Page last updated: 2024-10-27

gentamicin and Kernicterus

gentamicin has been researched along with Kernicterus in 2 studies

Gentamicins: A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.

Kernicterus: A term used pathologically to describe BILIRUBIN staining of the BASAL GANGLIA; BRAIN STEM; and CEREBELLUM and clinically to describe a syndrome associated with HYPERBILIRUBINEMIA. Clinical features include athetosis, MUSCLE SPASTICITY or hypotonia, impaired vertical gaze, and DEAFNESS. Nonconjugated bilirubin enters the brain and acts as a neurotoxin, often in association with conditions that impair the BLOOD-BRAIN BARRIER (e.g., SEPSIS). This condition occurs primarily in neonates (INFANT, NEWBORN), but may rarely occur in adults. (Menkes, Textbook of Child Neurology, 5th ed, p613)

Research Excerpts

ExcerptRelevanceReference
" The toxicity of the additives has already a negative influence on the LD50 for heterozygous Gunn rats when the low dosed Refobacin and Sulmicin vials are given."1.26The influence of various aminoglycoside preparations on bilirubin/albumin binding. ( Ballowitz, L; Hanefeld, F; Schmid, F, 1976)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19902 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ballowitz, L1
Hanefeld, F1
Schmid, F1
Windorfer, A1
Mihailova, K1
Pringsheim, W1

Other Studies

2 other studies available for gentamicin and Kernicterus

ArticleYear
The influence of various aminoglycoside preparations on bilirubin/albumin binding.
    Journal of perinatal medicine, 1976, Volume: 4, Issue:3

    Topics: Aminoglycosides; Animals; Animals, Newborn; Benzoates; Benzyl Alcohols; Bilirubin; Drug Stability; G

1976
[Does drug therapy increase the dangers of bilirubin encephalopathy during the newborn period?].
    Deutsche medizinische Wochenschrift (1946), 1973, Jun-22, Volume: 98, Issue:25

    Topics: Ampicillin; Bilirubin; Blood; Carbenicillin; Cephalothin; Child, Preschool; Colistin; Diazepam; Eryt

1973