gentamicin has been researched along with Kernicterus in 2 studies
Gentamicins: A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.
Kernicterus: A term used pathologically to describe BILIRUBIN staining of the BASAL GANGLIA; BRAIN STEM; and CEREBELLUM and clinically to describe a syndrome associated with HYPERBILIRUBINEMIA. Clinical features include athetosis, MUSCLE SPASTICITY or hypotonia, impaired vertical gaze, and DEAFNESS. Nonconjugated bilirubin enters the brain and acts as a neurotoxin, often in association with conditions that impair the BLOOD-BRAIN BARRIER (e.g., SEPSIS). This condition occurs primarily in neonates (INFANT, NEWBORN), but may rarely occur in adults. (Menkes, Textbook of Child Neurology, 5th ed, p613)
| Excerpt | Relevance | Reference |
|---|---|---|
| " The toxicity of the additives has already a negative influence on the LD50 for heterozygous Gunn rats when the low dosed Refobacin and Sulmicin vials are given." | 1.26 | The influence of various aminoglycoside preparations on bilirubin/albumin binding. ( Ballowitz, L; Hanefeld, F; Schmid, F, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ballowitz, L | 1 |
| Hanefeld, F | 1 |
| Schmid, F | 1 |
| Windorfer, A | 1 |
| Mihailova, K | 1 |
| Pringsheim, W | 1 |
2 other studies available for gentamicin and Kernicterus
| Article | Year |
|---|---|
The influence of various aminoglycoside preparations on bilirubin/albumin binding.
Topics: Aminoglycosides; Animals; Animals, Newborn; Benzoates; Benzyl Alcohols; Bilirubin; Drug Stability; G | 1976 |
[Does drug therapy increase the dangers of bilirubin encephalopathy during the newborn period?].
Topics: Ampicillin; Bilirubin; Blood; Carbenicillin; Cephalothin; Child, Preschool; Colistin; Diazepam; Eryt | 1973 |