gentamicin has been researched along with Nephritis, Interstitial in 24 studies
Gentamicins: A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.
Nephritis, Interstitial: Inflammation of the interstitial tissue of the kidney. This term is generally used for primary inflammation of KIDNEY TUBULES and/or surrounding interstitium. For primary inflammation of glomerular interstitium, see GLOMERULONEPHRITIS. Infiltration of the inflammatory cells into the interstitial compartment results in EDEMA, increased spaces between the tubules, and tubular renal dysfunction.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We report a case of a 51-year-old male who was treated with vancomycin and gentamicin for primary osteomyelitis with methicillin resistant Staphyloccocus aureus bacteremia." | 7.76 | Biopsy proven interstitial nephritis following treatment with vancomycin: a case report. ( Ehsan, M; Graeber, C; Matthews, M; Posadas, A; Salazar, MN, 2010) |
| "These data show that inhibition of NF-kappaB activation attenuates tubulointerstitial nephritis induced by gentamicin." | 7.72 | Inhibition of nuclear factor-kappaB activation attenuates tubulointerstitial nephritis induced by gentamicin. ( Coimbra, TM; Costa, RS; da Silva, CG; Volpini, RA, 2004) |
| "Two patients developed acute interstitial nephritis (AIN) following treatment with mezlocillin sodium." | 7.67 | Acute interstitial nephritis associated with mezlocillin, nafcillin, and gentamicin treatment for Pseudomonas infection. ( Bauman, J; Copley, JB; Cushner, HM; Hill, SC, 1985) |
| " We report a case of a 51-year-old male who was treated with vancomycin and gentamicin for primary osteomyelitis with methicillin resistant Staphyloccocus aureus bacteremia." | 3.76 | Biopsy proven interstitial nephritis following treatment with vancomycin: a case report. ( Ehsan, M; Graeber, C; Matthews, M; Posadas, A; Salazar, MN, 2010) |
| " We report a case of acute interstitial nephritis induced by immunoallergic drug mechanisms, in a 3-week-old infant who presented with acute renal failure associated with eosinophilia and hepatitis and who had received cefotaxime and gentamicin." | 3.76 | [A neonatal case of immunoallergic acute interstitial nephritis]. ( Allani-Essid, N; Bataille, J; Essid, A; Estournet, B; Rubinsztajn, R, 2010) |
| "These data show that inhibition of NF-kappaB activation attenuates tubulointerstitial nephritis induced by gentamicin." | 3.72 | Inhibition of nuclear factor-kappaB activation attenuates tubulointerstitial nephritis induced by gentamicin. ( Coimbra, TM; Costa, RS; da Silva, CG; Volpini, RA, 2004) |
| "Two patients developed acute interstitial nephritis (AIN) following treatment with mezlocillin sodium." | 3.67 | Acute interstitial nephritis associated with mezlocillin, nafcillin, and gentamicin treatment for Pseudomonas infection. ( Bauman, J; Copley, JB; Cushner, HM; Hill, SC, 1985) |
| "Interstitial nephritis with acute renal failure was observed in 5 cases out of 6 treated by the association of methicillin and gentamycin, wheras no case, was observed when each of these antibodies was used separately." | 3.65 | [The nephrotoxicity of the methicillin-gentamycin combination. Apropos of 5 cases]. ( Becq-Giraudon, B; Pourrat, O; Sudre, Y; Yver, L, 1976) |
| "Gentamicin is an aminoglycoside antibiotic that induces severe nephrotoxicity and acute renal failure." | 1.35 | Role of tissue kallikrein in prevention and recovery of gentamicin-induced renal injury. ( Bledsoe, G; Chao, J; Chao, L; Grass, D; Hagiwara, M; Mizell, B; Shen, B; Teuton, M; Yao, YY, 2008) |
| "Gentamicin-treated rats presented a transitory increase in plasma creatinine levels." | 1.33 | Increased expression of p38 mitogen-activated protein kinase is related to the acute renal lesions induced by gentamicin. ( Balbi, AP; Coimbra, TM; Costa, RS; Volpini, RA, 2006) |
