gentamicin has been researched along with Proteinuria in 75 studies
Gentamicins: A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.
Proteinuria: The presence of proteins in the urine, an indicator of KIDNEY DISEASES.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The influence of hyperfiltration-hypertrophy, proteinuria and glucosuria on the renal cortical uptake of gentamicin was studied in several experimental models." | 7.67 | Effect of hyperfiltration, proteinuria and diabetes mellitus on the uptake kinetics of gentamicin in the kidney cortex of rats. ( De Broe, ME; Giuliano, RA; Pattyn, VM; Verpooten, GA; Zheng, F, 1988) |
| " To investigate whether the sensitivity of the old kidney to gentamicin is a function of age, separate from the adverse effects arising from declining renal excretory function, the nephrotoxicity of 12 daily injections of this antibiotic was measured in rats." | 5.26 | Effect of aging on gentamicin nephrotoxicity and pharmacokinetics in rats. ( Engel, SG; McMartin, DN, 1982) |
| "Forty-one patients with urinary tract infections were randomly assigned to receive for six days gentamicin, amikacin, sisomicin or netilmicin." | 5.05 | Enzymuria in aminoglycoside-induced kidney damage. Comparative study of gentamicin, amikacin, sisomicin and netilmicin. ( Bertelli, A; Bertelli, AA; Cirami, C; Giovannini, L; Marchitiello, M; Palla, R; Tuoni, M, 1985) |
| " Treating col4a4 depleted zebrafish larvae (a model of Alport syndrome) with captopril reduced proteinuria in this system." | 4.12 | A novel nanoluciferase transgenic reporter measures proteinuria in zebrafish. ( Davenport, JB; Jackson-Crawford, A; Lemarie, E; Lennon, R; Lowe, M; Mironov, A; Naylor, RW, 2022) |
| "Compared with the controls rats, gentamicin caused hyperproteinuria, an increase in the level of gamma-GT in serum, a marked increase in lipoperoxides and a significant decrease of GSH-Px, catalase and SOD activity in the kidney." | 3.70 | Melatonin administration prevents the nephrotoxicity induced by gentamicin. ( Mizrak, B; Ozbek, E; Ozbek, M; Ozugurlu, F; Sahna, E; Turkoz, Y, 2000) |
| " Glomerular damage caused by puromycin aminonucleoside did not induce aminoaciduria until marked proteinuria occurred (day 9), and even then amino acid excretion was much less than that caused by gentamicin." | 3.68 | Aminoaciduria is an earlier index of renal tubular damage than conventional renal disease markers in the gentamicin-rat model of acute renal failure. ( Goldberg, DM; Macpherson, NA; Moscarello, MA, 1991) |
| "We delineated in rats, the relationship between trypsin inhibitory activity in the urine and the nephrotoxic effects of gentamicin, eg, proteinuria and deterioration of glomerular filtration rate (GFR), measured by creatinine clearance." | 3.67 | Enhanced urinary trypsin inhibitory activity in gentamicin-induced nephrotoxicity in rats. ( Bar-Khayim, Y; Birk, Y; Hurwitz, N; Khalef, S; Miskin, A; Nitsan, Z; Smetana, S, 1988) |
| "The influence of hyperfiltration-hypertrophy, proteinuria and glucosuria on the renal cortical uptake of gentamicin was studied in several experimental models." | 3.67 | Effect of hyperfiltration, proteinuria and diabetes mellitus on the uptake kinetics of gentamicin in the kidney cortex of rats. ( De Broe, ME; Giuliano, RA; Pattyn, VM; Verpooten, GA; Zheng, F, 1988) |
| "9 patients with chronic pyelonephritis were given gentamicin intramuscularly in an appropriate dosage for a period of 10 days." | 3.66 | [Urinary excretion kinetics of enzymes and proteins in the application of therapeutic doses of gentamycin]. ( Burchardt, U; Krosch, H; Müller, G; Neef, L; Schinköthe, G, 1978) |
