gentamicin has been researched along with Mediastinitis in 18 studies
Gentamicins: A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.
Mediastinitis: Inflammation of the mediastinum, the area between the pleural sacs.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The addition of a retrosternal gentamicin-releasing sponge further reduces the rate of mediastinitis." | 7.88 | Effect of chlorhexidine skin disinfection and retrosternal gentamicin sponge on post-sternotomy mediastinitis: results from a prospective controlled registry of 2340 patients. ( Birkner, C; Ghazy, T; Madej, T; Mahlmann, A; Matschke, K; Plötze, K; Waldow, T, 2018) |
| "We report a case of mediastinitis successfully treated with autovaccine therapy, once conventional surgical and medical therapies had failed." | 1.34 | Efficacy of autovaccination therapy on post-coronary artery bypass grafting methicillin-resistant Staphylococcus aureus mediastinitis. ( Brancaccio, G; De Vito, D; Rizzo, C; Rizzo, G, 2007) |
| "Descending necrotizing mediastinitis which may occur as a complication of neglected oropharynx infection is an uncommon disease, although it is lethal in most cases." | 1.30 | [Descending necrotizing mediastinitis. A case report]. ( al Aziz, S; Benosman, A; el Meslout, A; Kabiri, H; Manesouri, M; Smahi, M, 1999) |
| "Experience with closed mediastinitis management was also analysed." | 1.28 | [Prevention and treatment of infectious complications in myocardial revascularization]. ( Akchurin, RS; Dolgov, IM; Galiautdinov, DM; Shiriaev, AA, 1992) |
| " We sought to determine the degree of absorption and risk of either inadequate or toxic blood levels that might follow gentamicin absorption." | 1.28 | Gentamicin solution for mediastinal irrigation: systemic absorption, bactericidal activity, and toxicity. ( Finlayson, DC; Hall, RI; Jones, EL; Kopel, ME; Lampasona, V; Mullins, R; Riemersma, L; Tobia, V, 1989) |
| "100 suffered from mediastinitis, and 4 p." | 1.26 | [Prevention of post-operative infection in heart surgery with extracorporeal circulation (apropos of 295 cases)]. ( Coulombe, G; Hubscher, C; Laborde, F; Oksenhendler, G; Soyer, R; Winckler, C, 1979) |
| "Twenty-three cases of mediastinitis after cardiac surgery in children were treated by us between 1973 and 1976." | 1.26 | Treatment of mediastinitis in children after cardiac surgery. A study of 20 cases. ( Barois, A; Bourda, JL; Chapuis, C; Combes, A; Goulon, M; Grosbuis, S; Simon, N, 1978) |
| "A case of mediastinitis occurred following perforation of the pharynx by a pencil." | 1.25 | Mediastinitis in a child caused by perforation of pharynx. ( Emanuel, B; North, J, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (33.33) | 18.7374 |
| 1990's | 3 (16.67) | 18.2507 |
| 2000's | 4 (22.22) | 29.6817 |
| 2010's | 5 (27.78) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Waldow, T | 1 |
| Ghazy, T | 1 |
| Madej, T | 1 |
| Plötze, K | 1 |
| Birkner, C | 1 |
| Mahlmann, A | 1 |
| Matschke, K | 1 |
| Kowalewski, M | 1 |
| Pawliszak, W | 1 |
| Zaborowska, K | 1 |
| Navarese, EP | 1 |
| Szwed, KA | 1 |
| Kowalkowska, ME | 1 |
| Kowalewski, J | 1 |
| Borkowska, A | 1 |
| Anisimowicz, L | 1 |
| Lazar, HL | 1 |
| Friberg, O | 2 |
| Dahlin, LG | 1 |
| Källman, J | 2 |
| Kihlström, E | 1 |
| Söderquist, B | 2 |
| Svedjeholm, R | 1 |
