gentamicin has been researched along with Neuromuscular Blockade in 2 studies
Gentamicins: A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.
Neuromuscular Blockade: The intentional interruption of transmission at the NEUROMUSCULAR JUNCTION by external agents, usually neuromuscular blocking agents. It is distinguished from NERVE BLOCK in which nerve conduction (NEURAL CONDUCTION) is interrupted rather than neuromuscular transmission. Neuromuscular blockade is commonly used to produce MUSCLE RELAXATION as an adjunct to anesthesia during surgery and other medical procedures. It is also often used as an experimental manipulation in basic research. It is not strictly speaking anesthesia but is grouped here with anesthetic techniques. The failure of neuromuscular transmission as a result of pathological processes is not included here.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Neostigmine and calcium antagonized the neuromuscular blockade caused by gentamicin, but augmented that caused by clindamycin." | 3.74 | Calcium and neostigmine antagonize gentamicin, but augment clindamycin-induced tetanic fade in rat phrenic nerve-hemidiaphragm preparations. ( Lee, JH; Lee, JM; Lee, SC; Lee, SI, 2008) |
| "Aminoglycosides have been reported to produce a curare-like neuromuscular blockade in animals at serum concentrations higher than those obtained with traditional dosing (1-2 mg/kg every 8 h) in humans." | 1.29 | Does once-daily dosing of aminoglycosides affect neuromuscular function? ( Brown, G; Wong, J, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lee, SI | 1 |
| Lee, JH | 2 |
| Lee, SC | 1 |
| Lee, JM | 1 |
| Wong, J | 1 |
| Brown, G | 1 |
2 other studies available for gentamicin and Neuromuscular Blockade
| Article | Year |
|---|---|
Calcium and neostigmine antagonize gentamicin, but augment clindamycin-induced tetanic fade in rat phrenic nerve-hemidiaphragm preparations.
Topics: Animals; Anti-Bacterial Agents; Calcium; Clindamycin; Diaphragm; Electric Stimulation; Gentamicins; | 2008 |
Does once-daily dosing of aminoglycosides affect neuromuscular function?
Topics: Anti-Bacterial Agents; Drug Administration Schedule; Female; Gentamicins; Humans; Male; Middle Aged; | 1996 |