gentamicin has been researched along with Nerve Degeneration in 22 studies
Gentamicins: A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.
Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Although pulmonary infections caused by Pseudomonas aeruginosa can hardly be eradicated in patients with cystic fibrosis (CF, the most common genetic disease among Caucasians), these patients are mainly treated with intravenous and nebulized tobramycin." | 3.70 | Loss of spiral ganglion cells as primary manifestation of aminoglycoside ototoxicity. ( Paparella, MM; Schachern, PA; Sone, M, 1998) |
| " In the chinchilla, co-administration of GM and EA can produce hair cell lesions ranging from a small loss of outer hair cells (OHCs) in the base of the cochlea to complete destruction of all hair cells, depending on dosing parameters." | 1.32 | Time course of efferent fiber and spiral ganglion cell degeneration following complete hair cell loss in the chinchilla. ( Ding, D; Jiang, H; McFadden, SL; Salvi, RJ, 2004) |
| "Gentamicin (4%) was injected intratympanically into the middle ear of guinea pigs and the effects on the brainstem evaluated 28 days later by immunohistochemistry with an antibody against glial fibrillary acidic protein to detect astrocytes, and by cytochrome oxidase staining to detect metabolic activity." | 1.30 | Neurodegenerative changes in the guinea pig brainstem after intratympanic injection of gentamicin. ( Hill Britton, B; Rosen, JH; Thompson, AM; Thompson, GC, 1998) |
| " Amikacin causes the most pronounced physiological damage observed by the early loss of Preyer reflex and general toxic signs--these observations correspond with the morphological findings." | 1.26 | [Animal experiments concerning the neurotoxicity of aminoglycosid antibiotics. Electron microscopic findings regarding dose--depending mitochondrial damage in the cochlear nucleus of the guinea pig (author's transl)]. ( Theopold, HM, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (45.45) | 18.7374 |
| 1990's | 4 (18.18) | 18.2507 |
| 2000's | 4 (18.18) | 29.6817 |
| 2010's | 4 (18.18) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Guo, S | 1 |
| Xu, N | 1 |
| Chen, P | 1 |
| Liu, Y | 1 |
| Qi, X | 1 |
| Liu, S | 1 |
| Li, C | 1 |
| Tang, J | 1 |
| Affonso, AC | 1 |
| Machado, DG | 1 |
| Malgarin, F | 1 |
| Fraga, DB | 1 |
| Ghedim, F | 1 |
| Zugno, A | 1 |
| Streck, EL | 1 |
| Schuck, PF | 1 |
| Ferreira, GC | 1 |
| Yu, Q | 1 |
| Chang, Q | 1 |
| Liu, X | 1 |
| Wang, Y | 1 |
| Li, H | 1 |
| Gong, S | 1 |
| Ye, K | 1 |
| Lin, X | 1 |
| Song, BN | 1 |
| Li, YX | 1 |
| Han, DM | 1 |
| Brand, Y | 1 |
| Setz, C | 1 |
| Levano, S | 1 |
| Listyo, A | 1 |
| Chavez, E | 1 |
| Pak, K | 1 |
| Sung, M | 1 |
| Radojevic, V | 1 |
| Ryan, AF | 1 |
| Bodmer, D | 2 |
| McFadden, SL | 1 |
| Ding, D | 1 |
| Jiang, H | 1 |
| Salvi, RJ | 1 |
| Hirose, K | 1 |
| Westrum, LE | 1 |
| Cunningham, DE | 1 |
| Rubel, EW | 1 |
| Albinger-Hegyi, A | 1 |
| Hegyi, I | 1 |
| Nagy, I | 1 |
| Bodmer, M | 1 |
| Schmid, S | 1 |
| Cazals, Y | 1 |
| Aran, JM | 1 |
| Charlet de Sauvage, R | 1 |
| Yamane, H | 1 |
| Nakagawa, T | 1 |
| Iguchi, H | 1 |
| Shibata, S | 1 |
| Takayama, M | 1 |
| Nishimura, K | 1 |
| Nakai, Y | 1 |
| Zheng, JL | 1 |
| Gao, WQ | 1 |
| Sone, M | 1 |
| Schachern, PA | 1 |
| Paparella, MM | 1 |
| Rosen, JH | 1 |
| Thompson, GC | 1 |
| Hill Britton, B | 1 |
| Thompson, AM | 1 |
| Theopold, HM | 1 |
| Cevette, MJ | 1 |
| Franz, KB | 1 |
| Brey, RH | 1 |
| Robinette, MS | 1 |
| Hinojosa, R | 1 |
| Lerner, SA | 1 |
| Ohtani, I | 1 |
| Ohtsuki, K | 1 |
| Aikawa, T | 1 |
| Sato, Y | 1 |
| Anzai, T | 1 |
| Ouchi, J | 1 |
| Saito, T | 1 |
| Forge, A | 1 |
| Ylikoski, J | 4 |
| Wersäll, J | 1 |
| Björkroth, B | 1 |
22 other studies available for gentamicin and Nerve Degeneration
| Article | Year |
|---|---|
Rapamycin Protects Spiral Ganglion Neurons from Gentamicin-Induced Degeneration In Vitro.
Topics: Animals; Cells, Cultured; Female; Gentamicins; Male; Mechanistic Target of Rapamycin Complex 1; Mech | 2019 |
Increased susceptibility of brain acetylcholinesterase activity to methylmalonate in young rats with renal failure.