| Godbole, G | 1 |
| Pai, V | 1 |
| Kolvekar, S | 1 |
| Wilson, AP | 1 |
| Hajj-Chahine, J | 1 |
| Jacques, T | 1 |
| Hassan, H | 1 |
| Emilie, B | 1 |
| Jones, I | 1 |
| Sjöberg, L | 1 |
| Vikerfors, T | 1 |
| Eklund, AM | 1 |
| Valtonen, M | 1 |
| Werkkala, KA | 1 |
| Rizzo, C | 1 |
| Brancaccio, G | 1 |
| De Vito, D | 1 |
| Rizzo, G | 1 |
| Economopoulos, GC | 1 |
| Scherzer, HH | 1 |
| Gryboski, WA | 1 |
| Nomori, H | 1 |
| Horio, H | 1 |
| Kobayashi, R | 1 |
| Kabiri, H | 1 |
| Manesouri, M | 1 |
| Smahi, M | 1 |
| al Aziz, S | 1 |
| el Meslout, A | 1 |
| Benosman, A | 1 |
| Hubscher, C | 1 |
| Coulombe, G | 1 |
| Oksenhendler, G | 1 |
| Laborde, F | 1 |
| Soyer, R | 1 |
| Winckler, C | 1 |
| Barois, A | 1 |
| Grosbuis, S | 1 |
| Simon, N | 1 |
| Combes, A | 1 |
| Bourda, JL | 1 |
| Chapuis, C | 1 |
| Goulon, M | 1 |
| North, J | 1 |
| Emanuel, B | 1 |
| Akchurin, RS | 1 |
| Shiriaev, AA | 1 |
| Galiautdinov, DM | 1 |
| Dolgov, IM | 1 |
| Kopel, ME | 1 |
| Riemersma, L | 1 |
| Finlayson, DC | 1 |
| Tobia, V | 1 |
| Jones, EL | 1 |
| Hall, RI | 1 |
| Mullins, R | 1 |
| Lampasona, V | 1 |
| Astrozhnikov, IuV | 1 |
| Bogomolova, NS | 1 |
| Vinogradova, LN | 1 |
| Gorel'chenkova, VG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Topical Gentamicin and Vancomycin for Surgical Site Infection Prophylaxis in Patients Undergoing High-Risk Vascular Surgery[NCT04238923] | Phase 2/Phase 3 | 356 participants (Anticipated) | Interventional | 2020-05-01 | Not yet recruiting | ||
| Local Application of Collagen-Gentamicin in Addition to Fixation of the Sternum With Extra Sternal Wires for Prevention of Sternal Wound Infection in Cardiac Surgery[NCT00484055] | 1,358 participants (Actual) | Interventional | 2007-01-31 | Completed | |||
| A Randomized, Controlled, Phase 4 Study of Sternal Plating (Rapid Sternal Closure System, KLS Martin L.P.) in Cardiac Surgical Subjects at Higher Risk for Sternal Wound Complications.[NCT00638014] | Phase 4 | 51 participants (Actual) | Interventional | 2008-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The Data and Safety Monitoring Board reviewed source documents for all cases with possible sternal wound infection and sternal instability or non-union and made a determination as to the presence of these complications. (NCT00638014)
Timeframe: Up to 180 days
| Intervention | Participants (Number) |
|---|---|
| Conventional Wires Only | 1 |
| Talon | 1 |
Maximum incentive spirometry volume was measured at baseline (prior to surgery) and daily from postoperative day 1 through postoperative day 7 (or discharge if earlier) using a Coach 2 incentive spirometer with one way valve (Coach 2 model # 22-4000, Smiths Medical, Keene, NH). (NCT00638014)
Timeframe: Baseline, Maximum value during postoperatively days 1 thru 7
| Intervention | percentage change (Mean) |
|---|---|
| Conventional Wires Only | 58 |
| Talon | 67 |
2 reviews available for gentamicin and Mediastinitis
| Article | Year |
|---|---|
Gentamicin-collagen sponge reduces the risk of sternal wound infections after heart surgery: Meta-analysis.
Topics: Anti-Bacterial Agents; Cardiac Surgical Procedures; Chi-Square Distribution; Drug Carriers; Gentamic | 2015 |
Use of gentamicin-collagen sponges in closure of sternal wounds in cardiothoracic surgery to reduce wound infections.
