gentamicin and Pseudomonas Infections studies

Gentamicins: A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.

Research Excerpts

Excerpt	Relevance	Reference
"In a prospective multicentre open trial, hospitalised adult patients with acute lower respiratory tract infections, mainly pneumonia or bronchitis, were randomised to receive either isepamicin 8 or 15 mg/kg once daily depending on the severity of the infection or amikacin 7."	9.08	Comparison of the efficacy and safety of isepamicin and amikacin in the treatment of acute lower respiratory tract infections caused by gram-negative organisms. ( Covi, M; Velluti, G, 1995)
"A randomized cross-over study was undertaken to compare nebulized (1) ceftazidime with (2) a combination of gentamicin and carbenicillin, and (3) saline, each given for 4 months, in patients with cystic fibrosis infected with Pseudomonas aeruginosa."	9.06	Inhaled ceftazidime compared with gentamicin and carbenicillin in older patients with cystic fibrosis infected with Pseudomonas aeruginosa. ( Batten, JC; Hodson, ME; Stead, RJ, 1987)
"Forty hospitalized patients with complicated urinary tract infections were treated with gentamicin 240 mg die i."	9.05	Comparative non-blind trial of ceftriaxone and gentamicin in the treatment of complicated urinary tract infections. ( Calvosa, F; Castiello, G; Lentini, M; Scorza, C, 1982)
"The pharmacokinetics of tobramycin in adolescents or young adults with cystic fibrosis and in age-matched controls were prospectively compared."	9.05	Disposition of tobramycin in patients with cystic fibrosis: a prospective controlled study. ( Koup, JR; Levy, J; Ramsey, B; Smith, AL; Williams-Warren, J, 1984)
"A randomised controlled open comparison of azlocillin and gentamicin versus carbenicillin and gentamicin was carried out in patients with cystic fibrosis who were chronically infected with Pseudomonas aeruginosa."	9.05	Azlocillin compared with carbenicillin in the treatment of bronchopulmonary infection due to Pseudomonas aeruginosa in cystic fibrosis. ( Batten, JC; Gaya, H; Hodson, ME; Penketh, A, 1984)
"Sixteen adults with cystic fibrosis and chronic bronchopulmonary infection with Pseudomonas aeruginosa, admitted to hospital for chemotherapy, were randomized to treatment with either carbenicillin or ticarcillin."	9.05	Ticarcillin compared with carbenicillin in the treatment of exacerbations of bronchopulmonary infection in cystic fibrosis. ( Batten, JC; Hodson, ME; Penketh, AR, 1983)
"An open randomised comparison of a new intravenous cephalosporin, ceftazidime, with the established regimen of gentamicin and carbenicillin was carried out in patients with cystic fibrosis who had persisting pulmonary infection with Pseudomonas species and who developed acute exacerbations of respiratory symptoms."	9.05	Ceftazidime compared with gentamicin and carbenicillin in patients with cystic fibrosis, pulmonary pseudomonas infection, and an exacerbation of respiratory symptoms. British Thoracic Society Research Committee. ( , 1985)
"The effectiveness of ticarcillin against Pseudomonas aeruginosa in acute exacerbations of pulmonary infection in patients with cystic fibrosis was evaluated."	9.04	Treatment of pulmonary infections in patients with cystic fibrosis: a comparative study of ticarcillin and gentamicin. ( Denning, CR; Gaerlan, PF; Merlino, M; Neu, HC; Ores, CN; Parry, MF, 1977)
"The efficacy and safety of amikacin in treatment of patients with urinary tract infections were evaluated."	9.04	Amikacin Therapy of Urinary tract infections. ( Cox, CE, 1976)
"Literature searches were made in Medline and Pubmed using the search terms [Pseudomonas] or [Staphylococcus] and [fluoroquinolone] or [cephalosporin] or [gentamicin] and [keratitis] or [cornea]."	8.87	Review of resistance of ocular isolates of Pseudomonas aeruginosa and staphylococci from keratitis to ciprofloxacin, gentamicin and cephalosporins. ( Willcox, MD, 2011)
"To evaluate the efficacy of iontophoresis using a hydrogel probe containing gentamicin for the treatment of Pseudomonas keratitis in the rabbit cornea."	7.73	Iontophoretic treatment of experimental pseudomonas keratitis in rabbit eyes using gentamicin-loaded hydrogels. ( Domb, A; Eljarrat-Binstock, E; Frucht-Pery, J; Mechoulam, H; Raiskup, F; Shapiro, M, 2006)
"To determine ciprofloxacin resistance of corneal isolates of Pseudomonas and to review the clinical response to topical therapy in cases of ciprofloxacin-resistant Pseudomonas keratitis, where medical therapy was begun with 0."	7.70	Ciprofloxacin-resistant Pseudomonas keratitis. ( Garg, P; Rao, GN; Sharma, S, 1999)
"To report a case of ticlopidine-induced neutropenia resulting in Pseudomonas bacteremia."	7.69	Pseudomonas bacteremia precipitated by ticlopidine-induced neutropenia. ( Geletko, SM; Melbourne, KM; Mikolich, DJ, 1996)
"Experimental endophthalmitis was treated with single intravitreous administrations of cefotaxime (claforan) and gentamicin."	7.68	[Treatment of endophthalmitis with a single intravitreous administration of cefotaxime and gentamicin in an experiment]. ( Glinchuk, IaI; Gusev, IuA; Moroz, AF; Radkevich, SA, 1991)
"A study of 29 children and adolescents with cystic fibrosis over 2 years showed some evidence of benefit from the twice daily inhalation of 20 mg nebulized gentamicin when compared to the inhalation of a nebulized saline mixture."	7.67	Nebulized gentamicin in children and adolescents with cystic fibrosis. ( Kun, P; Landau, LI; Phelan, PD, 1984)
"Single intravitreal doses of ciprofloxacin, gentamicin, or imipenem were administered to rabbits with pseudomonas endophthalmitis for determination of the maximally effective dose."	7.67	Dose response of experimental Pseudomonas endophthalmitis to ciprofloxacin, gentamicin, and imipenem: evidence for resistance to "late" treatment of infections. ( Barza, M; Davey, PG; Stuart, M, 1987)
"The in vitro activity of aztreonam combined with tobramycin and with gentamicin was assessed in 78 clinical isolates of Pseudomonas aeruginosa and 11 clinical isolates of Pseudomonas cepacia from patients with cystic fibrosis."	7.67	In vitro activity of aztreonam combined with tobramycin and gentamicin against clinical isolates of Pseudomonas aeruginosa and Pseudomonas cepacia from patients with cystic fibrosis. ( Bosso, JA; Matsen, JM; Saxon, BA, 1987)
"Two patients developed acute interstitial nephritis (AIN) following treatment with mezlocillin sodium."	7.67	Acute interstitial nephritis associated with mezlocillin, nafcillin, and gentamicin treatment for Pseudomonas infection. ( Bauman, J; Copley, JB; Cushner, HM; Hill, SC, 1985)
"Treatment with gentamicin or tobramycin given intravenously with carbenicillin is compared in the treatment of bronchopulmonary infection in older patients with cystic fibrosis."	7.66	Tobramycin and carbenicillin compared with gentamicin and carbenicillin in the treatment of infection with Pseudomonas aeruginosa in adult patients with cystic fibrosis. ( Batten, JC; Hodson, ME; Wingfield, HJ, 1983)
"The combination of azlocillin and gentamicin or tobramycin, in the treatment of lower respiratory tract infection due to Pseudomonas aeruginosa in patients with cystic fibrosis, was evaluated."	7.66	Azlocillin in cystic fibrosis. ( Alfredsson, H; Malmborg, AS; Strandvik, B, 1983)
"In an experimental model of Pseudomonas keratitis produced by a gentamicin sulfate-resistant, tobramycin sulfate-sensitive strain of P aeruginosa, the results of two treatment regimens-(1) with gentamicin and tobramycin alone and (2) with gentamicin, tobramycin, and a steroid-were evaluated."	7.66	Combined gentamicin-tobramycin-corticosteroid treatment. II. Effect on gentamicin-resistant Pseudomonas keratitis. ( Leong-Sit, L; Okumoto, M; Smolin, G, 1980)
"In a quantitative model of experimental Pseudomonas aeruginosa keratitis in guinea pigs, topical solutions of amikacin, gentamicin and tobramycin were equally effective."	7.66	Relative efficacy of the topical use of amikacin, gentamicin and tobramycin in experimental Pseudomonas keratitis. ( Davis, SD; Hyndiuk, RA; Sarff, LD, 1980)
"The pharmacokinetics and therapeutic efficacy of gentamicin and cefsulodin were studied in an abscess model in the rat induced by Pseudomonas aeruginosa and a foreign body."	7.66	Gentamicin and cefsulodin efficacy in a rat abscess model. ( Dreznik, Z; Mark, Z; Rubinstein, E, 1982)
"In an experimental model of Pseudomonas keratitis caused by a gentamicin-resistant strain of Ps aeruginosa, the results of treatment with gentamicin alone and a gentamicin-steroid combination were evaluated."	7.66	The effect of combined gentamicin-corticosteroid treatment on gentamicin-resistant Pseudomonas keratitis. ( Friedlaender, M; Okumoto, M; Smolin, G; Stern, GA, 1980)
"30 urological patients with normal renal function were treated with netilmicin because of urinary tract infections, mostly recurrent and due to predisposing factors."	7.66	Netilmicin in urinary tract infections. ( Johnsen, NJ; Lund, F; Svare, J; Thomsen, J; Vejlsgaard, R; Vesterhauge, S, 1980)
"We evaluated the efficacy of topical gentamicin prophylaxis for experimental Pseudomonas keratitis in rabbits by applying gentamicin in concentrations of 0."	7.66	Factors that influence the efficacy of topical gentamicin prophylaxis for experimental Pseudomonas keratitis. ( Davis, SD; Divine, KS; Hyndiuk, RA; Nassif, KF; Sarff, LD, 1982)
"Pseudomonas keratitis in rabbit eyes was treated with Gentamicin and Tobramycin."	7.66	[Treatment of Pseudomonas aeruginosa keratitis with tobramycin and gentamicin: animal experiments (author's transl)]. ( Ansorg, R; Behrens-Baumann, W; Paul, HH, 1981)
"18 children with cystic fibrosis and mucoid pseudomonas lung infection were treated with courses either of gentamicin plus carbenicillin, or tobramycin plus carbenicillin, with 2 children each receiving two courses."	7.66	Gentamicin and tobramycin compared in the treatment of mucoid pseudomonas lung infections in cystic fibrosis. ( Anderson, CM; George, RH; Healing, DE; Martin, AJ; Smalley, CA, 1980)
"Thirty-eight adult patients with serious pleuropulmonary, soft-tissue, bone, and intra-abdominal infections caused by combinations of aerobic, facultative, and anaerobic bacteria were treated with parenterally given clindamycin phosphate and gentamicin sulfate and surgery when appropriate."	7.65	Clindamycin and gentamicin for aerobic and anaerobic sepsis. ( Fass, RJ; Gardner, WG; Rotilie, CA; Ruiz, DE, 1977)
"The aminoglycoside antibiotic, gentamicin, was used to treat staphylococcal infections in eighty-six patients in an open multicentre trial."	7.65	Gentamicin in the treatment of staphylococcal infections. ( Chambers, WB; Pallagrosi, AU, 1977)
"The levels of gentamicin in blood and in secretions of the tracheobronchial tree were measured in 14 children (8 with cystic fibrosis and 6 with tracheostomy) in a cross over fashion after the administration of 40 mg of gentamicin by aerosol or by endotracheal injection."	7.65	Concentration of gentamicin in bronchial secretions of children with cystic fibrosis of tracheostomy. (Comparison between the intramuscular route, the endotracheal instillation and aerosolization). ( Baran, D; Dachy, A; Klastersky, J, 1975)
"In rabbits with experimental Pseudomonas aeruginosa keratitis the subconjunctival administration of either ticarcillin or gentamicin significantly ameliorated the keratitis and reduced the number of organisms to be found in the cornea."	7.65	Ticarcillin in the treatment of experimental pseudomonas keratitis. ( Ahmad, A; Ohno, S; Okumoto, M; Smolin, G, 1977)
"When gentamicin was inhaled, blood concentrations were minimal, and were below concentrations known to cause systemic toxicity."	6.69	Dry powder versus intravenous and nebulized gentamicin in cystic fibrosis and bronchiectasis. A pilot study. ( Chrystyn, H; Crowther Labiris, NR; Holbrook, AM; Macleod, SM; Newhouse, MT, 1999)
