gentamicin has been researched along with Muscular Dystrophy, Duchenne in 23 studies
Gentamicins: A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.
Muscular Dystrophy, Duchenne: An X-linked recessive muscle disease caused by an inability to synthesize DYSTROPHIN, which is involved with maintaining the integrity of the sarcolemma. Muscle fibers undergo a process that features degeneration and regeneration. Clinical manifestations include proximal weakness in the first few years of life, pseudohypertrophy, cardiomyopathy (see MYOCARDIAL DISEASES), and an increased incidence of impaired mentation. Becker muscular dystrophy is a closely related condition featuring a later onset of disease (usually adolescence) and a slowly progressive course. (Adams et al., Principles of Neurology, 6th ed, p1415)
| Excerpt | Relevance | Reference |
|---|---|---|
| "A subset of patients with Duchenne and Becker muscular dystrophy similarly possess a nonsense mutation, causing premature termination of dystrophin translation." | 5.31 | Gentamicin treatment of Duchenne and Becker muscular dystrophy due to nonsense mutations. ( Burstein, AH; Escolar, DM; Fischbeck, KH; Gropman, AL; Hadley, DW; Hamed, S; Hoffman, EP; Wagner, KR, 2001) |
| "The objective of this study was to establish the feasibility of long-term gentamicin dosing to achieve stop codon readthrough and produce full-length dystrophin." | 2.75 | Gentamicin-induced readthrough of stop codons in Duchenne muscular dystrophy. ( Al-Dahhak, R; Banwell, B; Barohn, RJ; Bien-Willner, R; Campbell, KJ; Dasouki, M; Flanigan, KM; Hayes, J; King, W; Kota, J; Lewis, S; Mahan, JD; Malik, V; Mendell, JR; Rodino-Klapac, LR; Sahenk, Z; Serrano-Munuera, C; Shilling, CJ; Sivakumar, K; Viollet, L; Walker, CM; Wall, C; Watts, V, 2010) |
| "Since gentamicin is applied only for Duchenne muscular dystrophy caused by a nonsense mutation, genetic diagnosis of DMD is reviewed." | 2.42 | [Treatment of Duchenne muscular dystrophy with gentamicin]. ( Ishibashi, K; Matsuo, M; Takeshima, Y; Wada, H; Yagi, M, 2004) |
| "Gene transfer research for Duchenne muscular dystrophy (DMD) has brought the goal of successful treatment of this devastating, inherited disease closer to being a reality." | 2.41 | Progress in gene therapy for Duchenne muscular dystrophy. ( Clemens, PR; Duncan, FJ, 2001) |
| "A subset of patients with Duchenne and Becker muscular dystrophy similarly possess a nonsense mutation, causing premature termination of dystrophin translation." | 1.31 | Gentamicin treatment of Duchenne and Becker muscular dystrophy due to nonsense mutations. ( Burstein, AH; Escolar, DM; Fischbeck, KH; Gropman, AL; Hadley, DW; Hamed, S; Hoffman, EP; Wagner, KR, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (4.35) | 18.2507 |
| 2000's | 14 (60.87) | 29.6817 |
| 2010's | 7 (30.43) | 24.3611 |
| 2020's | 1 (4.35) | 2.80 |
| Authors | Studies |
|---|---|
| Bidou, L | 1 |
| Bugaud, O | 1 |
| Merer, G | 1 |
| Coupet, M | 1 |
| Hatin, I | 1 |
| Chirkin, E | 1 |
| Karri, S | 1 |
| Demais, S | 1 |
| François, P | 1 |
| Cintrat, JC | 1 |
| Namy, O | 1 |
| Takeshima, Y | 4 |
| Wolf, A | 1 |
| Schaack, J | 1 |
| Freikamp, L | 1 |
| Reutzel, S | 1 |
| Zündorf, I | 1 |
| Dingermann, T | 1 |
| Kondo, E | 1 |
| Kawamichi, Y | 1 |
| Sagara, Y | 1 |
| Saito, K | 1 |
| Matsuo, M | 3 |
| McNeil, DE | 1 |
| Davis, C | 1 |