Topics: Acetylcholinesterase; Amino Acid Metabolism, Inborn Errors; Analysis of Variance; Animals; Brain; Ch | 2013 |
Protection of spiral ganglion neurons from degeneration using small-molecule TrkB receptor agonists.
Topics: Action Potentials; Animals; Animals, Newborn; Anti-Bacterial Agents; Brain-Derived Neurotrophic Fact | 2013 |
Delayed electrical stimulation and BDNF application following induced deafness in rats.
Topics: Animals; Auditory Threshold; Brain-Derived Neurotrophic Factor; Cell Survival; Cochlea; Combined Mod | 2009 |
Simvastatin protects auditory hair cells from gentamicin-induced toxicity and activates Akt signaling in vitro.
Topics: Animals; Animals, Newborn; Disease Models, Animal; Gentamicins; Hair Cells, Auditory; Hearing Loss, | 2011 |
Time course of efferent fiber and spiral ganglion cell degeneration following complete hair cell loss in the chinchilla.
Topics: Acetylcholinesterase; Action Potentials; Animals; Cell Count; Cell Death; Chinchilla; Cochlear Micro | 2004 |
Electron microscopy of degenerative changes in the chick basilar papilla after gentamicin exposure.
Topics: Animals; Animals, Newborn; Chickens; Gentamicins; Microscopy, Electron; Nerve Degeneration; Organ of | 2004 |
Alteration of activator protein 1 DNA binding activity in gentamicin-induced hair cell degeneration.
Topics: Actins; Animals; Binding, Competitive; Cell Nucleus; Cells, Cultured; DNA; Electrophoretic Mobility | 2006 |
Artificial activation and degeneration of the cochlear nerve in guinea pigs.
Topics: Amikacin; Animals; Auditory Cortex; Auditory Perception; Cochlear Nerve; Electric Stimulation; Evoke | 1983 |
In vivo regeneration of vestibular hair cells of guinea pig.
Topics: Animals; Gentamicins; Guinea Pigs; Hair Cells, Vestibular; Nerve Degeneration; Nerve Regeneration | 1995 |
Differential damage to auditory neurons and hair cells by ototoxins and neuroprotection by specific neurotrophins in rat cochlear organotypic cultures.
Topics: Animals; Auditory Pathways; Cisplatin; Cochlea; Collagen; Gentamicins; Hair Cells, Auditory; Nerve D | 1996 |
Loss of spiral ganglion cells as primary manifestation of aminoglycoside ototoxicity.
Topics: Adolescent; Adult; Anti-Bacterial Agents; Child; Cystic Fibrosis; Gentamicins; Hair Cells, Auditory; | 1998 |
Neurodegenerative changes in the guinea pig brainstem after intratympanic injection of gentamicin.
Topics: Animals; Astrocytes; Auditory Pathways; Brain Stem; Ear, Middle; Gentamicins; Glial Fibrillary Acidi | 1998 |
[Animal experiments concerning the neurotoxicity of aminoglycosid antibiotics. Electron microscopic findings regarding dose--depending mitochondrial damage in the cochlear nucleus of the guinea pig (author's transl)].
Topics: Amikacin; Animals; Anti-Bacterial Agents; Cochlear Nerve; Gentamicins; Guinea Pigs; Kanamycin; Mitoc | 1976 |
Influence of dietary magnesium on the amplitude of wave V of the auditory brainstem response.
Topics: Animals; Auditory Threshold; Brain Stem; Evoked Potentials, Auditory; Female; Furosemide; Gentamicin | 1989 |
Cochlear neural degeneration without hair cell loss in two patients with aminoglycoside ototoxicity.
Topics: Adult; Cochlea; Female; Gentamicins; Hair Cells, Auditory; Hearing Disorders; Humans; Labyrinth Dise | 1987 |
Low ototoxicity and its mechanism of netilmicin.
Topics: Amikacin; Aminoglycosides; Animals; Dibekacin; Gentamicins; Hair Cells, Auditory; Kanamycin; Kidney; | 1985 |
Outer hair cell loss and supporting cell expansion following chronic gentamicin treatment.
Topics: Animals; Cell Count; Gentamicins; Guinea Pigs; Hair Cells, Auditory; Labyrinth Supporting Cells; Mic | 1985 |
Correlative studies on the cochlear pathology and hearing loss in guinea-pigs after intoxication with ototoxic antibiotics.
Topics: Animals; Auditory Threshold; Cochlea; Depression, Chemical; Gentamicins; Guinea Pigs; Hearing; Heari | 1974 |
Degeneration of neural elements in the cochlea of the guinea-pig after damage to the organ of corti by ototoxic antibiotics.
Topics: Animals; Cochlea; Depression, Chemical; Gentamicins; Golgi Apparatus; Guinea Pigs; Kanamycin; Neomyc | 1974 |
Correlation between pure tone audiogram and cochlear pathology in guinea-pigs intoxicated with ototoxic antibiotics.
Topics: Animals; Audiometry; Auditory Threshold; Cochlea; Depression, Chemical; Dose-Response Relationship, | 1974 |
Guinea-pig hair cell pathology from ototoxic antibiotics.
Topics: Animals; Cilia; Cochlea; Depression, Chemical; Dose-Response Relationship, Drug; Epithelial Cells; E | 1974 |