Page last updated: 2024-10-27

gentamicin and Muscular Dystrophies

gentamicin has been researched along with Muscular Dystrophies in 5 studies

Gentamicins: A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.

Muscular Dystrophies: A heterogeneous group of inherited MYOPATHIES, characterized by wasting and weakness of the SKELETAL MUSCLE. They are categorized by the sites of MUSCLE WEAKNESS; AGE OF ONSET; and INHERITANCE PATTERNS.

Research Excerpts

ExcerptRelevanceReference
"In this case report of a woman in her 30s with EBS-MD, before gentamicin treatment, the patient had mucocutaneous involvement, skeletal and respiratory muscle weakness, and myalgia that negatively affected her quality of life."8.12Evaluation of Systemic Gentamicin as Translational Readthrough Therapy for a Patient With Epidermolysis Bullosa Simplex With Muscular Dystrophy Owing to PLEC1 Pathogenic Nonsense Variants. ( de Arriba, MDC; de Lucas, R; Del Río, M; Duarte, B; Escámez, MJ; Esteban-Rodríguez, I; García, M; Guerrero-Aspizúa, S; Hernández-Fernández, CP; Illera, N; Larcher, F; Martínez-Santamaría, L; Mascías, J; Maseda, R; Membrilla, JA; Quintana, L; Sigüenza, AI; Woodley, DT, 2022)
"The suppression levels induced by gentamicin on premature stop codons, caused by primary nonsense mutations found in muscular dystrophy patients, were assessed using a very sensitive dual reporter gene assay."7.72Premature stop codons involved in muscular dystrophies show a broad spectrum of readthrough efficiencies in response to gentamicin treatment. ( Allamand, V; Bidou, L; Hatin, I; Panthier, JJ; Perez, N; Rousset, JP, 2004)
" In order to utilize other antibiotics with less side effects than gentamicin, we have shown that negamycin, a dipeptide antibiotic with read-through activity in prokaryotes, restored dystrophin in skeletal and cardiac muscles of mdx mouse, an animal model for Duchenne type muscular dystrophy caused by nonsense mutation."4.82[Possible chemotherapy of muscular dystrophy caused by nonsense mutation]. ( Arakawa, M; Matsuda, R; Shiozuka, M, 2004)
"In this case report of a woman in her 30s with EBS-MD, before gentamicin treatment, the patient had mucocutaneous involvement, skeletal and respiratory muscle weakness, and myalgia that negatively affected her quality of life."4.12Evaluation of Systemic Gentamicin as Translational Readthrough Therapy for a Patient With Epidermolysis Bullosa Simplex With Muscular Dystrophy Owing to PLEC1 Pathogenic Nonsense Variants. ( de Arriba, MDC; de Lucas, R; Del Río, M; Duarte, B; Escámez, MJ; Esteban-Rodríguez, I; García, M; Guerrero-Aspizúa, S; Hernández-Fernández, CP; Illera, N; Larcher, F; Martínez-Santamaría, L; Mascías, J; Maseda, R; Membrilla, JA; Quintana, L; Sigüenza, AI; Woodley, DT, 2022)
"The suppression levels induced by gentamicin on premature stop codons, caused by primary nonsense mutations found in muscular dystrophy patients, were assessed using a very sensitive dual reporter gene assay."3.72Premature stop codons involved in muscular dystrophies show a broad spectrum of readthrough efficiencies in response to gentamicin treatment. ( Allamand, V; Bidou, L; Hatin, I; Panthier, JJ; Perez, N; Rousset, JP, 2004)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (20.00)18.2507
2000's3 (60.00)29.6817
2010's0 (0.00)24.3611
2020's1 (20.00)2.80

Authors

AuthorsStudies
Martínez-Santamaría, L1
Maseda, R1
de Arriba, MDC1
Membrilla, JA1
Sigüenza, AI1
Mascías, J1
García, M1
Quintana, L1
Esteban-Rodríguez, I1
Hernández-Fernández, CP1
Illera, N1
Duarte, B1
Guerrero-Aspizúa, S1
Woodley, DT1
Del Río, M1
de Lucas, R1
Larcher, F1
Escámez, MJ1
Bidou, L2
Hatin, I1
Perez, N1
Allamand, V2
Panthier, JJ1
Rousset, JP2
Shiozuka, M2
Arakawa, M2
Matsuda, R2
Floquet, C1
Paturneau-Jouas, M1
Gartioux, C1
Butler-Browne, GS1
Mouly, V1
Ikeda, D1
Guicheney, P1
Mankin, AS1
Liebman, SW1

Reviews

1 review available for gentamicin and Muscular Dystrophies

ArticleYear
[Possible chemotherapy of muscular dystrophy caused by nonsense mutation].
    Rinsho shinkeigaku = Clinical neurology, 2004, Volume: 44, Issue:11

    Topics: Amino Acids, Diamino; Animals; Gentamicins; Humans; Muscular Dystrophies; Protein Biosynthesis

2004

Other Studies

4 other studies available for gentamicin and Muscular Dystrophies

ArticleYear
Evaluation of Systemic Gentamicin as Translational Readthrough Therapy for a Patient With Epidermolysis Bullosa Simplex With Muscular Dystrophy Owing to PLEC1 Pathogenic Nonsense Variants.
    JAMA dermatology, 2022, 04-01, Volume: 158, Issue:4

    Topics: Epidermolysis Bullosa Simplex; Female; Gentamicins; Humans; Muscular Dystrophies; Muscular Dystrophi

2022
Premature stop codons involved in muscular dystrophies show a broad spectrum of readthrough efficiencies in response to gentamicin treatment.
    Gene therapy, 2004, Volume: 11, Issue:7

    Topics: 3T3 Cells; Animals; Anti-Bacterial Agents; beta-Galactosidase; Codon, Nonsense; Codon, Terminator; C

2004
Drug-induced readthrough of premature stop codons leads to the stabilization of laminin alpha2 chain mRNA in CMD myotubes.
    The journal of gene medicine, 2008, Volume: 10, Issue:2

    Topics: Amino Acids, Diamino; Animals; Cells, Cultured; Codon, Nonsense; Gene Expression Regulation; Genes,

2008
Baby, don't stop!
    Nature genetics, 1999, Volume: 23, Issue:1

    Topics: Animals; Anti-Bacterial Agents; Codon, Nonsense; Genes, Bacterial; Genetic Engineering; Genetic Ther

1999