"Single daily dosage of netilmicin is generally accepted in systemic infections, due to biphasic bactericidal activity and prolonged postantibiotic effect of aminoglycosides."	6.68	Pharmacokinetics and bactericidal activity of a single daily dose of netilmicin in the treatment of CAPD-associated peritonitis. ( Anding, K; Böhler, J; Krumme, B; Pelz, K; Schollmeyer, P, 1996)
"Oral ciprofloxacin is a useful short-term treatment for patients with CF who are infected with Ps aeruginosa."	6.66	Oral ciprofloxacin compared with conventional intravenous treatment for Pseudomonas aeruginosa infection in adults with cystic fibrosis. ( Batten, JC; Butland, RJ; Hodson, ME; Roberts, CM; Smith, MJ, 1987)
"Nebulized gentamicin solution combined with systemic antibiotics appears to be safe and has comparable efficacy to other strategies in eradicating early Pa infections in children with CF."	5.51	Nebulized gentamicin in combination with systemic antibiotics for eradicating early Pseudomonas aeruginosa infection in children with cystic fibrosis. ( Morrow, BM; Van Stormbroek, B; Zampoli, M, 2019)
"The holmium laser has gained increasing acceptance as being safe and effective for endoscopic lithotripsy."	5.34	Bilateral endogenous endophthalmitis after holmium laser lithotripsy. ( Hu, V; Larkin, G; Muir, G; Stanford, M; Zaidi, F, 2007)
"Lomefloxacin is a new quinolone compound with a broad antibacterial spectrum and excellent penetration into the aqueous humor by topical application."	5.29	Application of topical lomefloxacin against experimental Pseudomonas endophthalmitis in rabbits. ( Hatano, H; Inoue, K; Liping, W; Shia, S, 1993)
"Pseudomonas otitis externa is one of the most common infections treated by otolaryngologists."	5.28	Gentamicin iontophoresis in the treatment of bacterial otitis externa in the guinea pig model. ( Estrem, SA; King, DM, 1990)
"Enoxacin is a broad-spectrum quinolone-derivative antibiotic."	5.27	Treatment of experimental Pseudomonas corneal ulcers with enoxacin, a quinolone antibiotic. ( Bien, PA; Cohen, MA; Griffin, TJ; Heifetz, CL; Mehta, S; Sugar, A, 1986)
"In 16 patients with serious Pseudomonas infections of the respiratory tract the good efficacy of azlocillin was shown."	5.26	Pseudomonas infections of the lung treated with azlocillin. Microbiology, pharmacokinetics, clinic. ( Daikos, GK; Giamarellou, H; Hadjipolydorou, K; Kanellakopoulou, K, 1979)
"Tobramycin is a new aminoglycoside antibiotic with pharmacological similarities to gentamicin."	5.26	Tobramycin in the treatment of severe and complicated urinary tract infections. ( Bailey, RR; Peddie, B, 1976)
"In a prospective multicentre open trial, hospitalised adult patients with acute lower respiratory tract infections, mainly pneumonia or bronchitis, were randomised to receive either isepamicin 8 or 15 mg/kg once daily depending on the severity of the infection or amikacin 7."	5.08	Comparison of the efficacy and safety of isepamicin and amikacin in the treatment of acute lower respiratory tract infections caused by gram-negative organisms. ( Covi, M; Velluti, G, 1995)
"A randomized cross-over study was undertaken to compare nebulized (1) ceftazidime with (2) a combination of gentamicin and carbenicillin, and (3) saline, each given for 4 months, in patients with cystic fibrosis infected with Pseudomonas aeruginosa."	5.06	Inhaled ceftazidime compared with gentamicin and carbenicillin in older patients with cystic fibrosis infected with Pseudomonas aeruginosa. ( Batten, JC; Hodson, ME; Stead, RJ, 1987)
"Forty hospitalized patients with complicated urinary tract infections were treated with gentamicin 240 mg die i."	5.05	Comparative non-blind trial of ceftriaxone and gentamicin in the treatment of complicated urinary tract infections. ( Calvosa, F; Castiello, G; Lentini, M; Scorza, C, 1982)
"The pharmacokinetics of tobramycin in adolescents or young adults with cystic fibrosis and in age-matched controls were prospectively compared."	5.05	Disposition of tobramycin in patients with cystic fibrosis: a prospective controlled study. ( Koup, JR; Levy, J; Ramsey, B; Smith, AL; Williams-Warren, J, 1984)
"A randomised controlled open comparison of azlocillin and gentamicin versus carbenicillin and gentamicin was carried out in patients with cystic fibrosis who were chronically infected with Pseudomonas aeruginosa."	5.05	Azlocillin compared with carbenicillin in the treatment of bronchopulmonary infection due to Pseudomonas aeruginosa in cystic fibrosis. ( Batten, JC; Gaya, H; Hodson, ME; Penketh, A, 1984)
"Sixteen adults with cystic fibrosis and chronic bronchopulmonary infection with Pseudomonas aeruginosa, admitted to hospital for chemotherapy, were randomized to treatment with either carbenicillin or ticarcillin."	5.05	Ticarcillin compared with carbenicillin in the treatment of exacerbations of bronchopulmonary infection in cystic fibrosis. ( Batten, JC; Hodson, ME; Penketh, AR, 1983)
"We evaluated the safety and efficacy of tobramycin and gentamicin sulfate ophthalmic solutions in the treatment of patients with bacterial infections of the conjunctivas."	5.05	A clinical comparison of tobramycin and gentamicin sulfate in the treatment of ocular infections. ( Cagle, G; Laibson, P; Michaud, R; Okumoto, M; Rosenthal, A; Smolin, G, 1981)
"An open randomised comparison of a new intravenous cephalosporin, ceftazidime, with the established regimen of gentamicin and carbenicillin was carried out in patients with cystic fibrosis who had persisting pulmonary infection with Pseudomonas species and who developed acute exacerbations of respiratory symptoms."	5.05	Ceftazidime compared with gentamicin and carbenicillin in patients with cystic fibrosis, pulmonary pseudomonas infection, and an exacerbation of respiratory symptoms. British Thoracic Society Research Committee. ( , 1985)
"The effectiveness of ticarcillin against Pseudomonas aeruginosa in acute exacerbations of pulmonary infection in patients with cystic fibrosis was evaluated."	5.04	Treatment of pulmonary infections in patients with cystic fibrosis: a comparative study of ticarcillin and gentamicin. ( Denning, CR; Gaerlan, PF; Merlino, M; Neu, HC; Ores, CN; Parry, MF, 1977)
"The efficacy and safety of amikacin in treatment of patients with urinary tract infections were evaluated."	5.04	Amikacin Therapy of Urinary tract infections. ( Cox, CE, 1976)
"When the ocular toxicity and the in vivo and in vitro effects of gentamicin, Nebcin, and saline solution were compared in experimentally induced Pseudomonas keratitis in rabbits, both antibiotics showed the same toxicity for the rabbits' conjunctival tissues."	5.04	Nebcin in the treatment of experimental Pseudomonas keratitis. ( Belfort, R; Kim, HB; Okumoto, M; Smolin, G, 1975)
", amikacin and tobramycin) have been shown to be tolerable and effective in the treatment of acute pulmonary exacerbations (APEs) in both pediatric and adult patients with cystic fibrosis."	4.89	Optimization of anti-pseudomonal antibiotics for cystic fibrosis pulmonary exacerbations: V. Aminoglycosides. ( Ampofo, K; Sherwin, CM; Spigarelli, MG; Stockmann, C; Waters, CD; Young, DC; Zobell, JT, 2013)
"Literature searches were made in Medline and Pubmed using the search terms [Pseudomonas] or [Staphylococcus] and [fluoroquinolone] or [cephalosporin] or [gentamicin] and [keratitis] or [cornea]."	4.87	Review of resistance of ocular isolates of Pseudomonas aeruginosa and staphylococci from keratitis to ciprofloxacin, gentamicin and cephalosporins. ( Willcox, MD, 2011)
" From the published evidence, the most promising associations are, for staphylococcal infections, gentamicin, erythromycin, kanamycin and fusidic acid."	4.76	Clinical use of rifampicin in combination for non-mycobacterial infections: a survey of published evidence. ( Fowst, G; Nessi, R, 1979)
" This paper explores the tolerance to 8 different antibiotics of 61 microbial keratitis isolates of Pseudomonas aeruginosa from Australia and India using the MBC/MIC ratio, with tolerance defined by a ratio ≥ 32, and tolerance to ciprofloxacin by an agar diffusion assay."	4.31	Ciprofloxacin resistance and tolerance of Pseudomonas aeruginosa ocular isolates. ( Khan, M; Ma, K; Wan, I; Willcox, MD, 2023)
" This protocol would have been appropriate in 85% of all neutropenic bacteremia episodes and 89% of episodes in febrile neutropenia patients compared with piperacillin/tazobactam (79%, P = 0."	3.88	Empiric antibiotic protocols for cancer patients with neutropenia: a single-center study of treatment efficacy and mortality in patients with bacteremia. ( Cahan, A; Cohen, MJ; Kleinhendler, E; Moses, AE; Paltiel, O; Strahilevitz, J, 2018)
" Thus, on suspicion of sepsis, empiric antibiotic treatment combining piperacillin, oxacillin and gentamicin can be proposed until identification of the causative microorganism is available."	3.80	Epidemiological and bacteriological profiles in children with burns. ( Ben Khalifa, S; Daiki, M; Fekih Hassen, A, 2014)
"Gentamicin is an aminoglycoside antibiotic commonly used for treating Pseudomonas infections, but its use is limited by a relatively short half-life."	3.78	Gentamicin-loaded nanoparticles show improved antimicrobial effects towards Pseudomonas aeruginosa infection. ( Abdelghany, SM; Donnelly, RF; Gilmore, BF; Ingram, RJ; Quinn, DJ; Scott, CJ; Taggart, CC, 2012)
"These results support the use of gentamicin in the contrast medium injected into the biliary system as an ancillary method to prevent post-ERCP sepsis."	3.76	Addition of gentamicin to endoscopic retrograde cholangiopancreatography (ERCP) contrast medium towards reducing the frequency of septic complications of ERCP. ( Graham, DY; Osato, MS; Ramirez, FC; Woods, KL, 2010)
"To compare the therapeutic effectiveness of a single intrastromal dose of gentamycin, tobramycin, ciprofloxacin and ofloxacin for the treatment of corneal ulcers due to Pseudomonas aeruginosa."	3.75	[Bacterial corneal ulcer treated with intrastromal antibiotic. Experimental model in vivo]. ( Naranjo-Tackman, R; Stangogiannis-Druya, C; Stangogiannis-Druya, E; Vanzzini, V; Villar-Kurí, J, 2009)
"To evaluate the efficacy of iontophoresis using a hydrogel probe containing gentamicin for the treatment of Pseudomonas keratitis in the rabbit cornea."	3.73	Iontophoretic treatment of experimental pseudomonas keratitis in rabbit eyes using gentamicin-loaded hydrogels. ( Domb, A; Eljarrat-Binstock, E; Frucht-Pery, J; Mechoulam, H; Raiskup, F; Shapiro, M, 2006)
"To determine ciprofloxacin resistance of corneal isolates of Pseudomonas and to review the clinical response to topical therapy in cases of ciprofloxacin-resistant Pseudomonas keratitis, where medical therapy was begun with 0."	3.70	Ciprofloxacin-resistant Pseudomonas keratitis. ( Garg, P; Rao, GN; Sharma, S, 1999)
"To report a case of ticlopidine-induced neutropenia resulting in Pseudomonas bacteremia."	3.69	Pseudomonas bacteremia precipitated by ticlopidine-induced neutropenia. ( Geletko, SM; Melbourne, KM; Mikolich, DJ, 1996)
"In continuous flow biofilm cultures in medium resembling cystic fibrosis bronchial secretions, Pseudomonas aeruginosa was not eradicated from biofilms by 1 week of treatment with high concentrations of ceftazidime and gentamicin, to which the strains were sensitive on conventional testing."	3.69	Ceftazidime, gentamicin, and rifampicin, in combination, kill biofilms of mucoid Pseudomonas aeruginosa. ( Ghani, M; Soothill, JS, 1997)
"To clarify the role of corneal collagen shields as a drug delivery device for the treatment of bacterial keratitis, the authors studied the effectiveness of topical gentamicin treatment, with and without the use of corneal collagen shields, in a rabbit model of Pseudomonas keratitis."	3.68	Evaluation of corneal collagen shields as a drug delivery device for the treatment of experimental Pseudomonas keratitis. ( Silbiger, J; Stern, GA, 1992)
"Experimental endophthalmitis was treated with single intravitreous administrations of cefotaxime (claforan) and gentamicin."	3.68	[Treatment of endophthalmitis with a single intravitreous administration of cefotaxime and gentamicin in an experiment]. ( Glinchuk, IaI; Gusev, IuA; Moroz, AF; Radkevich, SA, 1991)