| " coli-pyelonephritis facilitated by oestradiolundecylate, aminonucleoside nephrosis, aminoglycoside induced renal lesions and pyelonephritic animals treated with therapeutic and toxic doses of tobramycin." | 3.65 | The diagnostic value of enzymuria, cell excretion, and proteinuria in experimental renal diseases. ( Sack, K; Wilhelm, J, 1975) |
| "No cases of Fanconi syndrome have been reported in clinical trials of TAF." | 1.56 | Renal proximal tubulopathy in an HIV-infected patient treated with tenofovir alafenamide and gentamicin: a case report. ( Bloch, M; Gracey, DM; Heron, JE; Saunders, J; Vanguru, V, 2020) |
| "Gentamicin (GEN) is an aminoglycoside antibiotic employed in treatment of life-threatening gram-negative infections, but one of its major side effects is the induction of nephrotoxicity." | 1.46 | Ameliorative effect of gossypin against gentamicin-induced nephrotoxicity in rats. ( Katary, M; Salahuddin, A, 2017) |
| " Caution should be exercised during long-term use because production of antibodies to human recombinant and endogenous erythropoietin may lead to potentially serious side effects." | 1.31 | Use of human recombinant erythropoietin for the treatment of nonregenerative anemia in a rough-toothed dolphin (Steno bredanensis). ( Manire, CA; Rhinehart, HL, 2000) |
| " Now, for the establishment of a toxicity screening approach using 5/6 NX rats, our concept, "Differential toxicity synchronized with renal dysfunction process could be identified using 5/6 NX rats" was examined by dosing gentamicin." | 1.31 | Differential toxicity expression of gentamicine in five-sixths nephrectomized rats assigned to three progressive stages of renal dysfunction--establishment of a new screening approach. ( Barata, K; Harada, E; Hokao, R; Imai, S; Maekawa, A; Takahashi, S; Yoshida, M, 2001) |
| "coli-positive blood cultures died of septicemia." | 1.28 | Antimicrobial gentamicin activity in the presence of exogenous protease inhibitor (Bowman-Birk inhibitor) in gentamicin-induced nephrotoxicity in rats. ( Bar-Khayim, Y; Birk, Y; Khalef, S; Smetana, S, 1992) |
| " Ribostamycin caused slightly less nephrotoxicity in rats than kanamycin and far less than dibekacin at an equal dosage of 40 mg/kg per day for 14 days." | 1.28 | Comparative nephrotoxicity of ribostamycin and gentamicin in rats evaluated by urinalysis. ( Inouye, S; Kitasato, I; Niizato, T, 1989) |
| "Gentamicin was given to rats in the doses and intervals equivalent to those used in the patients." | 1.28 | [Studies of the effect of gentamicin on the kidneys of healthy young rats. I. Effect of gentamicin on serum urea and creatinine levels and urinary protein levels in experimental animals]. ( Rymgayłło-Katska, M, 1989) |
| "Nephrotoxicity of cefodizime sodium (THR-221), a new cephem antibiotic, was studied in rats by comparing its toxic effect with those of other cephem antibiotics including cephaloridine (CER), cefazolin (CEZ) and cefmetazol (CMZ)." | 1.27 | [Nephrotoxicity of cefodizime sodium in rats--single and 14-day repeated intravenous administration]. ( Hayashi, T; Irimura, K; Kuwata, M; Maruden, A; Morita, K, 1988) |
| "In gentamicin - treated patients LMWP elimination increased, especially LZM which rose markedly during treatment and returned to normal values after its end." | 1.26 | Gentamicin and sisomicin - induced renal tubular damage. ( Charmes, JP; Lachâtre, G; Merle, L; Nicot, G; Valette, JP, 1982) |
| "Netilmicin toxicity was initially compared to gentamicin toxicity at equal doses across a broad range." | 1.26 | The nephrotoxic potential of netilmicin as determined in a rat model. ( Luft, FC, 1980) |
