosing every 8 hours. ( Haddad, B; Leidwanger, C; Livingston, JC; Llata, E; Mabie, B; Rinehart, E; Sibai, B, 2003)
"We compared the pharmacokinetics of two methods for dosing gentamicin for the treatment of postpartum endometritis with the goal of achieving adequate peak serum concentrations (>12 mg/L) and prolonged trough levels below 2 mg/L."5.09Single daily dosing of gentamicin: pharmacokinetic comparison of two dosing methodologies for postpartum endometritis. ( Abate, B; Gonik, B; Liu, C; Reyes, M, 1999)
"In patients with post partum endometritis once daily intramuscular administration of gentamicin may be convenient in certain clinical settings."5.09Comparative pharmacokinetics of once daily intravenous and intramuscular gentamicin in patients with post partum endometritis. ( Gemer, O; Harari, D; Mishal, J; Segal, S, 2001)
"Patients with a clinical diagnosis of chorioamnionitis treated with ampicillin during labor and who required cesarean delivery for obstetric indications received preoperative intravenous clindamycin and gentamicin and were randomized into 2 groups."5.08Chorioamnionitis: is continuation of antibiotic therapy necessary after cesarean section? ( Brown, HL; Cook, CR; Cureton, AC; How, HY; O'Rourke, TP; Spinnato, JA; Turnquest, MA, 1998)
"Sixty-two patients who had postpartum endometritis were treated with clindamycin in combination with either aztreonam or the aminoglycoside gentamicin."5.06Comparison trial of clindamycin with aztreonam or gentamicin in the treatment of postpartum endometritis. ( Bollinger, M; Greenberg, RN; Ojile, JM; Reilly, PM; Weinandt, WJ; Wilson, KM, 1987)
"To evaluate the pharmacokinetics and cost of once-daily dosing with gentamicin in women with postpartum endometritis."3.70The pharmacokinetics of once-daily dosing with gentamicin in women with postpartum endometritis. ( Heine, RP; Sunyecz, JA; Wiesenfeld, HC, 1998)
"A prospective protocol consisting of clindamycin-gentamicin plus the selective addition of ampicillin or vancomycin cured 303 of 322 (94%) women with postcesarean endometritis."3.70Puerperal infection after cesarean delivery: evaluation of a standardized protocol. ( Andrews, WW; Brumfield, CG; Hauth, JC, 2000)
"Post-partum endometritis are frequent and account for the fifth cause of maternal death."2.48[Management of post-partum infections]. ( Delaporte, MO; Gauchotte, E; Judlin, P; Lamy, C; Morel, O; Perdriolle, E; Villeroy-de-Galhau, S; Wahl, D; Zuily, S, 2012)
" Traditional dosing regimens for gentamicin have called for 3 times daily dosing, but recent insights into the pharmacodynamics of the drug have led to multiple studies of once-daily dosing regimens."2.44Once-daily dosing of gentamicin in obstetrics and gynecology. ( Theiler, RN; Ward, K, 2008)
"Gentamicin is an aminoglycoside antibiotic frequently used in the treatment of mixed polymicrobial infections."1.27Delayed gentamicin elimination in patients with severe preeclampsia. ( Beitel, R; Dilts, PV; Lee, M; McNeeley, SG; Moise, C, 1985)