"A study of 29 children and adolescents with cystic fibrosis over 2 years showed some evidence of benefit from the twice daily inhalation of 20 mg nebulized gentamicin when compared to the inhalation of a nebulized saline mixture."	3.67	Nebulized gentamicin in children and adolescents with cystic fibrosis. ( Kun, P; Landau, LI; Phelan, PD, 1984)
" This inhibitor was therefore evaluated as an adjunct to antibiotics (gentamicin) treatment in experimentally induced Pseudomonas keratitis in rabbits."	3.67	The effect of 2-mercaptoacetyl-L-phenylalanyl-L-leucine, a specific inhibitor of Pseudomonas aeruginosa elastase, on experimental Pseudomonas keratitis in rabbit eyes. ( Kessler, E; Spierer, A, 1984)
"Single intravitreal doses of ciprofloxacin, gentamicin, or imipenem were administered to rabbits with pseudomonas endophthalmitis for determination of the maximally effective dose."	3.67	Dose response of experimental Pseudomonas endophthalmitis to ciprofloxacin, gentamicin, and imipenem: evidence for resistance to "late" treatment of infections. ( Barza, M; Davey, PG; Stuart, M, 1987)
"The in vitro activity of aztreonam combined with tobramycin and with gentamicin was assessed in 78 clinical isolates of Pseudomonas aeruginosa and 11 clinical isolates of Pseudomonas cepacia from patients with cystic fibrosis."	3.67	In vitro activity of aztreonam combined with tobramycin and gentamicin against clinical isolates of Pseudomonas aeruginosa and Pseudomonas cepacia from patients with cystic fibrosis. ( Bosso, JA; Matsen, JM; Saxon, BA, 1987)
"The effect of daily treatment with three current topical antibacterial agents and four experimental formulations of chlorhexidine was evaluated after 1 week in rats with full thickness burns."	3.67	Comparison of standard and chlorhexidine-derivative topical antibacterial agents on the infected burned rat wound. ( Coderre, S; Germann, E; Gillespie, K; Henry, D; Roberts, FJ; Snelling, CF, 1988)
"Two patients developed acute interstitial nephritis (AIN) following treatment with mezlocillin sodium."	3.67	Acute interstitial nephritis associated with mezlocillin, nafcillin, and gentamicin treatment for Pseudomonas infection. ( Bauman, J; Copley, JB; Cushner, HM; Hill, SC, 1985)
"The relationships between resistant pathogens, serum levels of gentamicin, and the outcomes of gangrenous or perforated appendicitis were analyzed in 147 patients."	3.66	Perforated and gangrenous appendicitis: an analysis of antibiotic failures. ( Appleman, MD; Berne, TV; Chenella, FC; Gill, MA; Heseltine, PN; Kern, JW; Yellin, AE, 1983)
"Treatment with gentamicin or tobramycin given intravenously with carbenicillin is compared in the treatment of bronchopulmonary infection in older patients with cystic fibrosis."	3.66	Tobramycin and carbenicillin compared with gentamicin and carbenicillin in the treatment of infection with Pseudomonas aeruginosa in adult patients with cystic fibrosis. ( Batten, JC; Hodson, ME; Wingfield, HJ, 1983)
"The combination of azlocillin and gentamicin or tobramycin, in the treatment of lower respiratory tract infection due to Pseudomonas aeruginosa in patients with cystic fibrosis, was evaluated."	3.66	Azlocillin in cystic fibrosis. ( Alfredsson, H; Malmborg, AS; Strandvik, B, 1983)
"In an experimental model of Pseudomonas keratitis produced by a gentamicin sulfate-resistant, tobramycin sulfate-sensitive strain of P aeruginosa, the results of two treatment regimens-(1) with gentamicin and tobramycin alone and (2) with gentamicin, tobramycin, and a steroid-were evaluated."	3.66	Combined gentamicin-tobramycin-corticosteroid treatment. II. Effect on gentamicin-resistant Pseudomonas keratitis. ( Leong-Sit, L; Okumoto, M; Smolin, G, 1980)
"In a quantitative model of experimental Pseudomonas aeruginosa keratitis in guinea pigs, topical solutions of amikacin, gentamicin and tobramycin were equally effective."	3.66	Relative efficacy of the topical use of amikacin, gentamicin and tobramycin in experimental Pseudomonas keratitis. ( Davis, SD; Hyndiuk, RA; Sarff, LD, 1980)
"The pharmacokinetics and therapeutic efficacy of gentamicin and cefsulodin were studied in an abscess model in the rat induced by Pseudomonas aeruginosa and a foreign body."	3.66	Gentamicin and cefsulodin efficacy in a rat abscess model. ( Dreznik, Z; Mark, Z; Rubinstein, E, 1982)
"In an experimental model of Pseudomonas keratitis caused by a gentamicin-resistant strain of Ps aeruginosa, the results of treatment with gentamicin alone and a gentamicin-steroid combination were evaluated."	3.66	The effect of combined gentamicin-corticosteroid treatment on gentamicin-resistant Pseudomonas keratitis. ( Friedlaender, M; Okumoto, M; Smolin, G; Stern, GA, 1980)
"This study was designed to determine whether intravenously administered gentamicin sulfate and tobramycin sulfate penetrate into the eschar of patients with severe burns."	3.66	Gentamicin and tobramycin penetration into burn eschar. Pharmacokinetics and microbiological effects. ( Hall, G; Haynes, BW; Kline, BJ; Mayhall, CG; Polk, RE; Smith, J; Swensson, E, 1983)
"30 urological patients with normal renal function were treated with netilmicin because of urinary tract infections, mostly recurrent and due to predisposing factors."	3.66	Netilmicin in urinary tract infections. ( Johnsen, NJ; Lund, F; Svare, J; Thomsen, J; Vejlsgaard, R; Vesterhauge, S, 1980)
"We evaluated the efficacy of topical gentamicin prophylaxis for experimental Pseudomonas keratitis in rabbits by applying gentamicin in concentrations of 0."	3.66	Factors that influence the efficacy of topical gentamicin prophylaxis for experimental Pseudomonas keratitis. ( Davis, SD; Divine, KS; Hyndiuk, RA; Nassif, KF; Sarff, LD, 1982)
"Pseudomonas keratitis in rabbit eyes was treated with Gentamicin and Tobramycin."	3.66	[Treatment of Pseudomonas aeruginosa keratitis with tobramycin and gentamicin: animal experiments (author's transl)]. ( Ansorg, R; Behrens-Baumann, W; Paul, HH, 1981)
" Staphylococcus aureus keratitis was treated either with neomycin sulfate or gentamicin sulfate, while Pseudomonas aeruginosa keratitis was treated either with gentamicin or polymyxin B sulfate."	3.66	Topically administered corticosteroids: effect on antibiotic-treated bacterial keratitis. ( Kupferman, A; Leibowitz, HM, 1980)
"18 children with cystic fibrosis and mucoid pseudomonas lung infection were treated with courses either of gentamicin plus carbenicillin, or tobramycin plus carbenicillin, with 2 children each receiving two courses."	3.66	Gentamicin and tobramycin compared in the treatment of mucoid pseudomonas lung infections in cystic fibrosis. ( Anderson, CM; George, RH; Healing, DE; Martin, AJ; Smalley, CA, 1980)
"Five burn patients with ecthyma gangrenosum were treated with gentamicin sulfate in an individualized aminoglycoside regimen."	3.66	Ecthyma gangrenosum: survival with individualized antibiotic therapy. ( Solem, LD; Strate, RG; Zaske, D, 1979)
"Thirty-eight adult patients with serious pleuropulmonary, soft-tissue, bone, and intra-abdominal infections caused by combinations of aerobic, facultative, and anaerobic bacteria were treated with parenterally given clindamycin phosphate and gentamicin sulfate and surgery when appropriate."	3.65	Clindamycin and gentamicin for aerobic and anaerobic sepsis. ( Fass, RJ; Gardner, WG; Rotilie, CA; Ruiz, DE, 1977)
"The aminoglycoside antibiotic, gentamicin, was used to treat staphylococcal infections in eighty-six patients in an open multicentre trial."	3.65	Gentamicin in the treatment of staphylococcal infections. ( Chambers, WB; Pallagrosi, AU, 1977)
" The patient was believed to have Pseudomonas bronchitis and was given parenteral gentamicin."	3.65	Failure of a "prophylactic" antimicrobial drug to prevent sepsis after fiberoptic bronchoscopy. ( Goldman, AL; Robbins, H, 1977)
"A patient with Pseudomonas aeruginosa pneumonia treated with gentamicin subsequently developed thoracovertebral osteomyelitis over the area of a preexisting compression fracture."	3.65	Vertebral osteomyelitis as a complication of Pseudomonas aeruginosa pneumonia. ( Watanakunakorn, C, 1975)
"Hospitalized patients with urinary tract infections caused by Pseudomonas aeruginosa or other bacterial pathogens are frequently treated with parenteral antibiotics such as gentamicin."	3.65	Effectiveness of achievable urinary concentrations of tetracyclines against "tetracycline-resistant" pathogenic bacteria. ( Holmes, T; Minuth, JN; Musher, DM; Thorsteinsson, SB, 1975)
"The levels of gentamicin in blood and in secretions of the tracheobronchial tree were measured in 14 children (8 with cystic fibrosis and 6 with tracheostomy) in a cross over fashion after the administration of 40 mg of gentamicin by aerosol or by endotracheal injection."	3.65	Concentration of gentamicin in bronchial secretions of children with cystic fibrosis of tracheostomy. (Comparison between the intramuscular route, the endotracheal instillation and aerosolization). ( Baran, D; Dachy, A; Klastersky, J, 1975)
"In rabbits with experimental Pseudomonas aeruginosa keratitis the subconjunctival administration of either ticarcillin or gentamicin significantly ameliorated the keratitis and reduced the number of organisms to be found in the cornea."	3.65	Ticarcillin in the treatment of experimental pseudomonas keratitis. ( Ahmad, A; Ohno, S; Okumoto, M; Smolin, G, 1977)
"To define factors contributing to the adverse prognosis of patients with gram-negative bacillemia and abscess formation, we studied the interaction between polymyxin B, colistin sulfate, gentamicin, or carbenicillin with purulent material."	3.65	Interaction of purulent material with antibiotics used to treat Pseudomonas infections. ( Bryant, RE; Hammond, D, 1974)
"When gentamicin was inhaled, blood concentrations were minimal, and were below concentrations known to cause systemic toxicity."	2.69	Dry powder versus intravenous and nebulized gentamicin in cystic fibrosis and bronchiectasis. A pilot study. ( Chrystyn, H; Crowther Labiris, NR; Holbrook, AM; Macleod, SM; Newhouse, MT, 1999)
" Adverse events were reported in 12% of patients in the isepamicin group and 6% in the amikacin group."	2.68	Comparison of the efficacy and safety of isepamicin and amikacin in the treatment of skin and skin structure infections. ( Esparza-Ahumada, S; Morfin-Otero, R; Rodriguez-Noriega, E, 1995)
"There is no established dosing schedule for once-daily aminoglycoside dosing regimens, and accepted guidelines for monitoring therapy are lacking."	2.68	Validation and nephrotoxicity of a simplified once-daily aminoglycoside dosing schedule and guidelines for monitoring therapy. ( de Blok, K; Prins, JM; Speelman, P; van Ketel, RJ; Weverling, GJ, 1996)
"Single daily dosage of netilmicin is generally accepted in systemic infections, due to biphasic bactericidal activity and prolonged postantibiotic effect of aminoglycosides."	2.68	Pharmacokinetics and bactericidal activity of a single daily dose of netilmicin in the treatment of CAPD-associated peritonitis. ( Anding, K; Böhler, J; Krumme, B; Pelz, K; Schollmeyer, P, 1996)
"Oral ciprofloxacin is a useful short-term treatment for patients with CF who are infected with Ps aeruginosa."	2.66	Oral ciprofloxacin compared with conventional intravenous treatment for Pseudomonas aeruginosa infection in adults with cystic fibrosis. ( Batten, JC; Butland, RJ; Hodson, ME; Roberts, CM; Smith, MJ, 1987)
"Azlocillin was an effective and safe therapy for the treatment of Ps."	2.65	Comparative clinical evaluation of azlocillin and gentamicin. ( Loza, L; Sabbaj, J; Torres, M, 1983)
"Tobramycin was given once daily or continuously to 52 patients with cystic fibrosis who in 10 days had no change in creatinine clearance or hearing despite maximum serum tobramycin concentrations of 40 mg/liter."	2.65	Once-daily vs. continuous aminoglycoside dosing: efficacy and toxicity in animal and clinical studies of gentamicin, netilmicin, and tobramycin. ( Bloxham, DD; Cash, HA; DiScenna, AO; Groden, DL; Grossniklaus, DA; Jacobs, MR; Klinger, JD; Luthe, MA; Powell, SH; Stern, RC; Thompson, WL, 1983)