| " To investigate whether the sensitivity of the old kidney to gentamicin is a function of age, separate from the adverse effects arising from declining renal excretory function, the nephrotoxicity of 12 daily injections of this antibiotic was measured in rats." | 1.26 | Effect of aging on gentamicin nephrotoxicity and pharmacokinetics in rats. ( Engel, SG; McMartin, DN, 1982) |
| "The proteinuria was analysed by means of immunoelectrophoresis, acetate cellulose electrophoresis, thin-layer polyacrylamide gel electrophoresis and sodium dodecylsulphate acrylamide gel electrophoresis." | 1.26 | Low molecular weight proteins as urinary markers of aminoglycoside nephrotoxicity in man. ( Benevent, D; Charmes, JP; Leroux-Robert, C; Merle, L; Nicot, G; Valette, JP, 1979) |
| " Decreased tubular resorption of glucose and phosphate were observed with the most toxic regimens after extensive renal damage had occurred." | 1.26 | Comparative nephrotoxicity of aminoglycoside antibiotics in rats. ( Bloch, R; Costello, R; Luft, FC; Maxwell, DR; Sloan, RS; Yum, MN, 1978) |
| "Gentamicin sulphate was administered to male Wistar rats by intramuscular injection at varying dosage and for varying periods." | 1.26 | Renal damage caused by gentamicin: a study of the effects on renal morphology and urinary enzyme excretion. ( Lovell, D; Thompson, AE; Tighe, JR; Wellwood, JM, 1976) |
| "8 patients with chronic pyelonephritis were given gentamycin intramuscularly injected in individual dosage during 8-10 days." | 1.25 | [The effect of therapeutic gentamycin doses on the enzyme secretion in urine]. ( Burchardt, U; Gründig, CA; Peters, JE, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 38 (50.67) | 18.7374 |
| 1990's | 16 (21.33) | 18.2507 |
| 2000's | 9 (12.00) | 29.6817 |
| 2010's | 10 (13.33) | 24.3611 |
| 2020's | 2 (2.67) | 2.80 |
| Authors | Studies |
|---|---|
| Naylor, RW | 1 |
| Lemarie, E | 1 |
| Jackson-Crawford, A | 1 |
| Davenport, JB | 1 |
| Mironov, A | 1 |
| Lowe, M | 1 |
| Lennon, R | 1 |
| Heron, JE | 1 |
| Bloch, M | 1 |
| Vanguru, V | 1 |
| Saunders, J | 1 |
| Gracey, DM | 1 |
| Zamorskii, II | 1 |
| Shchudrova, TS | 1 |
| Lin'kova, NS | 1 |
| Nichik, TE | 1 |
| Khavinson, VK | 1 |
| Uchino, H | 1 |
| Fujishima, J | 1 |
| Fukuoka, K | 1 |
| Iwakiri, T | 1 |
| Kamikuri, A | 1 |
| Maeda, H | 1 |
| Nakama, K | 1 |
| Ullah, N | 1 |
| Khan, MA | 1 |
| Rauf, A | 1 |
| Khan, T | 1 |
| Murtaza, G | 1 |
| Khan, S | 1 |
| Shah, I | 1 |
| Biro, A | 1 |
| Vaknine, H | 1 |
| Cohen-Armon, M | 1 |
| Matas, Z | 1 |
| Fux, A | 1 |
| Schreiber, L | 1 |
| Berger, E | 1 |
| Dan, M | 1 |
| Boaz, M | 1 |
| Gregoriev, O | 1 |
| Katzir, Z | 1 |
| Abuelezz, SA | 1 |
| Hendawy, N | 1 |
| Abdel Gawad, S | 1 |
| Liu, C | 1 |
| Kang, Y | 1 |
| Zhang, H | 1 |
| Zhu, L | 1 |
| Yu, H | 1 |
| Han, C | 1 |
| Katary, M | 1 |
| Salahuddin, A | 1 |
| Li, J | 1 |
| Li, QX | 1 |
| Xie, XF | 1 |
| Ao, Y | 1 |
| Tie, CR | 1 |
| Song, RJ | 1 |
| Romero, F | 1 |
| Pérez, M | 1 |
| Chávez, M | 1 |
| Parra, G | 1 |
| Durante, P | 1 |
| Abdel-Raheem, IT | 1 |
| El-Sherbiny, GA | 1 |
| Taye, A | 1 |
| Natarajan, A | 1 |
| Hindocha, D | 1 |
| Kular, N | 1 |
| Fergey, S | 1 |
| Davis, JR | 1 |
| Borisenok, OA | 1 |
| Bushma, MI | 2 |
| Baraban, OV | 1 |
| Zimatkin, SM | 1 |
| Bushma, KM | 1 |
| Kizyukevich, LS | 1 |
| Nechiporenko, NA | 1 |
| Muñoz-Castañeda, JR | 1 |
| Montilla, P | 1 |
| Muñoz, MC | 1 |
| Bujalance, I | 1 |
| Muntané, J | 1 |
| Túnez, I | 1 |
| Nicot, G | 2 |
| Merle, L | 2 |
| Valette, JP | 2 |
| Charmes, JP | 2 |
| Lachâtre, G | 1 |
| Viau, C | 1 |
| Bernard, A | 1 |
| Lauwerys, RR | 1 |
| Tulkens, P | 1 |
| Laurent, G | 1 |
| Maldague, P | 1 |
| Kojima, R | 2 |