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19906 (33.33)18.7374
1990's6 (33.33)18.2507
2000's4 (22.22)29.6817
2010's2 (11.11)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Moulton, LJ1
Lachiewicz, M1
Liu, X1
Goje, O1
Ward, K1
Theiler, RN1
Lamy, C1
Zuily, S1
Perdriolle, E1
Gauchotte, E1
Villeroy-de-Galhau, S1
Delaporte, MO1
Wahl, D1
Morel, O1
Judlin, P1
Livingston, JC1
Llata, E1
Rinehart, E1
Leidwanger, C1
Mabie, B1
Haddad, B1
Sibai, B1
Steudel, HC1
Gugler, R1
Montoya Romero, JD1
Pérez de Salazar, JL1
Kunhardt Rasch, J1
Díaz Loya, FD1
Ortiz Ibarra, FJ1
Figueroa, R1
Gutiérrez, C1
Carrillo, C1
Escudero, F1
Caciano, S1
García Hjarles, M1
Sunyecz, JA1
Wiesenfeld, HC1
Heine, RP1
Turnquest, MA1
How, HY1
Cook, CR1
O'Rourke, TP1
Cureton, AC1
Spinnato, JA1
Brown, HL1
Liu, C1
Abate, B1
Reyes, M1
Gonik, B1
Brumfield, CG1
Hauth, JC1
Andrews, WW1
Gemer, O1
Harari, D1
Mishal, J1
Segal, S1
Gibbs, RS1
Weinstein, AJ1
Lysikiewicz, A1
Sliwiński, W1
Stoukides, CA1
Souney, PF1
Greenberg, RN1
Reilly, PM1
Weinandt, WJ1
Wilson, KM1
Bollinger, M1
Ojile, JM1
McNeeley, SG1
Beitel, R1
Lee, M1
Moise, C1
Dilts, PV1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Randomized Clinical Trial Between Clindamycin Once and Thrice a Day in Septic Abortion.[NCT02309346]Phase 4190 participants (Anticipated)Interventional2014-12-31Recruiting
A Randomized Clinical Trial on the Use or Not of Antibiotics After Hospital Discharge in Septic Abortion.[NCT00353743]56 participants (Actual)Interventional2006-05-31Terminated (stopped due to Rate of cure was higher than expected, IRB suspended for no additional benefit)
Treatment Utility of Postpartum Antibiotics in Chorioamnionitis[NCT01585129]Phase 480 participants (Actual)Interventional2010-09-30Terminated (stopped due to Futility in patient enrollment)
Prolonged Treatment for Infected Abortion After Hospital Discharge.[NCT00376493]Phase 456 participants (Actual)Interventional2006-05-31Terminated (stopped due to The rate of cure in both arms was higher than expected)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Duration of Hospital Stay After Cesarean Delivery

This is the duration of hospital stay (in days) after their cesarean delivery. (NCT01585129)
Timeframe: Up to 7 Days

Interventiondays (Mean)
Postpartum Antibiotics4
No Postpartum Antibiotics4

Number of Paricipants With Endometritis

Endometritis is defined as uterine infection and is diagnosed by maternal temp > 38.0C on two occasions over a 4 hour period or any temp > 39.0C after delivery > 12 hours after delivery. Endometritis will be managed per currently accepted endometritis protocol - (Amp 2 gQ6, Gentamicin 5 mg/kg q24, Clindamycin 900 mg q8). (NCT01585129)
Timeframe: 7 days post-partum

InterventionParticipants (Count of Participants)
Postpartum Antibiotics4
No Postpartum Antibiotics3

Number of Participants With Infection-related Complications

Infection related complications will include common complications attributed to infections there are not the primary outcome (endometritis). This will include infections of the wound and pelvic abscesses. (NCT01585129)
Timeframe: 7 days post-partum

InterventionParticipants (Count of Participants)
Postpartum Antibiotics7
No Postpartum Antibiotics2

Reviews

2 reviews available for gentamicin and Puerperal Disorders

ArticleYear
Once-daily dosing of gentamicin in obstetrics and gynecology.
    Clinical obstetrics and gynecology, 2008, Volume: 51, Issue:3

    Topics: Adult; Anti-Bacterial Agents; Chorioamnionitis; Dose-Response Relationship, Drug; Drug Administratio

2008
[Management of post-partum infections].
    Journal de gynecologie, obstetrique et biologie de la reproduction, 2012, Volume: 41, Issue:8

    Topics: Anti-Bacterial Agents; Antibiotic Prophylaxis; Anticoagulants; Cesarean Section; Clindamycin; Drug T