"Sisomicin or a placebo was administered endotracheally to two groups of 18 and 20 unconscious patients, respectively, who had tracheostomies or endotracheal tubes in place and developed a severe gram-negative broncho-pneumonia."	2.65	Endotracheally administered antibiotics for gram-negative bronchopneumonia. ( Carpentier-Meunier, F; Kahan-Coppens, L; Klastersky, J; Thys, JP, 1979)
"Amikacin (BB-K8) is a semisynthetic derivative of kanamycin which is active in vitro against many gentamicin-resistant Gram-negative bacilli."	2.64	Amikacin therapy for severe gram-negative sepsis. Emphasis on infections with gentamicin-resistant organisms. ( Bartlett, JG; Gorbach, SL; Louie, TJ; Tally, FP; Weinstein, WM, 1975)
"Although cutaneous leishmaniasis is seen only rarely in the United States, it should be considered when diagnosing new skin lesions after travel to affected countries."	2.58	Cutaneous Leishmaniasis in an American Adolescent Returning From Israel. ( Ganjaei, KG; Gaur, S; Lawton, K, 2018)
"Bronchiectasis is a chronic respiratory disease characterised by abnormal and irreversible dilatation of the smaller airways and associated with a mortality rate greater than twice that of the general population."	2.58	Dual antibiotics for bronchiectasis. ( Armstrong, R; Felix, LM; Grundy, S; Harrison, H; Lynes, D; Milan, SJ; Spencer, S, 2018)
" The data were compared in terms of efficacy and renal adverse effects by independent t-test and repeated measure ANOVA."	2.44	Comparing the Efficacy and Safety of Nebulized Gentamicin Plus Amikacin ( Baniasadi, S; Hassanzad, M; Kouhestani, F, 2024)
"Antibiotic therapy in granulocytopenic cancer patients, the risk factors predisposing these patients to infection, and the signs, symptoms and types of infections occurring in these patients are reviewed."	2.36	Empiric therapy of febrile granulocytopenic patients. ( Hopefl, AW, 1979)
"Indications, side effects, dosage and several pharmacokinetic properties of gentamicin, tobramycin, sisomicin, kanamycin, amikacin, and streptomycin are delt with in the first part."	2.35	[Aminoglycoside antibiotics from clinical viewpoint]. ( Lüthy, R, 1975)
"Feline otitis externa is a dermatological disorder with a multifactorial complex etiology."	1.62	Otodectic and bacterial etiology of feline otitis externa in Tripoli, Libya. ( Altaeb, AA; Bennour, EM; Duro, EM; Ellraiss, OM; Elmishri, RA; Hiblu, MA; Karim, ES, 2021)
" Sterilization being an essential pre-requisite for the dosage form was carried out using ethylene oxide."	1.56	In vitro and in vivo evaluation of gentamicin sulphate-loaded PLGA nanoparticle-based film for the treatment of surgical site infection. ( Dhal, C; Mishra, R, 2020)
"Nebulized gentamicin solution combined with systemic antibiotics appears to be safe and has comparable efficacy to other strategies in eradicating early Pa infections in children with CF."	1.51	Nebulized gentamicin in combination with systemic antibiotics for eradicating early Pseudomonas aeruginosa infection in children with cystic fibrosis. ( Morrow, BM; Van Stormbroek, B; Zampoli, M, 2019)
"Otitis externa is a common presenting complaint in practice."	1.51	Determination of minimum inhibitory concentrations for silver sulfadiazine and other topical antimicrobial agents against strains of Pseudomonas aeruginosa isolated from canine otitis externa. ( Mueller, RS; von Silva-Tarouca, MSE; Wolf, G, 2019)
"Otitis externa is a common presentation to secondary care otolaryngology clinics."	1.48	Microbiology and antimicrobial susceptibility of otitis externa: a changing pattern of antimicrobial resistance. ( Cullen, M; Heward, E; Hobson, J, 2018)
"Pseudomonas peritonitis is a serious complication of peritoneal dialysis (PD)."	1.48	Peritoneal dialysis-related peritonitis caused by Pseudomonas species: Insight from a post-millennial case series. ( Chow, KM; Kwan, BC; Leung, CB; Li, PK; Lu, W; Pang, WF; Szeto, CC, 2018)
"Gentamicin resistance was associated with previous administration of a penicillin."	1.37	Risk factors for bacteraemia attributable to Pseudomonas aeruginosa resistant to imipenem, levofloxacin, or gentamicin. ( Goto, H; Higaki, M; Honda, K; Ishii, H; Mikura, S; Nakamura, M; Okazaki, M; Tsunoda, T; Wada, H; Watanabe, T; Yasutake, T, 2011)
"Vancomycin elution was enhanced by 146% with the addition of gentamicin liquid, and gentamicin elution was enhanced by 45% when combined with vancomycin."	1.35	Liquid gentamicin and vancomycin in bone cement: a potentially more cost-effective regimen. ( Chang, YH; Hsieh, PH; Lee, PC; Tai, CL, 2009)
"The holmium laser has gained increasing acceptance as being safe and effective for endoscopic lithotripsy."	1.34	Bilateral endogenous endophthalmitis after holmium laser lithotripsy. ( Hu, V; Larkin, G; Muir, G; Stanford, M; Zaidi, F, 2007)
" In an in vivo rabbit model of Pseudomonas keratitis, COL-1 demonstrated neither clinical nor microbicidal efficacy and appeared to have a very narrow dosage range, outside of which it appeared to be toxic to the ocular surface."	1.31	The use of antimicrobial peptides in ophthalmology: an experimental study in corneal preservation and the management of bacterial keratitis. ( Mannis, MJ, 2002)
"No cases of MOE in selective IgA deficiency have been reported in literature."	1.31	Malignant otitis externa in an infant with selective IgA deficiency: a case report. ( Balraj, A; Job, A; Justus, A; Kirubakaran, CP; Paul, AC, 2001)
"Otitis externa is a common condition in the tropics."	1.30	Otitis externa--the clinical pattern in a tertiary institution in Singapore. ( Kumarasinghe, G; Leong, HK; Loh, KS; Tan, KK; Yeoh, KH, 1998)
"Acute suppurative parotitis is a rare infection which usually occurs in hospitalized patients."	1.29	[Acute suppurative parotitis caused by Pseudomonas aeruginosa]. ( Mouallem, M; Regev, G, 1994)
"The bactericidal activities of arbekacin (ABK), vancomycin (VCM), gentamicin (GM) and netilmicin (NTL) in mixed culture with Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa were examined using an in vitro computer programmed pharmacokinetic simulation system and also the protective effect of these agents on systemic infection in neutropenic mice was examined."	1.29	[Evaluation of bactericidal activity of arbekacin in mixed culture with MRSA and Pseudomonas aeruginosa using an in vitro pharmacokinetic simulation system]. ( Goto, S; Sugano, T; Takada, T; Takase, Y; Tsuji, A; Yamaguchi, K; Yoshida, T, 1994)
"Lomefloxacin is a new quinolone compound with a broad antibacterial spectrum and excellent penetration into the aqueous humor by topical application."	1.29	Application of topical lomefloxacin against experimental Pseudomonas endophthalmitis in rabbits. ( Hatano, H; Inoue, K; Liping, W; Shia, S, 1993)
" The mare was sent home and treated with gentamicin at a dosage of 3."	1.29	Pseudomonas spp. associated vegetative endocarditis in two horses. ( Travers, CW; van den Berg, JS, 1995)
"Preseptal cellulitis has a typically benign course when treated with antibiotics, the clinical course depending on age of the patient, aetiology and the causative organism."	1.29	Pre-septal cellulitis--varied clinical presentations. ( Hans, R; Mehra, AK; Rao, VA, 1996)
"Ipsilateral sensorineural hearing loss (one patient) and external meatal stenosis were the main complications."	1.28	Biocompatible implantable antimicrobial release for necrotizing external otitis. ( Kupferberg, A; Ostfeld, EJ, 1991)
"The optimal dosing regimens and combination effects of gentamicin (GM), or astromicin (ASTM) and piperacillin (PIPC) against P."	1.28	[Studies of dosing regimens and combination effects of aminoglycosides and beta-lactam in an experimental Pseudomonas aeruginosa infection in mice]. ( Kikuchi, K, 1991)
" The repeated exposure of the neutropenic mice to an overall cytokine dosage of 7."	1.28	Antibacterial resistance induced by recombinant interleukin 1 in myelosuppressed mice: effect of treatment schedule and correlation with colony-stimulating activity in the bloodstream. ( Binaglia, L; Boraschi, D; Campanile, F; Fioretti, MC; Puccetti, P; Tagliabue, A, 1990)
"Treatment of disseminated Pseudomonas aeruginosa infection in leukopenic mice was evaluated using cefpirome alone and in combination with gentamicin and/or rifampin."	1.28	Comparative therapy with cefpirome alone and in combination with rifampin and/or gentamicin against a disseminated Pseudomonas aeruginosa infection in leukopenic mice. ( Baltch, AL; Franke, M; Michelsen, P; Ritz, WJ; Singh, J; Smith, RP; Valdes, JM; Williams, S, 1990)
"Pseudomonas otitis externa is one of the most common infections treated by otolaryngologists."	1.28	Gentamicin iontophoresis in the treatment of bacterial otitis externa in the guinea pig model. ( Estrem, SA; King, DM, 1990)
" In an attempt to determine whether the regulatory granulopoietic growth factor G-CSF could favorably affect survival when used in combination with antibiotics, we examined survival in a murine model of Pseudomonas aeruginosa burn wound infection."	1.28	The beneficial effect of granulocyte colony-stimulating factor (G-CSF) in combination with gentamicin on survival after Pseudomonas burn wound infection. ( Gamelli, RL; O'Reilly, M; Silver, GM, 1989)
"The objectives of this study were to (i) determine which of three simulated dosing regimens (gentamicin alone, simultaneous infusions of gentamicin and piperacillin, or staggered infusions of gentamicin and piperacillin) produced the fastest killing rate of Pseudomonas aeruginosa in serum, using the serum bactericidal rate (SBR) assay; and (ii) describe an alternative method of analysis of killing curves, the area under the killing curve (AUKC)."	1.28	Antipseudomonal activity of simulated infusions of gentamicin alone or with piperacillin assessed by serum bactericidal rate and area under the killing curve. ( Mylotte, JM; Pasko, MT; Tisdale, JE, 1989)
" Pharmacokinetic studies in mice showed a linear dose response in serum after the 20 and 50 mg/kg subcutaneous dose and urinary recoveries of administered dose of about 60% in 6 hours."	1.28	L-658,310, a new injectable cephalosporin. III. Experimental chemotherapeutics and pharmacokinetics in laboratory animals. ( Abruzzo, GK; Bland, JA; Fromtling, RA; Gadebusch, HH; Gilfillan, EC; Hadley, SK; Pelak, BA; Weissberger, BA, 1989)
"Gentamicin was administered intramuscularly in single doses of 10, 20 and 50 mg/kg."	1.27	[Ultrastructural changes in Pseudomonas aeruginosa cells as affected by gentamycin in in vitro and in vivo experiments]. ( Bykov, AS; Seleznev, AS, 1983)
"The efficacy of various dosage schedules of netilmicin against Pseudomonas aeruginosa has been compared using an in vivo model (normal and granulocytopenic mice)."	1.27	[Bolus injection, short infusion or intravenous drip of aminoglycoside antibiotics? In vivo study with netilmicin and Pseudomonas aeruginosa]. ( Brugger, HP; Feller-Segessenmann, C; Gerber, AU, 1983)
"To reach and maintain therapeutic drug concentrations, reliable estimates of the parameters describing the pharmacokinetic behavior of the drug are required."	1.27	Optimization of pharmacokinetic monitoring: I. Linear pharmacokinetics. ( Berg, MJ; Clarke, MI; Lantz, RK; Schoenwald, RD; Schottelius, DD, 1983)
"Penicillin G potassium was ineffective in the MTCM system, and gentamicin reagent solution was not uniformly effective against a gentamicin-sensitive strain of P aeruginosa."	1.27	Modified tissue culture medium for corneal storage I. Investigation of the effect of antibiotics on bacterial contamination. ( Jones, DB; Liesegang, TJ; Robinson, N, 1984)
"The influence of dosing intervals on the activity of gentamicin and ticarcillin against Pseudomonas aeruginosa was studied in vivo."	1.27	Impact of dosing intervals on activity of gentamicin and ticarcillin against Pseudomonas aeruginosa in granulocytopenic mice. ( Brandel, J; Brugger, HP; Craig, WA; Feller, C; Gerber, AU; Vastola, AP, 1983)