| Jillapalli, D | 1 |
| Targum, S | 1 |
| Durmowicz, A | 1 |
| Coté, TR | 1 |
| Nudelman, I | 1 |
| Glikin, D | 1 |
| Smolkin, B | 1 |
| Hainrichson, M | 1 |
| Belakhov, V | 1 |
| Baasov, T | 1 |
| Malik, V | 1 |
| Rodino-Klapac, LR | 1 |
| Viollet, L | 1 |
| Wall, C | 1 |
| King, W | 1 |
| Al-Dahhak, R | 1 |
| Lewis, S | 1 |
| Shilling, CJ | 1 |
| Kota, J | 1 |
| Serrano-Munuera, C | 1 |
| Hayes, J | 1 |
| Mahan, JD | 1 |
| Campbell, KJ | 1 |
| Banwell, B | 1 |
| Dasouki, M | 1 |
| Watts, V | 1 |
| Sivakumar, K | 1 |
| Bien-Willner, R | 1 |
| Flanigan, KM | 2 |
| Sahenk, Z | 1 |
| Barohn, RJ | 1 |
| Walker, CM | 1 |
| Mendell, JR | 1 |
| Pichavant, C | 1 |
| Aartsma-Rus, A | 1 |
| Clemens, PR | 2 |
| Davies, KE | 1 |
| Dickson, G | 1 |
| Takeda, S | 2 |
| Wilton, SD | 1 |
| Wolff, JA | 1 |
| Wooddell, CI | 1 |
| Xiao, X | 1 |
| Tremblay, JP | 1 |
| Yukihara, M | 1 |
| Ito, K | 2 |
| Tanoue, O | 1 |
| Goto, K | 1 |
| Matsushita, T | 1 |
| Matsumoto, Y | 1 |
| Masuda, M | 1 |
| Kimura, S | 2 |
| Ueoka, R | 1 |
| Kayali, R | 1 |
| Ku, JM | 1 |
| Khitrov, G | 1 |
| Jung, ME | 1 |
| Prikhodko, O | 1 |
| Bertoni, C | 1 |
| Politano, L | 1 |
| Nigro, G | 1 |
| Nigro, V | 1 |
| Piluso, G | 1 |
| Papparella, S | 1 |
| Paciello, O | 1 |
| Comi, LI | 1 |
| Arakawa, M | 1 |
| Shiozuka, M | 1 |
| Nakayama, Y | 1 |
| Hara, T | 1 |
| Hamada, M | 1 |
| Kondo, S | 1 |
| Ikeda, D | 1 |
| Takahashi, Y | 1 |
| Sawa, R | 1 |
| Nonomura, Y | 1 |
| Sheykholeslami, K | 1 |
| Kondo, K | 1 |
| Kaga, K | 1 |
| Kitamura, T | 1 |
| Suzuki-Miyagoe, Y | 1 |
| Matsuda, R | 1 |
| Yagi, M | 1 |
| Ishibashi, K | 1 |
| Wada, H | 1 |
| Miyagi, T | 1 |
| Hiranuma, T | 1 |
| Yoshioka, K | 1 |
| Ozasa, S | 1 |
| Matsukura, M | 1 |
| Ikezawa, M | 1 |
| Miike, T | 1 |
| Zhang, S | 1 |
| Xie, H | 1 |
| Zhou, G | 1 |
| Yang, Z | 1 |
| Senior, K | 1 |
| Howard, MT | 1 |
| Shirts, BH | 1 |
| Petros, LM | 1 |
| Gesteland, RF | 1 |
| Atkins, JF | 1 |
| Karpati, G | 1 |
| Lochmuller, H | 1 |
| Wagner, KR | 1 |
| Hamed, S | 1 |
| Hadley, DW | 1 |
| Gropman, AL | 1 |
| Burstein, AH | 1 |
| Escolar, DM | 1 |
| Hoffman, EP | 1 |
| Fischbeck, KH | 1 |
| Ishihara, T | 2 |
| Duncan, FJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Six Month Randomized, Clinical Trial of Gentamicin in Duchenne Muscular Dystrophy Subjects With Stop Codon Mutations[NCT00451074] | Phase 1 | 12 participants (Actual) | Interventional | 2007-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
8 reviews available for gentamicin and Muscular Dystrophy, Duchenne
| Article | Year |
|---|---|
[Genetic Diagnosis and Molecular Therapies for Duchenne Muscular Dystrophy].
Topics: Animals; Codon, Nonsense; Dibekacin; Dystrophin; Exons; Gentamicins; Humans; Mice; Molecular Targete | 2015 |
[Mutation-specific treatments for Duchenne muscular dystrophy].
Topics: Animals; Clinical Trials as Topic; Codon, Nonsense; Dystrophin; Exons; Frameshift Mutation; Genetic | 2009 |
Current status of pharmaceutical and genetic therapeutic approaches to treat DMD.
Topics: Dystrophin; Genetic Therapy; Gentamicins; Humans; Male; Muscle Fibers, Skeletal; Muscular Dystrophy, | 2011 |
[Treatment of Duchenne muscular dystrophy with gentamicin].
Topics: Animals; Codon, Nonsense; Dystrophin; Gentamicins; Humans; Mice; Molecular Diagnostic Techniques; Mu | 2004 |
Development of therapy for Duchenne muscular dystrophy.