| Suzuki, Y | 2 |
| Chahwala, SB | 1 |
| Harpur, ES | 2 |
| Rankin, LI | 2 |
| Krous, H | 1 |
| Fryer, AW | 1 |
| Whang, R | 1 |
| Burchardt, U | 3 |
| Schinköthe, G | 2 |
| Meinel, K | 1 |
| Anton, D | 1 |
| Krebbel, I | 1 |
| Neef, L | 2 |
| Luft, FC | 6 |
| McMartin, DN | 1 |
| Engel, SG | 1 |
| Kaloyanides, GJ | 1 |
| Pastoriza-Munoz, E | 1 |
| Xuan, W | 1 |
| Dong, M | 2 |
| Trachtman, H | 1 |
| Schwob, N | 1 |
| Maesaka, J | 1 |
| Valderrama, E | 1 |
| Ohno, I | 1 |
| Shibasaki, T | 1 |
| Nakano, H | 1 |
| Matsuda, H | 1 |
| Matsumoto, H | 1 |
| Misawa, T | 1 |
| Ishimoto, F | 1 |
| Sakai, O | 1 |
| Nergelius, G | 1 |
| Vinge, E | 1 |
| Lidgren, L | 1 |
| Scherberich, JE | 1 |
| Mondorf, WA | 1 |
| Davies, C | 1 |
| Forrester, SD | 1 |
| Troy, GC | 1 |
| Saunders, GK | 1 |
| Shell, LG | 1 |
| Johnston, SA | 1 |
| Ozbek, E | 1 |
| Turkoz, Y | 1 |
| Sahna, E | 1 |
| Ozugurlu, F | 1 |
| Mizrak, B | 1 |
| Ozbek, M | 1 |
| Connolly, JE | 1 |
| Wrobel, JS | 1 |
| Anderson, RF | 1 |
| Manire, CA | 1 |
| Rhinehart, HL | 1 |
| Pedraza-Chaverrí, J | 1 |
| Maldonado, PD | 1 |
| Medina-Campos, ON | 1 |
| Olivares-Corichi, IM | 1 |
| Granados-Silvestre, MA | 1 |
| Hernández-Pando, R | 1 |
| Ibarra-Rubio, ME | 1 |
| Barata, K | 1 |
| Yoshida, M | 1 |
| Hokao, R | 1 |
| Imai, S | 1 |
| Takahashi, S | 1 |
| Harada, E | 1 |
| Maekawa, A | 1 |
| Peters, JE | 1 |
| Gründig, CA | 1 |
| Benevent, D | 1 |
| Leroux-Robert, C | 1 |
| Patel, V | 2 |
| Yum, MN | 5 |
| Patel, B | 1 |
| Kleit, SA | 3 |
| Müller, G | 1 |
| Krosch, H | 1 |
| Cuppage, FE | 1 |
| Setter, K | 1 |
| Sullivan, P | 1 |
| Reitzes, EJ | 1 |
| Melnykovych, AO | 1 |
| Adelman, RD | 1 |
| Conzelman, G | 1 |
| Spangler, W | 1 |
| Ishizaki, G | 1 |
| Sloan, RS | 2 |
| Dinwiddie, CB | 1 |
| Isaacs, LL | 1 |
| Beck, H | 1 |
| Sack, K | 2 |
| Bloch, R | 1 |
| Costello, R | 1 |
| Maxwell, DR | 1 |
| Wellwood, JM | 2 |
| Simpson, PM | 1 |
| Tighe, JR | 2 |
| Thompson, AE | 2 |
| Wilhelm, J | 1 |
| Lovell, D | 1 |
| Kolaja, GJ | 1 |
| VanderMeer, DA | 1 |
| Packwood, WH | 1 |
| Satoh, PS | 1 |
| Brodersen, HP | 1 |
| Chmielnicka, J | 1 |
| Szymańska, JA | 1 |
| Brzeźnicka, EA | 1 |
| Kałuzyński, A | 1 |
| Smetana, S | 4 |
| Khalef, S | 4 |
| Bar-Khayim, Y | 4 |
| Birk, Y | 4 |
| Kopolovic, G | 1 |
| Kacew, S | 1 |
| Chan, MK | 1 |
| Chan, KW | 1 |
| Ng, WL | 1 |
| Jones, WT | 1 |
| Waterhouse, RL | 1 |
| Resnick, MI | 1 |
| Macpherson, NA | 1 |
| Moscarello, MA | 1 |
| Goldberg, DM | 1 |
| Hurwitz, N | 2 |
| Phipps, DJ | 1 |
| Spencer, AJ | 1 |
| Kitasato, I | 1 |
| Niizato, T | 1 |
| Inouye, S | 1 |
| Rymgayłło-Katska, M | 1 |
| Palla, R | 1 |
| Marchitiello, M | 1 |
| Tuoni, M | 1 |
| Cirami, C | 1 |
| Giovannini, L | 1 |
| Bertelli, AA | 1 |
| Bertelli, A | 1 |
| Endou, H | 1 |
| Koseki, C | 1 |
| Yamada, H | 1 |
| Obara, T | 1 |
| Godson, C | 1 |
| Ryan, MP | 1 |
| O'Halloran, D | 1 |
| Bourke, S | 1 |
| Brady, HR | 1 |
| FitzGerald, MX | 1 |
| Hayashi, T | 1 |
| Maruden, A | 1 |
| Irimura, K | 1 |
| Kuwata, M | 1 |
| Morita, K | 1 |
| Nitsan, Z | 1 |
| Miskin, A | 1 |
| Pattyn, VM | 1 |
| Verpooten, GA | 1 |
| Giuliano, RA | 1 |
| Zheng, F | 1 |
| De Broe, ME | 1 |
| Yosselson-Superstine, S | 1 |
| Sinai, Y | 1 |
| Beauchamp, D | 1 |
| Poirier, A | 1 |
| Bergeron, MG | 1 |
| Siegenthaler, W | 1 |
| Zimmermann, K | 1 |
| Kyle, RA | 1 |
| Pierre, RV | 1 |
| Bayrd, ED | 1 |
| Lagrue, G | 1 |
| Fournier, A | 1 |
| Fillastre, JP | 1 |
| Laumonier, R | 1 |
| Humbert, G | 1 |
| Dubois, D | 1 |
| Metayer, J | 1 |
| Delpech, A | 1 |
| Leroy, J | 1 |
| Robert, M | 1 |
1 review available for gentamicin and Proteinuria
| Article | Year |
|---|---|
[Aminoglycoside nephropathy].