| "Kidney histology of the tissue from GM-treated rats showed necrosis and desquamation of tubular epithelial cells in renal cortex as well as interstitial nephritis." | 1.31 | Protective effects of oral arabic gum administration on gentamicin-induced nephrotoxicity in rats. ( Al-Majed, AA; Al-Rikabi, AC; Al-Shabanah, OA; Mostafa, AM, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (66.67) | 18.7374 |
| 1990's | 1 (4.17) | 18.2507 |
| 2000's | 5 (20.83) | 29.6817 |
| 2010's | 2 (8.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Salazar, MN | 1 |
| Matthews, M | 1 |
| Posadas, A | 1 |
| Ehsan, M | 1 |
| Graeber, C | 1 |
| Essid, A | 1 |
| Allani-Essid, N | 1 |
| Rubinsztajn, R | 1 |
| Estournet, B | 1 |
| Bataille, J | 1 |
| Al-Majed, AA | 1 |
| Mostafa, AM | 1 |
| Al-Rikabi, AC | 1 |
| Al-Shabanah, OA | 1 |
| Volpini, RA | 2 |
| Costa, RS | 2 |
| da Silva, CG | 1 |
| Coimbra, TM | 2 |
| Rangan, GK | 1 |
| Wang, Y | 1 |
| Tay, YC | 1 |
| Coombes, JD | 1 |
| Harris, DC | 1 |
| Balbi, AP | 1 |
| Bledsoe, G | 1 |
| Shen, B | 1 |
| Yao, YY | 1 |
| Hagiwara, M | 1 |
| Mizell, B | 1 |
| Teuton, M | 1 |
| Grass, D | 1 |
| Chao, L | 1 |
| Chao, J | 1 |
| Pusey, CD | 3 |
| Saltissi, D | 3 |
| Bloodworth, L | 1 |
| Rainford, DJ | 3 |
| Christie, JL | 1 |
| Kourilsky, O | 1 |
| Solez, K | 1 |
| Morel-Maroger, L | 1 |
| Whelton, A | 1 |
| Duhoux, P | 1 |
| Sraer, JD | 1 |
| Cronin, RE | 1 |
| Bulger, RE | 1 |
| Southern, P | 1 |
| Henrich, WL | 1 |
| Bell, GM | 1 |
| Thomson, D | 1 |
| Thomsen, HS | 1 |
| Dorph, S | 1 |
| Larsen, S | 1 |
| Horn, T | 1 |
| Hemmingsen, L | 1 |
| Skaarup, P | 1 |
| Golman, K | 1 |
| Svendsen, O | 1 |
| Yver, L | 1 |
| Becq-Giraudon, B | 1 |
| Pourrat, O | 1 |
| Sudre, Y | 1 |
| Flynn, CT | 1 |
| Sweet, R | 1 |
| Houghton, DC | 1 |
| English, J | 1 |
| Bennett, WM | 1 |
| Chakŭrski, I | 1 |
| Minkova, V | 1 |
| Belovezhdov, N | 1 |
| Cushner, HM | 1 |
| Copley, JB | 1 |
| Bauman, J | 1 |
| Hill, SC | 1 |
| Fillastre, JP | 1 |
| Woodroffe, AJ | 1 |
| Thomson, NM | 1 |
| Meadows, R | 1 |
| Lawrence, JR | 1 |
| Plafker, J | 1 |
| Mioli, V | 1 |
| Albertazzi, A | 1 |
| Scolari, P | 1 |
| Bortolotti, GC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Double-Blind, Randomized, Placebo-Controlled, First-in-Human Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Orally Administered DF-003 Following Single (Part 1) and Multiple (Part 2) Ascending Doses in Healthy Subjects[NCT05997641] | Phase 1 | 96 participants (Anticipated) | Interventional | 2023-09-15 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
24 other studies available for gentamicin and Nephritis, Interstitial
| Article | Year |
|---|---|
Biopsy proven interstitial nephritis following treatment with vancomycin: a case report.
Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents; Biopsy; Gentamicins; Humans; Male; Methicillin-Resi | 2010 |
[A neonatal case of immunoallergic acute interstitial nephritis].
Topics: Acute Disease; Anti-Bacterial Agents; Cefotaxime; Eosinophilia; Gentamicins; Hepatitis; Humans; Infa | 2010 |
Protective effects of oral arabic gum administration on gentamicin-induced nephrotoxicity in rats.
Topics: Administration, Oral; Animals; Gentamicins; Gum Arabic; Injections, Intraperitoneal; Kidney Tubules, | 2002 |
Inhibition of nuclear factor-kappaB activation attenuates tubulointerstitial nephritis induced by gentamicin.
Topics: Animals; Creatinine; Female; Gentamicins; Immunohistochemistry; Kidney; Kidney Cortex; Macrophages; | 2004 |
Effect of nephrotoxins on tubulointerstitial injury and NF-kappaB activation in Adriamycin nephropathy.