Topics: Animals; Anti-Bacterial Agents; Cell Transplantation; Dystrophin; Gene Expression Regulation; Geneti | 2007 |
[Duchenne muscular dystrophy].
Topics: Animals; Diagnosis, Differential; Dystrophin; Genetic Therapy; Gentamicins; Heart Failure; Humans; I | 2001 |
[Becker muscular dystrophy].
Topics: Diagnosis, Differential; Dystrophin; Female; Genetic Therapy; Gentamicins; Heart Failure; Humans; In | 2001 |
Progress in gene therapy for Duchenne muscular dystrophy.
Topics: Anti-Bacterial Agents; Cytoskeletal Proteins; Genetic Therapy; Genetic Vectors; Gentamicins; Humans; | 2001 |
2 trials available for gentamicin and Muscular Dystrophy, Duchenne
| Article | Year |
|---|---|
Gentamicin-induced readthrough of stop codons in Duchenne muscular dystrophy.
Topics: Adolescent; Audiometry; Child; Child, Preschool; Codon, Terminator; Cohort Studies; Creatine Kinase; | 2010 |
Gentamicin administration in Duchenne patients with premature stop codon. Preliminary results.
Topics: Anti-Bacterial Agents; Child; Child, Preschool; Codon, Nonsense; Drug Administration Schedule; Dystr | 2003 |
13 other studies available for gentamicin and Muscular Dystrophy, Duchenne
| Article | Year |
|---|---|
2-Guanidino-quinazoline promotes the readthrough of nonsense mutations underlying human genetic diseases.
Topics: Cell Line; Codon, Nonsense; Codon, Terminator; Drug Evaluation, Preclinical; Genes, Reporter; Geneti | 2022 |
[Don't stop me now!].
Topics: Animals; Anti-Bacterial Agents; Cystic Fibrosis; Dystrophin; Gene Deletion; Genetic Therapy; Gentami | 2008 |
[Combination therapy of corticosteroid and gentamicin for Duchenne muscular dystrophy--a basic study].
Topics: Animals; Cells, Cultured; Drug Therapy, Combination; Dystrophin; Gentamicins; Humans; Male; Mice; Mi | 2009 |
Duchenne muscular dystrophy: Drug development and regulatory considerations.
Topics: Androgens; Animals; Clinical Trials as Topic; Drug Therapy; Gentamicins; Humans; Legislation, Drug; | 2010 |
Repairing faulty genes by aminoglycosides: development of new derivatives of geneticin (G418) with enhanced suppression of diseases-causing nonsense mutations.
Topics: Aminoglycosides; Animals; Codon, Nonsense; Cystic Fibrosis; Drug Design; Genetic Diseases, Inborn; G | 2010 |
Effective drug delivery system for duchenne muscular dystrophy using hybrid liposomes including gentamicin along with reduced toxicity.
Topics: Animals; Drug Delivery Systems; Female; Gentamicins; Liposomes; Male; Mice; Microscopy, Confocal; Mu | 2011 |
Read-through compound 13 restores dystrophin expression and improves muscle function in the mdx mouse model for Duchenne muscular dystrophy.
Topics: Animals; Codon, Nonsense; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, | 2012 |
Negamycin restores dystrophin expression in skeletal and cardiac muscles of mdx mice.
Topics: Amino Acids, Diamino; Animals; Body Weight; Brain Stem; Dystrophin; Gene Expression Regulation; Gent | 2003 |
A novel approach to identify Duchenne muscular dystrophy patients for aminoglycoside antibiotics therapy.
Topics: Anti-Bacterial Agents; Blotting, Western; Brain; Cells, Cultured; Codon, Nonsense; Codon, Terminator | 2005 |
Duchenne muscular dystrophy improved by gentamicin.
Topics: Animals; Cystic Fibrosis; Dystrophin; Female; Gentamicins; Humans; Male; Mice; Mice, Inbred mdx; Mus | 1999 |
Sequence specificity of aminoglycoside-induced stop condon readthrough: potential implications for treatment of Duchenne muscular dystrophy.
Topics: Animals; Anti-Bacterial Agents; Cells, Cultured; Codon, Nonsense; Codon, Terminator; Dystrophin; Gen | 2000 |
When running a stop sign may be a good thing.
Topics: Animals; Codon, Nonsense; Dystrophin; Gentamicins; Humans; Mice; Mice, Inbred mdx; Muscular Dystroph | 2001 |
Gentamicin treatment of Duchenne and Becker muscular dystrophy due to nonsense mutations.
Topics: Adolescent; Biopsy; Blotting, Western; Child; Codon, Nonsense; Creatine Kinase; Dystrophin; Gentamic | 2001 |