Topics: Acute Kidney Injury; Adult; Aminoglycosides; Ampicillin; Drug Synergism; Enzymes; Gentamicins; Glome | 1982 |
4 trials available for gentamicin and Proteinuria
| Article | Year |
|---|---|
Effects of compound injection of Pyrola rotundifolia L and Astragalus membranaceus Bge on experimental guinea pigs' gentamicin ototoxicity.
Topics: Aminoglycosides; Animals; Astragalus propinquus; Cochlea; Female; Gentamicins; Guinea Pigs; Hair Cel | 1995 |
Nephrotoxic potential of antiinfective drugs as assessed by tissue-specific proteinuria of renal antigens.
Topics: Adolescent; Adult; Animals; Anti-Bacterial Agents; Antigen-Antibody Complex; Biomarkers; CD13 Antige | 1998 |
Effects of a prostaglandin E1 analogue, misoprostol, on renal function in dogs receiving nephrotoxic doses of gentamicin.
Topics: Animals; Anti-Bacterial Agents; Blood Urea Nitrogen; Creatinine; Dogs; Electrolytes; Gentamicins; Gl | 1998 |
Enzymuria in aminoglycoside-induced kidney damage. Comparative study of gentamicin, amikacin, sisomicin and netilmicin.
Topics: Adolescent; Adult; Aged; alpha-Glucosidases; Amikacin; Creatinine; Female; gamma-Glutamyltransferase | 1985 |
70 other studies available for gentamicin and Proteinuria
| Article | Year |
|---|---|
A novel nanoluciferase transgenic reporter measures proteinuria in zebrafish.
Topics: Angiotensin II; Animals; Animals, Genetically Modified; Captopril; Cisplatin; Gentamicins; Humans; K | 2022 |
Renal proximal tubulopathy in an HIV-infected patient treated with tenofovir alafenamide and gentamicin: a case report.
Topics: Acute Disease; Alanine; Anti-Bacterial Agents; Antineoplastic Combined Chemotherapy Protocols; Antiv | 2020 |
Nephroprotective Effect of EDL Peptide at Acute Injury of Kidneys of Different Genesis.
Topics: Acute Kidney Injury; Animals; Animals, Outbred Strains; Antioxidants; Azotemia; Gentamicins; Kidney | 2017 |
Usefulness of urinary biomarkers for nephrotoxicity in cynomolgus monkeys treated with gentamicin, cisplatin, and puromycin aminonucleoside.
Topics: Acute Kidney Injury; Albuminuria; Animals; beta 2-Microglobulin; Biomarkers; Cisplatin; Clusterin; C | 2017 |
Nephrotoxic effects of Valeriana wallichii.
Topics: Animals; Anti-Bacterial Agents; Antioxidants; Electrolytes; Enzymes; Flavonoids; Gentamicins; Kidney | 2018 |
The effect of poly (ADP-ribose) polymerase inhibition on aminoglycoside-induced acute tubular necrosis in rats.
Topics: Animals; Anti-Bacterial Agents; Benzamides; Creatinine; Dilatation, Pathologic; Drug Interactions; E | 2016 |
Alleviation of renal mitochondrial dysfunction and apoptosis underlies the protective effect of sitagliptin in gentamicin-induced nephrotoxicity.
Topics: Adenosine Triphosphate; Animals; Antioxidants; Apoptosis; Apoptosis Regulatory Proteins; Biomarkers; | 2016 |
Establishment of Simple and Routine Methods in Early Diagnosis of Gentamicin-Induced Kidney Injury Based on a Rat Model.
Topics: Animals; Biomarkers; Body Weight; Diagnostic Tests, Routine; Disease Models, Animal; Drinking Water; | 2016 |
Ameliorative effect of gossypin against gentamicin-induced nephrotoxicity in rats.
Topics: Animals; Catalase; Chemokine CCL2; Flavonoids; Gentamicins; Interleukin-6; Kidney; Male; Proteinuria | 2017 |
Differential roles of dihydropyridine calcium antagonist nifedipine, nitrendipine and amlodipine on gentamicin-induced renal tubular toxicity in rats.
Topics: Acetylglucosaminidase; Amlodipine; Animals; Apoptosis; bcl-2-Associated X Protein; Blood Urea Nitrog | 2009 |
Effect of uric acid on gentamicin-induced nephrotoxicity in rats - role of matrix metalloproteinases 2 and 9.
Topics: Animals; Anti-Bacterial Agents; Gentamicins; Kidney; Kidney Function Tests; Kidney Tubular Necrosis, | 2009 |
Green tea ameliorates renal oxidative damage induced by gentamicin in rats.