2012

Trials

8 trials available for gentamicin and Puerperal Disorders

ArticleYear
Gentamicin and clindamycin therapy in postpartum endometritis: the efficacy of daily dosing versus dosing every 8 hours.
    American journal of obstetrics and gynecology, 2003, Volume: 188, Issue:1

    Topics: Adolescent; Adult; Body Weight; Chorioamnionitis; Clindamycin; Double-Blind Method; Endometritis; Fe

2003
[Treatment of puerperal endometritis].
    Ginecologia y obstetricia de Mexico, 1995, Volume: 63

    Topics: Bacteria; Bacteriological Techniques; Chloramphenicol; Clindamycin; Drug Therapy, Combination; Endom

1995
[Treatment of puerperal endometritis. Evaluation of the efficacy and safety of clindamycin + gentamycin vs. penicillin + chloramphenicol + gentamycin].
    Ginecologia y obstetricia de Mexico, 1994, Volume: 62

    Topics: Adult; Bacteria; Chloramphenicol; Clindamycin; Drug Therapy, Combination; Endometritis; Female; Gent

1994
Chorioamnionitis: is continuation of antibiotic therapy necessary after cesarean section?
    American journal of obstetrics and gynecology, 1998, Volume: 179, Issue:5

    Topics: Adult; Ampicillin; Anti-Bacterial Agents; Cesarean Section; Chorioamnionitis; Clindamycin; Drug Admi

1998
Chorioamnionitis: is continuation of antibiotic therapy necessary after cesarean section?
    American journal of obstetrics and gynecology, 1998, Volume: 179, Issue:5

    Topics: Adult; Ampicillin; Anti-Bacterial Agents; Cesarean Section; Chorioamnionitis; Clindamycin; Drug Admi

1998
Chorioamnionitis: is continuation of antibiotic therapy necessary after cesarean section?
    American journal of obstetrics and gynecology, 1998, Volume: 179, Issue:5

    Topics: Adult; Ampicillin; Anti-Bacterial Agents; Cesarean Section; Chorioamnionitis; Clindamycin; Drug Admi

1998
Chorioamnionitis: is continuation of antibiotic therapy necessary after cesarean section?
    American journal of obstetrics and gynecology, 1998, Volume: 179, Issue:5

    Topics: Adult; Ampicillin; Anti-Bacterial Agents; Cesarean Section; Chorioamnionitis; Clindamycin; Drug Admi

1998
Chorioamnionitis: is continuation of antibiotic therapy necessary after cesarean section?
    American journal of obstetrics and gynecology, 1998, Volume: 179, Issue:5

    Topics: Adult; Ampicillin; Anti-Bacterial Agents; Cesarean Section; Chorioamnionitis; Clindamycin; Drug Admi

1998
Chorioamnionitis: is continuation of antibiotic therapy necessary after cesarean section?
    American journal of obstetrics and gynecology, 1998, Volume: 179, Issue:5

    Topics: Adult; Ampicillin; Anti-Bacterial Agents; Cesarean Section; Chorioamnionitis; Clindamycin; Drug Admi

1998
Chorioamnionitis: is continuation of antibiotic therapy necessary after cesarean section?
    American journal of obstetrics and gynecology, 1998, Volume: 179, Issue:5

    Topics: Adult; Ampicillin; Anti-Bacterial Agents; Cesarean Section; Chorioamnionitis; Clindamycin; Drug Admi

1998
Chorioamnionitis: is continuation of antibiotic therapy necessary after cesarean section?
    American journal of obstetrics and gynecology, 1998, Volume: 179, Issue:5

    Topics: Adult; Ampicillin; Anti-Bacterial Agents; Cesarean Section; Chorioamnionitis; Clindamycin; Drug Admi

1998
Chorioamnionitis: is continuation of antibiotic therapy necessary after cesarean section?
    American journal of obstetrics and gynecology, 1998, Volume: 179, Issue:5