" The dose, dosing interval, and duration of therapy were varied, and the resulting antibiotic levels in serum and vegetations were correlated with bacterial clearance from vegetations."	1.27	The importance of pharmacodynamics in determining the dosing interval in therapy for experimental pseudomonas endocarditis in the rat. ( Ingerman, MJ; Levison, ME; Pitsakis, PG; Rosenberg, AF, 1986)
"Azlocillin was injected into mice either intravenously or intramuscularly in graduated doses of 50-500 mg/kg once daily."	1.27	Control of Pseudomonas sepsis in mice with azlocillin combined with gentamicin. ( Holá, V; Polívková, L, 1986)
"Gentamicin then was the first line antibiotic."	1.27	Nosocomial consequences of antibiotic usage. ( Falagas, M; Giamarellou, H; Kanellakopoulou, K; Koratzanis, G; Lelekis, M; Pagona, A; Petrikkos, G; Symeonides, J; Touliatou, K; Tsagarakis, J, 1986)
"Gentamicin treatment is effective in eliminating bacteria in this model and immunization has no additional benefit."	1.27	Pulmonary clearance of Pseudomonas aeruginosa in neutropenic mice. Effects of systemic immunization. ( Dunn, MM; Kamp, DW, 1987)
"Enoxacin is a broad-spectrum quinolone-derivative antibiotic."	1.27	Treatment of experimental Pseudomonas corneal ulcers with enoxacin, a quinolone antibiotic. ( Bien, PA; Cohen, MA; Griffin, TJ; Heifetz, CL; Mehta, S; Sugar, A, 1986)
" The effect of such dosing on bacterial time-kill curves and on survival was compared with the effect of identical amounts of drug given as a single-bolus injection."	1.27	Antibiotic therapy of infections due to Pseudomonas aeruginosa in normal and granulocytopenic mice: comparison of murine and human pharmacokinetics. ( Brugger, HP; Feller, C; Gerber, AU; Stalder, B; Stritzko, T, 1986)
"Cefpiramide and cefoperazone alone and in combination with gentamicin were compared for therapeutic efficacy against pseudomonal infections in normal mice and in mice made neutropenic by administration of cyclophosphamide."	1.27	Therapeutic efficacy of cefpiramide and cefoperazone alone and in combination with gentamicin against pseudomonal infections in neutropenic mice. ( Fu, KP; Gregory, FJ; Hetzel, N; Hung, PP, 1986)
" Antibiotic concentrations in cornea and aqueous humor were measured for 4 hrs following dosing using bioassay and radioimmunoassay."	1.27	Effect of inflammation on antibiotic penetration into the anterior segment of the rat eye. ( Badenoch, PR; Coster, DJ; McDonald, PJ, 1986)
"Netilmicin was the only antibiotic active in vitro against P aeruginosa that was administered to these patients."	1.27	Netilmicin in the treatment of Pseudomonas bacteremia. ( Linzmayer, MI; Lorber, RR, 1985)
"Carbenicillin was used alone and in combination with sisomicin in the treatment of experimental pseudomonas osteomyelitis."	1.26	Experimental osteomyelitis caused by Pseudomonas aeruginosa. ( Keleti, E; Norden, CW, 1980)
"Gentamicin was less effective than carbenicillin."	1.26	Effect of carbenicillin, gentamicin and vaccines on rats experimentally burned and infected with Pseudomonas aeruginosa. ( Ashour, SM; Hamed, IM; Toama, MA, 1980)
"For gentamicin, they were greater than 8 micrograms/ml for resistance and less than or equal to 6 micrograms/ml (not less than or equal to 4 micrograms/ml) for susceptibility."	1.26	Gentamicin and amikacin disk susceptibility tests with Pseudomonas aeruginosa: definition of minimal inhibitory concentration correlates for susceptible and resistant categories. ( Barry, AL; Jones, RN; Thornsberry, C, 1981)
"Netilmicin was intramuscularly injected at a daily dose of 200 mg, divided twice, for 5 to 10 days to 14 patients with complicated urinary tract infection caused by P."	1.26	[Clinical study on netilmicin in the treatment of complicated urinary tract infection caused by Pseudomonas aeruginosa]. ( Honda, M; Maeda, S; Murahashi, I; Takasaki, E, 1982)
" The initial dosage of netilmicin was 200 mg twice a day (2."	1.26	Netilmicin 200 mg twice a day for adult patients with life-threatening infections. A preliminary report. ( Amirak, ID; Noone, P; Perera, MR, 1980)
"Netilmicin was shown to be active against sensitive isolates and those strains with resistance patterns corresponding to the presence of: ANT(2"), ANT(2")+AAC(6'), ANT(4'), APH(2")+AAC(6'), APH(3')-IV and AAC(3)-I modifying enzymes."	1.26	Evaluation of netilmicin susceptibility discs using bacteria with known aminoglycoside resistance patterns: correlation of in vitro and in vivo test results. ( Hare, RS; Moss, EL; Sabatelli, FJ; Schaffer, TW; Waitz, JA, 1980)
"Sisomicin was the drug of choice for Ps."	1.26	Experimental infection in rabbits evoked by Pseudomonas aeruginosa, Proteus mirabilis, Escherichia coli and Klebsiella pneumoniae treated with gentamicin, amikacin and sisomicin. ( Bis, W; Jeljaszewicz, J; Kazanowski, A; Kuzniewski, P; Molska, J; Włodarczak, K, 1980)
"A retrospective and a prospective group of 38 and 20 patients respectively were studied with regard to bacterial strains, clinical effect, toxic side effects and serum concentration of gentamicin in severe surgical infections."	1.26	Gentamicin treatment in severe surgical infections--serum levels, interactions, toxicity and efficacy. ( Athlin, L; Domellöf, L; Holm, S, 1981)
"The clinical effect of measuring serum gentamicin concentrations and individualizing each patient's dosage regimen was determined 105 burn patients with severe gram-negative sepsis."	1.26	Increased burn patient survival with individualized dosages of gentamicin. ( Bootman, JL; Solem, LB; Strate, RG; Zaske, DE, 1982)
"Netilmicin was effective against E."	1.26	Netilmicin: its in vitro activity and synergism with penicillin compounds. ( Roy, I; Thadepalli, H, 1980)
" At moderate and high dosage levels, PC 904'S efficacy was comparable to carbenicillin's but much less than gentamicin's."	1.26	In vitro and in vivo effect of PC 904, a new broad-spectrum penicillin, on ocular strains of Pseudomonas aeruginosa. ( Dy-Liacco, J; Mintsioulis, G; Ohno, S; Okumoto, M; Smolin, G, 1978)
"Netilmicin may prove to be a useful agent, particularly for infections due to multiresistant Klebsiella or Serratia, or when prolonged aminoglycoside therapy is required."	1.26	Therapeutic experience with netilmicin. ( Bruce, AW; Chadwick, P; Cooke, TD; Hardy, GJ, 1978)
"A 3-month-old infant being treated for bronchitis developed a rapid onset but otherwise typical orbital cellulitis."	1.26	Pseudomonas orbital cellulitis. ( Weiss, IS, 1979)
" When a dosage level of 8 mg of gentamicin was exceeded in the combined treatment regimen, all of the infected mice died, and a high concentration of endotoxin could be detected in the mouse sera by the limulus assay."	1.26	The effect of triethylenetetramine dihydrochloride on the in vivo susceptibility of Pseudomonas aeruginosa to gentamicin. ( Light, B; Riggs, HG, 1979)
"In 16 patients with serious Pseudomonas infections of the respiratory tract the good efficacy of azlocillin was shown."	1.26	Pseudomonas infections of the lung treated with azlocillin. Microbiology, pharmacokinetics, clinic. ( Daikos, GK; Giamarellou, H; Hadjipolydorou, K; Kanellakopoulou, K, 1979)
"Gentamicin was slightly more effective than polymyxin B; both drugs were substantially more effective than colistin."	1.26	Topical antibiotic therapy of Pseudomonas aeruginosa keratitis. ( Kupferman, A; Leibowitz, HM, 1979)
"Gentamicin and Keflin were eluted from the cylinders in sufficient quantities to completely eliminate or markedly reduce the number of bacteria recovered from infected areas."	1.26	Antibiotics in acrylic bone cement. In vivo studies. ( Welch, AB, 1978)
"Netilmicin is an effective aminoglycoside with a spectrum of antibacterial activity similar to that of gentamicin sulfate and it appears to be less nephrotoxic."	1.26	Netilmicin in the treatment of infections in patients with cancer. ( Bodney, GP; Yap, BS, 1979)
"Amikacin sulfate was administered to 18 patients for the treatment of 19 severe infections."	1.26	Amikacin therapy for serious gram-negative infection. ( Berger, SA; Pollock, AA; Rahal, JJ; Richmond, AS; Simberkoff, MS, 1977)
"No gentamicin was detected in ventricular CSF of four patients at a time when gentamicin was being administered only intravenously."	1.26	Intraventricular and parenteral gentamicin therapy for ventriculitis in children. ( Blevins, J; Ericsson, CD; Miner, ME; Pickering, LK; Ruiz-Palacios, G, 1978)
"3 mug/ml; 31 to 47% of the drug was excreted within the 8-h dosage interval."	1.26	Clinico-pharmacological studies of sisomicin in ill children. ( Dugal, R; Hammerberg, S; Marks, MI; Vose, A, 1978)
"The malignant external otitis is characterized by the following symptoms: Severe neuralgic pain in the deep ear region is found in the elderly diabe-the cases with a facial palsy due to the infection of the outer ear."	1.26	[Diagnosis and therapy of the so-called malignant external otitis (author's transl)]. ( Theopold, HM, 1978)
" Netilmicin appears to be effective and safe in the treatment of aerobic gram-negative infections."	1.26	Clinical efficacy and toxicity of netilmicin in the treatment of gram-negative infections. ( Buckwold, FJ; Fox, L; Harding, GK; Lank, B; Ronald, AR; Thompson, L, 1979)
"Gentamicin alone was not significantly better than no specific therapy."	1.26	Experimental Pseudomonas pneumonia in leukopenic dogs: comparison of therapy with antibiotics and granulocyte transfusions. ( Dale, DC; Elin, RJ; Herzig, GP; Pennington, JE; Reynolds, HY, 1976)
"Gentamicin was at least as effective as carbenicillin regardless of inoculum size or duration of therapy."	1.26	Therapy of neutropenic rats infected with Pseudomonas aeruginosa. ( Lumish, RM; Norden, CW, 1976)
"Tobramycin is a new aminoglycoside antibiotic with pharmacological similarities to gentamicin."	1.26	Tobramycin in the treatment of severe and complicated urinary tract infections. ( Bailey, RR; Peddie, B, 1976)
" These results indicate that it is necessary to monitor gentamicin therapy by laboratory assay to ensure adequate dosage and that peak serum concentrations of 8 mug/ml or more are significantly correlated with successful treatment of pneumonia caused by coliforms and Ps."	1.26	Pneumonia caused by coliforms and Pseudomonas aeruginosa. ( Noone, P; Rogers, BT, 1976)
"The gentamicin half-life was found to be unusually short especially in the younger burn patients."	1.26	Increased dosage requirements of gentamicin in burn patients. ( Gerding, DN; Sawchuk, RJ; Strate, RG; Zaske, DE, 1976)
"Meningitis is a rare complication following stapedectomy."	1.25	Pseudomonas aeruginosa meningitis following stapedectomy. ( Clairmont, AA; Nicholson, WL; Turner, JS, 1975)
" Moreover, their combination made it possible to reduce the dosage of the antibiotics and thereby reduce their potential undesirable effect."	1.25	An experimental model of Pseudomonas aeruginosa renal infection in rats. ( Hatala, M; Konícková, L; Liska, M; Prát, V; Slugen, I, 1975)
"of gentamicin was 15 mug/ml but even in a concentration of 1,000 mug/ml carbenicillin was not bactericidal."	1.25	[In vitro experiments on the working of combinations of gentamicin and beta-lactam antibiotics against Pseudonomas aeruginosa (author's transl)]. ( Ullmann, U, 1975)
" Based on the determination of serum levels of Tobramycin and Amoxycillin in newborns general recommendations for the dosage of these new antibiotics are given."	1.25	[Antibiotics in newborns and young infants]. ( Simon, C, 1975)
"Ten cases of septic arthritis due to Pseudomonas occurred in users of heroin."	1.25	Septic arthritis due to pseudomonas in heroin addicts. ( Gifford, DB; Ivler, D; Patzakis, M; Swezey, RL, 1975)
"Gentamicin was nearly as active as polymyxin, all but 2 of the 141 strains tested with the diluted inoculum being inhibited by 6."	1.25	Susceptibility of recent isolates of Pseudomonas aeruginosa to gentamicin, polymyxin, and five penicillins, with observations on the pyocin and immunotypes of the strains. ( Adler, JL; Finland, M, 1971)