Topics: Animals; Antioxidants; Blood Urea Nitrogen; Camellia sinensis; Creatinine; Drug Evaluation, Preclini | 2010 |
Vasculitic rash: do not jump to conclusions.
Topics: Amoxicillin; Anemia; Anti-Bacterial Agents; Aortic Valve; Diagnosis, Differential; Echocardiography, | 2012 |
[Therapeutic effect of acetylcysteine on rats with gentamicin-induced nephropathy].
Topics: Acetylcysteine; Alkaline Phosphatase; Animals; Anti-Bacterial Agents; Creatinine; Female; Gentamicin | 2012 |
Role of individual structural features of rabbit kidneys in the predisposition to gentamicin nephrotoxicity.
Topics: Animals; Anti-Bacterial Agents; Gentamicins; Kidney; Nephrons; Proteinuria; Rabbits; Urea | 2004 |
Parachlorophenylalanine exacerbates oxidative stress induced by gentamicin in rats.
Topics: Animals; Blood Urea Nitrogen; Brain; Brain Chemistry; Catalase; Creatinine; Drug Synergism; Fencloni | 2005 |
Gentamicin and sisomicin - induced renal tubular damage.
Topics: Acetylglucosaminidase; Aminopeptidases; CD13 Antigens; Female; Gentamicins; Humans; Kidney Diseases; | 1982 |
Gentamicin nephrotoxicity in cadmium, lead and mercury pretreated rats.
Topics: Amino Acids; Animals; beta-Galactosidase; Cadmium Poisoning; Drug Interactions; Female; Gentamicins; | 1983 |
[Studies on the nephrotoxicity of aminoglycoside antibiotics and protection from these effects. (1). Nephrotoxicity of gentamicin and mercuric chloride].
Topics: Acute Kidney Injury; Animals; Blood Urea Nitrogen; Enzymes; Gentamicins; Kidney; Kidney Tubular Necr | 1984 |
[Studies on the nephrotoxicity of aminoglycoside antibiotics and protection from these effects. (2). Protective effect of latamoxef against gentamicin nephrotoxicity].
Topics: Acetylglucosaminidase; Acute Kidney Injury; Animals; Anti-Bacterial Agents; Blood Urea Nitrogen; Gen | 1984 |
Gentamicin-induced hypercalciuria in the rat.
Topics: Animals; Calcium; Drinking; Eating; Electrolytes; Enzymes; Gentamicins; Hydrogen-Ion Concentration; | 1983 |
Enhancement of gentamicin nephrotoxicity by magnesium depletion in the rat.
Topics: Acute Kidney Injury; Animals; Blood Urea Nitrogen; Creatinine; Gentamicins; Kidney; Magnesium Defici | 1984 |
The nephrotoxic potential of netilmicin as determined in a rat model.
Topics: Aminoglycosides; Animals; Anti-Bacterial Agents; Dose-Response Relationship, Drug; Gentamicins; Hexo | 1980 |
Effect of aging on gentamicin nephrotoxicity and pharmacokinetics in rats.
Topics: Aging; Animals; Dose-Response Relationship, Drug; Enzymes; Gentamicins; Kidney; Kidney Tubules; Kine | 1982 |
Aminoglycoside nephrotoxicity.
Topics: Aminoglycosides; Animals; Anti-Bacterial Agents; Biological Transport; Cephalosporins; Diffusion; Dr | 1980 |
Dietary vitamin E supplementation ameliorates renal injury in chronic puromycin aminonucleoside nephropathy.
Topics: Animals; Blood Pressure; Chronic Disease; Diet; Dose-Response Relationship, Drug; Gentamicins; Kidne | 1995 |
Effect of Sairei-to on gentamicin nephrotoxicity in rats.
Topics: Acetylglucosaminidase; Animals; Creatinine; Drugs, Chinese Herbal; Gentamicins; Kidney Cortex; Kidne | 1993 |
Gentamicin-free bone cement does not alter proteinuria after hip arthroplasty.
Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; Bone Cements; Female; Gentamicins; Hip Prosthesis; H | 1997 |
Melatonin administration prevents the nephrotoxicity induced by gentamicin.
Topics: Animals; Antioxidants; Catalase; gamma-Glutamyltransferase; Gentamicins; Glutathione; Kidney Tubules | 2000 |
Primary closure of infected diabetic foot wounds. A report of closed instillation in 30 cases.
Topics: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Comorbidity; Diabetic Foot; Drainage; Gentami | 2000 |
Use of human recombinant erythropoietin for the treatment of nonregenerative anemia in a rough-toothed dolphin (Steno bredanensis).
Topics: Anemia; Animals; Anti-Bacterial Agents; Anti-Ulcer Agents; Dolphins; Enzyme-Linked Immunosorbent Ass | 2000 |
Garlic ameliorates gentamicin nephrotoxicity: relation to antioxidant enzymes.
