gentamicin has been researched along with Muscular Dystrophies in 5 studies
Gentamicins: A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.
Muscular Dystrophies: A heterogeneous group of inherited MYOPATHIES, characterized by wasting and weakness of the SKELETAL MUSCLE. They are categorized by the sites of MUSCLE WEAKNESS; AGE OF ONSET; and INHERITANCE PATTERNS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In this case report of a woman in her 30s with EBS-MD, before gentamicin treatment, the patient had mucocutaneous involvement, skeletal and respiratory muscle weakness, and myalgia that negatively affected her quality of life." | 8.12 | Evaluation of Systemic Gentamicin as Translational Readthrough Therapy for a Patient With Epidermolysis Bullosa Simplex With Muscular Dystrophy Owing to PLEC1 Pathogenic Nonsense Variants. ( de Arriba, MDC; de Lucas, R; Del Río, M; Duarte, B; Escámez, MJ; Esteban-Rodríguez, I; García, M; Guerrero-Aspizúa, S; Hernández-Fernández, CP; Illera, N; Larcher, F; Martínez-Santamaría, L; Mascías, J; Maseda, R; Membrilla, JA; Quintana, L; Sigüenza, AI; Woodley, DT, 2022) |
| "The suppression levels induced by gentamicin on premature stop codons, caused by primary nonsense mutations found in muscular dystrophy patients, were assessed using a very sensitive dual reporter gene assay." | 7.72 | Premature stop codons involved in muscular dystrophies show a broad spectrum of readthrough efficiencies in response to gentamicin treatment. ( Allamand, V; Bidou, L; Hatin, I; Panthier, JJ; Perez, N; Rousset, JP, 2004) |
| " In order to utilize other antibiotics with less side effects than gentamicin, we have shown that negamycin, a dipeptide antibiotic with read-through activity in prokaryotes, restored dystrophin in skeletal and cardiac muscles of mdx mouse, an animal model for Duchenne type muscular dystrophy caused by nonsense mutation." | 4.82 | [Possible chemotherapy of muscular dystrophy caused by nonsense mutation]. ( Arakawa, M; Matsuda, R; Shiozuka, M, 2004) |
| "In this case report of a woman in her 30s with EBS-MD, before gentamicin treatment, the patient had mucocutaneous involvement, skeletal and respiratory muscle weakness, and myalgia that negatively affected her quality of life." | 4.12 | Evaluation of Systemic Gentamicin as Translational Readthrough Therapy for a Patient With Epidermolysis Bullosa Simplex With Muscular Dystrophy Owing to PLEC1 Pathogenic Nonsense Variants. ( de Arriba, MDC; de Lucas, R; Del Río, M; Duarte, B; Escámez, MJ; Esteban-Rodríguez, I; García, M; Guerrero-Aspizúa, S; Hernández-Fernández, CP; Illera, N; Larcher, F; Martínez-Santamaría, L; Mascías, J; Maseda, R; Membrilla, JA; Quintana, L; Sigüenza, AI; Woodley, DT, 2022) |
| "The suppression levels induced by gentamicin on premature stop codons, caused by primary nonsense mutations found in muscular dystrophy patients, were assessed using a very sensitive dual reporter gene assay." | 3.72 | Premature stop codons involved in muscular dystrophies show a broad spectrum of readthrough efficiencies in response to gentamicin treatment. ( Allamand, V; Bidou, L; Hatin, I; Panthier, JJ; Perez, N; Rousset, JP, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 3 (60.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Martínez-Santamaría, L | 1 |
| Maseda, R | 1 |
| de Arriba, MDC | 1 |
| Membrilla, JA | 1 |
| Sigüenza, AI | 1 |
| Mascías, J | 1 |
| García, M | 1 |
| Quintana, L | 1 |
| Esteban-Rodríguez, I | 1 |
| Hernández-Fernández, CP | 1 |
| Illera, N | 1 |
| Duarte, B | 1 |
| Guerrero-Aspizúa, S | 1 |
| Woodley, DT | 1 |
| Del Río, M | 1 |
| de Lucas, R | 1 |
| Larcher, F | 1 |
| Escámez, MJ | 1 |
| Bidou, L | 2 |
| Hatin, I | 1 |
| Perez, N | 1 |
| Allamand, V | 2 |
| Panthier, JJ | 1 |
| Rousset, JP | 2 |
| Shiozuka, M | 2 |
| Arakawa, M | 2 |
| Matsuda, R | 2 |
| Floquet, C | 1 |
| Paturneau-Jouas, M | 1 |
| Gartioux, C | 1 |
| Butler-Browne, GS | 1 |
| Mouly, V | 1 |
| Ikeda, D | 1 |
| Guicheney, P | 1 |
| Mankin, AS | 1 |
| Liebman, SW | 1 |
1 review available for gentamicin and Muscular Dystrophies
| Article | Year |
|---|---|
[Possible chemotherapy of muscular dystrophy caused by nonsense mutation].
Topics: Amino Acids, Diamino; Animals; Gentamicins; Humans; Muscular Dystrophies; Protein Biosynthesis | 2004 |
4 other studies available for gentamicin and Muscular Dystrophies
| Article | Year |
|---|---|
Evaluation of Systemic Gentamicin as Translational Readthrough Therapy for a Patient With Epidermolysis Bullosa Simplex With Muscular Dystrophy Owing to PLEC1 Pathogenic Nonsense Variants.
Topics: Epidermolysis Bullosa Simplex; Female; Gentamicins; Humans; Muscular Dystrophies; Muscular Dystrophi | 2022 |
Premature stop codons involved in muscular dystrophies show a broad spectrum of readthrough efficiencies in response to gentamicin treatment.
Topics: 3T3 Cells; Animals; Anti-Bacterial Agents; beta-Galactosidase; Codon, Nonsense; Codon, Terminator; C | 2004 |
Drug-induced readthrough of premature stop codons leads to the stabilization of laminin alpha2 chain mRNA in CMD myotubes.
Topics: Amino Acids, Diamino; Animals; Cells, Cultured; Codon, Nonsense; Gene Expression Regulation; Genes, | 2008 |
Baby, don't stop!
Topics: Animals; Anti-Bacterial Agents; Codon, Nonsense; Genes, Bacterial; Genetic Engineering; Genetic Ther | 1999 |