Topics: Animals; Biopsy, Needle; Disease Models, Animal; Dose-Response Relationship, Drug; Doxorubicin; Ferr | 2005 |
Increased expression of p38 mitogen-activated protein kinase is related to the acute renal lesions induced by gentamicin.
Topics: Animals; Anti-Bacterial Agents; Blotting, Western; Creatinine; Female; Fibrosis; Gentamicins; Immuno | 2006 |
Role of tissue kallikrein in prevention and recovery of gentamicin-induced renal injury.
Topics: Acute Kidney Injury; Animals; Anti-Bacterial Agents; Apoptosis; Blood Pressure; Blood Urea Nitrogen; | 2008 |
Drug associated acute interstitial nephritis: clinical and pathological features and the response to high dose steroid therapy.
Topics: Acetaminophen; Acute Disease; Adult; Ampicillin; Anti-Infective Agents, Urinary; Bendroflumethiazide | 1983 |
The pathology of acute renal failure due to interstitial nephritis in man with comments on the role of interstitial inflammation and sex in gentamicin nephrotoxicity.
Topics: Acute Kidney Injury; Animals; Creatinine; Female; Fluorescent Antibody Technique; Gentamicins; Human | 1982 |
Natural history of aminoglycoside nephrotoxicity in the dog.
Topics: Animals; Dogs; Electrolytes; Gentamicins; Glomerular Filtration Rate; Glucose; Glycosuria; Kidney Tu | 1980 |
Acute interstitial nephritis associated with gentamicin and lincomycin therapy.
Topics: Acute Disease; Aged; Female; Gentamicins; Humans; Kidney Tubules; Lincomycin; Nephritis, Interstitia | 1980 |
Urine profiles and kidney histologic findings after intravenous injection of mannitol and iohexol in the degeneration phase of gentamicin nephropathy in rats.
Topics: Animals; Blood Chemical Analysis; Disease Models, Animal; Gentamicins; Injections, Intravenous; Iohe | 1993 |
[The nephrotoxicity of the methicillin-gentamycin combination. Apropos of 5 cases].
Topics: Adolescent; Adult; Aged; Drug Therapy, Combination; Eosinophilia; Fever; Gentamicins; Hematuria; Hum | 1976 |
Recurrent acute renal failure due to antibiotic-induced interstitial nephritis.
Topics: Acute Kidney Injury; Drug Combinations; Gentamicins; Humans; Male; Middle Aged; Nephritis, Interstit | 1979 |
Antibiotic-induced interstitial nephritis?
Topics: Drug Combinations; Gentamicins; Humans; Male; Nephritis, Interstitial; Sulfamethoxazole; Trimethopri | 1979 |
Antibiotic-induced interstitial nephritis?
Topics: Gentamicins; Humans; Kidney; Nephritis, Interstitial | 1979 |
Ampicillin sodium and nephrotoxicity.
Topics: Acute Kidney Injury; Ampicillin; Gentamicins; Humans; Kidney; Nephritis, Interstitial | 1977 |
Chronic tubulointerstitial nephritis and renal insufficiency associated with long-term "subtherapeutic" gentamicin.
Topics: Animals; Autoradiography; Gentamicins; Glomerular Filtration Rate; Inulin; Kidney Failure, Chronic; | 1988 |
[Acute interstitial nephritis following the use of gentamycin].
Topics: Acute Disease; Gentamicins; Humans; Male; Middle Aged; Nephritis, Interstitial; Time Factors | 1986 |
Acute interstitial nephritis associated with mezlocillin, nafcillin, and gentamicin treatment for Pseudomonas infection.
Topics: Acute Disease; Aged; Creatinine; Drug Synergism; Gentamicins; Humans; Male; Mezlocillin; Nafcillin; | 1985 |
[Tubulointerstitial nephropathies due to antibiotics].
Topics: Acute Kidney Injury; Anti-Bacterial Agents; Cephalexin; Cephaloridine; Cephalothin; Drug Hypersensit | 1973 |
Nephropathy associated with methicillin administration.
Topics: Acidosis; Aged; Biopsy; Chlorides; Eosinophilia; Female; Gentamicins; Humans; Immunoglobulins; Kanam | 1974 |
Penicillin-related nephritis and myocarditis: a case report.
Topics: Aged; Ampicillin; Cephalothin; Chloramphenicol; Gentamicins; Humans; Kidney; Male; Myocarditis; Myoc | 1971 |
[Study of the nephrotoxicity of gentamicin in humans].
Topics: Adult; Aged; Female; Gentamicins; Humans; Kidney; Kidney Diseases; Kidney Function Tests; Male; Midd | 1971 |