Research

Studies (825)

Authors

Clinical Trials (2)

Trial Overview

Trial Outcomes

Complications

Timeframe	Studies, this research(%)	All Research%
pre-1990	630 (76.36)	18.7374
1990's	67 (8.12)	18.2507
2000's	56 (6.79)	29.6817
2010's	48 (5.82)	24.3611
2020's	24 (2.91)	2.80

Authors	Studies
Rahuman, HBH	1
Dhandapani, R	1
Palanivel, V	1
Thangavelu, S	1
Paramasivam, R	1
Muthupandian, S	1
Dorotkiewicz-Jach, A	1
Markwitz, P	1
Drulis-Kawa, Z	2
Mumtaz, K	1
Munir, S	1
Muddassir, M	1
Raza, A	1
Waqas, K	1
Shoaib Ahmed, S	1
Malik, A	1
Haider Naqvi, SZ	1
Shahri, FN	1
Izanloo, A	1
Goharrizi, MASB	1
Jamali, A	1
Bagheri, H	1
Hjimohammadi, A	1
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Trial	Phase	Enrollment	Study Type	Start Date	Status
Aerosolized Antibiotics in the Treatment of Ventilator Associated Pneumonia: A Pilot Study[NCT02478710]	Phase 4	16 participants (Actual)	Interventional	2015-06-30	Terminated
Operative and Non-operative Treatment of Traumatic Arthrotomies: A Prospective Observational Study[NCT02841644]		180 participants (Actual)	Observational	2015-04-30	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Complications were defined as septic arthritis, return to the OR, rehospitalization, and osteomyelitis of the injured joint. (NCT02841644)
Timeframe: 12 months

Cost of Treatments

Intervention	Participants (Count of Participants)
Traumatic Arthrotomy- Treated Nonoperatively	4
Traumatic Arthrotomy- Treated Operatively	18

To compare the cost of medical care in patients with traumatic arthrotomies treated with surgical irrigation and debridement versus non-operative treatment with local wound care. To estimate cost associated with TAs, total charge data was acquired for all patients treated at the lead site. (NCT02841644)
Timeframe: 12 months

Comparing 3-Month Change in Veterans RAND 12-Item Health Survey (VR-12) by Treatment Method

Intervention	USD (Median)
Traumatic Arthrotomy- Treated Nonoperatively	1089
Traumatic Arthrotomy- Treated Operatively	11,973

The veteran rand 12-tem health survey is used to determine change in health related quality of life to estimate disease burden. It is summarized into two scores, a physical component scores (PCS) (range 0-100) and mental component scores (range- 0-100). Higher score indicate better outcomes. (NCT02841644)
Timeframe: baseline, 3 months

Intervention	score on a scale (Mean)
	VR-12 Physical Health: Baseline	VR-12 Mental Health: Baseline	VR-12 Physical Health: 3 month	VR-12 Mental Health: 3 Month	VR-12 Physical Health: Difference	VR-12 Mental Health: Difference
Traumatic Arthrotomy- Treated Nonoperatively	49	50.7	36.9	41.9	-12.2	-8.8
Traumatic Arthrotomy- Treated Operatively	48.1	51.8	32.1	46.8	-16.0	-5.1