    Topics: Adult; Ampicillin; Anti-Bacterial Agents; Cesarean Section; Chorioamnionitis; Clindamycin; Drug Admi

1998
Single daily dosing of gentamicin: pharmacokinetic comparison of two dosing methodologies for postpartum endometritis.
    Infectious diseases in obstetrics and gynecology, 1999, Volume: 7, Issue:3

    Topics: Adolescent; Adult; Anti-Bacterial Agents; Dose-Response Relationship, Drug; Endometritis; Female; Ge

1999
Comparative pharmacokinetics of once daily intravenous and intramuscular gentamicin in patients with post partum endometritis.
    Archives of gynecology and obstetrics, 2001, Volume: 265, Issue:1

    Topics: Anti-Bacterial Agents; Endometritis; Female; Gentamicins; Humans; Injections, Intramuscular; Injecti

2001
Bacteriologic effects of prophylactic antibiotics in cesarean section.
    American journal of obstetrics and gynecology, 1976, Sep-15, Volume: 126, Issue:2

    Topics: Ampicillin; Bacteria; Cesarean Section; Clindamycin; Clinical Trials as Topic; Drug Therapy, Combina

1976
Comparison trial of clindamycin with aztreonam or gentamicin in the treatment of postpartum endometritis.
    Clinical therapeutics, 1987, Volume: 10, Issue:1

    Topics: Adolescent; Adult; Aztreonam; Clindamycin; Clinical Trials as Topic; Drug Therapy, Combination; Endo

1987

Other Studies

8 other studies available for gentamicin and Puerperal Disorders

ArticleYear
Endomyometritis after cesarean delivery in the era of antibiotic prophylaxis: incidence and risk factors.
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2018, Volume: 31, Issue:9

    Topics: Adult; Antibiotic Prophylaxis; Cefazolin; Cesarean Section; Chorioamnionitis; Clindamycin; Endometri

2018
[Postpartum pseudomembranous colitis].
    Der Internist, 1984, Volume: 25, Issue:12

    Topics: Adult; Cefotaxime; Colon; Colonoscopy; Drug Therapy, Combination; Enterocolitis, Pseudomembranous; F

1984
[Sisomycin sulfate in obstetric and gynecologic infections].
    Ginecologia y obstetricia de Mexico, 1981, Volume: 48, Issue:291

    Topics: Abortion, Induced; Adult; Aged; Bacterial Infections; Drug Evaluation; Female; Genital Diseases, Fem

1981
The pharmacokinetics of once-daily dosing with gentamicin in women with postpartum endometritis.
    Infectious diseases in obstetrics and gynecology, 1998, Volume: 6, Issue:4

    Topics: Adolescent; Adult; Drug Costs; Endometritis; Female; Gentamicins; Humans; Puerperal Disorders

1998
Puerperal infection after cesarean delivery: evaluation of a standardized protocol.
    American journal of obstetrics and gynecology, 2000, Volume: 182, Issue:5

    Topics: Ampicillin; Anti-Bacterial Agents; Cesarean Section; Clindamycin; Drug Resistance, Microbial; Drug T

2000
[Use of garamycin and gentamicin preparations in obstetrics and gynecology].
    Ginekologia polska, 1975, Volume: 46, Issue:8

    Topics: Cephalothin; Drug Therapy, Combination; Female; Genital Diseases, Female; Gentamicins; Humans; Infec

1975
Postpartum gentamicin dosing and endometritis.
    American journal of obstetrics and gynecology, 1990, Volume: 162, Issue:4

    Topics: Costs and Cost Analysis; Dose-Response Relationship, Drug; Endometritis; Female; Gentamicins; Humans

1990
Delayed gentamicin elimination in patients with severe preeclampsia.
    American journal of obstetrics and gynecology, 1985, Dec-01, Volume: 153, Issue:7

    Topics: Adult; Endometritis; Female; Gentamicins; Half-Life; Humans; Kinetics; Pre-Eclampsia; Pregnancy; Pue

1985