Topics: Anti-Bacterial Agents; Benchmarking; Cardiac Surgical Procedures; Collagen; Drug Implants; Drug Resi | 2012 |
2 trials available for gentamicin and Mediastinitis
| Article | Year |
|---|---|
Collagen-gentamicin implant for prevention of sternal wound infection; long-term follow-up of effectiveness.
Topics: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Antibiotic Prophylaxis; Chemistry, Pharmaceut | 2009 |
Prophylaxis of sternal wound infections with gentamicin-collagen implant: randomized controlled study in cardiac surgery.
Topics: Analysis of Variance; Antibiotic Prophylaxis; Coronary Artery Bypass; Drug Implants; Female; Gentami | 2005 |
14 other studies available for gentamicin and Mediastinitis
| Article | Year |
|---|---|
Effect of chlorhexidine skin disinfection and retrosternal gentamicin sponge on post-sternotomy mediastinitis: results from a prospective controlled registry of 2340 patients.
Topics: Adult; Aged; Aged, 80 and over; Animals; Anti-Bacterial Agents; Chemoprevention; Chlorhexidine; Fema | 2018 |
Topical antibiotics help to reduce sternal infections.
Topics: Anti-Bacterial Agents; Cardiac Surgical Procedures; Drug Carriers; Gentamicins; Humans; Mediastiniti | 2015 |
eComment: do gentamicin-collagen sponges decrease the risk of mediastinitis?
Topics: Anti-Bacterial Agents; Cardiac Surgical Procedures; Collagen; Gentamicins; Humans; Mediastinitis; St | 2012 |
Antibiotic concentrations in serum and wound fluid after local gentamicin or intravenous dicloxacillin prophylaxis in cardiac surgery.
Topics: Adult; Aged; Aged, 80 and over; Antibiotic Prophylaxis; Biological Availability; Cardiac Surgical Pr | 2003 |
Efficacy of autovaccination therapy on post-coronary artery bypass grafting methicillin-resistant Staphylococcus aureus mediastinitis.
Topics: Aged; Anti-Bacterial Agents; Anti-Infective Agents, Local; Coronary Artery Bypass; Coronary Stenosis | 2007 |
Successful management of mediastinitis, pleural empyema, and aortopulmonary fistula from odontogenic infection.
Topics: Adult; Aortic Diseases; Drainage; Empyema; Fistula; Focal Infection, Dental; Gentamicins; Hematoma; | 1983 |
Descending necrotizing mediastinitis secondary to pharyngitis. A case report.
Topics: Adult; Clindamycin; Combined Modality Therapy; Drainage; Drug Therapy, Combination; Female; Gentamic | 1997 |
[Descending necrotizing mediastinitis. A case report].
Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Clavulanic Acid; Drainage; Drug Therapy, Combination; Fem | 1999 |
[Prevention of post-operative infection in heart surgery with extracorporeal circulation (apropos of 295 cases)].
Topics: Adolescent; Adult; Aged; Asepsis; Bacterial Infections; Cardiac Surgical Procedures; Cephradine; Cro | 1979 |
Treatment of mediastinitis in children after cardiac surgery. A study of 20 cases.
Topics: Child; Child, Preschool; Gentamicins; Heart Defects, Congenital; Humans; Infant; Infusions, Parenter | 1978 |
Mediastinitis in a child caused by perforation of pharynx.
Topics: Abscess; Ampicillin; Child, Preschool; Citrobacter; Emphysema; Enterobacter; Gentamicins; Humans; Kl | 1975 |
[Prevention and treatment of infectious complications in myocardial revascularization].
Topics: Cefazolin; Cefotaxime; Combined Modality Therapy; Drainage; Drug Therapy, Combination; Gentamicins; | 1992 |
Gentamicin solution for mediastinal irrigation: systemic absorption, bactericidal activity, and toxicity.
Topics: Absorption; Adult; Aged; Aged, 80 and over; Body Surface Area; Body Weight; Creatinine; Female; Gent | 1989 |
[Use of getamicin in reconstructive surgery].
Topics: Abscess; Adult; Bacterial Infections; Child; Cholangitis; Empyema; Escherichia coli; Gentamicins; Hu | 1974 |