Article	Year
Cutaneous Leishmaniasis in an American Adolescent Returning From Israel. Journal of the Pediatric Infectious Diseases Society, 2018, Aug-17, Volume: 7, Issue:3 Topics: Adolescent; Antiprotozoal Agents; Biopsy; Cellulitis; Diagnostic Errors; Female; Gentamicins; Humans	2018
Dual antibiotics for bronchiectasis. The Cochrane database of systematic reviews, 2018, 06-11, Volume: 6 Topics: Adult; Anti-Bacterial Agents; Bronchiectasis; Ciprofloxacin; Gentamicins; Humans; Middle Aged; Pseud	2018
Juvenile ecthyma gangrenosum caused by Pseudomonas aeruginosa revealing an underlying neutropenia: case report and review of the literature. Journal of the European Academy of Dermatology and Venereology : JEADV, 2019, Volume: 33, Issue:4 Topics: Anti-Bacterial Agents; Ecthyma; Female; Gangrene; Gentamicins; Granulocyte Colony-Stimulating Factor	2019
Optimization of anti-pseudomonal antibiotics for cystic fibrosis pulmonary exacerbations: V. Aminoglycosides. Pediatric pulmonology, 2013, Volume: 48, Issue:11 Topics: Adult; Amikacin; Aminoglycosides; Anti-Bacterial Agents; Child; Cystic Fibrosis; Disease Progression	2013
Review of resistance of ocular isolates of Pseudomonas aeruginosa and staphylococci from keratitis to ciprofloxacin, gentamicin and cephalosporins. Clinical & experimental optometry, 2011, Volume: 94, Issue:2 Topics: Anti-Bacterial Agents; Anti-Infective Agents; Cephalosporins; Ciprofloxacin; Drug Resistance, Bacter	2011
Gentamicin as gene therapy. Journal of molecular medicine (Berlin, Germany), 2002, Volume: 80, Issue:9 Topics: Animals; Anti-Bacterial Agents; Cystic Fibrosis; Genetic Therapy; Gentamicins; Humans; Models, Genet	2002
[Anti-Pseudomonas aerosol therapy in cystic fibrosis: improvement with tobramycin]. Revue de pneumologie clinique, 2002, Volume: 58, Issue:3 Pt 1 Topics: Administration, Inhalation; Adolescent; Aerosols; Anti-Bacterial Agents; Carbenicillin; Child; Colis	2002
Late-onset Pseudomonas keratitis after radial keratotomy and subsequent laser in situ keratomileusis: case report and literature review. Canadian journal of ophthalmology. Journal canadien d'ophtalmologie, 2005, Volume: 40, Issue:2 Topics: Adult; Cefazolin; Cornea; Drug Therapy, Combination; Eye Infections, Bacterial; Female; Gentamicins;	2005
Treatment of bacterial ulcers of the cornea in the rabbit: a comparison of administration by eye drops and subconjunctival injections. Transactions of the American Ophthalmological Society, 1982, Volume: 80 Topics: Animals; Anti-Bacterial Agents; Bacterial Infections; Cefazolin; Conjunctiva; Corneal Ulcer; Gentami	1982
Clinical aspects of pseudomonas infections. The West Virginia medical journal, 1981, Volume: 77, Issue:12 Topics: Agammaglobulinemia; Blood Transfusion; Burns; Carbenicillin; Cystic Fibrosis; Drug Therapy, Combinat	1981
Experimental Pseudomonas keratitis. Transactions of the American Ophthalmological Society, 1981, Volume: 79 Topics: Animals; Cornea; Corneal Injuries; Gentamicins; Keratitis; Male; Microscopy, Electron; Microscopy, E	1981
Combination antibiotic therapy of bacterial endocarditis. Annals of internal medicine, 1980, Volume: 92, Issue:3 Topics: Aminoglycosides; Animals; Anti-Bacterial Agents; Disease Models, Animal; Drug Therapy, Combination;	1980
Infections following nail puncture wound of the foot: case reports and review of the literature. Israel journal of medical sciences, 1993, Volume: 29, Issue:4 Topics: Abscess; Adolescent; Cellulitis; Child; Debridement; Emergencies; Female; Foot Injuries; Gentamicins	1993
Technical report: precautions regarding the use of aerosolized antibiotics. Committee on Infectious Diseases and Committee on Drugs. Pediatrics, 2000, Volume: 106, Issue:6 Topics: Administration, Inhalation; Adolescent; Adult; Anti-Bacterial Agents; Bronchoconstriction; Child; Cy	2000
Making sense of antimicrobial use and resistance surveillance data: application of ARIMA and transfer function models. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 2001, Volume: 7 Suppl 5 Topics: Amikacin; Anti-Bacterial Agents; Ceftazidime; Drug Resistance, Microbial; Gentamicins; Models, Theor	2001
Pseudomonas diseases. Advances in internal medicine, 1975, Volume: 20 Topics: Animals; Antibodies, Bacterial; Antigens, Bacterial; Carbenicillin; Cross Infection; gamma-Globulins	1975
[Recent trends in and dangers of gram negative bacillus infections]. Nihon rinsho. Japanese journal of clinical medicine, 1977, Volume: 35, Issue:3 Topics: Bacterial Infections; Drug Resistance, Microbial; Enterobacteriaceae Infections; Gentamicins; Humans	1977
Clinical uses of gentamicin. Modern veterinary practice, 1977, Volume: 58, Issue:9 Topics: Animals; Bronchitis; Cat Diseases; Cats; Cattle; Cattle Diseases; Conjunctivitis; Diarrhea; Dog Dise	1977
Empiric therapy of febrile granulocytopenic patients. American journal of hospital pharmacy, 1979, Volume: 36, Issue:2 Topics: Agranulocytosis; Amikacin; Anti-Bacterial Agents; Bacterial Infections; Blood Transfusion; Cephalosp	1979
Clinical use of rifampicin in combination for non-mycobacterial infections: a survey of published evidence. The Journal of international medical research, 1979, Volume: 7, Issue:3 Topics: Amphotericin B; Cephalosporins; Chloramphenicol; Colistin; Drug Therapy, Combination; Endocarditis,	1979
[Aminoglycoside antibiotics from clinical viewpoint]. International journal of clinical pharmacology and biopharmacy, 1975, Volume: 11, Issue:2 Topics: Amikacin; Aminoglycosides; Anti-Bacterial Agents; Drug Combinations; Enterobacteriaceae Infections;	1975
Acute bacterial infection of the eye: bacterial keratitis and endophthalmitis. Transactions of the ophthalmological societies of the United Kingdom, 1986, Volume: 105 ( Pt 1) Topics: Acute Disease; Bacterial Infections; Cefazolin; Corneal Ulcer; Eye Diseases; Gentamicins; Humans; Ke	1986
Shunt infections: prevention and treatment. Clinical neurosurgery, 1985, Volume: 32 Topics: Amikacin; Anti-Bacterial Agents; Bacterial Infections; Cerebrospinal Fluid Shunts; Drug Resistance,	1985
[Gentamicin resistance in clinical strains of microorganisms: genetic control and biochemical mechanisms of resistance]. Antibiotiki i meditsinskaia biotekhnologiia = Antibiotics and medical biotechnology, 1985, Volume: 30, Issue:1 Topics: Acetyltransferases; Enterobacteriaceae; Enterobacteriaceae Infections; Gentamicins; Humans; Klebsiel	1985
The pathogenesis of infections owing to Pseudomonas aeruginosa using the burned mouse model: experimental studies from the Shriners Burns Institute, Cincinnati. Canadian journal of microbiology, 1985, Volume: 31, Issue:4 Topics: ADP Ribose Transferases; Animals; Bacterial Toxins; Burns; Disease Models, Animal; Endopeptidases; E	1985
Antibiotics in the treatment of burns. The Surgical clinics of North America, 1970, Volume: 50, Issue:6 Topics: Adult; Anti-Bacterial Agents; Burns; Child; Chloramphenicol; Clostridium Infections; Enterobacter; g	1970
[Burn therapy in foreign countries]. Zhonghua yi xue za zhi, 1973, Volume: 4 Topics: Animals; Antitoxins; Burns; Dogs; gamma-Globulins; Gentamicins; Humans; Pseudomonas aeruginosa; Pseu	1973
[Sulfonamide and antibiotic usage in otolaryngology (author's transl)]. HNO, 1974, Volume: 22, Issue:6 Topics: Adult; Anti-Bacterial Agents; Cephalosporins; Child; Chloramphenicol; Erythromycin; Escherichia coli	1974
Bacteremic shock due to gram-negative bacilli. Some concepts of pathogenesis and management based on recent developments. Geriatrics, 1969, Volume: 24, Issue:4 Topics: Animals; Bacteroides Infections; Chloramphenicol; Enterobacter; Escherichia coli Infections; Gentami	1969
The management of bacteremic shock. International anesthesiology clinics, 1969,Winter, Volume: 7, Issue:4 Topics: Acute Kidney Injury; Animals; Anti-Bacterial Agents; Burns; Catheterization; Cephaloridine; Cephalot	1969
Diagnosis and treatment of urinary tract infections. The Medical clinics of North America, 1971, Volume: 55, Issue:6 Topics: Anti-Bacterial Agents; Anti-Infective Agents, Urinary; Bacteriuria; Cephalosporins; Chloramphenicol;	1971
Pseudomonas aeruginosa infections. CRC critical reviews in clinical laboratory sciences, 1972, Volume: 3, Issue:3 Topics: Animals; Antibodies, Bacterial; Antineoplastic Agents; Arthritis, Infectious; Bone Diseases; Burns;	1972
Sepsis neonatorum. Pediatric clinics of North America, 1974, Volume: 21, Issue:3 Topics: Ampicillin; Bacteria; Bacterial Infections; Enterobacteriaceae; Gentamicins; Humans; Infant, Newborn	1974
Antimicrobiol therapy: therapeutic recommendations and a review of newer drugs. Part I. Therapy of infectious conditions. The Journal of pediatrics, 1974, Volume: 85, Issue:3 Topics: Adolescent; Ampicillin; Anti-Bacterial Agents; Arthritis, Infectious; Bacteroides Infections; Brain	1974
Cardiocirculatory adaptation to chronic hypoxia. 3. Comparative study of cardiac output, pulmonary and systemic circulation between sea level and high altitude residents. Revue europeenne d'etudes cliniques et biologiques. European journal of clinical and biological research, 1972, Volume: 17, Issue:5 Topics: Bacterial Infections; Carbenicillin; Drug Stability; Drug Synergism; Escherichia coli; Gentamicins;	1972
Advances in antibiotics. The Practitioner, 1969, Volume: 203, Issue:216 Topics: Adult; Anti-Bacterial Agents; Cephaloridine; Enterobacteriaceae Infections; Fusidic Acid; Gentamicin	1969
Gentamicin. The Medical clinics of North America, 1970, Volume: 54, Issue:5 Topics: Absorption; Drug Synergism; Enterobacteriaceae; Enterobacteriaceae Infections; Gentamicins; Humans;	1970
Topical therapy. The Surgical clinics of North America, 1970, Volume: 50, Issue:6 Topics: Acidosis; Burns; Chlorides; Gentamicins; Humans; Hyponatremia; Pseudomonas Infections; Silver Nitrat	1970
Burn therapy--a current appraisal. Surgery annual, 1971, Volume: 3, Issue:0 Topics: Administration, Topical; Adolescent; Adult; Animals; Burns; Child; Child, Preschool; Duodenal Ulcer;	1971
[Pneumonia caused by Pseudomonas aeruginosa]. Polski tygodnik lekarski (Warsaw, Poland : 1960), 1971, May-10, Volume: 26, Issue:19 Topics: Antibody Formation; Cell Membrane Permeability; Chloramphenicol; Colistin; Drug Resistance, Microbia	1971
[Experimental pyelonephritis, chemotherapeutic studies (review of the literature)]. Farmakologiia i toksikologiia, 1971, Volume: 34, Issue:2 Topics: Acute Disease; Ampicillin; Animals; Anti-Bacterial Agents; Chloramphenicol; Chronic Disease; Coryneb	1971