Topics: Acetylglucosaminidase; Animals; Blood Urea Nitrogen; Catalase; Diet; Garlic; Gene Expression Regulat | 2000 |
Differential toxicity expression of gentamicine in five-sixths nephrectomized rats assigned to three progressive stages of renal dysfunction--establishment of a new screening approach.
Topics: Albumins; Amino Acid Sequence; Animals; Anti-Bacterial Agents; Blood Proteins; Creatinine; Disease M | 2001 |
[The effect of therapeutic gentamycin doses on the enzyme secretion in urine].
Topics: Alkaline Phosphatase; Aminopeptidases; Arylsulfatases; Female; gamma-Glutamyltransferase; Gentamicin | 1975 |
Low molecular weight proteins as urinary markers of aminoglycoside nephrotoxicity in man.
Topics: Aminoglycosides; beta 2-Microglobulin; Cephalosporins; gamma-Globulins; Gentamicins; Humans; Immunog | 1979 |
Experimental aminoglycoside nephrotoxicity.
Topics: alpha-L-Fucosidase; Aminoglycosides; Animals; Blood Urea Nitrogen; Gentamicins; Hexosaminidases; Inc | 1975 |
[Urinary excretion kinetics of enzymes and proteins in the application of therapeutic doses of gentamycin].
Topics: Acetylglucosaminidase; Adult; alpha-Galactosidase; Aminopeptidases; Enzymes; Gentamicins; Humans; Ly | 1978 |
Gentamicin nephrotoxicity. II. Physiological, biochemical and morphological effects of prolonged administration to rats.
Topics: Animals; Blood Urea Nitrogen; Gentamicins; Glomerular Filtration Rate; Kidney; Male; Microscopy, Ele | 1977 |
Comparative nephrotoxicity of gentamicin and netilmicin: functional and morphological correlations with urinary enzyme activities.
Topics: Acetylglucosaminidase; Animals; Dogs; Enzymes; Gentamicins; Glucuronidase; Kidney; Male; Muramidase; | 1979 |
Comparative nephrotoxicity of SCH 21420 and amikacin in rats.
Topics: Amikacin; Animals; Creatinine; Enzymes; Gentamicins; Kanamycin; Kidney Diseases; Male; Proteinuria; | 1979 |
[Experimental study on the renal compatibility of the aminoglycosides gentamicin B and O-2-amino-2-deoxy-6-C-methyl-alpha-D-glucopyranosyl-(1 greater than 4)-garamine (G-418)].
Topics: Animals; Enzymes; Female; Gentamicins; Kidney Diseases; Proteinuria; Rats | 1979 |
Comparative nephrotoxicity of aminoglycoside antibiotics in rats.
Topics: Amikacin; Aminoglycosides; Animals; Blood Urea Nitrogen; Dose-Response Relationship, Drug; Gentamici | 1978 |
Nephrotoxicity of cephalosporin-gentamicin combinations in rats.
Topics: Animals; Cephalosporins; Drug Combinations; Enzymes; Gentamicins; Kidney; Kidney Diseases; Kidney Fu | 1976 |
Comparative nephrotoxicities of netilmicin and gentamicin in rats.
Topics: Animals; Anti-Bacterial Agents; Blood Urea Nitrogen; Dose-Response Relationship, Drug; Gentamicins; | 1976 |
Evidence of gentamicin nephrotoxicity in patients with renal allografts.
Topics: Acetylglucosaminidase; Alkaline Phosphatase; Anti-Infective Agents; Biopsy; Creatinine; Galactosidas | 1975 |
The diagnostic value of enzymuria, cell excretion, and proteinuria in experimental renal diseases.
Topics: Animals; Clinical Enzyme Tests; Enzymes; Female; Gentamicins; Humans; Kidney Diseases; Kidney Tubula | 1975 |
Renal damage caused by gentamicin: a study of the effects on renal morphology and urinary enzyme excretion.
Topics: Acetylglucosaminidase; Alkaline Phosphatase; Animals; Galactosidases; Gentamicins; Kidney; Kidney Di | 1976 |
The use of sodium dodecyl sulfate-polyacrylamide gel electrophoresis to detect renal damage in Sprague-Dawley rats treated with gentamicin sulfate.
Topics: Acetylglucosaminidase; Animals; Blood Urea Nitrogen; Creatinine; Dose-Response Relationship, Drug; E | 1992 |
Analysis of the proteinuria caused by very high doses of gentamicin in rats.
Topics: Animals; Gentamicins; Proteinuria; Rats | 1992 |
Changes in concentration of essential metals in kidneys and urine as indices of gentamicin nephrotoxicity in female Wistar rats.
Topics: Animals; Copper; Female; Gentamicins; Kidney; Kidney Tubular Necrosis, Acute; Kidney Tubules, Proxim | 1992 |
Antimicrobial gentamicin activity in the presence of exogenous protease inhibitor (Bowman-Birk inhibitor) in gentamicin-induced nephrotoxicity in rats.
