gentamicin has been researched along with Muscular Dystrophies in 5 studies
Gentamicins: A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.
Muscular Dystrophies: A heterogeneous group of inherited MYOPATHIES, characterized by wasting and weakness of the SKELETAL MUSCLE. They are categorized by the sites of MUSCLE WEAKNESS; AGE OF ONSET; and INHERITANCE PATTERNS.
Excerpt | Relevance | Reference |
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"In this case report of a woman in her 30s with EBS-MD, before gentamicin treatment, the patient had mucocutaneous involvement, skeletal and respiratory muscle weakness, and myalgia that negatively affected her quality of life." | 8.12 | Evaluation of Systemic Gentamicin as Translational Readthrough Therapy for a Patient With Epidermolysis Bullosa Simplex With Muscular Dystrophy Owing to PLEC1 Pathogenic Nonsense Variants. ( de Arriba, MDC; de Lucas, R; Del Río, M; Duarte, B; Escámez, MJ; Esteban-Rodríguez, I; García, M; Guerrero-Aspizúa, S; Hernández-Fernández, CP; Illera, N; Larcher, F; Martínez-Santamaría, L; Mascías, J; Maseda, R; Membrilla, JA; Quintana, L; Sigüenza, AI; Woodley, DT, 2022) |
"The suppression levels induced by gentamicin on premature stop codons, caused by primary nonsense mutations found in muscular dystrophy patients, were assessed using a very sensitive dual reporter gene assay." | 7.72 | Premature stop codons involved in muscular dystrophies show a broad spectrum of readthrough efficiencies in response to gentamicin treatment. ( Allamand, V; Bidou, L; Hatin, I; Panthier, JJ; Perez, N; Rousset, JP, 2004) |
" In order to utilize other antibiotics with less side effects than gentamicin, we have shown that negamycin, a dipeptide antibiotic with read-through activity in prokaryotes, restored dystrophin in skeletal and cardiac muscles of mdx mouse, an animal model for Duchenne type muscular dystrophy caused by nonsense mutation." | 4.82 | [Possible chemotherapy of muscular dystrophy caused by nonsense mutation]. ( Arakawa, M; Matsuda, R; Shiozuka, M, 2004) |
"In this case report of a woman in her 30s with EBS-MD, before gentamicin treatment, the patient had mucocutaneous involvement, skeletal and respiratory muscle weakness, and myalgia that negatively affected her quality of life." | 4.12 | Evaluation of Systemic Gentamicin as Translational Readthrough Therapy for a Patient With Epidermolysis Bullosa Simplex With Muscular Dystrophy Owing to PLEC1 Pathogenic Nonsense Variants. ( de Arriba, MDC; de Lucas, R; Del Río, M; Duarte, B; Escámez, MJ; Esteban-Rodríguez, I; García, M; Guerrero-Aspizúa, S; Hernández-Fernández, CP; Illera, N; Larcher, F; Martínez-Santamaría, L; Mascías, J; Maseda, R; Membrilla, JA; Quintana, L; Sigüenza, AI; Woodley, DT, 2022) |
"The suppression levels induced by gentamicin on premature stop codons, caused by primary nonsense mutations found in muscular dystrophy patients, were assessed using a very sensitive dual reporter gene assay." | 3.72 | Premature stop codons involved in muscular dystrophies show a broad spectrum of readthrough efficiencies in response to gentamicin treatment. ( Allamand, V; Bidou, L; Hatin, I; Panthier, JJ; Perez, N; Rousset, JP, 2004) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 1 (20.00) | 18.2507 |
2000's | 3 (60.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 1 (20.00) | 2.80 |
Authors | Studies |
---|---|
Martínez-Santamaría, L | 1 |
Maseda, R | 1 |
de Arriba, MDC | 1 |
Membrilla, JA | 1 |
Sigüenza, AI | 1 |
Mascías, J | 1 |
García, M | 1 |
Quintana, L | 1 |
Esteban-Rodríguez, I | 1 |
Hernández-Fernández, CP | 1 |
Illera, N | 1 |
Duarte, B | 1 |
Guerrero-Aspizúa, S | 1 |
Woodley, DT | 1 |
Del Río, M | 1 |
de Lucas, R | 1 |
Larcher, F | 1 |
Escámez, MJ | 1 |
Bidou, L | 2 |
Hatin, I | 1 |
Perez, N | 1 |
Allamand, V | 2 |
Panthier, JJ | 1 |
Rousset, JP | 2 |
Shiozuka, M | 2 |
Arakawa, M | 2 |
Matsuda, R | 2 |
Floquet, C | 1 |
Paturneau-Jouas, M | 1 |
Gartioux, C | 1 |
Butler-Browne, GS | 1 |
Mouly, V | 1 |
Ikeda, D | 1 |
Guicheney, P | 1 |
Mankin, AS | 1 |
Liebman, SW | 1 |
1 review available for gentamicin and Muscular Dystrophies
Article | Year |
---|---|
[Possible chemotherapy of muscular dystrophy caused by nonsense mutation].
Topics: Amino Acids, Diamino; Animals; Gentamicins; Humans; Muscular Dystrophies; Protein Biosynthesis | 2004 |
4 other studies available for gentamicin and Muscular Dystrophies
Article | Year |
---|---|
Evaluation of Systemic Gentamicin as Translational Readthrough Therapy for a Patient With Epidermolysis Bullosa Simplex With Muscular Dystrophy Owing to PLEC1 Pathogenic Nonsense Variants.
Topics: Epidermolysis Bullosa Simplex; Female; Gentamicins; Humans; Muscular Dystrophies; Muscular Dystrophi | 2022 |
Premature stop codons involved in muscular dystrophies show a broad spectrum of readthrough efficiencies in response to gentamicin treatment.
Topics: 3T3 Cells; Animals; Anti-Bacterial Agents; beta-Galactosidase; Codon, Nonsense; Codon, Terminator; C | 2004 |
Drug-induced readthrough of premature stop codons leads to the stabilization of laminin alpha2 chain mRNA in CMD myotubes.
Topics: Amino Acids, Diamino; Animals; Cells, Cultured; Codon, Nonsense; Gene Expression Regulation; Genes, | 2008 |
Baby, don't stop!
Topics: Animals; Anti-Bacterial Agents; Codon, Nonsense; Genes, Bacterial; Genetic Engineering; Genetic Ther | 1999 |