Article	Year
Aerosol carbenicillin and gentamicin treatment of Pseudomonas aeruginosa infection in patients with cystic fibrosis. Lancet (London, England), 1981, Nov-21, Volume: 2, Issue:8256 Topics: Adolescent; Adult; Aerosols; Carbenicillin; Chronic Disease; Clinical Trials as Topic; Cystic Fibros	1981
Comparative non-blind trial of ceftriaxone and gentamicin in the treatment of complicated urinary tract infections. The Journal of international medical research, 1982, Volume: 10, Issue:3 Topics: Adult; Aged; Cefotaxime; Ceftriaxone; Clinical Trials as Topic; Female; Gentamicins; Humans; Injecti	1982
A comparison of azlocillin and gentamicin in the treatment of serious infections caused by Pseudomonas aeruginosa. The Journal of antimicrobial chemotherapy, 1983, Volume: 11 Suppl B Topics: Adult; Azlocillin; Clinical Trials as Topic; Female; Gentamicins; Humans; Male; Penicillins; Pregnan	1983
A comparative study of the efficacy and safety of azlocillin and gentamicin in the treatment of serious infections. The Journal of antimicrobial chemotherapy, 1983, Volume: 11 Suppl B Topics: Adolescent; Adult; Aged; Azlocillin; Bacterial Infections; Child; Child, Preschool; Clinical Trials	1983
Disposition of tobramycin in patients with cystic fibrosis: a prospective controlled study. The Journal of pediatrics, 1984, Volume: 105, Issue:1 Topics: Adolescent; Adult; Body Surface Area; Child; Clinical Trials as Topic; Cystic Fibrosis; Female; Gent	1984
[Effectiveness of netilmicin in the treatment of urinary tract infections]. Polski tygodnik lekarski (Warsaw, Poland : 1960), 1983, Oct-10, Volume: 38, Issue:41 Topics: Adult; Aged; Bacillus subtilis; Bacteriuria; Clinical Trials as Topic; Enterobacteriaceae Infections	1983
Azlocillin compared with carbenicillin in the treatment of bronchopulmonary infection due to Pseudomonas aeruginosa in cystic fibrosis. Thorax, 1984, Volume: 39, Issue:4 Topics: Adolescent; Adult; Azlocillin; Carbenicillin; Clinical Trials as Topic; Cystic Fibrosis; Drug Therap	1984
Comparative clinical evaluation of azlocillin and gentamicin. The Journal of antimicrobial chemotherapy, 1983, Volume: 11 Suppl B Topics: Adolescent; Adult; Aged; Azlocillin; Bacterial Infections; Child; Female; Gentamicins; Humans; Male;	1983
Once-daily vs. continuous aminoglycoside dosing: efficacy and toxicity in animal and clinical studies of gentamicin, netilmicin, and tobramycin. The Journal of infectious diseases, 1983, Volume: 147, Issue:5 Topics: Adult; Animals; Anti-Bacterial Agents; Cystic Fibrosis; Dogs; Dose-Response Relationship, Drug; Drug	1983
Ticarcillin compared with carbenicillin in the treatment of exacerbations of bronchopulmonary infection in cystic fibrosis. British journal of diseases of the chest, 1983, Volume: 77, Issue:2 Topics: Adolescent; Adult; Bronchial Diseases; Carbenicillin; Cystic Fibrosis; Drug Therapy, Combination; Fe	1983
A clinical comparison of tobramycin and gentamicin sulfate in the treatment of ocular infections. American journal of ophthalmology, 1981, Volume: 92, Issue:6 Topics: Adult; Aged; Anti-Bacterial Agents; Bacteria; Bacterial Infections; Clinical Trials as Topic; Conjun	1981
Is anti-Pseudomonas therapy warranted in acute respiratory exacerbations in children with cystic fibrosis? The Journal of pediatrics, 1980, Volume: 97, Issue:1 Topics: Carbenicillin; Child; Cloxacillin; Cystic Fibrosis; Drug Therapy, Combination; Gentamicins; Humans;	1980
Patient compliance with short-term topical aural antibiotic therapy. Clinical otolaryngology and allied sciences, 1994, Volume: 19, Issue:2 Topics: Administration, Topical; Adolescent; Adult; Aged; Child; Clioquinol; Dexamethasone; Drug Combination	1994
Isepamicin versus amikacin in the treatment of urinary tract infection. Journal of chemotherapy (Florence, Italy), 1995, Volume: 7 Suppl 2 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amikacin; Anti-Bacterial Agents; Escherichia coli Infect	1995
Comparison of the efficacy and safety of isepamicin and amikacin in the treatment of acute lower respiratory tract infections caused by gram-negative organisms. Journal of chemotherapy (Florence, Italy), 1995, Volume: 7 Suppl 2 Topics: Adult; Aged; Aged, 80 and over; Amikacin; Anti-Bacterial Agents; Bronchitis; Drug Administration Sch	1995
Comparison of the efficacy and safety of isepamicin and amikacin in the treatment of skin and skin structure infections. Journal of chemotherapy (Florence, Italy), 1995, Volume: 7 Suppl 2 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amikacin; Anti-Bacterial Agents; Drug Administration Sch	1995
Validation and nephrotoxicity of a simplified once-daily aminoglycoside dosing schedule and guidelines for monitoring therapy. Antimicrobial agents and chemotherapy, 1996, Volume: 40, Issue:11 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Female; Gentamicins; Humans; Kidn	1996
Pharmacokinetics and bactericidal activity of a single daily dose of netilmicin in the treatment of CAPD-associated peritonitis. International journal of clinical pharmacology and therapeutics, 1996, Volume: 34, Issue:11 Topics: Acinetobacter; Acinetobacter Infections; Adult; Aged; Drug Administration Schedule; Escherichia coli	1996
Dry powder versus intravenous and nebulized gentamicin in cystic fibrosis and bronchiectasis. A pilot study. American journal of respiratory and critical care medicine, 1999, Volume: 160, Issue:5 Pt 1 Topics: Aerosols; Anti-Bacterial Agents; Bronchiectasis; Chronic Disease; Cross-Over Studies; Cystic Fibrosi	1999
A comparative study of ticarcillin plus tobramycin versus carbenicillin plus gentamicin for the treatment of serious infections due to gram-negative bacilli. The American journal of medicine, 1978, Volume: 64, Issue:6 Topics: Anti-Bacterial Agents; Carbenicillin; Cystic Fibrosis; Drug Therapy, Combination; Gentamicins; Gram-	1978
Therapy of infection in patients with granulocytopenia. The Medical clinics of North America, 1977, Volume: 61, Issue:5 Topics: Agranulocytosis; Amikacin; Anti-Bacterial Agents; Blood Transfusion; Carbenicillin; Cephalothin; Cli	1977
Prospective trials of dexamethasone and aerosolized gentamicin in the treatment of inhalation injury in the burned patient. The Journal of trauma, 1978, Volume: 18, Issue:3 Topics: Adult; Aerosols; Burns; Burns, Inhalation; Clinical Trials as Topic; Dexamethasone; Gentamicins; Hum	1978
Endotracheally administered antibiotics for gram-negative bronchopneumonia. Chest, 1979, Volume: 75, Issue:5 Topics: Bacterial Infections; Bronchi; Bronchopneumonia; Carbenicillin; Clinical Trials as Topic; Double-Bli	1979
Treatment of pulmonary infections in patients with cystic fibrosis: a comparative study of ticarcillin and gentamicin. The Journal of pediatrics, 1977, Volume: 90, Issue:1 Topics: Adolescent; Adult; Child; Child, Preschool; Clinical Trials as Topic; Cystic Fibrosis; Female; Genta	1977
Amikacin Therapy of Urinary tract infections. The Journal of infectious diseases, 1976, Volume: 134 SUPPL Topics: Adolescent; Adult; Aged; Amikacin; Clinical Trials as Topic; Enterobacteriaceae Infections; Female;	1976
Nebcin in the treatment of experimental Pseudomonas keratitis. The British journal of ophthalmology, 1975, Volume: 59, Issue:12 Topics: Animals; Anti-Bacterial Agents; Clinical Trials as Topic; Gentamicins; Keratitis; Pseudomonas aerugi	1975
Amikacin therapy for severe gram-negative sepsis. Emphasis on infections with gentamicin-resistant organisms. Annals of internal medicine, 1975, Volume: 83, Issue:4 Topics: Aged; Amikacin; Clinical Trials as Topic; Drug Resistance, Microbial; Enterobacteriaceae; Enterobact	1975
Ceftazidime compared with gentamicin and carbenicillin in patients with cystic fibrosis, pulmonary pseudomonas infection, and an exacerbation of respiratory symptoms. British Thoracic Society Research Committee. Thorax, 1985, Volume: 40, Issue:5 Topics: Adolescent; Adult; Carbenicillin; Ceftazidime; Child; Cystic Fibrosis; Female; Gentamicins; Humans;	1985
Oral ciprofloxacin compared with conventional intravenous treatment for Pseudomonas aeruginosa infection in adults with cystic fibrosis. Lancet (London, England), 1987, Jan-31, Volume: 1, Issue:8527 Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Azlocillin; Ciprofloxacin; Clinical Trials a	1987
The role of Pseudomonas species in patients treated with ampicillin and Sulbactam for gangrenous and perforated appendicitis. Surgery, gynecology & obstetrics, 1985, Volume: 161, Issue:4 Topics: Adult; Ampicillin; Appendicitis; Clindamycin; Double-Blind Method; Drug Therapy, Combination; Female	1985
Inhaled ceftazidime compared with gentamicin and carbenicillin in older patients with cystic fibrosis infected with Pseudomonas aeruginosa. British journal of diseases of the chest, 1987, Volume: 81, Issue:3 Topics: Adolescent; Adult; Aerosols; Carbenicillin; Ceftazidime; Clinical Trials as Topic; Cystic Fibrosis;	1987
Intensive treatment of pseudomonas chest infection in cystic fibrosis: a comparison of tobramycin and ticarcillin, and netilmicin and ticarcillin. Acta paediatrica Scandinavica, 1985, Volume: 74, Issue:1 Topics: Adolescent; Adult; Child; Child, Preschool; Clinical Trials as Topic; Cystic Fibrosis; Drug Combinat	1985
Local chemoprophylaxis for burns with gentamicin and other agents. Lancet (London, England), 1968, Mar-30, Volume: 1, Issue:7544 Topics: Anti-Bacterial Agents; Burns; Drug Resistance, Microbial; Gentamicins; Humans; Ointments; Proteus; P	1968
Endotracheal gentamicin for the prevention of bronchial infections in patients with tracheotomy. International journal of clinical pharmacology, therapy and toxicology, 1973, Volume: 7, Issue:4 Topics: Bacterial Infections; Bronchial Diseases; Clinical Trials as Topic; Drug Resistance, Microbial; Esch	1973
A controlled study of isolation and endogenous microbial suppression in acute myelocytic leukemia patients. Cancer, 1973, Volume: 32, Issue:6 Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Gentamicins; Hemorrhage; Humans; Infection Control;	1973
Endotracheally administered gentamicin for the prevention of infections of the respiratory tract in patients with tracheostomy: a double-blind study. Chest, 1974, Volume: 65, Issue:6 Topics: Adult; Bacteria; Bacterial Infections; Clinical Trials as Topic; Drug Resistance, Microbial; Female;	1974
Clinical and laboratory studies with tobramycin. Chemotherapy, 1974, Volume: 20, Issue:4 Topics: Adult; Aminoglycosides; Anti-Bacterial Agents; Bacillus; Clinical Trials as Topic; Drug Synergism; E	1974
Gentamicin and kanamycin in the treatment of gram-negative sepsis: a comparative study. The Journal of infectious diseases, 1971, Volume: 124 Suppl Topics: Bacterial Infections; Body Temperature; Drug Synergism; Gentamicins; Humans; Kanamycin; Kidney Disea	1971
Infections in cancer patients. Results with gentamicin sulfate therapy. Cancer, 1972, Volume: 29, Issue:6 Topics: Adolescent; Adult; Aged; Agranulocytosis; Blood Urea Nitrogen; Cellulitis; Child; Clinical Trials as	1972
Therapy with carbenicillin and gentamicin for patients with cancer and severe infections caused by gram-negative rods. Cancer, 1973, Volume: 31, Issue:2 Topics: Bacteria; Bacterial Infections; Carbenicillin; Clinical Trials as Topic; Escherichia coli Infections	1973
Tobramycin: clinical and microbiological evaluation. International journal of clinical pharmacology, therapy and toxicology, 1973, Volume: 8, Issue:3 Topics: Aged; Aminoglycosides; Anti-Bacterial Agents; Arthritis; Bacteriuria; Biliary Tract Diseases; Clinic	1973
Comparative clinical study of tobramycin and gentamicin. Antimicrobial agents and chemotherapy, 1974, Volume: 5, Issue:2 Topics: Aminoglycosides; Anti-Bacterial Agents; Bacteria; Bacterial Infections; Clinical Trials as Topic; Dr	1974
Gentamicin. Clinical and pharmacological studies. Internationale Zeitschrift fur klinische Pharmakologie, Therapie, und Toxikologie. International journal of clinical pharmacology, therapy, and toxicology, 1970, Volume: 3, Issue:2 Topics: Acinetobacter Infections; Bacteroides Infections; Biliary Tract Diseases; Cellulitis; Clinical Trial	1970
Treatment of severe pseudomonas infections of the bronchi. British medical journal, 1970, Mar-14, Volume: 1, Issue:5697 Topics: Aerosols; Aged; Bronchial Diseases; Bronchiectasis; Clinical Trials as Topic; Colistin; Gentamicins;	1970
Evaluation of gentamicin with carbenicillin in infections due to gram-negative bacilli. Current therapeutic research, clinical and experimental, 1971, Volume: 13, Issue:3 Topics: Adolescent; Adult; Aged; Carbenicillin; Clinical Trials as Topic; Drug Synergism; Enterobacteriaceae	1971
[Problems in the therapy of pseudomonas infections of the urinary tract. Alternating comparison of carbenicillin and gentamycin in children]. Deutsche medizinische Wochenschrift (1946), 1971, Jan-29, Volume: 96, Issue:5 Topics: Child; Child, Preschool; Diuresis; Drug Synergism; Gentamicins; Humans; Infant; Microbial Sensitivit	1971

gentamicin and Pseudomonas Infections