Topics: Animals; Creatinine; Escherichia coli Infections; Female; Gentamicins; Kidney; Proteinuria; Rats; Ra | 1992 |
Effect of interaction between gentamicin and pyridoxal-5-phosphate on functional and metabolic parameters in kidneys of female Sprague-Dawley rats.
Topics: Animals; Creatinine; Female; Gentamicins; Glomerular Filtration Rate; Kidney; Metabolic Clearance Ra | 1992 |
Amelioration of gentamicin nephrotoxicity by phospholipids.
Topics: Acetylglucosaminidase; Animals; Creatinine; Gentamicins; Kidney; Male; Phospholipids; Proteinuria; R | 1991 |
The evaluation of urinary protein patterns in a stone-forming animal model using two-dimensional polyacrylamide gel electrophoresis.
Topics: Animals; Calcium Oxalate; Chromatography, Gel; Electrophoresis, Polyacrylamide Gel; Gentamicins; Kid | 1991 |
Aminoaciduria is an earlier index of renal tubular damage than conventional renal disease markers in the gentamicin-rat model of acute renal failure.
Topics: Acetylglucosaminidase; Acute Kidney Injury; Alanine; Amino Acids; Animals; Biomarkers; Creatinine; G | 1991 |
Influence of exogenous protease inhibitor (Bowmann-Birk inhibitor) in gentamicin-induced nephrotoxicity in rats.
Topics: Animals; Female; Gentamicins; Glomerular Filtration Rate; Kidney Diseases; Necrosis; Proteinuria; Ra | 1990 |
Comparison of the renal response of male Fischer 344, Sprague-Dawley and Wistar rats to administration of gentamicin.
Topics: Acetylglucosaminidase; Animals; Blood Urea Nitrogen; Calcium; Gentamicins; Injections, Subcutaneous; | 1990 |
Comparative nephrotoxicity of ribostamycin and gentamicin in rats evaluated by urinalysis.
Topics: Animals; Anti-Bacterial Agents; Enzymes; Gentamicins; Kidney; Kidney Cortex; Kidney Diseases; Kidney | 1989 |
[Studies of the effect of gentamicin on the kidneys of healthy young rats. I. Effect of gentamicin on serum urea and creatinine levels and urinary protein levels in experimental animals].
Topics: Age Factors; Animals; Creatinine; Dose-Response Relationship, Drug; Gentamicins; Kidney; Kidney Func | 1989 |
Evaluation of nephrotoxicity using isolated nephron segments.
Topics: Aminopeptidases; Animals; CD13 Antigens; gamma-Glutamyltransferase; Gentamicins; In Vitro Techniques | 1986 |
Investigation of aminoglycoside nephrotoxicity in cystic fibrosis patients.
Topics: Acetylglucosaminidase; Adolescent; Adult; Cystic Fibrosis; Electrophoresis, Polyacrylamide Gel; Gent | 1988 |
[Nephrotoxicity of cefodizime sodium in rats--single and 14-day repeated intravenous administration].
Topics: Animals; Cefazolin; Cefmetazole; Cefotaxime; Cephaloridine; Drug Administration Schedule; Drug Thera | 1988 |
Enhanced urinary trypsin inhibitory activity in gentamicin-induced nephrotoxicity in rats.
Topics: Animals; Creatinine; Female; Gentamicins; Glomerular Filtration Rate; Kidney; Proteinuria; Rats; Rat | 1988 |
Effect of hyperfiltration, proteinuria and diabetes mellitus on the uptake kinetics of gentamicin in the kidney cortex of rats.
Topics: Animals; Diabetes Mellitus, Experimental; Female; Gentamicins; Glomerular Filtration Rate; Hypertrop | 1988 |
Drug interference with urine protein determination.
Topics: Albumins; Anti-Bacterial Agents; Azo Compounds; Coloring Agents; Drug Interactions; False Positive R | 1986 |
Increased nephrotoxicity of gentamicin in pyelonephritic rats.
Topics: Animals; beta-Galactosidase; Diuresis; Escherichia coli Infections; Female; Gentamicins; Glomerular | 1985 |
[Short- or long-term antibiotic therapy in chronic pyelonephritis].
Topics: Ampicillin; Anti-Bacterial Agents; Bacteria; Bacteriuria; Carbenicillin; Cephalosporins; Chloramphen | 1974 |
Primary amyloidosis and acute leukemia associated with melphalan therapy.
Topics: Amyloidosis; Blood Cell Count; Blood Platelets; Blood Transfusion; Bone Marrow Examination; Cephalot | 1974 |
[Nephrology in 1972].
Topics: Bone Resorption; Calcium; Dextrans; Female; Fluorescent Antibody Technique; Gentamicins; Glomerulone | 1972 |
Acute renal failure associated with combined gentamicin and cephalothin therapy.
Topics: Acute Kidney Injury; Adult; Cephalothin; Creatinine; Drug Interactions; Female; Furosemide; Gentamic | 1973 |